Talk:Implantation - Revision history

Z8600021 at 22:47, 9 Haziran 2020

2020-06-09T22:47:12Z

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			==2020==
			A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules

			https://www.pnas.org/content/early/2020/06/05/2000810117

			In many mammalian species, embryo implantation and processes of early pregnancy occur in a hypoxic environment. However, the mechanisms underlying maternal adaptation to hypoxia during early pregnancy remain unclear. This work has uncovered an important mechanism in mammalian reproduction and development by identifying maternal secretory granules that mediate molecular dialogue between the maternal tissue compartments during early pregnancy. This dialogue, which is the molecular basis of adaptation to hypoxia, is critical for embryo implantation and establishment of pregnancy.


	==2019==		==2019==

Z8600021 at 23:30, 2 December 2019

2019-12-02T23:30:46Z

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	==~~10 Most Recent~~==		==2019==
	{{~~10 Most Recent~~}}		{{#pmid:31276203}}
	~~===Embryo Implantation===~~
	~~<pubmed limit=5>Embryo Implantation</pubmed>~~

	~~===Uterine Implantation===~~		N-glycosylation of uterine endometrium determines its receptivity.
	~~<pubmed limit=5>Uterine Implantation</pubmed>~~

	~~===Activin Implantation===~~
	~~<pubmed limit=5>Activin Implantation</pubmed>~~

	~~===Human Blastocyst Implantation===~~
	~~<pubmed limit=5>Human Blastocyst Implantation</pubmed>~~

	~~===Ectopic Implantation===~~
	~~<pubmed limit=5>Ectopic Implantation</pubmed>~~

			Abstract
			Glycosylation alters the molecular and functional features of glycoproteins, which is closely related with many physiological processes and diseases. During "window of implantation", uterine endometrium transforms into a receptive status to accept the embryo, thereby establishing successful embryo implantation. In this article, we aimed at investigating the role of N-glycosylation, a major modification type of glycoproteins, in the process of endometrial receptivity establishment. Results found that human uterine endometrial tissues at mid-secretory phase exhibited Lectin PHA-E+L (recognizes the branched N-glycans) positive N-glycans as measured by the Lectin fluorescent staining analysis. By utilizing in vitro implantation model, we found that de-N-glycosylation of human endometrial Ishikawa and RL95-2 cells by tunicamycin (inhibitor of N-glycosylation) and peptide-N-glycosidase F (PNGase F) impaired their receptive ability to human trophoblastic JAR cells. Meanwhile, N-glycosylation of integrin αvβ3 and leukemia inhibitory factor receptor (LIFR) are found to play key roles in regulating the ECM-dependent FAK/Paxillin and LIF-induced STAT3 signaling pathways, respectively, thus affecting the receptive potentials of endometrial cells. Furthermore, in vivo experiments and primary mouse endometrial cells-embryos coculture model further verified that N-glycosylation of mouse endometrial cells contributed to the successful implantation. Our results provide new evidence to show that N-glycosylation of uterine endometrium is essential for maintaining the receptive functions, which gives a better understanding of the glycobiology of implantation.
			© 2019 Wiley Periodicals, Inc.
			KEYWORDS:
			N-glycosylation, LIFR; avβ3; embryo implantation; endometrial receptivity
			PMID: 31276203 DOI: 10.1002/jcp.29022

	==2018==		==2018==

Z8600021 at 03:30, 25 Haziran 2018

2018-06-25T03:30:09Z

@@ Line 17: / Line 17: @@
 ===Ectopic Implantation===
 <pubmed limit=5>Ectopic Implantation</pubmed>
 ==2016==

Z8600021 at 23:36, 7 August 2016

2016-08-07T23:36:45Z

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	==2016==		==2016==

			===Local and systemic factors and implantation: what is the evidence?===

			Fertil Steril. 2016 Apr;105(4):873-84. doi: 10.1016/j.fertnstert.2016.02.018. Epub 2016 Mar 3.

			Fox C1, Morin S2, Jeong JW3, Scott RT Jr2, Lessey BA4.

