Talk:2009 Lecture 2 - Revision history

S8600021 at 05:44, 23 October 2009

2009-10-23T05:44:20Z

← Older revision		Revision as of 16:44, 23 October 2009
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			PMID: 18753611

			"Whether or not oogenesis continues in the ovaries of mammalian females during postnatal life was heavily debated from the late 1800s through the mid-1900s. However, in 1951 Lord Solomon Zuckerman published what many consider to be a landmark paper summarizing his personal views of data existing at the time for and against the possibility of postnatal oogenesis. In Zuckerman's opinion, none of the evidence he considered was inconsistent with Waldeyer's initial proposal in 1870 that female mammals cease production of oocytes at or shortly after birth. This conclusion rapidly became dogma, and remained essentially unchallenged until just recently, despite the fact that Zuckerman did not offer a single experiment proving that adult female mammals are incapable of oogenesis. Instead, 20 years later he reemphasized that his conclusion was based solely on an absence of data he felt would be inconsistent with the idea of a nonrenewable oocyte pool provided at birth. However, in the immortal words of Carl Sagan, an "absence of evidence is not evidence of absence." Indeed, building on the efforts of a few scientists who continued to question this dogma after Zuckerman's treatise in 1951, we reported several data sets in 2004 that were very much inconsistent with the widely held belief that germ cell production in female mammals ceases at birth. Perhaps not surprisingly, given the magnitude of the paradigm shift being proposed, this work reignited a vigorous debate that first began more than a century ago. Our purpose here is to review the experimental evidence offered in recent studies arguing support for and against the possibility that adult mammalian females replenish their oocyte reserve. "Never discourage anyone who continually makes progress, no matter how slow."-Plato (427-347 BC)."


	== '''Cell Division''' ==		== '''Cell Division''' ==
	[[Image:Historic 1882 mitosis drawing.jpg]]		[[Image:Historic 1882 mitosis drawing.jpg]]

S8600021 at 07:34, 1 August 2009

2009-08-01T07:34:59Z

← Older revision		Revision as of 18:34, 1 August 2009
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	[[2009 Lecture 17\|Cell Death 1]] \| [[Course_Timetable\|Course Timetable]]		[[2009 Lecture 17\|Cell Death 1]] \| [[Course_Timetable\|Course Timetable]]











	~~Template~~

	~~[[Category:2009ANAT2341]][[Category:Science-Undergraduate]]~~


	~~== Introduction ==~~

	~~==UNSW Embryology Links==~~

	* [http://embryology.med.unsw.edu.au/Science/ANAT2341lecture02.htm Lecture 2 2008]
	* [http://php.med.unsw.edu.au/cellbiology/index.php?title=2009_Lecture_16 ANAT3231 Cell Division]


	~~== Next Lecture ==~~
	~~[[2009 Lecture 3\|Lecture 3]] \| [[ANAT2341_Embryology_2009#Course_Timetable\|Course Timetable]]~~

	~~:''Dr Mark Hill 2009'' UNSW CRICOS Provider Code No. 00098G~~

MarkHill: /* Articles */

2009-07-28T01:47:15Z

Articles

← Older revision		Revision as of 12:47, 28 July 2009
Line 275:		Line 275:
	====Articles====		====Articles====

