2014 Group Project 7
| 2014 Student Projects | ||||
|---|---|---|---|---|
| 2014 Student Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7 | Group 8 | ||||
| The Group assessment for 2014 will be an online project on Fetal Development of a specific System.
This page is an undergraduate science embryology student and may contain inaccuracies in either description or acknowledgements. | ||||
Neural - CNS
--Mark Hill (talk) 15:19, 26 August 2014 (EST) OK you have nothing here, not even a project title (that I added). I will be asking your group questions in the lab tomorrow. How about some content, references, sources for each section. See Lab 3 Assessment.
Introduction
Research History/Historic findings
<pubmed>19339620</pubmed> <pubmed>8005032</pubmed> <pubmed>9311417</pubmed> <pubmed>17848161</pubmed>
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Development during fetal period
<pubmed>21042938</pubmed> <pubmed>12060827</pubmed> <pubmed>23727529</pubmed> <pubmed>16905335</pubmed> <pubmed>17848161</pubmed> <pubmed>18760424</pubmed> <pubmed>16971596</pubmed> <pubmed>17032846</pubmed>
timeline: (1) First trimester development: Neurulation = ectoderm (outer layer) forms initial structure of the CNS, and folds upon itself to form neural tube towards the end of week 3. The head portion of the neural tube becomes the brain and the middle portion becomes the brain stem. The head (cephalic) portion further differentiates into the forebrain, midbrain and hindbrain. In turn, these structures differentiate such that the rudiments of the adult brain are recognizable by the fifth week of gestation. By about the fifth week, the neural tube differentiates into the three primary structural units of the brain: the proencephalon (forebrain), the mesencephalon (midbrain) and the rhombencephalon (hindbrain). By the seventh week two additional structures are formed, creating the five primary units that will become the mature brain. The two additional structures are created when the prosencephalon and the rhombencephalon divide in two. The prosencephalon divides into the telencephalon and the diencephalon, while the rhombencephalon divides into the metencephalon and the myelencephalon.
(2) cell proliferation neurons and glia that comprise the nervous system are created begins within the germinal matrix following closure of the neural tube begins around the 40th embryonic day and completes by the sixth month of gestation
(3) cell migration primary migration: weeks 8-16 of gestation, lesser activity continuing until week 25 passive migration for cells to reach their final position
(4) cell differentiation
(5) myelination
(6) cell death (apoptosis)
Current research models and findings
<pubmed>19786578</pubmed> <pubmed>21501576</pubmed> <pubmed>21492152</pubmed> <pubmed>24664314</pubmed> <pubmed>24639464</pubmed> <pubmed>24284205</pubmed> <pubmed>24177053</pubmed> <pubmed>24051984</pubmed> <pubmed>24996922</pubmed>
Abnormalities
<pubmed>12454899</pubmed> <pubmed>25007063</pubmed> <pubmed>16530991</pubmed> <pubmed>7504639</pubmed> <pubmed>19651588</pubmed> <pubmed>25135350</pubmed> <pubmed>25128525</pubmed> <pubmed>24397701</pubmed>
