Talk:Assisted Reproductive Technology - Revision history

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	'''Follicle size indicates oocyte maturity and blastocyst formation but not blastocyst euploidy following controlled ovarian hyperstimulation of oocyte donors'''		'''Follicle size indicates oocyte maturity and blastocyst formation but not blastocyst euploidy following controlled ovarian hyperstimulation of oocyte donors'''


	Abstract		Abstract

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 '''Follicle size indicates oocyte maturity and blastocyst formation but not blastocyst euploidy following controlled ovarian hyperstimulation of oocyte donors'''

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 '''The cytokine profile of follicular fluid changes during ovarian ageing'''

Z8600021 at 01:14, 5 March 2020

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			==2020==
			{{#pmid:32028036}}
			'''The cytokine profile of follicular fluid changes during ovarian ageing'''

			OBJECTIVE:
			Ovarian ageing is one of the commonest causes of infertility in patients consulting for assisted reproductive technology. The composition of the follicular fluid (FF), which reflects the exchanges between the oocyte and its microenvironment, has been extensively investigated to determine the metabolic pathways involved in various ovarian disorders. Considering the importance of cytokines in folliculogenesis, we focused on the cytokine profile of the FF during ovarian ageing.
			MATERIAL AND METHODS:
			Our cross-sectional study assesses the levels of 27 cytokines and growth factors in the FF of two groups of women undergoing in vitro fertilization. One group included 28 patients with ovarian ageing clinically characterized by a diminished ovarian reserve (DOR), and the other group included 29 patients with a normal ovarian reserve (NOR), serving as controls.
			RESULTS:
			With univariate analysis, the cytokine profile was found to differ significantly between the two groups. After adjustment of the p-values, platelet-derived growth factor-BB (PDGF-BB) was the only cytokine with a significantly lower concentration in the DOR group (7.34 ± 16.11 pg/mL) than in the NOR group (24.39 ± 41.38 pg/mL) (p = 0.005), independently of chronological age.
			CONCLUSION:
			Thus, PDGF-BB would seem to be implicated in the physiopathology of DOR, potentially in relation to its role in folliculogenesis or in the protection against oxidative stress.
			Copyright © 2020 Elsevier Masson SAS. All rights reserved.
			KEYWORDS:
			Cytokine profile; Diminished ovarian reserve; Follicular fluid; Ovarian ageing; Platelet-derived growth factor BB
			PMID: 32028036 DOI: 10.1016/j.jogoh.2020.101704

	==2019==		==2019==

Z8600021 at 02:47, 4 April 2019

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	~~IVF page 20 March 2013~~, ~~at 05~~:58. IVF ~~page has been accessed 13~~,~~901 times~~. ~~Redirected to ART page~~.		==2019==
			===Association of In Vitro Fertilization With Childhood Cancer in the United States===
			Spector LG, Brown MB, Wantman E, et al. Association of In Vitro Fertilization With Childhood Cancer in the United States. JAMA Pediatr. Published online April 01, 2019. doi:10.1001/jamapediatrics.2019.0392


			This study found a small association of IVF with overall cancers of early childhood, but it did observe an increased rate of embryonal cancers, particularly hepatic tumors, that could not be attributed to IVF rather than to underlying infertility. Continued follow-up for cancer occurrence among children conceived via IVF is warranted.

	~~==10 Most Recent==~~
	~~{{10 Most Recent}}~~
	~~===Assisted Reproductive Technology===~~
	~~<pubmed limit=5>Assisted+Reproductive+Technology</pubmed>~~

	~~===In Vitro Fertilization===~~		Conclusions
	~~<pubmed limit=5>In+Vitro+Fertilization</pubmed>~~		We found, at most, a small, marginally significant association between IVF and overall cancer in childhood. We found no association of specific modes of IVF treatment or indication for IVF with overall cancer or embryonal tumors. Although we observed increased rates of embryonal cancers, particularly hepatic tumors, these cancers remained rare in absolute terms. We also could not attribute the increased rate to treatment per se rather than to underlying infertility. Despite the large size of the study, these results do not definitively establish an association between IVF and embryonal tumors. These results suggest that continued follow-up of children conceived via IVF for cancer occurrence is warranted, while other approaches to understanding potential mechanisms should also be pursued, for instance, by comparing the somatic epigenetic landscape of tumors in children conceived via IVF with children conceived naturally.

	~~===In Vitro Maturation===~~
	~~<pubmed limit=5>In+Vitro+Maturation</pubmed>~~

			see also earlier paper 26908669
	==2018==		==2018==

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	==2013==		==2013==

			IVF page 20 March 2013, at 05:58. IVF page has been accessed 13,901 times. Redirected to ART page.

