Vision - Lens Development - Revision history

Z8600021 at 01:27, 25 Ocak 2024

2024-01-25T01:27:51Z

← Older revision		Revision as of 11:27, 25 Ocak 2024
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	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Lens+Embryology ''Lens Embryology'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Lens+Embryology ''Lens Embryology'']

	~~<pubmed limit=5>Lens Embryology</pubmed>~~
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	==Development Overview==		==Development Overview==

Z8600021 at 01:01, 9 Mayıs 2018

2018-05-09T01:01:22Z

← Older revision		Revision as of 11:01, 9 Mayıs 2018
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	The lens or crystalline lens or aquula (Latin, ''aquula'' = a little stream) has a key role in focussing light (with the cornea) upon the neural retina. The lens embryonic origin is from surface ectoderm of the sensory placodes that form in the head region (More? [[Placodes]]).		The lens or crystalline lens or aquula (Latin, ''aquula'' = a little stream) has a key role in focussing light (with the cornea) upon the neural retina. The lens embryonic origin is from surface ectoderm of the sensory placodes that form in the head region (More? [[Placodes]]).

	The lens focusses by refracting light as it passes through the biconvex lens, which can be altered in shape (accommodation) by surrounding ciliary muscles. These ciliary muscles are activated (contracted) by parasympathetic innervation from the ciliary ganglion itself innervated by the oculomotor nerve (Cranial Nerve III).		The lens focusses by refracting light as it passes through the biconvex lens, which can be altered in shape (accommodation) by surrounding ciliary muscles. These ciliary muscles are activated (contracted) by parasympathetic innervation from the ciliary ganglion itself innervated by the oculomotor nerve (Cranial Nerve {{CN III}}).

	The lens has recently been shown in the chicken model to not be required for specification of the iris and ciliary body.~~<ref><pubmed>~~17275804~~</pubmed></ref>~~		The lens has recently been shown in the chicken model to not be required for specification of the iris and ciliary body.{{#pmid:17275804\|PMID17275804}}


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	* '''Review - The cellular and molecular mechanisms of vertebrate lens development'''~~<ref name=PMID25406393><pubmed>~~25406393~~</pubmed></ref>~~\| ~~[http://dev.biologists.org/content/141/23/4432.full?sid=9c0c0b67-790f-42a6-8551-73876896a0d6 Development]~~ "The ocular lens is a model system for understanding important aspects of embryonic development, such as cell specification and the spatiotemporally controlled formation of a three-dimensional structure. The lens, which is characterized by transparency, refraction and elasticity, is composed of a bulk mass of fiber cells attached to a sheet of lens epithelium. Although lens induction has been studied for over 100 years, recent findings have revealed a myriad of extracellular signaling pathways and gene regulatory networks, integrated and executed by the transcription factor Pax6, that are required for lens formation in vertebrates."		* '''Review - The cellular and molecular mechanisms of vertebrate lens development'''{{#pmid:25406393\|PMID25406393}} "The ocular lens is a model system for understanding important aspects of embryonic development, such as cell specification and the spatiotemporally controlled formation of a three-dimensional structure. The lens, which is characterized by transparency, refraction and elasticity, is composed of a bulk mass of fiber cells attached to a sheet of lens epithelium. Although lens induction has been studied for over 100 years, recent findings have revealed a myriad of extracellular signaling pathways and gene regulatory networks, integrated and executed by the transcription factor Pax6, that are required for lens formation in vertebrates."
	* '''Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development'''~~<ref><pubmed>~~25184676~~</pubmed></ref>~~ "While lens development is critically dependent on the presence of the HD1 domain, it is not affected by the lack of the HD2 domain, indicating that Bcl9/9l act in this context in a β-catenin-independent manner. Furthermore, we uncover a new regulatory circuit in which Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription."
	* '''On the growth and internal structure of the human lens'''~~<ref><pubmed>~~20171212~~</pubmed></ref>~~ "Growth of the human lens and the development of its internal features are examined using in vivo and in vitro observations on dimensions, weights, cell sizes, protein gradients and other properties. In vitro studies have shown that human lens growth is biphasic, asymptotic until just after birth and linear for most of postnatal life."		* '''Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development'''{{#pmid:25184676\|PMID25184676}} "While lens development is critically dependent on the presence of the HD1 domain, it is not affected by the lack of the HD2 domain, indicating that Bcl9/9l act in this context in a β-catenin-independent manner. Furthermore, we uncover a new regulatory circuit in which Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription."
	* '''Activated Ras alters lens and corneal development'''~~<ref><pubmed>~~20105280~~</pubmed></ref>~~ "The murine lens and cornea have a common embryonic origin and arise from adjacent regions of the surface ectoderm. ...Collectively, these results suggest that Ras activation a) induces distinct sets of downstream targets in the lens and cornea resulting in distinct cellular responses and b) is sufficient for initiation but not completion of lens fiber differentiation."
			* '''On the growth and internal structure of the human lens'''{{#pmid:20171212\|PMID20171212}} "Growth of the human lens and the development of its internal features are examined using in vivo and in vitro observations on dimensions, weights, cell sizes, protein gradients and other properties. In vitro studies have shown that human lens growth is biphasic, asymptotic until just after birth and linear for most of postnatal life."

