Salivary Gland Development - Revision history

Z8600021 at 03:30, 30 July 2020

2020-07-30T03:30:59Z

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	* [[1897_Human_Embryology_26#Salivary_Glands\|1897 Glands]] draft only.		* [[1897_Human_Embryology_26#Salivary_Glands\|1897 Glands]] draft only.

	===Reviews===		===Reviews===

	{{#pmid:26589923}}		{{#pmid:26589923}}

			{{#pmid:24333774}}

	===Articles===		===Articles===

Z8600021 at 03:29, 30 July 2020

2020-07-30T03:29:32Z

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	==Submandibular Gland==		==Submandibular Gland==
	The submandibular gland is also called the {{submaxillary gland}}.		The submandibular gland is also called the {{submaxillary gland}} are located along the side of the mandible.

	===Timeline===		===Timeline===

Z8600021 at 03:28, 30 July 2020

2020-07-30T03:28:32Z

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	==Submandibular Gland==		==Submandibular Gland==
			The submandibular gland is also called the {{submaxillary gland}}.

	===Timeline===		===Timeline===
	Embryonic development of {{submandibular gland}} during week 7 and 8 based upon Streeter.<ref name=Streeter1957>{{Ref-Streeter1957}}</ref>		Embryonic development of {{submandibular gland}} during week 7 and 8 based upon Streeter.<ref name=Streeter1957>{{Ref-Streeter1957}}</ref>
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	\|}		\|}

			:'''Links:''' [http://www.ncbi.nlm.nih.gov/pubmed/?term=Submandibular+Gland+Development ''Submandibular Gland Development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Submaxillary+Gland+Development ''Submaxillary Gland Development'']
	==Parotid Gland==		==Parotid Gland==
	{\|		{\|

Z8600021 at 23:00, 4 February 2020

2020-02-04T23:00:19Z

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			{{Gland links}}
	~~:'''Links:''' {{submandibular gland}} \| {{parotid gland}} \|~~ {{~~sublingual gland~~}} ~~\|[[BGDB Practical - Upper Gastrointestinal Tract Histology\|Medicine - Upper GIT Histology]] \| [[Head Development]] \| [[Gastrointestinal Tract Development]]~~		<br>

	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
	! Additional Links		! Additional Links

Z8600021 at 06:08, 18 March 2019

2019-03-18T06:08:32Z

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	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Salivary+Gland+Development ''Salivary Gland Development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Salivary+Gland+Embryology ''Salivary Gland Embryology'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Salivary+Gland+Development ''Salivary Gland Development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Salivary+Gland+Embryology ''Salivary Gland Embryology''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Submandibular+Gland+Development ''Submandibular Gland Development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Parotid+Gland+Development ''Parotid Gland Development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Sublingual+Gland+Development ''Sublingual Gland Development'']

	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"

Z8600021 at 06:05, 18 March 2019

2019-03-18T06:05:54Z

← Older revision		Revision as of 17:05, 18 March 2019
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	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Salivary+Gland+Development ''Salivary Gland Development'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Salivary+Gland+Development ''Salivary Gland Development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Salivary+Gland+Embryology ''Salivary Gland Embryology'']

	\|}		\|}
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	===Cystic Fibrosis===		===Cystic Fibrosis===
			{\|
			\|-bgcolor="FEF9E7"
			\| {{ICD-11}} {{ICD11weblink}}514403112 '''CA25''' Cystic fibrosis] - {{ICD11weblink}}290257878
			CA25.0 Classical cystic fibrosis] \| {{ICD11weblink}}955958081 CA25.1 Atypical cystic fibrosis] \| {{ICD11weblink}} 1323966141 CA25.2 Subclinical cystic fibrosis]

