Talk:Sensory - Touch Development - Revision history

Z8600021 at 00:48, 19 November 2019

2019-11-19T00:48:06Z

← Older revision		Revision as of 10:48, 19 November 2019
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	==2018==		==2018==
	{{#pmid:29241683}}		{{#pmid:29241683}}
	~~===Notch pathway signaling in the skin antagonizes Merkel cell development===~~

	~~Dev Biol. 2018 Feb 15;434(2):207-214. doi: 10.1016/j.ydbio.2017.12.007. Epub 2017 Dec 11.~~

	~~Logan GJ1, Wright MC2, Kubicki AC3, Maricich SM4.~~
	~~Author information~~
	~~Abstract~~
	Merkel cells are mechanosensitive skin cells derived from the epidermal lineage whose development requires expression of the basic helix-loop-helix transcription factor Atoh1. The genes and pathways involved in regulating Merkel cell development during embryogenesis are poorly understood. Notch pathway signaling antagonizes Atoh1 expression in many developing body regions, so we hypothesized that Notch signaling might inhibit Merkel cell development. We found that conditional, constitutive overexpression of the Notch intracellular domain (NICD) in mouse epidermis significantly decreased Merkel cell numbers in whisker follicles and touch domes of hairy skin. Conversely, conditional deletion of the obligate NICD binding partner RBPj in the epidermis significantly increased Merkel cell numbers in whisker follicles, led to the development of ectopic Merkel cells outside of touch domes in hairy skin epidermis, and altered the distribution of Merkel cells in touch domes. Deletion of the downstream Notch effector gene Hes1 also significantly increased Merkel cell numbers in whisker follicles. Together, these data demonstrate that Notch signaling regulates Merkel cell production and patterning.		Merkel cells are mechanosensitive skin cells derived from the epidermal lineage whose development requires expression of the basic helix-loop-helix transcription factor Atoh1. The genes and pathways involved in regulating Merkel cell development during embryogenesis are poorly understood. Notch pathway signaling antagonizes Atoh1 expression in many developing body regions, so we hypothesized that Notch signaling might inhibit Merkel cell development. We found that conditional, constitutive overexpression of the Notch intracellular domain (NICD) in mouse epidermis significantly decreased Merkel cell numbers in whisker follicles and touch domes of hairy skin. Conversely, conditional deletion of the obligate NICD binding partner RBPj in the epidermis significantly increased Merkel cell numbers in whisker follicles, led to the development of ectopic Merkel cells outside of touch domes in hairy skin epidermis, and altered the distribution of Merkel cells in touch domes. Deletion of the downstream Notch effector gene Hes1 also significantly increased Merkel cell numbers in whisker follicles. Together, these data demonstrate that Notch signaling regulates Merkel cell production and patterning.
	KEYWORDS:		KEYWORDS:

Z8600021 at 00:47, 19 November 2019

2019-11-19T00:47:44Z

← Older revision		Revision as of 10:47, 19 November 2019
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	==2018==		==2018==
			{{#pmid:29241683}}
	===Notch pathway signaling in the skin antagonizes Merkel cell development===		===Notch pathway signaling in the skin antagonizes Merkel cell development===

Z8600021 at 00:46, 19 November 2019

2019-11-19T00:46:40Z

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 {{Talk Page}}
 ==2018==
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 ==2016==
 ===Making sense out of spinal cord somatosensory development===

Z8600021 at 02:18, 13 Ocak 2019

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 PMID: 29241683 DOI: 10.1016/j.ydbio.2017.12.007
 [Indexed for MEDLINE]
 ===The development of human digital Meissner's and Pacinian corpuscles===
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 Children; Crossmodal; Development; Multisensory; Touch; Vision
 PMID: 29783043 DOI: 10.1016/j.jecp.2018.04.014

Z8600021 at 03:13, 8 August 2018

2018-08-08T03:13:36Z

← Older revision		Revision as of 13:13, 8 August 2018
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	==2018==		==2018==

			===Notch pathway signaling in the skin antagonizes Merkel cell development===

			Dev Biol. 2018 Feb 15;434(2):207-214. doi: 10.1016/j.ydbio.2017.12.007. Epub 2017 Dec 11.