	[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.7151 TGFBeta signaling.] '''Molecular Cell Biology''' -> Cancer -> Mutations Causing Loss of Cell-Cycle Control[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.6902 Current models of the intracellular pathways leading to cell death by apoptosis or to trophic factor-mediated cell survival in mammalian cells.] '''Molecular Cell Biology''' -> Cell Interactions in Development -> Cell Death and Its Regulation[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.6758 TGFBeta signaling pathway.] '''Molecular Cell Biology''' -> Integrating Cells into Tissues -> Cell-Cell Adhesion and Communication[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.6129 Origin of the resting potential in a typical vertebrate neuron.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> From Plasma Membrane to Nucleus[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5867 Elevation of cytosolic Ca][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5867 2 ][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5867 via the inositol-lipid signaling pathway.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> MAP Kinase Pathways[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5784 Activation of adenylyl cyclase following binding of an appropriate hormone (e.g., epinephrine, glucagon) to a Gs protein - coupled receptor.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> Identification and Purification of Cell-Surface Receptors[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5737 Common intracellular signaling proteins.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> Overview of Extracellular Signaling[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5522 Proposed alternative mechanisms for chromosome congression.] '''Molecular Cell Biology''' -> Cell Motility and Shape II: Microtubules and Intermediate Filaments -> Microtubule Dynamics and Motor Proteins during Mitosis[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5509 Centromeric attachment of microtubules.] '''Molecular Cell Biology''' -> Cell Motility and Shape II: Microtubules and Intermediate Filaments -> Microtubule Dynamics and Motor Proteins during Mitosis[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5500 The stages of mitosis and cytokinesis in an animal cell.] '''Molecular Cell Biology''' -> Cell Motility and Shape I: Microfilaments -> Cell Locomotion[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5188 The coupling of ATP hydrolysis to movement of myosin along an actin filament.] '''Molecular Cell Biology''' -> Cell Motility and Shape I: Microfilaments -> Myosin: The Actin Motor Protein[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5147 The three phases of G-actin polymerization in vitro.] '''Molecular Cell Biology''' -> Protein Sorting: Organelle Biogenesis and Protein Secretion -> Insertion of Membrane Proteins into the ER Membrane[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4760 Synthesis of secretory proteins on the rough ER.] '''Molecular Cell Biology''' -> Protein Sorting: Organelle Biogenesis and Protein Secretion -> Overview of the Secretory Pathway[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4668 Overview of sorting of nuclear-encoded proteins in eukaryotic cells.] '''Molecular Cell Biology''' -> Cellular Energetics: Glycolysis, Aerobic Oxidation, and Photosynthesis -> Photosynthetic Stages and Light-Absorbing Pigments[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4407 Model of the structure of ATP synthase (the F0F1 ATPase complex) in the bacterial plasma membrane.] '''Molecular Cell Biology''' -> Cellular Energetics: Glycolysis, Aerobic Oxidation, and Photosynthesis -> Electron Transport and Oxidative Phosphorylation[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4101 Proposed model for operation of the two-Na/one-glucose symporter.] '''Molecular Cell Biology''' -> Transport across Cell Membranes -> Active Transport by ATP-Powered Pumps[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4061 Transmembrane forces acting on Na ions.] Drosophila embryo and localization of their gene products within the embryo. Drosophila embryos. '''Molecular Cell Biology''' -> Regulation of the Eukaryotic Cell Cycle -> Overview of the Cell Cycle and Its Control[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.3208 Mechanism of action of telomerase.] E. coli replication proteins at a growing fork. E. coli DNA polymerase III to DNA, thereby increasing its processivity. '''Molecular Cell Biology''' -> DNA Replication, Repair, and Recombination -> The DNA Replication Machinery[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.3167 