			:''Cystic fibrosis (CF) is a genetic disorder characterized by the production of sweat with a high salt content and mucus secretions with an abnormal viscosity. The disease is chronic and generally progressive, with onset usually occurring during early childhood or, occasionally, at birth (meconium ileus). Virtually any internal organ may be involved but the principle manifestations concern the breathing apparatus (chronic bronchitis), pancreas (pancreatic insufficiency, adolescent diabetes and occasionally pancreatitis) and, more rarely, the intestine (stercoral obstruction) or liver (cirrhosis). The usual presenting symptoms and signs include persistent pulmonary infection, pancreatic insufficiency, and elevated sweat chloride levels. However, many patients demonstrate mild or atypical symptoms, and clinicians should remain alert to the possibility of CF even when only a few of the usual features are present. Both criteria; clinical symptoms consistent with CF in at least one organ system and evidence of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction must be met to diagnose cystic fibrosis.''
			\|}

	The absence of the transmembrane conductance regulator (CFTR) affects not only respiratory tract exocrine secretion, but also secretion in salivary glands.{{#pmid:26351748\|PMID26351748}}		The absence of the transmembrane conductance regulator (CFTR) affects not only respiratory tract exocrine secretion, but also secretion in salivary glands.{{#pmid:26351748\|PMID26351748}}

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	===Primary Sjögren's syndrome===		===Primary Sjögren's syndrome===
			{\|
			\|-bgcolor="FEF9E7"
			\| {{ICD-11}} {{ICD11weblink}}1923044320 4A43.2 Sjögren syndrome - {{ICD11weblink}}899463360 4A43.20 Primary Sjögren syndrome]
			:''Sjögren syndrome is a slowly progressive, systemic inflammatory autoimmune disease affecting primarily the exocrine glands. Lymphocytic infiltrates replace functional epithelium, leading to oral and ocular dryness. Characteristic autoantibodies (e.g., anti-Ro/SS-A and/or anti-La/SS-B) are produced. The disorder can occur alone (it is then known as "primary-SS") or in association with another autoimmune disease (it is then known as "secondary-SS").''
			\|}

			Primary Sjögren's syndrome (pSS) results in the destruction of the salivary and the lacrimal glands through a mononuclear cell infiltration.{{#pmid:29504848\|PMID29504848}}

	~~Primary Sjögren's syndrome (pSS) results in the destruction of the salivary and the lacrimal glands through by mononuclear cell infiltration.{{#pmid:29504848\|PMID29504848}}~~

Z8600021 at 05:58, 18 March 2019

2019-03-18T05:58:49Z

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	{\|		{\|
	\|-bgcolor="FEF9E7"		\|-bgcolor="FEF9E7"
	\| {{ICD-11}} {{ICD11weblink}}~~62012456~~ LB10 Structural developmental anomalies of salivary glands or ducts] - ''Any condition caused by failure of the salivary glands and ducts to correctly develop during the antenatal period.''		\| {{ICD-11}} {{ICD11weblink}}262012456 LB10 Structural developmental anomalies of salivary glands or ducts] - ''Any condition caused by failure of the salivary glands and ducts to correctly develop during the antenatal period.''
	\|}		\|}

Z8600021 at 05:56, 18 March 2019

2019-03-18T05:56:46Z

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	==Abnormalities==		==Abnormalities==
			===LB10 Structural developmental anomalies of salivary glands or ducts===
			{\|
			\|-bgcolor="FEF9E7"
			\| {{ICD-11}} {{ICD11weblink}}62012456 LB10 Structural developmental anomalies of salivary glands or ducts] - ''Any condition caused by failure of the salivary glands and ducts to correctly develop during the antenatal period.''
			\|}

	===Cystic Fibrosis===		===Cystic Fibrosis===
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			'''Links:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=salivary+gland+abnormality PubMed - salivary gland abnormality]

