User:Z3331264 - Revision history

Z8600021 at 04:31, 10 November 2012

2012-11-10T04:31:24Z

← Older revision		Revision as of 15:31, 10 November 2012
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	<pubmed>22633650</pubmed>		<pubmed>22633650</pubmed>


			Mark Hill - Excellent answers 10/10

	==Lab 2:Embryo Development==		==Lab 2:Embryo Development==
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	<pubmed>21471197</pubmed>		<pubmed>21471197</pubmed>


			Mark Hill - Excellent answers 10/10

	==Lab 3==		==Lab 3==
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	Mescher, L.A. (2010) Junqueira's Basic Histology. McGraw Hill, Singapore. Chapters 5,7,8.		Mescher, L.A. (2010) Junqueira's Basic Histology. McGraw Hill, Singapore. Chapters 5,7,8.

			Mark Hill - Good answers to both question. I find it interesting that your answer was from a Histology textbook and not an embryology text and appears asa direct quotation rather than your own work 8/10


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	<pubmed>16099997</pubmed>		<pubmed>16099997</pubmed>

			Mark Hill - Good answers 10/10

	==Lab 7==		==Lab 7==
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	Scelsi R,2001, 'Skeletal Muscle Pathology after Spinal Cord Injury' ''Basic Appl Myol'', 11(2):75-85.		Scelsi R,2001, 'Skeletal Muscle Pathology after Spinal Cord Injury' ''Basic Appl Myol'', 11(2):75-85.

			Mark Hill - Good answers 10/10

	==Peer Assessment==		==Peer Assessment==
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	Good luck!		Good luck!

			Mark Hill - You have made a very good peer assessment of the group projects, in sufficient detail that provides useful information for other students. 10/10

	==Lab 9 Assessment==		==Lab 9 Assessment==
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	<pubmed>12640730</pubmed>		<pubmed>12640730</pubmed>

			Mark Hill - You have identified a protein [http://omim.org/entry/603118 OMIM CDH16] that is expressed in developing thyroid gland. You have also identified the germ cell layer contribution to teeth, perhaps you could have also identified what each formed within the tooth. 10/10

	==Lab 11 Assessment==		==Lab 11 Assessment==
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	==References==		==References==
	<references/>		<references/>

			Mark Hill - Excellent 10/10

Z8600021: /* Lab Attendance */

2012-10-19T21:01:25Z

Lab Attendance

← Older revision		Revision as of 08:01, 20 October 2012
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	--[[User:Z3331264\|Z3331264]] 10:13, 17 October 2012 (EST)		--[[User:Z3331264\|Z3331264]] 10:13, 17 October 2012 (EST)


			Lab attendance logged for 11 practicals. --Mark Hill 07:50, 18 October 2012 (EST)

	==Lab 1: Fertilisation==		==Lab 1: Fertilisation==

Z3331264 at 23:13, 16 October 2012

2012-10-16T23:13:54Z

← Older revision		Revision as of 10:13, 17 October 2012
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	--[[User:Z3331264\|Z3331264]] 11:07, 10 October 2012 (EST)		--[[User:Z3331264\|Z3331264]] 11:07, 10 October 2012 (EST)

			--[[User:Z3331264\|Z3331264]] 10:13, 17 October 2012 (EST)

	==Lab 1: Fertilisation==		==Lab 1: Fertilisation==

Z3331264: /* Lab 11 Assessment */

2012-10-15T21:20:23Z

Lab 11 Assessment

← Older revision		Revision as of 08:20, 16 October 2012
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	==Lab 11 Assessment==		==Lab 11 Assessment==

	A study by Koichi Oki ''et. al'' focused on examining the long-term changes after transplantation of human iPSC-derived cells in the stroke-damaged brain. The use of embryonic or fetal stem cell-derived neural stem cells in treating Ischemic stroke in a rodent brain have been somewhat successful.<ref name="PMID20877642"><pubmed>20877642</pubmed></ref> Studies have observed their differentation into neurons and the improvement of some impaired functions.<ref name="PMID20877642"><pubmed>20877642</pubmed></ref> <ref name="PMID18286199"><pubmed>18286199</pubmed></ref>These transplanted neural stem cells have also been shown to promote recovery even if differentiation into neurons does not occur. Such recovery is believed to be through the transplanted cells ability to modulate inflammation, stimulate angiogenesis and enhance brain plasticity.		A study by Koichi Oki ''et. al'' focused on examining the long-term changes after transplantation of human iPSC-derived cells in the stroke-damaged brain.<ref name="PMID22495829"><pubmed>22495829</pubmed></ref> The use of embryonic or fetal stem cell-derived neural stem cells in treating Ischemic stroke in a rodent brain have been somewhat successful.<ref name="PMID20877642"><pubmed>20877642</pubmed></ref> Studies have observed their differentation into neurons and the improvement of some impaired functions.<ref name="PMID20877642"><pubmed>20877642</pubmed></ref> <ref name="PMID18286199"><pubmed>18286199</pubmed></ref>These transplanted neural stem cells have also been shown to promote recovery even if differentiation into neurons does not occur. Such recovery is believed to be through the transplanted cells ability to modulate inflammation, stimulate angiogenesis and enhance brain plasticity.