			* '''Activated Ras alters lens and corneal development'''{{#pmid:20105280\|PMID20105280}} "The murine lens and cornea have a common embryonic origin and arise from adjacent regions of the surface ectoderm. ...Collectively, these results suggest that Ras activation a) induces distinct sets of downstream targets in the lens and cornea resulting in distinct cellular responses and b) is sufficient for initiation but not completion of lens fiber differentiation."
	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"

Z8600021 at 00:35, 9 Mayıs 2018

2018-05-09T00:35:08Z

← Older revision		Revision as of 10:35, 9 Mayıs 2018
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	==Week 8==		==Week 8==
	The images below link to virtual slides of the human developing eye at [[Carnegie stage ~~22]]~~. Click on the image to open or select specific regions from the regions of interest links.		{{Streeter1957 fig6 gallery}}
			<br>
			The images below link to virtual slides of the human developing eye at Carnegie stage {{CS22}}. Click on the image to open or select specific regions from the regions of interest links.

	{\|		{\|
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	</gallery>		</gallery>

	'''Links:''' [[Carnegie stage ~~22]]~~ \| [[Embryo Virtual Slides]]		'''Links:''' Carnegie stage {{CS22}} \| [[Embryo Virtual Slides]]

	==Molecular Signaling==		==Molecular Signaling==
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	{{Historic Disclaimer}}		{{Historic Disclaimer}}

	{{~~Week 7-8 Lens~~ gallery}}		{{Streeter1957 fig6 gallery}}


	{{Glossary}}		{{Glossary}}

Z8600021 at 00:29, 9 Mayıs 2018

2018-05-09T00:29:07Z

← Older revision		Revision as of 10:29, 9 Mayıs 2018
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	<references/>		<references/>

			===Reviews===

			===Articles===

	==Additional Images==		==Additional Images==
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	{{Historic Disclaimer}}		{{Historic Disclaimer}}

	{{Week 7-8 Lens gallery}}		{{Week 7-8 Lens gallery}}

Z8600021 at 00:28, 9 Mayıs 2018

2018-05-09T00:28:14Z

← Older revision		Revision as of 10:28, 9 Mayıs 2018
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	{{Historic Disclaimer}}		{{Historic Disclaimer}}

	{{~~Ref~~-~~Streeter1957}}~~		{{Week 7-8 Lens gallery}}
	<gallery>
	~~File:Streeter1957 fig06.jpg\|Stage 19-23~~
	~~File:Streeter1957 fig06-19.jpg\|[[Carnegie stage 19]] (Embryo {{CE409}})~~
	~~File:Streeter1957 fig06-20.jpg\|[[Carnegie stage 20]] (Embryo {{CE462}})~~
	~~File:Streeter1957 fig06-21.jpg\|[[Carnegie stage 21]] (Embryo {{CE1358F}})~~
	~~File:Streeter1957 fig06-22.jpg\|[[Carnegie stage 22]] (Embryo {{CE4339}})~~
	~~File:Streeter1957 fig06-23.jpg\|[[Carnegie stage 23]] (Embryo {{CE4570~~}})
	~~</gallery>~~

