2010 Group Project 5

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Fetal Fibronectin


Fetal Fibronectin

The Fetal Fibronectin (fFN) test measures the amount of secretions of fFN from a woman's vagina and cervix. This technique is used to determine the likelihood of a premature birth occurring. Fetal fibronectin is a protein based plasma that acts as a form of glue attaching the amniotic sac to the uterine wall. Fetal fibronectin is commonly present between 22 to 35 weeks of pregnancy. It is released into the upper vagina towards the onset of labour. If the test finds fFN between this period, the woman will have a chance of going into labour. Hence, if there is no fFN found, it is most likely that they woman will not going into pre-term labour. Therefore, this test allows the woman to see if they are at risk or not.

About pre-term births

History of Fetal Fibronectin


Test Results


The FFN remains relatively very low levels throughout the first 22 weeks of gestation.The following dramatically increase of the concentration that reaches 50 ng/mL or over from 22nd week onwards associates with the increase of the incidence of preterm labor before week 37th of gastation.[1] According to a study carried out in a teaching hospital, the presence of fetal fibronectin in the cervicovaginal secretions of preterm birth symptomatic women indicates a significant risk for subsequent preterm birth while the absence of fetal fibronectin in this group of woman is a very strong indication that subsequent preterm birth is unlikely to occur.[2] The findings are ,the preterm birth (before 37 weeks of gestation) rate in the population studied was 19.1%. Fetal fibronectin predicted preterm birth with sensitivity of 63%, specificity of 95.6%, positive predictive value of 77.3%, and negative predictive value of 91.6%. A negative test accurately excluded (97.9%) the chance of subsequent birth during the three weeks interval following sampling.[2]A study with objective to determine the accuracy with which cervico-vaginal fetal fibronectin predicts preterm delivery using systematic quantitative overview of the available literature ,concludes that fetal fibronectin test is the most accurate in predicting spontaneous preterm birth within 7 to 10 days after the test of symptomatic woman before advanced cervical dilatation.A total of 26 876 women involved in the study and among asymptomatic women the best summary likelihood ratio for positive results was 5.42 for predicting birth within 7-10 days of testing, with corresponding ratio for negative results of 0.25.[3]



Further Research



  1. Akush Ginekol (Sofiia). 2010;49(2):39-42. Bulgarian.
  2. 2.0 2.1 <pubmed>8688390</pubmed>
  3. <pubmed>117763</pubmed>

2010 ANAT2341 Group Projects

Project 1 - Ultrasound | Project 2 - Chorionic villus sampling | Project 3 - Amniocentesis | Group Project 4 - Percutaneous Umbilical Cord Blood Sampling | Project 5 - Fetal Fibronectin | Project 6 - Maternal serum alpha-fetoprotein | Group Assessment Criteria

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Cite this page: Hill, M.A. (2021, July 28) Embryology 2010 Group Project 5. Retrieved from https://embryology.med.unsw.edu.au/embryology/index.php/2010_Group_Project_5

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© Dr Mark Hill 2021, UNSW Embryology ISBN: 978 0 7334 2609 4 - UNSW CRICOS Provider Code No. 00098G