Difference between revisions of "2014 Group Project 4"

From Embryology
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==System Development==
 
==System Development==
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{| class="wikitable"
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|-
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! Weeks !! Female !! Male
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|-
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| FERTILIZATION || both male and female are same at this point- only difference is presence of XY or XX chromosome
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|-
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|WEEKS 1-7 || GENITAL DEVELOPMENT IS UNDIFFERENTIATED. gonads derived from: * mesothelium lining posterior abdominal wall *underlying mesenchyme *primordial germ cells.
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|-
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| WEEK 5 || '''development of indifferent gonads''' * thickened area of mesothelium develops on medial side of mesonephros [primitive kidney] * this + proliferation of underlying mesenchyme = gonadal ridge * fingerlike epithelial chords = gonadal chords
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* gonad = cortex + medulla
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|-
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|WEEK 8 || seminiferous tubules begin to release androgens ||
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|-
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|WEEK 10 || || rudimental rete ovarii forms from indifferent gonads
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|-
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|WEEK 12 || *testosterone determining factor induces '''seminiferous chords''' from indifferent gonads --> branch to '''rete testis'''
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* tunica albiguinea develops
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|-
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|WEEK 16 ||  || primordial follicles begin to develop
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|
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|}
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Genital system development is an extremely interesting area of embryology as it is not until the later stages of embryogenesis (around week 4-6) that sexual differentiation occurs in the fetus, and the sexual organs actually look very similar up until this point, and the formation of the correct sex organs depend really on whether the genital ridge releases Testosterone or oestrogen  
 
Genital system development is an extremely interesting area of embryology as it is not until the later stages of embryogenesis (around week 4-6) that sexual differentiation occurs in the fetus, and the sexual organs actually look very similar up until this point, and the formation of the correct sex organs depend really on whether the genital ridge releases Testosterone or oestrogen  
  

Revision as of 22:54, 16 September 2014

2014 Student Projects
2014 Student Projects: Group 1 | Group 2 | Group 3 | Group 4 | Group 5 | Group 6 | Group 7 | Group 8
The Group assessment for 2014 will be an online project on Fetal Development of a specific System.

This page is an undergraduate science embryology student and may contain inaccuracies in either description or acknowledgements.

Genital

--Mark Hill (talk) 15:13, 26 August 2014 (EST) No sub-headings yet and I even had to add your project title! Get moving.

--Mark Hill (talk) 11:53, 6 September 2014 (EST) Just references not much else here yet.

System Development

Weeks Female Male
FERTILIZATION both male and female are same at this point- only difference is presence of XY or XX chromosome
WEEKS 1-7 GENITAL DEVELOPMENT IS UNDIFFERENTIATED. gonads derived from: * mesothelium lining posterior abdominal wall *underlying mesenchyme *primordial germ cells.
WEEK 5 development of indifferent gonads * thickened area of mesothelium develops on medial side of mesonephros [primitive kidney] * this + proliferation of underlying mesenchyme = gonadal ridge * fingerlike epithelial chords = gonadal chords
  • gonad = cortex + medulla
WEEK 8 seminiferous tubules begin to release androgens
WEEK 10 rudimental rete ovarii forms from indifferent gonads
WEEK 12 *testosterone determining factor induces seminiferous chords from indifferent gonads --> branch to rete testis
  • tunica albiguinea develops
WEEK 16 primordial follicles begin to develop

Genital system development is an extremely interesting area of embryology as it is not until the later stages of embryogenesis (around week 4-6) that sexual differentiation occurs in the fetus, and the sexual organs actually look very similar up until this point, and the formation of the correct sex organs depend really on whether the genital ridge releases Testosterone or oestrogen

<pubmed>24240231</pubmed> <pubmed>24928207</pubmed> <pubmed>24741072</pubmed> --Z3416697 (talk) 20:06, 26 August 2014 (EST)

Current Research Models and Findings

--Z3417753 (talk) 22:43, 26 August 2014 (EST)

<pubmed>18367374</pubmed> <pubmed>15086026</pubmed> <pubmed>14641326</pubmed> <pubmed>11684660</pubmed> <pubmed>22127979</pubmed>

Historic Finding

--Z3415716 (talk) 01:10, 27 August 2014 (EST)

<pubmed>18462432</pubmed> <pubmed>17232227</pubmed> Martyn P. L. Williams, John M. Huston The history of ideas about testicular descent. Pediatric Surgery International: 1991, 6(3):180-184 The history of ideas about testicular descent

Abnormalities

Female

Male

Cryptorchidism

Hypospadias

In males the most common congenital malformation of the external genitalia is hypospadias, it’s also the second most common developmental disorder. It occurs due to the midline fusion of the male urethra, as a result the urethral meatus is misplaced. There are several sites where this abnormality may occur: granular, penile, penoscrotal, scrotal and perineal. (3). Its believed that genetic factors contribute to the presence of the disorder, however endocrine and environmental factors are also of significance. (1) Treatment The surgical methods currently used to treat distal hypospadias, include tabularized incised plate and meatal advancement and glansplasty intergrated repair. For proximal forms two staged procedures are employed. (2)

References

--Z3417458 (talk) 21:01, 26 August 2014 (EST)

<<pubmed>24290348</pubmed>>

<<pubmed>25064170</pubmed>>

<<pubmed>23168057</pubmed>>

A review on spermatogenesis and cyptorchidism a common in males, results in an absence of testes either one or both.

<<pubmed>24829558</pubmed>>


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