2015 Group Project 1

2015 Student Projects
2015 Projects: Three Person Embryos | Ovarian Hyper-stimulation Syndrome | Polycystic Ovarian Syndrome | Male Infertility | Oncofertility | Preimplantation Genetic Diagnosis | Students
2015 Group Project Topic - Assisted Reproductive Technology
This page is an undergraduate science embryology student and may contain inaccuracies in either description or acknowledgements.

Possible topics

Your own selected topic (consult coordinator)

oocyte quality

spermatozoa quality

frozen oocytes

in vitro oocyte development

assisted hatching

cryopreserved ovarian tissue

3 person embryos

fertility drugs

Three Person Embryos

(intro) Here is a good source for overview and status of 3 Person IVF. http://www.geneticsandsociety.org/article.php?id=6527

Benefits

PMID 25629662 Mitocondrial donation--how many women could benefit? This is a statistical analysis of the prevalence of women of child bearing age that have pathogenic mutation to their mitochondria that could benefit from mitochondrial donation in the UK. And the affects of the mitochondrial mutation on fertility as compared to background natural birth rate. They found no difference in fertility rates and 4% of women at risk of passing on symptomatic mitochondrial disease.

Methods

PMID 20393463 Pronuclear tranfer in human embryos to prevent transmition of mitochondrial DNA disease As the name suggest this paper looks at pronuclear transfer as way to remove donor mitochondria measured by mt-DNA. And it effectiveness in doing so. And the processes that occur in the oocyte when this method is used.

Further Reading

useful publications:

PMID: 23608245 The ethics of creating children with three genetic parents.

PMID: 24382342 Three-Parent IVF: Gene Replacement for the Prevention of Inherited Mitochondrial Diseases.

PMID: 20933103 Mitochondrial function in the human oocyte and embryo and their role in developmental competence.

PMID: 26020522 Mitochondrial reshaping accompanies neural differentiation in the developing spinal cord.

PMID: 25421171 The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility.

PMID: 26239841 The ethical challenges of the clinical introduction of mitochondrial replacement techniques.

PMID: 21059727 Ethics of mitochondrial gene replacement: from bench to bedside.

PMID: 25888328 Mitochondrial replacement to prevent the transmission of mitochondrial DNA disease.

PMID: 25859028 Medicine. Transatlantic lessons in regulation of mitochondrial replacement therapy.

PMID: 25807984 Risks inherent to mitochondrial replacement.