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	This current study transplanted long-term expandable neuro-epithelial-like stem cells (lt-NES) cells generated from adult human fibroblast-derived iPSCs, into stroke damaged mouse and rat brain. It was shown that the iPSC-derived grafts survived long- term and contained a high proportion of cells with morphological and electrophysiological properties of neurons. These neurons received afferent inputs from the host brain and extended their axons to an appropriate target area. They were then able to send axonal projections throughout the host brain, receive synaptic input from surrounding host neurons, and improve motor recovery in behavioral tests relevant for human stroke.		This current study transplanted long-term expandable neuro-epithelial-like stem cells (lt-NES) cells generated from adult human fibroblast-derived iPSCs, into stroke damaged mouse and rat brain<ref name="PMID22495829"><pubmed>22495829</pubmed></ref>. It was shown that the iPSC-derived grafts survived long- term and contained a high proportion of cells with morphological and electrophysiological properties of neurons. These neurons received afferent inputs from the host brain and extended their axons to an appropriate target area. They were then able to send axonal projections throughout the host brain, receive synaptic input from surrounding host neurons, and improve motor recovery in behavioral tests relevant for human stroke.

	==References==		==References==
	<references/>		<references/>

Z3331264: /* Lab 11 Assessment */

2012-10-15T21:18:15Z

Lab 11 Assessment

← Older revision		Revision as of 08:18, 16 October 2012
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	A study by Koichi Oki ''et. al'' focused on examining the long-term changes after transplantation of human iPSC-derived cells in the stroke-damaged brain. The use of embryonic or fetal stem cell-derived neural stem cells in treating Ischemic stroke in a rodent brain have been somewhat successful.<ref name="PMID20877642"><pubmed>20877642</pubmed></ref> Studies have observed their differentation into neurons and the improvement of some impaired functions.<ref name="PMID20877642"><pubmed>20877642</pubmed></ref> <ref name="PMID18286199"><pubmed>18286199</pubmed></ref>These transplanted neural stem cells have also been shown to promote recovery even if differentiation into neurons does not occur. Such recovery is believed to be through the transplanted cells ability to modulate inflammation, stimulate angiogenesis and enhance brain plasticity.		A study by Koichi Oki ''et. al'' focused on examining the long-term changes after transplantation of human iPSC-derived cells in the stroke-damaged brain. The use of embryonic or fetal stem cell-derived neural stem cells in treating Ischemic stroke in a rodent brain have been somewhat successful.<ref name="PMID20877642"><pubmed>20877642</pubmed></ref> Studies have observed their differentation into neurons and the improvement of some impaired functions.<ref name="PMID20877642"><pubmed>20877642</pubmed></ref> <ref name="PMID18286199"><pubmed>18286199</pubmed></ref>These transplanted neural stem cells have also been shown to promote recovery even if differentiation into neurons does not occur. Such recovery is believed to be through the transplanted cells ability to modulate inflammation, stimulate angiogenesis and enhance brain plasticity.


	Previous studies have also shown that autologous transplantation of neurons generated from iPSCs seems more favourable since they can differentaite into specific neuronal subtypes such as dopamingeric or motor neurons.<ref name="PMID20216552"><pubmed> 20216552</pubmed></ref> Recent studies have reported that implanted mouse iPSCs into the rodent brain generate large numbers of neuroblasts whereby a few differentiate but form tumours.<ref name="PMID20216552"><pubmed>20216552</pubmed></ref> Human Fibroblast derived iPSCs implanted into the striatum of stroke-damaged rats improved short-term sensorimotor recovery. <ref name="PMID21465238"><pubmed>21465238</pubmed></ref>		Previous studies have also shown that autologous transplantation of neurons generated from iPSCs seems more favourable since they can differentaite into specific neuronal subtypes such as dopamingeric or motor neurons.<ref name="PMID20216552"><pubmed> 20216552</pubmed></ref> Recent studies have reported that implanted mouse iPSCs into the rodent brain generate large numbers of neuroblasts whereby a few differentiate but form tumours.<ref name="PMID20216552"><pubmed>20216552</pubmed></ref> Human Fibroblast derived iPSCs implanted into the striatum of stroke-damaged rats improved short-term sensorimotor recovery. <ref name="PMID21465238"><pubmed>21465238</pubmed></ref>