			Logan GJ1, Wright MC2, Kubicki AC3, Maricich SM4.
			Author information
			Abstract
			Merkel cells are mechanosensitive skin cells derived from the epidermal lineage whose development requires expression of the basic helix-loop-helix transcription factor Atoh1. The genes and pathways involved in regulating Merkel cell development during embryogenesis are poorly understood. Notch pathway signaling antagonizes Atoh1 expression in many developing body regions, so we hypothesized that Notch signaling might inhibit Merkel cell development. We found that conditional, constitutive overexpression of the Notch intracellular domain (NICD) in mouse epidermis significantly decreased Merkel cell numbers in whisker follicles and touch domes of hairy skin. Conversely, conditional deletion of the obligate NICD binding partner RBPj in the epidermis significantly increased Merkel cell numbers in whisker follicles, led to the development of ectopic Merkel cells outside of touch domes in hairy skin epidermis, and altered the distribution of Merkel cells in touch domes. Deletion of the downstream Notch effector gene Hes1 also significantly increased Merkel cell numbers in whisker follicles. Together, these data demonstrate that Notch signaling regulates Merkel cell production and patterning.
			KEYWORDS:
			Development; Skin; Somatosensation
			PMID: 29241683 DOI: 10.1016/j.ydbio.2017.12.007
			[Indexed for MEDLINE]

	===The development of human digital Meissner's and Pacinian corpuscles===		===The development of human digital Meissner's and Pacinian corpuscles===

Z8600021 at 02:42, 8 August 2018

2018-08-08T02:42:38Z

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 Development; Glabrous skin; Human; Meissner’s corpuscles; Pacinian corpuscles; Sensory corpuscles
 PMID: 29842990 DOI: 10.1016/j.aanat.2018.05.001
 ===Developmental changes in the perception of visuotactile simultaneity===

Z8600021 at 23:00, 20 Haziran 2018

2018-06-20T23:00:26Z

← Older revision		Revision as of 09:00, 21 Haziran 2018
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	==2018==		==2018==

			===The development of human digital Meissner's and Pacinian corpuscles===

			Ann Anat. 2018 May 26;219:8-24. doi: 10.1016/j.aanat.2018.05.001. [Epub ahead of print]

			Feito J1, García-Suárez O2, García-Piqueras J2, García-Mesa Y2, Pérez-Sánchez A3, Suazo I4, Cabo R2, Suárez-Quintanilla J5, Cobo J6, Vega JA7.

			Abstract

			Meissner's and Pacinian corpuscles are cutaneous mechanoreceptors responsible for different modalities of touch. The development of these sensory formations in humans is poorly known, especially regarding the acquisition of the typical immunohistochemical profile related to their full functional maturity. Here we used a panel of antibodies (to specifically label the main corpuscular components: axon, Schwann-related cells and endoneurial-perineurial-related cells) to investigate the development of digital Meissner's and Pacinian corpuscles in a representative sample covering from 11 weeks of estimated gestational age (wega) to adulthood. Development of Pacinian corpuscles starts at 13 wega, and it is completed at 4 months of life, although their basic structure and immunohistochemical characteristics are reached at 36 wega. During development, around the axon, a complex network of S100 positive Schwann-related processes is progressively compacted to form the inner core, while the surrounding mesenchyme is organized and forms the outer core and the capsule. Meissner's corpuscles start to develop at 22 wega and complete their typical morphology and immunohistochemical profile at 8 months of life. In developing Meissner's corpuscles, the axons establish complex relationships with the epidermis and are progressively covered by Schwann-like cells until they complete the mature arrangement late in postnatal life. The present results demonstrate an asynchronous development of the Meissner's and Pacini's corpuscles and show that there is not a total correlation between morphological and immunohistochemical maturation. The correlation of the present results with touch-induced cortical activity in developing humans is discussed.
			KEYWORDS:
			Development; Glabrous skin; Human; Meissner’s corpuscles; Pacinian corpuscles; Sensory corpuscles
			PMID: 29842990 DOI: 10.1016/j.aanat.2018.05.001

	===Developmental changes in the perception of visuotactile simultaneity===		===Developmental changes in the perception of visuotactile simultaneity===

Z8600021 at 22:49, 20 Haziran 2018

2018-06-20T22:49:44Z

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 PMID 27414798
 ==2015==
 ===Merkel cells and neurons keep in touch===

Z8600021 at 22:46, 20 Haziran 2018

2018-06-20T22:46:27Z

← Older revision		Revision as of 08:46, 21 Haziran 2018
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	{{Talk Page}}		{{Talk Page}}

			==2018==

			===Developmental changes in the perception of visuotactile simultaneity===

			J Exp Child Psychol. 2018 Sep;173:304-317. doi: 10.1016/j.jecp.2018.04.014. Epub 2018 May 21.