Three mechanisms of DNA strand growth that are consistent with semiconservative replication.] '''Molecular Cell Biology''' -> RNA Processing, Nuclear Transport, and Post-Transcriptional Control -> Processing of Eukaryotic mRNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2887 Diagram of interactions between pre-mRNA, U1 snRNA, and U2 snRNA early in the splicing process.] '''Molecular Cell Biology''' -> RNA Processing, Nuclear Transport, and Post-Transcriptional Control -> Processing of Eukaryotic mRNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2647 Model for cooperative assembly of an activated transcription-initiation complex at the ][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2647 Molecular Cell Biology][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2647 -> Regulation of Transcription Initiation -> Molecular Mechanisms of Eukaryotic Transcriptional Control][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2272 Model for the packing of chromatin and the chromosome scaffold in metaphase chromosomes.] '''Molecular Cell Biology''' -> Molecular Structure of Genes and Chromosomes -> Mobile DNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1987 General procedure for producing transgenic mice.] '''Molecular Cell Biology''' -> Genetic Analysis in Cell Biology -> Gene Replacement and Transgenic Animals[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1719 The polymerase chain reaction.] '''Molecular Cell Biology''' -> Recombinant DNA and Genomics -> Identifying, Analyzing, and Sequencing Cloned DNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1592 Isolation of DNA fragments from a mixture by cloning in a plasmid vector.] '''Molecular Cell Biology''' -> Recombinant DNA and Genomics -> DNA Cloning with Plasmid Vectors[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1437 Retroviral life cycle.] '''Molecular Cell Biology''' -> Manipulating Cells and Viruses in Culture -> Growth of Animal Cells in Culture[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1197 The synthesis and release of secretory proteins in acinar cells of the rat pancreas.] '''Molecular Cell Biology''' -> Biomembranes and the Subcellular Organization of Eukaryotic Cells -> Microscopy and Cell Architecture[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.916 Model of protein synthesis on circular polysomes and recycling of ribosomal subunits.] E. coli'' ribosomes. '''Molecular Cell Biology''' -> Nucleic Acids, the Genetic Code, and the Synthesis of Macromolecules -> Nucleic Acid Synthesis[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.844 Transcription of DNA into RNA is catalyzed by RNA polymerase, which can initiate the synthesis of strands de novo on DNA templates.] '''Molecular Cell Biology''' -> Protein Structure and Function -> Purifying, Detecting, and Characterizing Proteins[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.639 SDS-polyacrylamide gel electrophoresis, a common technique for separating proteins at good resolution.] '''Molecular Cell Biology''' -> Protein Structure and Function -> Folding, Modification, and Degradation of Proteins[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.554 Chaperone-mediated protein folding.] '''Molecular Cell Biology''' -> Chemical Foundations -> Biochemical Energetics[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.218 Cell division.] '''Molecular Cell Biology''' -> The Dynamic Cell -> The Life Cycle of Cells		[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.7151 TGFBeta signaling.] '''Molecular Cell Biology''' -> Cancer -> Mutations Causing Loss of Cell-Cycle Control[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.6902 Current models of the intracellular pathways leading to cell death by apoptosis or to trophic factor-mediated cell survival in mammalian cells.] '''Molecular Cell Biology''' -> Cell Interactions in Development -> Cell Death and Its Regulation[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.6758 TGFBeta signaling pathway.] '''Molecular Cell Biology''' -> Integrating Cells into Tissues -> Cell-Cell Adhesion and Communication[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.6129 Origin of the resting potential in a typical vertebrate neuron.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> From Plasma Membrane to Nucleus[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5867 Elevation of cytosolic Ca][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5867 2 ][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5867 via the inositol-lipid signaling pathway.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> MAP Kinase Pathways