	{{Glossary}}		{{Glossary}}

Z8600021 at 00:26, 9 Mayıs 2018

2018-05-09T00:26:01Z

← Older revision		Revision as of 10:26, 9 Mayıs 2018
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	<gallery>		<gallery>
	File:Streeter1957 fig06.jpg\|Stage 19-23		File:Streeter1957 fig06.jpg\|Stage 19-23
	File:Streeter1957 fig06-19.jpg\|[[Carnegie stage 19]] (~~[[:Category:Carnegie Embryo 409\|~~Embryo ~~409]]~~)		File:Streeter1957 fig06-19.jpg\|[[Carnegie stage 19]] (Embryo {{CE409}})
	File:Streeter1957 fig06-20.jpg\|[[Carnegie stage 20]] (~~[[:Category:Carnegie Embryo 462\|~~Embryo ~~462]]~~)		File:Streeter1957 fig06-20.jpg\|[[Carnegie stage 20]] (Embryo {{CE462}})
	File:Streeter1957 fig06-21.jpg\|[[Carnegie stage 21]] (~~[[:Category:Carnegie~~ Embryo ~~1358F\|Embryo 1358F]]~~)		File:Streeter1957 fig06-21.jpg\|[[Carnegie stage 21]] (Embryo {{CE1358F}})
	File:Streeter1957 fig06-22.jpg\|[[Carnegie stage 22]] (~~[[:Category:Carnegie Embryo 4339\|~~Embryo ~~4339]]~~)		File:Streeter1957 fig06-22.jpg\|[[Carnegie stage 22]] (Embryo {{CE4339}})
	File:Streeter1957 fig06-23.jpg\|[[Carnegie stage 23]] (~~[[:Category:Carnegie~~ Embryo ~~4570\|Embryo 4570]]~~)		File:Streeter1957 fig06-23.jpg\|[[Carnegie stage 23]] (Embryo {{CE4570}})
	</gallery>		</gallery>

Z8600021 at 04:22, 21 November 2017

2017-11-21T04:22:05Z

← Older revision		Revision as of 14:22, 21 November 2017
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	[[Category:Placode]]		[[Category:Placode]]
			[[Category:Lens]]

Z8600021 at 22:53, 2 November 2017

2017-11-02T22:53:07Z

← Older revision		Revision as of 08:53, 3 November 2017
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	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
	! More recent papers		! More recent papers
	\|-		\|-
	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

Z8600021 at 10:56, 15 March 2017

2017-03-15T10:56:37Z

← Older revision		Revision as of 20:56, 15 March 2017
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	<references/>		<references/>

			==Additional Images==
			<gallery>
			</gallery>

			===Historic Images===
			{{Historic Disclaimer}}

			{{Ref-Streeter1957}}
			<gallery>
			File:Streeter1957 fig06.jpg\|Stage 19-23
			File:Streeter1957 fig06-19.jpg\|[[Carnegie stage 19]] ([[:Category:Carnegie Embryo 409\|Embryo 409]])
			File:Streeter1957 fig06-20.jpg\|[[Carnegie stage 20]] ([[:Category:Carnegie Embryo 462\|Embryo 462]])
			File:Streeter1957 fig06-21.jpg\|[[Carnegie stage 21]] ([[:Category:Carnegie Embryo 1358F\|Embryo 1358F]])
			File:Streeter1957 fig06-22.jpg\|[[Carnegie stage 22]] ([[:Category:Carnegie Embryo 4339\|Embryo 4339]])
			File:Streeter1957 fig06-23.jpg\|[[Carnegie stage 23]] ([[:Category:Carnegie Embryo 4570\|Embryo 4570]])
			</gallery>

