Lecture Notice - Mark Hill

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Neural Crest Development

Introduction

The neural crest are bilaterally paired strips of cells arising in the ectoderm at the margins of the neural tube. These cells migrate to many different locations and differentiate into many cell types within the embryo. This means that many different systems (neural, skin, teeth, head, face, heart, endocrine, gastrointestinal tract) will also have a contribution fron the neural crest cells.

In the body region, neural crest cells also contribute the peripheral nervous system (both neurons and glia) consisting of sensory ganglia (dorsal root ganglia), sympathetic and parasympathetic ganglia and neural plexuses within specific tissues/organs.

In the head region, neural crest cells migrate into the pharyngeal arches (as shown in movie below) forming ectomesenchyme contributing tissues which in the body region are typically derived from mesoderm (cartilage, bone, and connective tissue). General neural development is also covered in Neural Notes.

Lecture Objectives

Human Embryo (Carnegie stage 13) caudal trunk^[1]

Understand the structures derived from ectoderm.
Understand the formation of neural folds.
Identify the initial location of neural crest cells in the trilaminar embryo.
Identify pathways of neural crest migration throughout the embryo.
To know the major tissues to which neural crest cells contribute.
To know how abnormalities in development that result from abnormal neural crest cell migration.
Understand how neural crest cells contribute to the pharyngeal arches and the head structures they form.

Textbook References

The Developing Human: Clinically Oriented Embryology (8th Edition) by Keith L. Moore and T.V.N Persaud - Moore & Persaud Chapter 4 p61-63 - p71,75, 385, 392 p393-94 (figure showing cell types); Chapter 10 The Pharyngeal Apparatus pp201 - 240,
Larsen’s Human Embryology by GC. Schoenwolf, SB. Bleyl, PR. Brauer and PH. Francis-West - Chapter 4 p74-82 - Chapter 5, experimental methods; Chapter 12 Development of the Head, the Neck, the Eyes, and the Ears pp349 - 418
Neural Crest Development

Neural Crest Migration in the Head

<Flowplayer width="408" height="320" autoplay="true">Chicken-neural crest migration 01.flv</Flowplayer>

Chicken embryo sequence shows the migration of DiI-labeled neural crest cells towards the branchial arches as the embryo. White rings indicate migration of individual cells. Each image represents 10 confocal sections separated by 10 microns.

Movie Source: Original Neural Crest movies kindly provided by Paul Kulesa.

Reference

Glossary Links

Glossary: A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z | Numbers | Symbols | Term Link

Course Content 2010

Cite this page: Hill, M.A. (2024, April 19) Embryology 2010 Lecture 12. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/2010_Lecture_12

What Links Here?

↑ <pubmed>18689800</pubmed>| Hum Mol Genet.

[1] <pubmed>18689800</pubmed>| Hum Mol Genet.

[1]