			[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5784 Activation of adenylyl cyclase following binding of an appropriate hormone (e.g., epinephrine, glucagon) to a Gs protein - coupled receptor.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> Identification and Purification of Cell-Surface Receptors

			[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5737 Common intracellular signaling proteins.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> Overview of Extracellular Signaling


			[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5522 Proposed alternative mechanisms for chromosome congression.] '''Molecular Cell Biology''' -> Cell Motility and Shape II: Microtubules and Intermediate Filaments -> Microtubule Dynamics and Motor Proteins during Mitosis

			[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5509 Centromeric attachment of microtubules.] '''Molecular Cell Biology''' -> Cell Motility and Shape II: Microtubules and Intermediate Filaments -> Microtubule Dynamics and Motor Proteins during Mitosis

			[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5500 The stages of mitosis and cytokinesis in an animal cell.] '''Molecular Cell Biology''' -> Cell Motility and Shape I: Microfilaments -> Cell Locomotion

			[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5188 The coupling of ATP hydrolysis to movement of myosin along an actin filament.] '''Molecular Cell Biology''' -> Cell Motility and Shape I: Microfilaments -> Myosin: The Actin Motor Protein[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5147 The three phases of G-actin polymerization in vitro.] '''Molecular Cell Biology''' -> Protein Sorting: Organelle Biogenesis and Protein Secretion -> Insertion of Membrane Proteins into the ER Membrane[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4760 Synthesis of secretory proteins on the rough ER.] '''Molecular Cell Biology''' -> Protein Sorting: Organelle Biogenesis and Protein Secretion -> Overview of the Secretory Pathway[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4668 Overview of sorting of nuclear-encoded proteins in eukaryotic cells.] '''Molecular Cell Biology''' -> Cellular Energetics: Glycolysis, Aerobic Oxidation, and Photosynthesis -> Photosynthetic Stages and Light-Absorbing Pigments[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4407 Model of the structure of ATP synthase (the F0F1 ATPase complex) in the bacterial plasma membrane.] '''Molecular Cell Biology''' -> Cellular Energetics: Glycolysis, Aerobic Oxidation, and Photosynthesis -> Electron Transport and Oxidative Phosphorylation[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4101 Proposed model for operation of the two-Na/one-glucose symporter.] '''Molecular Cell Biology''' -> Transport across Cell Membranes -> Active Transport by ATP-Powered Pumps[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4061 Transmembrane forces acting on Na ions.] Drosophila embryo and localization of their gene products within the embryo. Drosophila embryos. '''Molecular Cell Biology''' -> Regulation of the Eukaryotic Cell Cycle -> Overview of the Cell Cycle and Its Control[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.3208 Mechanism of action of telomerase.] E. coli replication proteins at a growing fork. E. coli DNA polymerase III to DNA, thereby increasing its processivity. '''Molecular Cell Biology''' -> DNA Replication, Repair, and Recombination -> The DNA Replication Machinery[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.3167 Three mechanisms of DNA strand growth that are consistent with semiconservative replication.] '''Molecular Cell Biology''' -> RNA Processing, Nuclear Transport, and Post-Transcriptional Control -> Processing of Eukaryotic mRNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2887 Diagram of interactions between pre-mRNA, U1 snRNA, and U2 snRNA early in the splicing process.] '''Molecular Cell Biology''' -> RNA Processing, Nuclear Transport, and Post-Transcriptional Control -> Processing of Eukaryotic mRNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2647 Model for cooperative assembly of an activated transcription-initiation complex at the ][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2647 Molecular Cell Biology][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2647 -> Regulation of Transcription Initiation -> Molecular Mechanisms of Eukaryotic Transcriptional Control][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2272 Model for the packing of chromatin and the chromosome scaffold in metaphase chromosomes.] '''Molecular Cell Biology''' -> Molecular Structure of Genes and Chromosomes -> Mobile DNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1987 General procedure for producing transgenic mice.] '''Molecular Cell Biology''' -> Genetic Analysis in Cell Biology -> Gene Replacement and Transgenic Animals[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1719 The polymerase chain reaction.] '''Molecular Cell Biology''' -> Recombinant DNA and Genomics -> Identifying, Analyzing, and Sequencing Cloned DNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1592 Isolation of DNA fragments from a mixture by cloning in a plasmid vector.] '''Molecular Cell Biology''' -> Recombinant DNA and Genomics -> DNA Cloning with Plasmid Vectors[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1437 Retroviral life cycle.] '''Molecular Cell Biology''' -> Manipulating Cells and Viruses in Culture -> Growth of Animal Cells in Culture[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1197 The synthesis and release of secretory proteins in acinar cells of the rat pancreas.] '''Molecular Cell Biology''' -> Biomembranes and the Subcellular Organization of Eukaryotic Cells -> Microscopy and Cell Architecture[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.916 Model of protein synthesis on circular polysomes and recycling of ribosomal subunits.] E. coli'' ribosomes. '''Molecular Cell Biology''' -> Nucleic Acids, the Genetic Code, and the Synthesis of Macromolecules -> Nucleic Acid Synthesis[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.844 Transcription of DNA into RNA is catalyzed by RNA polymerase, which can initiate the synthesis of strands de novo on DNA templates.] '''Molecular Cell Biology''' -> Protein Structure and Function -> Purifying, Detecting, and Characterizing Proteins[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.639 SDS-polyacrylamide gel electrophoresis, a common technique for separating proteins at good resolution.] '''Molecular Cell Biology''' -> Protein Structure and Function -> Folding, Modification, and Degradation of Proteins[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.554 Chaperone-mediated protein folding.] '''Molecular Cell Biology''' -> Chemical Foundations -> Biochemical Energetics[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.218 Cell division.] '''Molecular Cell Biology''' -> The Dynamic Cell -> The Life Cycle of Cells

