2012 Group Project 5: Difference between revisions

From Embryology
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'''History'''
'''History'''
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LCA was first recongnised by Dr Theodor Leber in 1869. He published the paper ''Ueber Retinitis pigmentosa und angeborene Amaurosa''(About Retinitis pigmentosa and congenital Amaurosa) in '''Archiv fur Ophthalmologie'''(now known as Graefes Archive of clinical and experimental ophthalmology).<ref>http://www.springerlink.com/content/rmj766pjrq130011/</ref>
LCA was first recongnised by Dr Theodor Leber in 1869. He published the paper ''Ueber Retinitis pigmentosa und angeborene Amaurosa'' (About Retinitis pigmentosa and congenital Amaurosa) in '''Archiv fur Ophthalmologie''' (now known as Graefes Archive of clinical and experimental ophthalmology).<ref>http://www.springerlink.com/content/rmj766pjrq130011/</ref>


'''Research Timeline'''
'''Research Timeline'''

Revision as of 18:00, 1 September 2012

Abnormal Vision

Introduction

Normal Eye Development

Retinal Development


Abnormal development

Genetic


Leber Congenital Amaurosis


Leber Congenital Amaurosis (LCA) is an inherited retinal degenerative disorder that causes blindness or loss of sight at birth.[1]

History


LCA was first recongnised by Dr Theodor Leber in 1869. He published the paper Ueber Retinitis pigmentosa und angeborene Amaurosa (About Retinitis pigmentosa and congenital Amaurosa) in Archiv fur Ophthalmologie (now known as Graefes Archive of clinical and experimental ophthalmology).[2]

Research Timeline


From 1869-2009, the major contributers to LCA research: "Courtesy: National Eye Institute, National Institutes of Health (NEI/NIH)."

  • 1869- Dr. Theodor Leber (1840-1917), German ophthalmologist, first describes what is now known as Leber congenital amaurosis, an inherited retinal disease that causes severe visual impairment early in childhood [3]
  • 1932-34- George Wald, Ph.D. first identified vitamin A in the retina during a National Research Council fellowship in biology [4]
  • 1965- Human adeno-associated virus (AAV) was discovered.[5]


Epidemiology


LCA has a recessive pattern of inheritance where there is a 25% chance for a child to contract LCA.[6]


Aetiology


Pathology


Outcome and Treatment


New Research Development


Congenital Cataracts


Environmental


Glossary

References


External Links

External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

--Mark Hill 12:22, 15 August 2012 (EST) Please leave the content listed below the line at the bottom of your project page.


2012 Projects: Vision | Somatosensory | Taste | Olfaction | Abnormal Vision | Hearing