			Chen YC1, Lewis TL2, Shore DI2, Spence C3, Maurer D4.

			Abstract

			A simultaneity judgment (SJ) task was used to measure the developmental trajectory of visuotactile simultaneity perception in children (aged 7, 9, 11, and 13 years) and adults. Participants were presented with a visual flash in the center of a computer monitor and a tap on their right index finger (located 20° below the flash) with 13 possible stimulus onset asynchronies (SOAs). Participants reported whether the flash and tap were presented at the same time. Compared with the adult group, children aged 7 and 9 years made more simultaneous responses when the tap led by more than 300 ms and when the flash led by more than 200 ms, whereas they made fewer simultaneous responses at the 0 ms SOA. Model fitting demonstrated that the window of visuotactile simultaneity became narrower with development and reached adult-like levels between 9 and 11 years of age. Response errors decreased continuously until 11 years of age. The point of subjective simultaneity (PSS) was located on the tactile-leading side in all participants tested, indicating that 7-year olds (the youngest age tested) are adult-like on this measure. In summary, the perception of visuotactile simultaneity is not fully mature until 11 years of age. The protracted development of visuotactile simultaneity perception may be related to the need for crossmodal recalibration as the body grows and to the developmental improvements in the ability to optimally integrate visual and tactile signals.
			KEYWORDS:
			Children; Crossmodal; Development; Multisensory; Touch; Vision
			PMID: 29783043 DOI: 10.1016/j.jecp.2018.04.014

Z8600021 at 03:51, 16 August 2017

2017-08-16T03:51:10Z

← Older revision		Revision as of 13:51, 16 August 2017
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	Van Keymeulen A, Mascre G, Youseff KK, Harel I, Michaux C, De Geest N, Szpalski C, Achouri Y, Bloch W, Hassan BA, Blanpain C.		Van Keymeulen A, Mascre G, Youseff KK, Harel I, Michaux C, De Geest N, Szpalski C, Achouri Y, Bloch W, Hassan BA, Blanpain C.
	~~Source~~
	Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Université Libre de Bruxelles, Brussels B-1070, Belgium.		Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire, Université Libre de Bruxelles, Brussels B-1070, Belgium.

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	PMID 19786578		PMID 19786578


			==2005==
			===Human Merkel cells- aspects of cell biology, distribution and functions===
			Eur J Cell Biol. 2005 Mar;84(2-3):259-71.

			Moll I1, Roessler M, Brandner JM, Eispert AC, Houdek P, Moll R.

			Abstract

			Human Merkel cells were first described by Friedrich S. Merkel in 1875 and named "Tastzellen" (touch cells) assuming a sensory touch function within the skin. Only ultrastructural research revealed their characteristics such as dense-core granules, plasma membrane spines and dendrites as well as a loosely arranged cytoskeleton. Biochemical analysis identified the expression of very specific cytokeratins (most notably CK 20) allowing the immunohistochemical detection of Merkel cells. In humans, they occur within the basal epidermis, being concentrated in eccrine glandular ridges of glabrous skin and in Haarscheiben of hairy skin, within belt-like clusters of hair follicles, and in certain mucosal tissues. Within the human skin, the dense-core granules contain heterogeneously distributed neuropeptides, some of which might work as neurotransmitters through which Merkel cells and their associated nerves exert their classical function as slowly adapting mechanoreceptors type I. This is the case in the Haarscheiben, small sensory organs containing keratinocytes with a special program of differentiation that includes the expression of CK 17 and Ber-EP4. Other peptides may act as growth factors and thus might participate in growth, differentiation and homeostasis of cutaneous structures. It is not yet clear whether the Merkel cell carcinomas, aggressive skin carcinomas, indeed arise from Merkel cells. We summarize and discuss data on the distribution, function and heterogeneity of human Merkel cells in normal and diseased skin.
			PMID: 15819406 DOI: 10.1016/j.ejcb.2004.12.023