	===Assisted reproductive technology surveillance -- United States, 2010===		===Assisted reproductive technology surveillance -- United States, 2010===

Z8600021 at 00:27, 4 November 2018

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	==2018==		==2018==

			===Mitochondrial replacement therapy and assisted reproductive technology: A paradigm shift toward treatment of genetic diseases in gametes or in early embryos===
			Reprod Med Biol. 2018 Sep 19;17(4):421-433. doi: 10.1002/rmb2.12230. eCollection 2018 Oct.

			Tachibana M1, Kuno T1, Yaegashi N1.

			Abstract

			BACKGROUND:
			Recent technological development allows nearly complete replacement of the cytoplasm of egg/embryo, eliminating the transmission of undesired defective mitochondria (mutated mitochondrial DNA: mtDNA) for patients with inherited mitochondrial diseases, which is called mitochondrial replacement therapy (MRT).
			METHODS:
			We review and summarize the mitochondrial biogenesis and mitochondrial diseases, the research milestones and future research agenda of MRT and also discuss MRT-derived potential application in common assisted reproductive technology (ART) treatment for subfertile patients.
			MAIN FINDINGS:
			Emerging techniques, involving maternal spindle transfer (MST) and pronuclear transfer (PNT), have demonstrated in preventing carryover of the unbidden (mutated) mtDNA in egg or in early embryos. The House of Parliament in the United Kingdom passed regulations permitting the use of MST and PNT in 2015. Furthermore, the Human Fertilization and Embryology Authority (HFEA) to granted licenses world first use of those techniques in March 2017. However, recent evidence demonstrated gradual loss of donor mtDNA and reversal to the nuclear DNA-matched haplotype in MRT derivatives.
			CONCLUSION:
			While further studies are needed to clarify mitochondrial biogenesis responsible for reversion, ruling in United Kingdom may shift the current worldwide consensus that prohibits gene modification in human gametes or embryos, toward allowing the correction of altered genes in germline.
			KEYWORDS:
			germ line gene therapy; maternal spindle transfer (MST); mitochondrial bottleneck effect; mitochondrial diseases; mitochondrial replacement therapy (MRT)
			PMID: 30377395 PMCID: PMC6194288 DOI: 10.1002/rmb2.12230

	===Severity of congenital heart defects associated with assisted reproductive technologies: Case series and review of the literature===		===Severity of congenital heart defects associated with assisted reproductive technologies: Case series and review of the literature===

Z8600021 at 01:56, 19 July 2018

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 Cryopreservation; In vitro fertilization; Oocyte donation; Vitrification
 PMID: 29304839 PMCID: PMC5755289 DOI: 10.1186/s13048-017-0378-4
 ==2016==

Z8600021 at 05:56, 8 Mayıs 2018

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	==2018==		==2018==

			===Severity of congenital heart defects associated with assisted reproductive technologies: Case series and review of the literature===

			Birth Defects Res. 2018 May 1;110(8):654-661. doi: 10.1002/bdr2.1228.

			Patil AS1, Nguyen C2, Groff K2, Wu J2, Elliott J1, Gunatilake RP1.

			Abstract

			OBJECTIVE:
			Assisted reproductive technology (ART) has been associated with a higher incidence of congenital anomalies, including a specific increase in the rate of congenital heart defects (CHD). In this study, the rate of CHD in pregnancies resulting from ART at a single high-risk pregnancy referral center are compared to the published literature.
			METHODS:
			Pregnancies were screened by fetal echocardiography for the indication of ART over a 2-year period. CHD were classified as either mild or severe based on the need for postnatal surgical intervention. Results were compared to findings from a literature review of studies examining CHD in pregnancies resulting from ART since 1980.
			RESULTS:
			Over the course of two years, 363 fetuses in 264 pregnancies from our cohort were screened for CHD. The incidence of mild CHD in fetuses from ART pregnancies was 2.75% (10 out of 363 fetuses). None of the affected fetuses had severe CHD. Review of the literature yielded 20 studies since 1980 that examined CHD in pregnancies resulting from ART. Composite data from the studies was described based on characterization of severity of the CHD anomalies. The incidence of mild CHD in ART pregnancies was 2.2%, compared to 1% in non-ART pregnancies (out of 332,157 infants). The incidence of severe CHD in ART pregnancies and naturally conceived pregnancies was 1.4% and 1.2%, respectively (out of 661,455 infants). The incidence of unspecified CHD in ART pregnancies was 1.8%, compared to 1% in naturally conceived pregnancies (out of 1,593,277 infants).
			CONCLUSION:
			The greatest increase in risk appears to be for mild CHD (nonsurgical), which may inform counseling of patients prior to use of assisted reproductive technologies.
			© 2018 Wiley Periodicals, Inc.
			KEYWORDS:
			IVF; atrial septal defects; coarctation of the aorta; congenital heart defects; hypoplastic left heart syndrome; tetralogy of fallot; ventricular septal defects
			PMID: 29714054 DOI: 10.1002/bdr2.1228