	== Links ==		== Links ==

MarkHill at 01:45, 28 July 2009

2009-07-28T01:45:03Z

← Older revision		Revision as of 12:45, 28 July 2009
Line 275:		Line 275:
	====Articles====		====Articles====

	*		[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.7151 TGFBeta signaling.] '''Molecular Cell Biology''' -> Cancer -> Mutations Causing Loss of Cell-Cycle Control[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.6902 Current models of the intracellular pathways leading to cell death by apoptosis or to trophic factor-mediated cell survival in mammalian cells.] '''Molecular Cell Biology''' -> Cell Interactions in Development -> Cell Death and Its Regulation[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.6758 TGFBeta signaling pathway.] '''Molecular Cell Biology''' -> Integrating Cells into Tissues -> Cell-Cell Adhesion and Communication[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.6129 Origin of the resting potential in a typical vertebrate neuron.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> From Plasma Membrane to Nucleus[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5867 Elevation of cytosolic Ca][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5867 2 ][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5867 via the inositol-lipid signaling pathway.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> MAP Kinase Pathways[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5784 Activation of adenylyl cyclase following binding of an appropriate hormone (e.g., epinephrine, glucagon) to a Gs protein - coupled receptor.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> Identification and Purification of Cell-Surface Receptors[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5737 Common intracellular signaling proteins.] '''Molecular Cell Biology''' -> Cell-to-Cell Signaling: Hormones and Receptors -> Overview of Extracellular Signaling[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5522 Proposed alternative mechanisms for chromosome congression.] '''Molecular Cell Biology''' -> Cell Motility and Shape II: Microtubules and Intermediate Filaments -> Microtubule Dynamics and Motor Proteins during Mitosis[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5509 Centromeric attachment of microtubules.] '''Molecular Cell Biology''' -> Cell Motility and Shape II: Microtubules and Intermediate Filaments -> Microtubule Dynamics and Motor Proteins during Mitosis[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5500 The stages of mitosis and cytokinesis in an animal cell.] '''Molecular Cell Biology''' -> Cell Motility and Shape I: Microfilaments -> Cell Locomotion[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5188 The coupling of ATP hydrolysis to movement of myosin along an actin filament.] '''Molecular Cell Biology''' -> Cell Motility and Shape I: Microfilaments -> Myosin: The Actin Motor Protein[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.5147 The three phases of G-actin polymerization in vitro.] '''Molecular Cell Biology''' -> Protein Sorting: Organelle Biogenesis and Protein Secretion -> Insertion of Membrane Proteins into the ER Membrane[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4760 Synthesis of secretory proteins on the rough ER.] '''Molecular Cell Biology''' -> Protein Sorting: Organelle Biogenesis and Protein Secretion -> Overview of the Secretory Pathway[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4668 Overview of sorting of nuclear-encoded proteins in eukaryotic cells.] '''Molecular Cell Biology''' -> Cellular Energetics: Glycolysis, Aerobic Oxidation, and Photosynthesis -> Photosynthetic Stages and Light-Absorbing Pigments[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4407 Model of the structure of ATP synthase (the F0F1 ATPase complex) in the bacterial plasma membrane.] '''Molecular Cell Biology''' -> Cellular Energetics: Glycolysis, Aerobic Oxidation, and Photosynthesis -> Electron Transport and Oxidative Phosphorylation[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4101 Proposed model for operation of the two-Na/one-glucose symporter.] '''Molecular Cell Biology''' -> Transport across Cell Membranes -> Active Transport by ATP-Powered Pumps[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.4061 Transmembrane forces acting on Na ions.] Drosophila embryo and localization of their gene products within the embryo. Drosophila embryos. '''Molecular Cell Biology''' -> Regulation of the Eukaryotic Cell Cycle -> Overview of the Cell Cycle and Its Control[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.3208 Mechanism of action of telomerase.] E. coli replication proteins at a growing fork. E. coli DNA polymerase III to DNA, thereby increasing its processivity. '''Molecular Cell Biology''' -> DNA Replication, Repair, and Recombination -> The DNA Replication Machinery[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.3167 Three mechanisms of DNA strand growth that are consistent with semiconservative replication.] '''Molecular Cell Biology''' -> RNA Processing, Nuclear Transport, and Post-Transcriptional Control -> Processing of Eukaryotic mRNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2887 Diagram of interactions between pre-mRNA, U1 snRNA, and U2 snRNA early in the splicing process.] '''Molecular Cell Biology''' -> RNA Processing, Nuclear Transport, and Post-Transcriptional Control -> Processing of Eukaryotic mRNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2647 Model for cooperative assembly of an activated transcription-initiation complex at the ][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2647 Molecular Cell Biology][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2647 -> Regulation of Transcription Initiation -> Molecular Mechanisms of Eukaryotic Transcriptional Control][http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.2272 Model for the packing of chromatin and the chromosome scaffold in metaphase chromosomes.] '''Molecular Cell Biology''' -> Molecular Structure of Genes and Chromosomes -> Mobile DNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1987 General procedure for producing transgenic mice.] '''Molecular Cell Biology''' -> Genetic Analysis in Cell Biology -> Gene Replacement and Transgenic Animals[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1719 The polymerase chain reaction.] '''Molecular Cell Biology''' -> Recombinant DNA and Genomics -> Identifying, Analyzing, and Sequencing Cloned DNA[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1592 Isolation of DNA fragments from a mixture by cloning in a plasmid vector.] '''Molecular Cell Biology''' -> Recombinant DNA and Genomics -> DNA Cloning with Plasmid Vectors[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1437 Retroviral life cycle.] '''Molecular Cell Biology''' -> Manipulating Cells and Viruses in Culture -> Growth of Animal Cells in Culture[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.1197 The synthesis and release of secretory proteins in acinar cells of the rat pancreas.] '''Molecular Cell Biology''' -> Biomembranes and the Subcellular Organization of Eukaryotic Cells -> Microscopy and Cell Architecture[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.916 Model of protein synthesis on circular polysomes and recycling of ribosomal subunits.] E. coli'' ribosomes. '''Molecular Cell Biology''' -> Nucleic Acids, the Genetic Code, and the Synthesis of Macromolecules -> Nucleic Acid Synthesis[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.844 Transcription of DNA into RNA is catalyzed by RNA polymerase, which can initiate the synthesis of strands de novo on DNA templates.] '''Molecular Cell Biology''' -> Protein Structure and Function -> Purifying, Detecting, and Characterizing Proteins[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.639 SDS-polyacrylamide gel electrophoresis, a common technique for separating proteins at good resolution.] '''Molecular Cell Biology''' -> Protein Structure and Function -> Folding, Modification, and Degradation of Proteins[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.554 Chaperone-mediated protein folding.] '''Molecular Cell Biology''' -> Chemical Foundations -> Biochemical Energetics[http://www.ncbi.nlm.nih.gov/books/bv.fcgi?&rid=mcb.figgrp.218 Cell division.] '''Molecular Cell Biology''' -> The Dynamic Cell -> The Life Cycle of Cells

