Talk:Placenta Development - Revision history

Z8600021 at 09:45, 9 February 2022

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	Maternal platelets at the first trimester maternal-placental interface - Small players with great impact on placenta development		Maternal platelets at the first trimester maternal-placental interface - Small players with great impact on placenta development

	{{~~PMID34920861~~}}		{{#pmid:34920861}}

	DOI: 10.1016/j.placenta.2021.12.009		DOI: 10.1016/j.placenta.2021.12.009

Z8600021 at 09:44, 9 February 2022

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			==2021==

			Maternal platelets at the first trimester maternal-placental interface - Small players with great impact on placenta development

			{{PMID34920861}}

			DOI: 10.1016/j.placenta.2021.12.009

			Abstract

			In human pregnancy, maternal platelet counts decrease with each trimester, reaching a reduction by approximately ten percent at term in uncomplicated cases and recover to the levels of the non-pregnant state a few weeks postpartum. The time when maternal platelets start to occur in the early human placenta most likely coincides with the appearance of loosely cohesive endovascular trophoblast plugs showing capillary-sized channels by mid first trimester. At that time, platelets accumulate in intercellular gaps of anchoring parts of trophoblast columns and start to adhere to the surface of placental villi and the chorionic plate. This is considered as normal process that contributes to placenta development by acting on both the extravillous- and the villous trophoblast compartment. Release of platelet cargo into intercellular gaps of anchoring cell columns may affect partial epithelial-to-mesenchymal transition and invasiveness of extravillous trophoblasts as well as deposition of fibrinoid in the basal plate. Activation of maternal platelets on the villous surface leads to perivillous fibrin-type fibrinoid deposition, contributing to the shaping of the developing placental villi and the intervillous space. In contrast, excess platelet activation at the villous surface leads to deregulation of the endocrine activity, sterile inflammation and local apoptosis of the syncytiotrophoblast. Platelets and their released cargo are adapted to pregnancy, and may be altered in high-risk pregnancies. Identification of different maternal platelet subpopulations, which show differential procoagulant ability and different response to anti-platelet therapy, are promising new future directions in deciphering the role of maternal platelets in human placenta physiology.


	==2020==		==2020==

Z8600021 at 22:25, 9 Haziran 2020

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			==2020==

			FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies

			https://www.pnas.org/content/117/23/12943.abstract?etoc

			Transport of IgG antibodies from the maternal to the fetal circulation is a key process for neonatal immunity, as neonates cannot sufficiently generate IgG antibodies to reach protective levels during the first months after birth. In humans and other primates, maternal to fetal transport of IgG antibodies is largely mediated through the placental tissue. FcRn has been previously identified as the major driver of IgG transplacental transport. Here we examine whether other receptors, such as FcγRs, also contribute to the maternal-fetal IgG transfer. By characterizing the Fc domain structure of paired maternal-fetal IgG samples and modeling transplacental IgG transport in genetically engineered mouse strains, we determined that FcRn, but not FcγRs, is the major receptor that mediates transplacental IgG transport.


	==Historic Embryology - Placenta and Fetal Membranes==		==Historic Embryology - Placenta and Fetal Membranes==

Z8600021 at 01:57, 6 December 2019

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	:Historic: [[Book_-_The_Elements_of_Embryology_-_Mammalian_2\|1883 Embryonic Membranes]] \| [[Atlas_of_the_Development_of_Man_1_-_Part_3\|1907 Development Atlas]] \| [[Book_-_Manual_of_Human_Embryology_7\|1910 Textbook]] \| [[Book_-_A_Laboratory_Manual_and_Text-book_of_Embryology_4\|1917 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19\|1921 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19#The_Foetal_Membranes_in_Man\|1921 Foetal Membranes]] \| [[Book_-_Contributions_to_Embryology_Carnegie_Institution_No.64\|1921 Pig implantation]]		:Historic: [[Book_-_The_Elements_of_Embryology_-_Mammalian_2\|1883 Embryonic Membranes]] \| [[Atlas_of_the_Development_of_Man_1_-_Part_3\|1907 Development Atlas]] \| [[Book_-_Manual_of_Human_Embryology_7\|1910 Textbook]] \| [[Book_-_A_Laboratory_Manual_and_Text-book_of_Embryology_4\|1917 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19\|1921 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19#The_Foetal_Membranes_in_Man\|1921 Foetal Membranes]] \| [[Book_-_Contributions_to_Embryology_Carnegie_Institution_No.64\|1921 Pig implantation]]

