Talk:Lecture - Early Vascular Development - Revision history

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			==2016==

			[[Media:Lecture_2016_-_Early Vascular Development.pdf\|2016 Lecture - Print PDF]]



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			! ECHO360 Recording
			\|-
			\| [[File:ECHO360_icon.gif\|right\|link=https://lectures.unsw.edu.au/ess/portal/section/691ba9a0-7c35-4ad2-8fd0-846db7771557]]

			Links only work with currently enrolled UNSW students.

			[[Lecture - Early Vascular Development\|Lecture 7]] - [https://lectures.unsw.edu.au/ess/echo/presentation/5a915a64-6868-4e18-80c0-14e0bf963075 Rich Media Playback] \|
			[https://lectures.unsw.edu.au/ess/echo/presentation/5a915a64-6868-4e18-80c0-14e0bf963075/media.m4v Vodcast Playback] \| [https://lectures.unsw.edu.au/ess/echo/presentation/5a915a64-6868-4e18-80c0-14e0bf963075/media.mp3 Podcast Playback]

			\|}

	[[Media:ANAT2341_Lecture_7_-_2014_Early_Vascular_Development.pdf\|2014 Lecture 7 PDF]]		[[Media:ANAT2341_Lecture_7_-_2014_Early_Vascular_Development.pdf\|2014 Lecture 7 PDF]]

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			[[Media:ANAT2341_Lecture_7_-_2014_Early_Vascular_Development.pdf\|2014 Lecture 7 PDF]]

	====Cardiovascular Notes====		====Cardiovascular Notes====

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	[http://lectopia.telt.unsw.edu.au/lectopia/lectopia.lasso?ut=153&id=110462 2011 Lecture 7 Audio]		[http://lectopia.telt.unsw.edu.au/lectopia/lectopia.lasso?ut=153&id=110462 2011 Lecture 7 Audio]

			Lecture page was last modified on 13 August 2012, at 04:19 been accessed 2,023 times.

	Mol Syst Biol. 2010 Jun 22;6:381.		Mol Syst Biol. 2010 Jun 22;6:381.

Z8600021: /* Cardiovascular Notes */

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Cardiovascular Notes

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	Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems-level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting the functional architecture of organ development, we combined detailed phenotype information from deleterious mutations in 255 genes with high-confidence experimental interactome data, and coupled the results to thorough experimental validation. Hereby, we made the first systematic analysis of spatio-temporal protein networks driving many stages of a developing organ identifying several novel signaling modules. Our results show that organ development relies on surprisingly few, extensively recycled, protein modules that integrate into complex higher-order networks. This design allows the formation of a complicated organ using simple building blocks, and suggests how mutations in the same genes can lead to diverse phenotypes. We observe a striking temporal correlation between organ complexity and the number of discrete functional modules coordinating morphogenesis. Our analysis elucidates the organization and composition of spatio-temporal protein networks that drive the formation of organs, which in the future may lay the foundation of novel approaches in treatments, diagnostics, and regenerative medicine.		Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems-level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting the functional architecture of organ development, we combined detailed phenotype information from deleterious mutations in 255 genes with high-confidence experimental interactome data, and coupled the results to thorough experimental validation. Hereby, we made the first systematic analysis of spatio-temporal protein networks driving many stages of a developing organ identifying several novel signaling modules. Our results show that organ development relies on surprisingly few, extensively recycled, protein modules that integrate into complex higher-order networks. This design allows the formation of a complicated organ using simple building blocks, and suggests how mutations in the same genes can lead to diverse phenotypes. We observe a striking temporal correlation between organ complexity and the number of discrete functional modules coordinating morphogenesis. Our analysis elucidates the organization and composition of spatio-temporal protein networks that drive the formation of organs, which in the future may lay the foundation of novel approaches in treatments, diagnostics, and regenerative medicine.

	PMID: 20571530		PMID 20571530

	~~http://www.ncbi.nlm.nih.gov/pubmed/20571530~~

	http://www.nature.com/msb/journal/v6/n1/full/msb201036.html		http://www.nature.com/msb/journal/v6/n1/full/msb201036.html

Z8600021 at 23:57, 8 August 2012

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	====Cardiovascular Notes====		====Cardiovascular Notes====

			[http://lectopia.telt.unsw.edu.au/lectopia/lectopia.lasso?ut=153&id=110462 2011 Lecture 7 Audio]


	Mol Syst Biol. 2010 Jun 22;6:381.		Mol Syst Biol. 2010 Jun 22;6:381.

