Talk:Birth - Macrosomia - Revision history

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 ===High Birthweight===
 <pubmed limit=5>High+Birthweight</pubmed>
 ==2014==

Z8600021 at 22:42, 19 Haziran 2014

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	PMID 24941024		PMID 24941024

			http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0100192
	==2012==		==2012==

Z8600021 at 22:36, 19 Haziran 2014

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			==2014==

			===Searching for the Definition of Macrosomia through an Outcome-Based Approach===

			PLoS One. 2014 Jun 18;9(6):e100192. doi: 10.1371/journal.pone.0100192. eCollection 2014.

			Ye J, Zhang L, Chen Y, Fang F, Luo Z, Zhang J.

			Abstract

			BACKGROUND:
			Macrosomia has been defined in various ways by obstetricians and researchers. The purpose of the present study was to search for a definition of macrosomia through an outcome-based approach.
			METHODS:
			In a study of 30,831,694 singleton term live births and 38,053 stillbirths in the U.S. Linked Birth-Infant Death Cohort datasets (1995-2004), we compared the occurrence of stillbirth, neonatal death, and 5-min Apgar score less than four in subgroups of birthweight (4000-4099 g, 4100-4199 g, 4200-4299 g, 4300-4399 g, 4400-4499 g, 4500-4999 g vs. reference group 3500-4000 g) and birthweight percentile for gestational age (90th-94th percentile, 95th-96th, and ≥97th percentile, vs. reference group 75th-90th percentile).
			RESULTS:
			There was no significant increase in adverse perinatal outcomes until birthweight exceeded the 97th percentile. Weight-specific odds ratios (ORs) elevated substantially to 2 when birthweight exceeded 4500 g in Whites. In Blacks and Hispanics, the aORs exceeded 2 for 5-min Apgar less than four when birthweight exceeded 4300 g. For vaginal deliveries, the aORs of perinatal morbidity and mortality were larger for most of the subgroups, but the patterns remained the same.
			CONCLUSIONS:
			A birthweight greater than 4500 g in Whites, or 4300 g in Blacks and Hispanics regardless of gestational age is the optimal threshold to define macrosomia. A birthweight greater than the 97th percentile for a given gestational age, irrespective of race is also reasonable to define macrosomia. The former may be more clinically useful and simpler to apply.


			PMID 24941024

	==2012==		==2012==

Z8600021 at 00:07, 21 April 2013

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	==2012==		==2012==

			===Prediction and prevention of the macrosomic fetus===

			Eur J Obstet Gynecol Reprod Biol. 2012 Jun;162(2):125-30. doi: 10.1016/j.ejogrb.2012.03.005. Epub 2012 Mar 27.

			Walsh JM, McAuliffe FM.
			Source
			UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland. jennifer.walsh@ucd.ie

			Abstract

			Fetal macrosomia is associated with significant maternal and neonatal morbidity. In the long term, infants who are large for gestational age are more likely than other infants to be obese in childhood, adolescence and early adulthood, and are inherently at higher risk of cardiovascular and metabolic complications in adulthood. With over one billion adults in the world now overweight and more than 600 million clinically obese, preventing the vicious cycle effect of fetal macrosomia and childhood obesity is an increasingly pertinent issue. Fetal growth is determined by a complex interplay of various genetic and environmental influences. Consequently the prediction of pregnancies at risk of pathological overgrowth is difficult. Many risk factors for fetal macrosomia, such as maternal obesity and advanced maternal age, are also conversely associated with intrauterine growth restriction. Sonographic detection of fetal macrosomia is notoriously fraught with difficulties, with dozens of formulas for estimated fetal weight proposed but few with sufficient sensitivity to alter clinical practice. This calls into question policies of elective delivery based on projected estimated fetal weight cut-offs alone. More recently the identification of markers of fetal adiposity and maternal serum biomarkers are being investigated to improve the antenatal detection of the large for gestational age fetus. Prevention of fetal macrosomia is entirely dependent upon correct identification of those at risk. Maternal weight, gestational weight gain and glycaemic control are the risk factors for fetal macrosomia that are most amenable to intervention, and have potential maternal health benefits beyond pregnancy and childbirth. The ideal method of optimising maternal weight and glucose homeostasis is yet to be elucidated, though a number of promising advances are recently being reported. In this review we outline the contemporary evidence for the prediction and prevention of fetal macrosomia, which is indeed a contemporary dilemma.
			Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

			PMID 22459652

	===Occurrence of fetal macrosomia rate and its maternal and neonatal complications: a 5-year cohort study===		===Occurrence of fetal macrosomia rate and its maternal and neonatal complications: a 5-year cohort study===

Z8600021 at 02:40, 12 December 2012

2012-12-12T02:40:57Z

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			==2012==

	==~~2011~~==		===Occurrence of fetal macrosomia rate and its maternal and neonatal complications: a 5-year cohort study===
			ISRN Obstet Gynecol. 2012;2012:353791. doi: 10.5402/2012/353791. Epub 2012 Nov 14.