	This current study transplanted long-term expandable neuro-epithelial-like stem cells (lt-NES) cells generated from adult human fibroblast-derived iPSCs, into stroke damaged mouse and rat brain. It was shown that the iPSC-derived grafts survived long- term and contained a high proportion of cells with morphological and electrophysiological properties of neurons. These neurons received afferent inputs from the host brain and extended their axons to an appropriate target area. They were then able to send axonal projections throughout the host brain, receive synaptic input from surrounding host neurons, and improve motor recovery in behavioral tests relevant for human stroke.		This current study transplanted long-term expandable neuro-epithelial-like stem cells (lt-NES) cells generated from adult human fibroblast-derived iPSCs, into stroke damaged mouse and rat brain. It was shown that the iPSC-derived grafts survived long- term and contained a high proportion of cells with morphological and electrophysiological properties of neurons. These neurons received afferent inputs from the host brain and extended their axons to an appropriate target area. They were then able to send axonal projections throughout the host brain, receive synaptic input from surrounding host neurons, and improve motor recovery in behavioral tests relevant for human stroke.

Z3331264: /* Lab 11 Assessment */

2012-10-15T21:17:46Z

Lab 11 Assessment

← Older revision		Revision as of 08:17, 16 October 2012
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	==Lab 11 Assessment==		==Lab 11 Assessment==

	A study by Koichi Oki ''et. al'' focused on examining the long-term changes after transplantation of human iPSC-derived cells in the stroke-damaged brain. The use of embryonic or fetal stem cell-derived neural stem cells in treating Ischemic stroke in a rodent brain have been somewhat successful.<ref name="~~20877642~~"><pubmed>20877642</pubmed></ref> Studies have observed their differentation into neurons and the improvement of some impaired functions.<ref name="~~20877642~~"><pubmed>20877642</pubmed></ref> <ref name="~~18286199~~"><pubmed>18286199</pubmed></ref>These transplanted neural stem cells have also been shown to promote recovery even if differentiation into neurons does not occur. Such recovery is believed to be through the transplanted cells ability to modulate inflammation, stimulate angiogenesis and enhance brain plasticity.		A study by Koichi Oki ''et. al'' focused on examining the long-term changes after transplantation of human iPSC-derived cells in the stroke-damaged brain. The use of embryonic or fetal stem cell-derived neural stem cells in treating Ischemic stroke in a rodent brain have been somewhat successful.<ref name="PMID20877642"><pubmed>20877642</pubmed></ref> Studies have observed their differentation into neurons and the improvement of some impaired functions.<ref name="PMID20877642"><pubmed>20877642</pubmed></ref> <ref name="PMID18286199"><pubmed>18286199</pubmed></ref>These transplanted neural stem cells have also been shown to promote recovery even if differentiation into neurons does not occur. Such recovery is believed to be through the transplanted cells ability to modulate inflammation, stimulate angiogenesis and enhance brain plasticity.

	Previous studies have also shown that autologous transplantation of neurons generated from iPSCs seems more favourable since they can differentaite into specific neuronal subtypes such as dopamingeric or motor neurons.<ref name=" ~~20216552~~"><pubmed> 20216552</pubmed></ref> Recent studies have reported that implanted mouse iPSCs into the rodent brain generate large numbers of neuroblasts whereby a few differentiate but form tumours.<ref name=" ~~20216552~~"><pubmed>20216552</pubmed></ref> Human Fibroblast derived iPSCs implanted into the striatum of stroke-damaged rats improved short-term sensorimotor recovery. <ref name="~~21465238~~"><pubmed>21465238</pubmed></ref>		Previous studies have also shown that autologous transplantation of neurons generated from iPSCs seems more favourable since they can differentaite into specific neuronal subtypes such as dopamingeric or motor neurons.<ref name="PMID20216552"><pubmed> 20216552</pubmed></ref> Recent studies have reported that implanted mouse iPSCs into the rodent brain generate large numbers of neuroblasts whereby a few differentiate but form tumours.<ref name="PMID20216552"><pubmed>20216552</pubmed></ref> Human Fibroblast derived iPSCs implanted into the striatum of stroke-damaged rats improved short-term sensorimotor recovery. <ref name="PMID21465238"><pubmed>21465238</pubmed></ref>

	This current study transplanted long-term expandable neuro-epithelial-like stem cells (lt-NES) cells generated from adult human fibroblast-derived iPSCs, into stroke damaged mouse and rat brain. It was shown that the iPSC-derived grafts survived long- term and contained a high proportion of cells with morphological and electrophysiological properties of neurons. These neurons received afferent inputs from the host brain and extended their axons to an appropriate target area. They were then able to send axonal projections throughout the host brain, receive synaptic input from surrounding host neurons, and improve motor recovery in behavioral tests relevant for human stroke.		This current study transplanted long-term expandable neuro-epithelial-like stem cells (lt-NES) cells generated from adult human fibroblast-derived iPSCs, into stroke damaged mouse and rat brain. It was shown that the iPSC-derived grafts survived long- term and contained a high proportion of cells with morphological and electrophysiological properties of neurons. These neurons received afferent inputs from the host brain and extended their axons to an appropriate target area. They were then able to send axonal projections throughout the host brain, receive synaptic input from surrounding host neurons, and improve motor recovery in behavioral tests relevant for human stroke.

