2012 Group Project 2
--Mark Hill 12:23, 15 August 2012 (EST) This is a better project title.
- Touch, Pain, Hot/Cold, Pressure Reception
History of Discoveries
Central Somatosensory Differentiation
This is just preliminary work and will be edited later:
Making Connections between Afferent Sensory Fibres and the Central Nervous System (CNS)
- Axons of primary afferent neurons extend to the spinal cord. When these afferent neurons reach the CNS, axons of these afferent neurons bifurcate and begin to extend into the Primordium of the dorsal funiculus
- the afferent axons have extended 1 segment rostrally and 1 segment caudally relative to the axons' point of entry
- the afferents start to grow within the white matter (periphery of Spinal Cord)
Stage 28 –
- unbranched afferent axonal fibres invade gray matter at the border of Dorsal horn
- axonal fibres extend rostrally and caudally and start sending fine collateral fibres into the gray matter of spinal cord (the cellular, central region of spinal cord)
- afferent fibres have extended 100-200μm into gray matter of the Dorsal Horn
Adult Central Somatosensory Pathway
- Convey information regarding the temperature of the nerve ending in the tissue
o Free nerve endings
o Ion channels responsible for action potentials are called Transient Receptor Potential channels. Their activity is modulated by temperature
- Two type, warm and cold
- Warm- 30-45
- Cold – 20 – 30
- Frequency of action potentials codes for the relevant temperature
o As temperature increases, the frequency of warm thermoreceptors increases
o As temperature decreases, the frequency of cold thermoreceptors increases.
o Warm – TYPV1 to V4
o Cold – TRPM8 and TRPA1
Some current research (2)
1. Stanfield, C. L., and W. J. Germann. 2011. Principles of human physiology. Pearson/Benjamin Cummings, San Francisco, CA.
2. Hjerling-Leffler, J., F. Marmigere, M. Heglind, A. Cederberg, M. Koltzenburg, S. Enerback, and P. Ernfors. 2005. The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes. Development 132:2623-2632.
- The thermosensitive neurons travel in the dorsal root ganglion, as with other sensory neurons such as proprioceptive, mechanosensitive and nociceptive neurons.
- DRG neurons pseudounipolar
o One process detects the stimuli in the tissues
o The other relays it into the dorsal horn
- Mixture of small-diameter, slow, unmyelinated C fibers and larger, faster Aδ fibers
- This article is great for understanding how temperature sensation works, but not to great on the embryology behind it(1)
- Another good article for a more molecular understanding(2)
- Understanding – more recent(3)
1. Patapoutian A, Peier AM, Story GM, Viswanath V. ThermoTRP channels and beyond: mechanisms of temperature sensation. Nature reviews Neuroscience. [Review]. 2003 Jul;4(7):529-39.
2. Bandell M, Macpherson LJ, Patapoutian A. From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Current opinion in neurobiology. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review]. 2007 Aug;17(4):490-7.
3. Schepers RJ, Ringkamp M. Thermoreceptors and thermosensitive afferents. Neuroscience and biobehavioral reviews. [Review]. 2010 Feb;34(2):177-84.
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--Mark Hill 12:22, 15 August 2012 (EST) Please leave the content listed below the line at the bottom of your project page.