MarkHill at 04:39, 27 July 2009

2009-07-27T04:39:53Z

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2009-07-27T03:58:47Z

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	[[2009 Lecture 3\|Lecture 3]] \| [[ANAT2341_Embryology_2009#Course_Timetable\|Course Timetable]]		[[2009 Lecture 3\|Lecture 3]] \| [[ANAT2341_Embryology_2009#Course_Timetable\|Course Timetable]]

	:''Dr Mark Hill 2009''		:''Dr Mark Hill 2009'' UNSW CRICOS Provider Code No. 00098G

MarkHill at 03:57, 27 July 2009

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	== Introduction ==		== Introduction ==

			==UNSW Embryology Links==

			* [http://embryology.med.unsw.edu.au/Science/ANAT2341lecture02.htm Lecture 2 2008]
			* [http://php.med.unsw.edu.au/cellbiology/index.php?title=2009_Lecture_16 ANAT3231 Cell Division]


	== Next Lecture ==		== Next Lecture ==

MarkHill at 03:57, 27 July 2009

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	== Introduction ==		== Introduction ==

			== Next Lecture ==
			[[2009 Lecture 3\|Lecture 3]] \| [[ANAT2341_Embryology_2009#Course_Timetable\|Course Timetable]]

			:''Dr Mark Hill 2009''

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