2012 Group Project 4

From Embryology

Olfaction Development

Introduction

The sense of smell, or otherwise known as Olfaction is the sense mediated by sensory cells located in the nasal cavity. Chemo receptors within the naval cavity are activated by chemicals in the air which are known as odorants. Odorants produce olfactory sensation at very low concentration, and through the reaction with chemoreceptors enables the sense of smell in humans. The olfactory system are often divide into a peripheral mechanism, activated by an external stimulus and transforming it into an electric signal in neurons, and a central mechanism where all signals formed by olfactory are integrated in the central nervous system and processed to recognise odour.

History of Discovery

Julius Kollmann The 2004 Nobel Prize in Physiology or Medicine was won by Linda B. Buck and Richard Axel for their work on the olfactory system.

Timeline of developmental process

Of the development of Olfaction system

Week 1

Week 2

Week 3

Week 4

Structure

During different stages of embryonic development

Normal Function

The Neurology of Smell

The Neurobiology of Olfaction

Abnormalities

Kallman Syndrome

[1]

Genetic and Molecular Basis

Characteristic Features

  • hypogonadotropic [2]
  • hypogonadism
  • anosmia

Treatment

Congenital Anosmia

Genetic and Molecular Basis

Characteristic Features

Treatment

Genes involved

Current Research

Olfactory Systems Laboratory

Glossary and Abbreviation

Olfactory bulb: The primary part of brain which processes olfactory information.

Olfactory epithelium: mucous membrane superior to the nasal cavity which contain olfactory nerve cells.

Olfactory nerve cell: Cells in the olfactory epithelium which detect various odors and signal the information to the CNS.

Pheromone: Any molecules (scent) released by animals and affect the behavior of organisms of the same species via the olfactory system.

References

  1. Schoenwolf, G. C. & Larsen, W. J. (2013). Human Embryology (4th ed.). Philadelphia, PA: Elsevier Inc.
  2. <pubmed>16932275</pubmed>


External Links

The Neural Basis of Olfaction

Development of the Olfactory System

The Development of the Olfactory System 2

General Physiology of Olfaction

Neural Development


External Links Notice - The dynamic nature of the internet may mean that some of these listed links may no longer function. If the link no longer works search the web with the link text or name. Links to any external commercial sites are provided for information purposes only and should never be considered an endorsement. UNSW Embryology is provided as an educational resource with no clinical information or commercial affiliation.

--Mark Hill 12:22, 15 August 2012 (EST) Please leave the content listed below the line at the bottom of your project page.


2012 Projects: Vision | Somatosensory | Taste | Olfaction | Abnormal Vision | Hearing