Z3331264: /* Lab 9 Assessment */

2012-10-15T21:16:06Z

Lab 9 Assessment

← Older revision		Revision as of 08:16, 16 October 2012
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	<pubmed>12640730</pubmed>		<pubmed>12640730</pubmed>


			==Lab 11 Assessment==

			A study by Koichi Oki ''et. al'' focused on examining the long-term changes after transplantation of human iPSC-derived cells in the stroke-damaged brain. The use of embryonic or fetal stem cell-derived neural stem cells in treating Ischemic stroke in a rodent brain have been somewhat successful.<ref name="20877642"><pubmed>20877642</pubmed></ref> Studies have observed their differentation into neurons and the improvement of some impaired functions.<ref name="20877642"><pubmed>20877642</pubmed></ref> <ref name="18286199"><pubmed>18286199</pubmed></ref>These transplanted neural stem cells have also been shown to promote recovery even if differentiation into neurons does not occur. Such recovery is believed to be through the transplanted cells ability to modulate inflammation, stimulate angiogenesis and enhance brain plasticity.

			Previous studies have also shown that autologous transplantation of neurons generated from iPSCs seems more favourable since they can differentaite into specific neuronal subtypes such as dopamingeric or motor neurons.<ref name=" 20216552"><pubmed> 20216552</pubmed></ref> Recent studies have reported that implanted mouse iPSCs into the rodent brain generate large numbers of neuroblasts whereby a few differentiate but form tumours.<ref name=" 20216552"><pubmed>20216552</pubmed></ref> Human Fibroblast derived iPSCs implanted into the striatum of stroke-damaged rats improved short-term sensorimotor recovery. <ref name="21465238"><pubmed>21465238</pubmed></ref>

			This current study transplanted long-term expandable neuro-epithelial-like stem cells (lt-NES) cells generated from adult human fibroblast-derived iPSCs, into stroke damaged mouse and rat brain. It was shown that the iPSC-derived grafts survived long- term and contained a high proportion of cells with morphological and electrophysiological properties of neurons. These neurons received afferent inputs from the host brain and extended their axons to an appropriate target area. They were then able to send axonal projections throughout the host brain, receive synaptic input from surrounding host neurons, and improve motor recovery in behavioral tests relevant for human stroke.

			==References==
			<references/>

Z3331264: /* Lab Attendance */

2012-10-10T00:07:43Z

Lab Attendance

← Older revision		Revision as of 11:07, 10 October 2012
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	--[[User:Z3331264\|Z3331264]] 10:08, 3 October 2012 (EST)		--[[User:Z3331264\|Z3331264]] 10:08, 3 October 2012 (EST)

			--[[User:Z3331264\|Z3331264]] 11:07, 10 October 2012 (EST)

	==Lab 1: Fertilisation==		==Lab 1: Fertilisation==

Z3331264 at 00:08, 3 October 2012

2012-10-03T00:08:48Z

← Older revision		Revision as of 11:08, 3 October 2012
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	--[[User:Z3331264\|Z3331264]] 10:45, 26 September 2012 (EST)		--[[User:Z3331264\|Z3331264]] 10:45, 26 September 2012 (EST)

			--[[User:Z3331264\|Z3331264]] 10:08, 3 October 2012 (EST)

	==Lab 1: Fertilisation==		==Lab 1: Fertilisation==

Z3331264: /* embryonic layers and tissues that contribute to the developing teeth */

2012-10-02T23:33:27Z

embryonic layers and tissues that contribute to the developing teeth

← Older revision		Revision as of 10:33, 3 October 2012
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	<pubmed>22028439</pubmed>		<pubmed>22028439</pubmed>

	===~~embryonic~~ layers and tissues that contribute to the developing teeth===		===Embryonic layers and tissues that contribute to the developing teeth===
	The ectoderm, mesenchyme and neural crest ectomesenchyme all contribute to the development of the tooth.		The ectoderm, mesenchyme and neural crest ectomesenchyme all contribute to the development of the tooth.
	Additionally, local ectoderm thickening of the enamel epithelium signals the underlying mesenchyme of the odonotblasts to condense and differentiate.		Additionally, local ectoderm thickening of the enamel epithelium signals the underlying mesenchyme of the odonotblasts to condense and differentiate.

	<pubmed>12640730</pubmed>		<pubmed>12640730</pubmed>