			===Internet Archive===

			Maughs GMB. [https://archive.org/details/101199053.nlm.nih.gov/page/n2 Placenta praevia]. (1879)

			by Maughs, G. M. B. (George Madison Brown), 1821-1901, author

Z8600021 at 01:56, 6 December 2019

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	:Historic: [[Book_-_The_Elements_of_Embryology_-_Mammalian_2\|1883 Embryonic Membranes]] \| [[Atlas_of_the_Development_of_Man_1_-_Part_3\|1907 Development Atlas]] \| [[Book_-_Manual_of_Human_Embryology_7\|1910 Textbook]] \| [[Book_-_A_Laboratory_Manual_and_Text-book_of_Embryology_4\|1917 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19\|1921 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19#The_Foetal_Membranes_in_Man\|1921 Foetal Membranes]] \| [[Book_-_Contributions_to_Embryology_Carnegie_Institution_No.64\|1921 Pig implantation]]		:Historic: [[Book_-_The_Elements_of_Embryology_-_Mammalian_2\|1883 Embryonic Membranes]] \| [[Atlas_of_the_Development_of_Man_1_-_Part_3\|1907 Development Atlas]] \| [[Book_-_Manual_of_Human_Embryology_7\|1910 Textbook]] \| [[Book_-_A_Laboratory_Manual_and_Text-book_of_Embryology_4\|1917 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19\|1921 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19#The_Foetal_Membranes_in_Man\|1921 Foetal Membranes]] \| [[Book_-_Contributions_to_Embryology_Carnegie_Institution_No.64\|1921 Pig implantation]]



			Adams F. [https://archive.org/details/b30563768 On the construction of the human placenta : an historical sketch] (1858)
			by Adams, Francis


			Ercolani GB. [https://archive.org/details/reproductiveproc02erco/page/n6 The reproductive process: its histology, physiology, and pathology]. Demonstrating the unity of the anatomical type of the placenta in all the Mammalia, and the physiological unity of the nutrition of the fœtus in all the vertebrates. (1884)

			In two volumes: one a quarto atlas of illustrations, engraved by Bettini, and reproduced by the heliotype process. Tr. by Henry O. Marcy . by Ercolani, G. B. (Giovanni Battista), 1819-1883; Marcy, Henry O. (Henry Orlando), 1837-1924



			Marcy HO. [https://archive.org/details/reproductiveproc00erco/page/n6 The reproductive process: its histology, physiology, and pathology]. Demonstrating the unity of the anatomical type of the placenta in all the Mammalia, and the physiological unity of the nutrition of the fœtus in all the vertebrates. (1884)

			In two volumes: one a quarto atlas of illustrations, engraved by Bettini, and reproduced by the heliotype process. Tr. by Henry O. Marcy ..
			by Ercolani, G. B. (Giovanni Battista), 1819-1883; Marcy, Henry O. (Henry Orlando), 1837-1924, tr



			Turner W. [https://archive.org/details/lecturesoncompar00turn/page/n6 Lectures on the comparative anatomy of the placenta](1875) first series : delivered before the Royal college of surgeons of England, June, (1875)


	==2019==		==2019==

Z8600021 at 00:11, 4 December 2019

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	==2019==		==2019==
			{{#pmid:31776138}}

			Development of the human placenta.

			Abstract
			The placenta is essential for normal in utero development in mammals. In humans, defective placental formation underpins common pregnancy disorders such as pre-eclampsia and fetal growth restriction. The great variation in placental types across mammals means that animal models have been of limited use in understanding human placental development. However, new tools for studying human placental development, including 3D organoids, stem cell culture systems and single cell RNA sequencing, have brought new insights into this field. Here, we review the morphological, molecular and functional aspects of human placental formation, with a focus on the defining cell of the placenta - the trophoblast.
			© 2019. Published by The Company of Biologists Ltd.

			KEYWORDS:
			Development; Maternal; Placenta; Trophoblast
			PMID: 31776138 DOI: 10.1242/dev.163428

	===Associations Between the Features of Gross Placental Morphology and Birthweight===		===Associations Between the Features of Gross Placental Morphology and Birthweight===

Z8600021 at 11:53, 1 Haziran 2019

2019-06-01T11:53:32Z

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	==2019==		==2019==

			===Associations Between the Features of Gross Placental Morphology and Birthweight===
			Pediatr Dev Pathol. 2019 May-Jun;22(3):194-204. doi: 10.1177/1093526618789310. Epub 2018 Jul 16.


			Freedman AA1, Hogue CJ1, Marsit CJ1,2, Rajakumar A3, Smith AK3, Goldenberg RL4, Dudley DJ5, Saade GR6, Silver RM7, Gibbins KJ7, Stoll BJ8, Bukowski R9, Drews-Botsch C1.