	===New national outcome data on fresh versus cryopreserved donor oocytes===		===New national outcome data on fresh versus cryopreserved donor oocytes===

Z8600021 at 00:22, 18 Ocak 2018

2018-01-18T00:22:34Z

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	<pubmed limit=5>In+Vitro+Maturation</pubmed>		<pubmed limit=5>In+Vitro+Maturation</pubmed>

			==2018==

			===New national outcome data on fresh versus cryopreserved donor oocytes===
			J Ovarian Res. 2018 Jan 5;11(1):2. doi: 10.1186/s13048-017-0378-4.

			Kushnir VA1,2, Darmon SK3, Barad DH3,4, Gleicher N3,4,5,6.

			Abstract

			BACKGROUND:
			Improvements in oocyte cryopreservation techniques and establishment of cryopreserved donor oocyte banks have led to improved access to and lower cost of donor oocytes, upending the traditional practice of fresh oocyte donation. The objective of this study was to examine national trends in utilization and live birth rates with fresh versus cryopreserved donor oocytes.
			METHODS:
			A retrospective analysis of 2013 through 2015 aggregate U.S. national data reported by the Society for Assisted Reproductive Technology which included 30,160 IVF cycles with either fresh or cryopreserved donor oocytes was performed.
			RESULTS:
			During the study period utilization of fresh oocyte donations rapidly declined by 32.9%, while cryopreserved oocyte donation increased by 44.4%. Fresh donor oocytes produced significantly higher live birth rates per recipient cycle start than cryopreserved donor oocytes (51.1% vs. 39.7%). Over the three-year study period fresh donor oocytes produced stable live birth rates per recipient cycle start while those with cryopreserved oocytes significantly declined year-by-year.
			CONCLUSION:
			Despite rising popularity of cryopreserved donor oocytes, prospective patients should be counselled that fresh donor oocytes still represent standard of care due to higher live birth rates.
			KEYWORDS:
			Cryopreservation; In vitro fertilization; Oocyte donation; Vitrification
			PMID: 29304839 PMCID: PMC5755289 DOI: 10.1186/s13048-017-0378-4

	==2016==		==2016==

Z8600021 at 01:22, 30 March 2016

2016-03-30T01:22:00Z

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	<pubmed limit=5>In+Vitro+Maturation</pubmed>		<pubmed limit=5>In+Vitro+Maturation</pubmed>


			==2016==

			===Does Embryo Culture Medium Influence the Health and Development of Children Born after In Vitro Fertilisation?===

			PLoS One. 2016 Mar 23;11(3):e0150857. doi: 10.1371/journal.pone.0150857. eCollection 2016.

			Bouillon C1, Léandri R2, Desch L3, Ernst A4, Bruno C3, Cerf C4, Chiron A5, Souchay C4, Burguet A6, Jimenez C7, Sagot P8, Fauque P3.

			Abstract

			In animal studies, extensive data revealed the influence of culture medium on embryonic development, foetal growth and the behaviour of offspring. However, this impact has never been investigated in humans. For the first time, we investigated in depth the effects of embryo culture media on health, growth and development of infants conceived by In Vitro Fertilization until the age of 5 years old. This single-centre cohort study was based on an earlier randomized study. During six months, in vitro fertilization attempts (No. 371) were randomized according to two media (Single Step Medium-SSM group) or Global medium (Global group). This randomized study was stopped prematurely as significantly lower pregnancy and implantation rates were observed in the SSM group. Singletons (No. 73) conceived in the randomized study were included (42 for Global and 31 for SSM). The medical data for gestational, neonatal and early childhood periods were extracted from medical records and parental interviews (256 variables recorded). The developmental profiles of the children in eight domains (social, self-help, gross motor, fine motor, expressive language, language comprehension, letter knowledge and number knowledge - 270 items) were compared in relation to the culture medium. The delivery rate was significantly lower in the SSM group than in the Global group (p<0.05). The culture medium had no significant effect on birthweight, risk of malformation (minor and major), growth and the frequency of medical concerns. However, the children of the Global group were less likely than those of the SSM group to show developmental problems (p = 0.002), irrespective of the different domains. In conclusion, our findings showed that the embryo culture medium may have an impact on further development.

			PMID 27008092

			[http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150857 PLoS One.]
	==2015==		==2015==