S8600021 at 04:08, 15 August 2011

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	====Cardiovascular Notes====		====Cardiovascular Notes====

			Mol Syst Biol. 2010 Jun 22;6:381.
			Dissecting spatio-temporal protein networks driving human heart development and related disorders.
			Lage K, Møllgård K, Greenway S, Wakimoto H, Gorham JM, Workman CT, Bendsen E, Hansen NT, Rigina O, Roque FS, Wiese C, Christoffels VM, Roberts AE, Smoot LB, Pu WT, Donahoe PK, Tommerup N, Brunak S, Seidman CE, Seidman JG, Larsen LA.
			Source
			Pediatric Surgical Research Laboratories, MassGeneral Hospital for Children, Massachusetts General Hospital, Boston, MA 02114, USA. lage.kasper@mgh.harvard.edu
			Abstract
			Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems-level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting the functional architecture of organ development, we combined detailed phenotype information from deleterious mutations in 255 genes with high-confidence experimental interactome data, and coupled the results to thorough experimental validation. Hereby, we made the first systematic analysis of spatio-temporal protein networks driving many stages of a developing organ identifying several novel signaling modules. Our results show that organ development relies on surprisingly few, extensively recycled, protein modules that integrate into complex higher-order networks. This design allows the formation of a complicated organ using simple building blocks, and suggests how mutations in the same genes can lead to diverse phenotypes. We observe a striking temporal correlation between organ complexity and the number of discrete functional modules coordinating morphogenesis. Our analysis elucidates the organization and composition of spatio-temporal protein networks that drive the formation of organs, which in the future may lay the foundation of novel approaches in treatments, diagnostics, and regenerative medicine.

			PMID: 20571530

			http://www.ncbi.nlm.nih.gov/pubmed/20571530

			http://www.nature.com/msb/journal/v6/n1/full/msb201036.html

			This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial Share Alike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.


	* [[Cardiovascular System Development]]		* [[Cardiovascular System Development]]

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	~~==UNSW Embryology Links==~~		Cardiovascular Slides [[2010_Lecture_7\|2009 Lecture]] \| [http://embryology.med.unsw.edu.au/Science/ANAT2341lecture07.htm 2008 Lecture]

	~~====~~Cardiovascular Slides~~====~~
	* [[2010_Lecture_7\|2009 Lecture]] \| [http://embryology.med.unsw.edu.au/Science/ANAT2341lecture07.htm 2008 Lecture]

			===Recent Reviews===
			<pubmed>11891982</pubmed>
			<pubmed>12746463</pubmed>
			<pubmed>12807866</pubmed>
			<pubmed>11909814</pubmed>

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			====Cardiovascular Notes====

			* [[Cardiovascular System Development]]
			* [[Cardiac_Embryology\|Cardiac Embryology Tutorial]] - [[Basic Cardiac Embryology]] \| [[Intermediate Cardiac Embryology]] [[Advanced Cardiac Embryology]]
			* Original Notes pages - [http://embryology.med.unsw.edu.au/Notes/heart.htm Introduction] \| [http://embryology.med.unsw.edu.au/Notes/heart2.htm Abnormalities] \| [http://embryology.med.unsw.edu.au/Notes/heart3.htm Stage 13/14] \| [http://embryology.med.unsw.edu.au/Notes/heart4.htm Stage 22] \| [http://embryology.med.unsw.edu.au/Notes/heart5.htm Stage 22 Selected Highpower] \| [http://embryology.med.unsw.edu.au/Notes/heart6.htm Heart] \| [http://embryology.med.unsw.edu.au/Notes/heart8.htm Heart Rate] \| [http://embryology.med.unsw.edu.au/Notes/heart20.htm Blood][http://embryology.med.unsw.edu.au/Notes/heart19.htm Blood Vessels] \| [http://embryology.med.unsw.edu.au/Notes/heart11.htm Molecular] \| [http://embryology.med.unsw.edu.au/Notes/heart31.htm Lymphatic] \| [http://embryology.med.unsw.edu.au/Child/heart.htm Postnatal] \| [http://embryology.med.unsw.edu.au/history/page2b.htm#Harvey History - Harvey]


	==UNSW Embryology Links==		==UNSW Embryology Links==

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			==UNSW Embryology Links==

			====Cardiovascular Slides====
			* [[2010_Lecture_7\|2009 Lecture]] \| [http://embryology.med.unsw.edu.au/Science/ANAT2341lecture07.htm 2008 Lecture]



	==Take the Quiz==		==Take the Quiz==
	<quiz display=simple>		<quiz display=simple>