2014 Group Project 8: Difference between revisions
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==Background Embryonic development== | ==Background Embryonic development== | ||
Mesenchymal progenitor cells from somites(occiptal, cervical, thoracic, lumbar, sacral), undergo multiple differentiation stages to create muscle fibers. | Mesenchymal progenitor cells from somites(occiptal, cervical, thoracic, lumbar, sacral), undergo multiple differentiation stages to create muscle fibers. | ||
http://www.mdconsult.com/books/figure.do?figure=true&eid=4-u1.0-B978-1-4377-2002-0..00015-1--f0025§ionEid=4-u1.0-B978-1-4377-2002-0..00015-1&isbn=978-1-4377-2002-0&uniqId=464007141-2 (demonstration of myotomes in week 6 and 8) | |||
==Second Trimester Muscular development== | |||
Cranial muscles originate from head mesoderm | Cranial muscles originate from head mesoderm | ||
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4th Arch: Levator Palatini, Intrinsic Muscles of Larynx and Pharynx | 4th Arch: Levator Palatini, Intrinsic Muscles of Larynx and Pharynx | ||
Myotomes from Somites (From lect) | |||
C3,4,5: supply the diaphragm for breathing. | |||
C5: supply shoulder muscles and muscles to bend our elbow. | |||
C6: for bending the wrist back. | |||
C7: for straightening the elbow. | |||
C8: bends the fingers. | |||
T1: spreads the fingers. | |||
T1-T12: supplies the chest wall and abdominal muscles. | |||
L2: bends the hip. | |||
L3: straightens the knee. | |||
L4: pulls the foot up. | |||
L5: wiggles the toes. | |||
S1: pulls the foot down. | |||
S3,4,5: supply the bladder, bowel, sex organs, anal and other pelvic muscles. | |||
==Third Trimester Muscular development== | ==Third Trimester Muscular development== | ||
Revision as of 11:55, 17 September 2014
| 2014 Student Projects | ||||
|---|---|---|---|---|
| 2014 Student Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7 | Group 8 | ||||
| The Group assessment for 2014 will be an online project on Fetal Development of a specific System.
This page is an undergraduate science embryology student and may contain inaccuracies in either description or acknowledgements. | ||||
Musculoskeletal
--Mark Hill (talk) 15:21, 26 August 2014 (EST) OK you have nothing here, not even a project title (that I added). I will be asking your group questions in the lab tomorrow. How about some content, references, sources for each section. See Lab 3 Assessment.
Making Gains
For all you big boys out there who want to get jacked this is where it all starts in 2 easy steps. To be expanded upon...THIS IS NOT BROSCIENCE
Muscle development General Timeline
Background Embryonic development
Mesenchymal progenitor cells from somites(occiptal, cervical, thoracic, lumbar, sacral), undergo multiple differentiation stages to create muscle fibers.
http://www.mdconsult.com/books/figure.do?figure=true&eid=4-u1.0-B978-1-4377-2002-0..00015-1--f0025§ionEid=4-u1.0-B978-1-4377-2002-0..00015-1&isbn=978-1-4377-2002-0&uniqId=464007141-2 (demonstration of myotomes in week 6 and 8)
Second Trimester Muscular development
Cranial muscles originate from head mesoderm
1st Arch Muscles for Mastication:
2nd Arch Muscles for Facial Expression:
3rd Arch: Stylopharyngeus
4th Arch: Levator Palatini, Intrinsic Muscles of Larynx and Pharynx
Myotomes from Somites (From lect) C3,4,5: supply the diaphragm for breathing. C5: supply shoulder muscles and muscles to bend our elbow. C6: for bending the wrist back. C7: for straightening the elbow. C8: bends the fingers. T1: spreads the fingers. T1-T12: supplies the chest wall and abdominal muscles. L2: bends the hip. L3: straightens the knee. L4: pulls the foot up. L5: wiggles the toes. S1: pulls the foot down. S3,4,5: supply the bladder, bowel, sex organs, anal and other pelvic muscles.
Third Trimester Muscular development
NeoNatal
Not all embryonic muscle fibers persist; many of them fail to establish themselves as necessary units of the muscle and soon degenerate. (Moore: The Developing Human, 9th ed.)
Histological Development
Primary myofibers develop in first trimester, Secondary myofibers develop during Second and Third Trimester We should do a brief overview of primary myofiber formation, and extensive overview of secondary myofiber formation)
Muscle Fiber types
slow twitch (Type I) fast twitch (Type IIa) fast twitch (Type IIb)
For fiber types I think we should only do that of the skeletal muscle fiber types since cardiac and smooth muscle are not part of the musculo-skeletal system
Abnormalities
References
Anatomy and variations of palmaris longus in fetuses.[1]
Development of the rectus abdominis and its sheath in the human fetus.[2]
Sonic hedgehog acts cell-autonomously on muscle precursor cells to generate limb muscle diversity.[3]
The normal growth of the biceps brachii muscle in human fetuses.[4]
Abnormalities
1 Scoliosis 2. Duchenne Muscular Dystrophy 3. Syndactyly : split-hand malformation
R Geoffrey Burwell, Peter H Dangerfield, Alan Moulton and Theodoros B Grivas. (2011). Adolescent idiopathic scoliosis (AIS), environment, exposome and epigenetics: a molecular perspective of postnatal normal spinal growth and the etiopathogenesis of AIS with consideration of a network . Scoliosis. 6 (6), p1-26
(links: http://www.scoliosisjournal.com/content/6/1/26)
Patrizia Pessina, Daniel Cabrera, María Gabriela Morales, Cecilia A Riquelme, Jaime Gutiérrez, Antonio L Serrano, Enrique Brandan and Pura Muñoz-Cánoves. (2014). Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy. Skeletal Muscle. 4 (7), p1-17
(links: http://www.skeletalmusclejournal.com/content/4/1/7)
Naeimeh Tayebi, Aleksander Jamsheer34, Ricarda Flöttmann1, Anna Sowinska-Seidler, Sandra C Doelken. (2014). Deletions of exons with regulatory activity at the DYNC1I1 locus are associated with split-hand/split-foot malformation: array CGH screening of 134 unrelated families. Orphanet Journal of Rare Disease. 9 (108), p1-9
(links: http://www.ojrd.com/content/9/1/108)