	{{Glossary}}		{{Glossary}}

Z8600021 at 11:30, 3 March 2015

2015-03-03T11:30:46Z

← Older revision		Revision as of 21:30, 3 March 2015
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			* '''Review - The cellular and molecular mechanisms of vertebrate lens development'''<ref name=PMID25406393><pubmed>25406393</pubmed></ref>\| [http://dev.biologists.org/content/141/23/4432.full?sid=9c0c0b67-790f-42a6-8551-73876896a0d6 Development] "The ocular lens is a model system for understanding important aspects of embryonic development, such as cell specification and the spatiotemporally controlled formation of a three-dimensional structure. The lens, which is characterized by transparency, refraction and elasticity, is composed of a bulk mass of fiber cells attached to a sheet of lens epithelium. Although lens induction has been studied for over 100 years, recent findings have revealed a myriad of extracellular signaling pathways and gene regulatory networks, integrated and executed by the transcription factor Pax6, that are required for lens formation in vertebrates."
	* '''Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development'''<ref><pubmed>25184676</pubmed></ref> "While lens development is critically dependent on the presence of the HD1 domain, it is not affected by the lack of the HD2 domain, indicating that Bcl9/9l act in this context in a β-catenin-independent manner. Furthermore, we uncover a new regulatory circuit in which Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription."		* '''Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development'''<ref><pubmed>25184676</pubmed></ref> "While lens development is critically dependent on the presence of the HD1 domain, it is not affected by the lack of the HD2 domain, indicating that Bcl9/9l act in this context in a β-catenin-independent manner. Furthermore, we uncover a new regulatory circuit in which Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription."
	* '''On the growth and internal structure of the human lens'''<ref><pubmed>20171212</pubmed></ref> "Growth of the human lens and the development of its internal features are examined using in vivo and in vitro observations on dimensions, weights, cell sizes, protein gradients and other properties. In vitro studies have shown that human lens growth is biphasic, asymptotic until just after birth and linear for most of postnatal life."		* '''On the growth and internal structure of the human lens'''<ref><pubmed>20171212</pubmed></ref> "Growth of the human lens and the development of its internal features are examined using in vivo and in vitro observations on dimensions, weights, cell sizes, protein gradients and other properties. In vitro studies have shown that human lens growth is biphasic, asymptotic until just after birth and linear for most of postnatal life."

← Older revision		Revision as of 10:26, 9 Mayıs 2018
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	<gallery>		<gallery>
	File:Streeter1957 fig06.jpg\|Stage 19-23		File:Streeter1957 fig06.jpg\|Stage 19-23
	File:Streeter1957 fig06-19.jpg\|[[Carnegie stage 19]] (~~[[:Category:Carnegie Embryo 409\|~~Embryo ~~409]]~~)		File:Streeter1957 fig06-19.jpg\|[[Carnegie stage 19]] (Embryo {{CE409}})
	File:Streeter1957 fig06-20.jpg\|[[Carnegie stage 20]] (~~[[:Category:Carnegie Embryo 462\|~~Embryo ~~462]]~~)		File:Streeter1957 fig06-20.jpg\|[[Carnegie stage 20]] (Embryo {{CE462}})
	File:Streeter1957 fig06-21.jpg\|[[Carnegie stage 21]] (~~[[:Category:Carnegie~~ Embryo ~~1358F\|Embryo 1358F]]~~)		File:Streeter1957 fig06-21.jpg\|[[Carnegie stage 21]] (Embryo {{CE1358F}})
	File:Streeter1957 fig06-22.jpg\|[[Carnegie stage 22]] (~~[[:Category:Carnegie Embryo 4339\|~~Embryo ~~4339]]~~)		File:Streeter1957 fig06-22.jpg\|[[Carnegie stage 22]] (Embryo {{CE4339}})
	File:Streeter1957 fig06-23.jpg\|[[Carnegie stage 23]] (~~[[:Category:Carnegie~~ Embryo ~~4570\|Embryo 4570]]~~)		File:Streeter1957 fig06-23.jpg\|[[Carnegie stage 23]] (Embryo {{CE4570}})
	</gallery>		</gallery>