			Najafian M, Cheraghi M.
			Source
			Department of Obstetrics & Gynecology, School of Medicine, Ahwaz Jundishapur University of Medical Sciences, Ahwaz 61357-15794, Iran.
			Abstract
			Background. Macrosomia is defined as an infant's birth weight of more than 4000 g at term which is to different maternal and neonatal complications. Several studies have been done on factors influencing risk of macrosomia, but there is lack of information and study in our country regarding macrosomia complications. Objective. The aim of this study was to determine the prevalence of macrosomia and its complications. Method. A cohort study was conducted from 2007 to 2011 at Obstetrics and Gynecology Department, Razi Hospital in Ahvaz city, Iran. All pregnant mothers who were referred to Obstetrics and Gynecology Department for delivery were included in this study. The total number of 201,102 pregnant mothers was recruited and divided into case and control groups after delivery (macrosomia (case) and normal weight infants (control) groups). Results. Out of total deliveries (201,102), there were 1800 macrosomia, (9%). Gestational diabetes, maternal obesity (BMI), maternal aged and positive history of previous macrosomia were the major risk factors for macrosomia which were compared with the normal weight infant groups (P < 0.001 for all parameters). Neonatal complications associated with macrosomia included humerus-clavicle fractures and arm-brachial plexus injury which were significant compared to the control group (P < 0.001 for all parameters). Conclusion. The macrosomia is potentially dangerous for the mother and the neonate. It is important to recognize the suspected fetal macrosomia to prevent its risk factors and complications. There is a need to provide all delivery facilities and care services to prevent and reduce the maternal and neonatal macrosomia complications.

			PMID 23209925

			==2011==
	===Maternal serum adiponectin at 11 to 13 weeks of gestation in the prediction of macrosomia===		===Maternal serum adiponectin at 11 to 13 weeks of gestation in the prediction of macrosomia===
	Prenat Diagn. 2011 May;31(5):479-83. doi: 10.1002/pd.2723. Epub 2011 Mar 10.		Prenat Diagn. 2011 May;31(5):479-83. doi: 10.1002/pd.2723. Epub 2011 Mar 10.

Z8600021 at 02:39, 12 December 2012

2012-12-12T02:39:34Z

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	{{Talk Page}}		{{Talk Page}}


	==10 Most Recent==		==10 Most Recent==
	{{10 Most Recent}}		{{10 Most Recent}}
	===~~Preterm Birth~~===		===Macrosomia===
	<pubmed limit=5>Macrosomia</pubmed>		<pubmed limit=5>Macrosomia</pubmed>

	===~~Preterm Birth~~===		===High Birthweight===
	<pubmed limit=5>High+Birthweight</pubmed>		<pubmed limit=5>High+Birthweight</pubmed>

Z8600021 at 02:37, 12 December 2012

2012-12-12T02:37:21Z

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	{{Talk Page}}		{{Talk Page}}

			==10 Most Recent==
			{{10 Most Recent}}
			===Preterm Birth===
			<pubmed limit=5>Macrosomia</pubmed>

			===Preterm Birth===
			<pubmed limit=5>High+Birthweight</pubmed>



	==2011==		==2011==

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2011

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 ==2011==
 ===Maternal serum adiponectin at 11 to 13 weeks of gestation in the prediction of macrosomia===
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 PMID 21501437
 ==2010==

Z8600021: /* 2011 */

2012-02-25T23:50:52Z

2011

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 {{Talk Page}}
 ==2011==
 ===Effect of screening and management of diabetes during pregnancy on stillbirths===
 BMC Public Health. 2011 Apr 13;11 Suppl 3:S2.

Z8600021 at 23:43, 25 February 2012

2012-02-25T23:43:15Z

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			==2011==
			===Effect of screening and management of diabetes during pregnancy on stillbirths===
			BMC Public Health. 2011 Apr 13;11 Suppl 3:S2.


			Syed M, Javed H, Yakoob MY, Bhutta ZA.
			Source
			Division of Women & Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan.
			Abstract
			BACKGROUND:
			Diabetes during pregnancy is associated with significant risk of complications to the mother, fetus and newborn. We reviewed the potential impact of early detection and control of diabetes mellitus during pregnancy on stillbirths for possible inclusion in the Lives Saved Tool (LiST).
			METHODS:
			A systematic literature search up to July 2010 was done to identify all published randomized controlled trials and observational studies. A standardized data abstraction sheet was employed and data were abstracted by two independent authors. Meta-analyses were performed with different sub-group analyses. The analyses were graded according to the CHERG rules using the adapted GRADE criteria and recommendations made after assessing the overall quality of the studies included in the meta-analyses.
			RESULTS:
			A total of 70 studies were selected for data extraction including fourteen intervention studies and fifty six observational studies. No randomized controlled trials were identified evaluating early detection of diabetes mellitus in pregnancy versus standard screening (glucose challenge test between 24th to 28th week of gestation) in pregnancy. Intensive management of gestational diabetes (including specialized dietary advice, increased monitoring and tailored dietary therapy) during pregnancy (3 studies: 3791 participants) versus conventional management (dietary advice and insulin as required) was associated with a non-significant reduction in the risk of stillbirths (RR 0.20; 95% CI: 0.03-1.10) ('moderate' quality evidence). Optimal control of serum blood glucose versus sub-optimal control was associated with a significant reduction in the risk of perinatal mortality (2 studies, 5286 participants: RR = 0.40, 95% CI 0.25- 0.63), but not stillbirths (3 studies, 2469 participants: RR = 0.51, 95% CI 0.14-1.88). Preconception care of diabetes (information about need for optimization of glycemic control before pregnancy, assessment of diabetes complications, review of dietary habits, intensification of capillary blood glucose self-monitoring and optimization of insulin therapy) versus none (3 studies: 910 participants) was associated with a reduction in perinatal mortality (RR = 0.29, 95% CI 0.14 -0.60). Using the Delphi process for estimating effect size of optimal diabetes recognition and management yielded a median effect size of 10% reduction in stillbirths.
			CONCLUSIONS:
			Diabetes, especially pre-gestational diabetes with its attendant vascular complications, is a significant risk factor for stillbirth and perinatal death. Our review highlights the fact that very few studies of adequate quality are available that can provide estimates of the effect of screening for aid management of diabetes in pregnancy on stillbirth risk. Using the Delphi process we recommend a conservative 10% reduction in the risk of stillbirths, as a point estimate for inclusion in the LiST.

			PMID 21501437

	==2010==		==2010==