			Abstract

			Significant progress has been made in the understanding of embryonic competence and endometrial receptivity since the inception of assisted reproductive technology. The endometrium is a highly dynamic tissue that plays a crucial role in the establishment and maintenance of normal pregnancy. In response to steroid sex hormones, the endometrium undergoes marked changes during the menstrual cycle that are critical for acceptance of the nascent embryo. There is also a wide body of literature on systemic factors that impact assisted reproductive technology outcomes. Patient prognosis is impacted by an array of factors that tip the scales in her favor or against success. Recognizing the local and systemic factors will allow clinicians to better understand and optimize the maternal environment at the time of implantation. This review will address the current literature on endometrial and systemic factors related to impaired implantation and highlight recent advances in this area of reproductive medicine.
			Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
			KEYWORDS:
			Endometrium; IVF; immune factors; implantation; thyroid; vitamin D

			PMID 26945096

	===The role of CX3CL1 in fetal-maternal interaction during human gestation===		===The role of CX3CL1 in fetal-maternal interaction during human gestation===

Z8600021 at 01:44, 12 Ocak 2016

2016-01-12T01:44:52Z

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	==2015==		==2015==

			===The adherens junction is lost during normal pregnancy but not during ovarian hyper stimulated pregnancy===

			Acta Histochem. 2015 Dec 28. pii: S0065-1281(15)30033-7. doi: 10.1016/j.acthis.2015.12.004. [Epub ahead of print]

			Dowland SN1, Madawala RJ2, Lindsay LA2, Murphy CR2.

			Abstract

			During early pregnancy in the rat, the luminal uterine epithelial cells (UECs) must transform to a receptive state to permit blastocyst attachment and implantation. The implantation process involves penetration of the epithelial barrier, so it is expected that the transformation of UECs includes alterations in the lateral junctional complex. Previous studies have demonstrated a deepening of the tight junction (zonula occludens) and a reduction in the number of desmosomes (macula adherens) in UECs at the time of implantation. However, the adherens junction (zonula adherens), which is primarily responsible for cell-cell adhesion, has been little studied during early pregnancy. This study investigated the adherens junction in rat UECs during the early stages of normal pregnancy and ovarian hyperstimulated (OH) pregnancy using transmission electron microscopy. The adherens junction is present in UECs at the time of fertilisation, but is lost at the time of blastocyst implantation during normal pregnancy. Interestingly, at the time of implantation after OH, adherens junctions are retained and may impede blastocyst penetration of the epithelium. The adherens junction anchors the actin-based terminal web, which is known to be disrupted in UECs during early pregnancy. However, artificial disruption of the terminal web, using cytochalasin D, did not cause removal of the adherens junction in UECs. This study revealed that adherens junction disassembly occurs during early pregnancy, but that this process does not occur during OH pregnancy. Such disassembly does not appear to depend on the disruption of the terminal web.
			Copyright © 2015 Elsevier GmbH. All rights reserved.
			KEYWORDS:
			Adherens junction; Epithelium; Implantation; Ovarian hyperstimulation; Pregnancy; Uterine receptivity
			PMID 26738975

	===Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation===		===Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation===

Z8600021 at 01:43, 12 Ocak 2016

2016-01-12T01:43:01Z

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	<pubmed limit=5>Ectopic Implantation</pubmed>		<pubmed limit=5>Ectopic Implantation</pubmed>

	==~~2015~~==		==2016==

	===The role of CX3CL1 in fetal-maternal interaction during human gestation===		===The role of CX3CL1 in fetal-maternal interaction during human gestation===
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	PMID 26745855		PMID 26745855

			==2015==

	===Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation===		===Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation===

Z8600021 at 01:42, 12 Ocak 2016

2016-01-12T01:42:31Z

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	==2015==		==2015==

			===The role of CX3CL1 in fetal-maternal interaction during human gestation===
			Cell Adh Migr. 2016 Jan 8:0. [Epub ahead of print]

			Demirci EK1, Salamonsen LA2,3, Gauster M4.