			The placenta plays a critical role in regulating fetal growth. Recent studies suggest that there may be sex-specific differences in placental development. The purpose of our study was to evaluate the associations between {{birthweight}} and placental morphology in models adjusted for covariates and to assess sex-specific differences in these associations. We analyzed data from the Stillbirth Collaborative Research Network's population-based case-control study conducted between 2006 and 2008, which recruited cases of stillbirth and population-based controls in 5 states. Our analysis was restricted to singleton live births with a placental examination (n = 1229). Characteristics of placental morphology evaluated include thickness, surface area, difference in diameters, shape, and umbilical cord insertion site. We used linear regression to model birthweight as a function of placental morphology and covariates. Surface area had the greatest association with birthweight; a reduction in surface area of 83 cm2, which reflects the interquartile range, is associated with a 260.2-g reduction in birthweight (95% confidence interval, -299.9 to -220.6), after adjustment for other features of placental morphology and covariates. Reduced placental thickness was also associated with lower birthweight. These associations did not differ between males and females. Our results suggest that reduced placental thickness and surface area are independently associated with lower birthweight and that these relationships are not related to sex.

			KEYWORDS:
			birthweight; fetal; neonatal; placenta; placental shape; placental size
			PMID: 30012074 PMCID: PMC6335186 [Available on 2020-05-01] DOI: 10.1177/1093526618789310

	===The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling===		===The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling===

Z8600021 at 02:00, 31 Mayıs 2019

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	:Historic: [[Book_-_The_Elements_of_Embryology_-_Mammalian_2\|1883 Embryonic Membranes]] \| [[Atlas_of_the_Development_of_Man_1_-_Part_3\|1907 Development Atlas]] \| [[Book_-_Manual_of_Human_Embryology_7\|1910 Textbook]] \| [[Book_-_A_Laboratory_Manual_and_Text-book_of_Embryology_4\|1917 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19\|1921 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19#The_Foetal_Membranes_in_Man\|1921 Foetal Membranes]] \| [[Book_-_Contributions_to_Embryology_Carnegie_Institution_No.64\|1921 Pig implantation]]		:Historic: [[Book_-_The_Elements_of_Embryology_-_Mammalian_2\|1883 Embryonic Membranes]] \| [[Atlas_of_the_Development_of_Man_1_-_Part_3\|1907 Development Atlas]] \| [[Book_-_Manual_of_Human_Embryology_7\|1910 Textbook]] \| [[Book_-_A_Laboratory_Manual_and_Text-book_of_Embryology_4\|1917 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19\|1921 Textbook]] \| [[Book_-_Text-Book_of_Embryology_19#The_Foetal_Membranes_in_Man\|1921 Foetal Membranes]] \| [[Book_-_Contributions_to_Embryology_Carnegie_Institution_No.64\|1921 Pig implantation]]

			==2019==
			===The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling===

			FASEB J. 2019 Feb;33(2):2944-2956. doi: 10.1096/fj.201801193R. Epub 2018 Oct 18.

			Michelsen TM1,2, Henriksen T2, Reinhold D3, Powell TL4, Jansson T1.

			We sought to identify proteins secreted by the human placenta into the maternal and fetal circulations. Blood samples from the maternal radial artery and uterine vein and umbilical artery and vein were obtained during cesarean section in 35 healthy women with term pregnancy. Slow off-rate modified aptamer (SOMA) protein-binding technology was used to quantify 1310 known proteins. The uteroplacental and umbilical venoarterial concentration differences were calculated. Thirty-four proteins were significantly secreted by the placenta into the maternal circulation, including placental growth factor, growth/differentiation factor 15, and matrix metalloproteinase 12. There were 341 proteins significantly secreted by the placenta into the fetal circulation. Only 7 proteins were secreted into both the fetal and maternal circulations, suggesting a distinct directionality in placental protein release. We examined changes across gestation in the proteins found to be significantly secreted by the placenta into the maternal circulation using serial blood samples from healthy women. Among the 34 proteins secreted into the maternal circulation, 8 changed significantly across gestation. The identified profiles of secreted placental proteins will allow us to identify novel minimally invasive biomarkers for human placental function across gestation and discover previously unknown proteins secreted by the human placenta that regulate maternal physiology and fetal development.-Michelsen, T. M., Henriksen, T., Reinhold, D., Powell, T. L., Jansson, T. The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4-vessel sampling.
			KEYWORDS:
			placental physiology; pregnancy proteins; proteomics; trophoblast
			PMID: 30335547 DOI: 10.1096/fj.201801193R

Z8600021 at 02:02, 18 December 2018

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	~~==10 Most Recent Papers==~~
	~~{{10 Most Recent}}~~


	==Historic Embryology - Placenta and Fetal Membranes==		==Historic Embryology - Placenta and Fetal Membranes==

Z8600021 at 02:02, 18 December 2018

2018-12-18T02:02:31Z

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	==10 Most Recent Papers==		==10 Most Recent Papers==
	{{10 Most Recent}}		{{10 Most Recent}}

	~~===Placenta===~~

	~~<pubmed limit=10>Placenta</pubmed>~~

	==Historic Embryology - Placenta and Fetal Membranes==		==Historic Embryology - Placenta and Fetal Membranes==