2015 Group Project 1: Difference between revisions

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=History=
=History=
Case of Alana Saarinen???


=Benefits=
=Benefits=

Revision as of 12:44, 28 August 2015

2015 Student Projects 
2015 Projects: Three Person Embryos | Ovarian Hyper-stimulation Syndrome | Polycystic Ovarian Syndrome | Male Infertility | Oncofertility | Preimplantation Genetic Diagnosis | Students
2015 Group Project Topic - Assisted Reproductive Technology
This page is an undergraduate science embryology student and may contain inaccuracies in either description or acknowledgements.

Possible topics

Your own selected topic (consult coordinator)

oocyte quality

spermatozoa quality

frozen oocytes

in vitro oocyte development

assisted hatching

cryopreserved ovarian tissue

3 person embryos

fertility drugs


Three Person Embryos

(intro) Here is a good source for overview and status of 3 Person IVF. http://www.geneticsandsociety.org/article.php?id=6527

History

Case of Alana Saarinen???

Benefits

PMID 25629662 Mitochondrial donation--how many women could benefit?[1] This is a statistical analysis of the prevalence of women of child bearing age that have pathogenic mutation to their mitochondria that could benefit from mitochondrial donation in the UK. And the affects of the mitochondrial mutation on fertility as compared to background natural birth rate. They found no difference in fertility rates and 4% of women at risk of passing on symptomatic mitochondrial disease.

PMID 18674747 Pathogenic mitochondrial DNA mutations are common in the general population.[2] Another on the prevalence of mitochondrial mutations in the populous. This time via mtDNA sequencing from umbilical samples from live births, looking for ten specific mt-DNA mutations. It found a frequency rate of 0.54% for these mutations. Although they had limited data on the prevalence of these mutations maternally.

Methods

PMID 20393463 Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease[3] As the name suggest this paper looks at pronuclear transfer as way to remove donor mitochondria measured by mt-DNA. And it effectiveness in doing so. And the processes that occur in the oocyte when this method is used.

Ethics

1.PMID 26239841 The ethical challenges of the clinical introduction of mitochondrial replacement techniques. [4] The first part of the paper evaluates the three concerns about the safety of mitochondrial replacement techniques including whether it is ethical; persons with three genetic contributors and the trust of society. And then, two recommendations are made.

2.PMID 21059727 Ethics of mitochondrial gene replacement: from bench to bedside. [5] Both of the risks and benefits are accessed in this paper after the briefly introduction of mitochondrial replacement techniques. And then the question of when are enough safeguards made to justify introducing mitochondrial gene replacement into the clinic is discussed.

3.PMID 25888328 Mitochondrial replacement to prevent the transmission of mitochondrial DNA disease. [6] This paper discussed about the ethics and feasibility of mitochondrial replacement techniques. The possibility of preventing the transmission of mtDNA disease by MRT is first discussed. Moreover, the four big challenges mainly ethics are discussed.

Legal Status

Further Reading

useful publications:

PMID: 23608245 The ethics of creating children with three genetic parents. [7]

PMID: 24382342 Three-Parent IVF: Gene Replacement for the Prevention of Inherited Mitochondrial Diseases.[8]

PMID: 20933103 Mitochondrial function in the human oocyte and embryo and their role in developmental competence.[9]

PMID: 26020522 Mitochondrial reshaping accompanies neural differentiation in the developing spinal cord.[10]

PMID: 25421171 The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility.[11]

PMID: 25807984 Risks inherent to mitochondrial replacement.[12]

Glossary

References

  1. <pubmed> 25629662 </pubmed>
  2. <pubmed> 18674747 </pubmed>
  3. <pubmed> 20393463 </pubmed>
  4. <pubmed>26239841</pubmed>
  5. <pubmed>21059727</pubmed>
  6. <pubmed>25888328</pubmed>
  7. <pubmed> 23608245</pubmed>
  8. <pubmed> 24382342</pubmed>
  9. <pubmed> 20933103 </pubmed>
  10. <pubmed> 26020522 </pubmed>
  11. <pubmed> 25421171</pubmed>
  12. <pubmed> 25807984</pubmed>

External Links