			Abstract

			Embryo implantation and subsequent placentation require a fine balanced fetal-maternal cross-talk of hormones, cytokines and chemokines. Amongst the group of chemokines, CX3CL1 (also known as fractalkine) has recently attracted attention in the field of reproductive research. It exists both as membrane-bound and soluble isoforms. On the basis of current experimental evidence, fractalkine is suggested to regulate adhesion and migration processes in fetal-maternal interaction at different stages of human pregnancy. Expressed by uterine glandular epithelial cells, predominantly during the mid-secretory phase of the menstrual cycle, fractalkine appears to prime the blastocyst for forthcoming implantation. After implantation, fractalkine is suggested to regulate invasion of extravillous trophoblasts by altering their expression profile of adhesion molecules. With onset of perfusion of the intervillous space at the end of first trimester, fractalkine present at the apical microvillous plasma membrane of the syncytiotrophoblast may mediate close interaction of placental villi with circulating maternal blood cells.
			KEYWORDS:
			Fractalkine; fetal-maternal cross-talk; implantation; invasion; trophoblast

			PMID 26745855

	===Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation===		===Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation===

Z8600021 at 01:40, 9 August 2015

2015-08-09T01:40:11Z

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	==2015==		==2015==

			===Cellular Regulation of the Uterine Microenvironment That Enables Embryo Implantation===

			Front Immunol. 2015 Jun 17;6:321. doi: 10.3389/fimmu.2015.00321. eCollection 2015.

			Zenclussen AC1, Hämmerling GJ2.

			Abstract

			Implantation of the fertilized egg into the maternal uterus is a crucial step in pregnancy establishment. Increasing evidence suggests that its success depends on various cell types of the innate immune system and on the fine balance between inflammatory and anti-inflammatory processes. In addition, it has recently been established that regulatory T cells play a superordinate role in dictating the quality of uterine environment required for successful pregnancy. Here, we discuss the cellular regulation of uterine receptivity with emphasis on the function and regulation of cells from the innate and adaptive immune system.
			KEYWORDS:
			Treg cells; implantation; macrophages; mast cells; neutrophils; uterine DCs; uterine NK cells; uterine environment

			PMID 26136750

			http://journal.frontiersin.org/article/10.3389/fimmu.2015.00321/full
			© 2015 Zenclussen and Hämmerling. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

	===Where and when should natural killer cells be tested in women with repeated implantation failure?===		===Where and when should natural killer cells be tested in women with repeated implantation failure?===

Z8600021 at 01:31, 9 August 2015

2015-08-09T01:31:04Z

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	==2013==		==2013==

			===Physiological and molecular determinants of embryo implantation===
			Mol Aspects Med. 2013 Oct;34(5):939-80. doi: 10.1016/j.mam.2012.12.011. Epub 2013 Jan 2.

			Zhang S1, Lin H, Kong S, Wang S, Wang H, Wang H, Armant DR.

			Abstract

			Embryo implantation involves the intimate interaction between an implantation-competent blastocyst and a receptive uterus, which occurs in a limited time period known as the window of implantation. Emerging evidence shows that defects originating during embryo implantation induce ripple effects with adverse consequences on later gestation events, highlighting the significance of this event for pregnancy success. Although a multitude of cellular events and molecular pathways involved in embryo-uterine crosstalk during implantation have been identified through gene expression studies and genetically engineered mouse models, a comprehensive understanding of the nature of embryo implantation is still missing. This review focuses on recent progress with particular attention to physiological and molecular determinants of blastocyst activation, uterine receptivity, blastocyst attachment and uterine decidualization. A better understanding of underlying mechanisms governing embryo implantation should generate new strategies to rectify implantation failure and improve pregnancy rates in women.
			Copyright © 2012 Elsevier Ltd. All rights reserved.
			KEYWORDS:
			Blastocyst activation; Blastocyst attachment; Decidualization; Embryo implantation; Uterine receptivity
			PMID 23290997


	===Mucins help to avoid alloreactivity at the maternal feral interface===		===Mucins help to avoid alloreactivity at the maternal feral interface===

Z8600021 at 01:35, 26 February 2015

2015-02-26T01:35:08Z

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 ===Ectopic Implantation===
 <pubmed limit=5>Ectopic Implantation</pubmed>
 ==2014==