	== References ==		== References ==

Z8600021 at 01:10, 26 February 2019

2019-02-26T01:10:50Z

← Older revision		Revision as of 12:10, 26 February 2019
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	\|-bgcolor="F5FAFF"		\|-bgcolor="F5FAFF"
	\|		\|
			* '''Runx1 mediates the development of the granular convoluted tubules in the submandibular glands'''{{#pmid:28877240\|PMID28877240}} "The mouse granular convoluted tubules (GCTs), which are only located in the submandibular gland (SMG) are known to develop and maintain their structure in an androgen-dependent manner. We previously demonstrated that the GCTs are involuted by the epithelial deletion of core binding factor β (CBFβ), a transcription factor that physically interacts with any of the Runt-related transcription factor (RUNX) proteins (RUNX1, 2 and 3). This result clearly demonstrates that the Runx /Cbfb signaling pathway is indispensable in the development of the GCTs. However, it is not clear which of the RUNX proteins plays useful role in the development of the GCTs by activating the Runx /Cbfb signaling pathway. Past studies have revealed that the Runx /Cbfb signaling pathway plays important roles in various aspects of development and homeostatic events. Moreover, the Runx genes have different temporospatial requirements depending on the biological situation. In the present study, the GCTs of the SMG showed a remarkable phenotype of, which phenocopied the epithelial deletion of Cbfb, in epithelial-specific Runx1 conditional knock-out (cKO) mice. The results indicate that Runx1 works as a partner of Cbfb during the development of the GCTs. We also discovered that the depletion of Runx1 resulted in the reduced secretion of saliva in male mice. Consistent with this finding, one of the water channels, Aquaporin-5 (AQP5) was mislocalized in the cytoplasm of the Runx1 mutants, suggesting a novel role of Runx1 in the membrane trafficking of AQP5. In summary, the present findings demonstrated that RUNX1 is essential for the development of the GCTs. Furthermore, RUNX1 could also be involved in the membrane trafficking of the AQP5 protein of the acinar cells in the SMG in order to allow for the proper secretion of saliva."

	* '''Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development'''{{#pmid:28506998\|PMID28506998}} "Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk region) identities that produce the acini and higher order ducts, respectively. Little is known about the factors that regulate progenitor expansion and specialisation in the different parts of the gland. Here, we show that Sox9 is involved in establishing the identity of the distal compartment before the initiation of branching morphogenesis. Sox9 is expressed throughout the gland at the initiation stage before becoming restricted to the distal epithelium from the bud stage and throughout branching morphogenesis. Deletion of Sox9 in the epithelium results in loss of the distal epithelial progenitors, a reduction in proliferation and a subsequent failure in branching. We demonstrate that Sox9 is positively regulated by mesenchymal Fgf10, a process that requires active Erk signalling. These results provide new insights into the factors required for the expansion of salivary gland epithelial progenitors, which can be useful for organ regeneration therapy."		* '''Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development'''{{#pmid:28506998\|PMID28506998}} "Salivary glands are formed by branching morphogenesis with epithelial progenitors forming a network of ducts and acini (secretory cells). During this process, epithelial progenitors specialise into distal (tips of the gland) and proximal (the stalk region) identities that produce the acini and higher order ducts, respectively. Little is known about the factors that regulate progenitor expansion and specialisation in the different parts of the gland. Here, we show that Sox9 is involved in establishing the identity of the distal compartment before the initiation of branching morphogenesis. Sox9 is expressed throughout the gland at the initiation stage before becoming restricted to the distal epithelium from the bud stage and throughout branching morphogenesis. Deletion of Sox9 in the epithelium results in loss of the distal epithelial progenitors, a reduction in proliferation and a subsequent failure in branching. We demonstrate that Sox9 is positively regulated by mesenchymal Fgf10, a process that requires active Erk signalling. These results provide new insights into the factors required for the expansion of salivary gland epithelial progenitors, which can be useful for organ regeneration therapy."

Z8600021 at 04:39, 19 February 2019

2019-02-19T04:39:33Z

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	==Introduction==		==Introduction==
	[[File:Adult gastrointestinal tract cartoon.jpg\|thumb\|300px\|Adult Gastrointestinal Tract]]		[[File:Adult gastrointestinal tract cartoon.jpg\|thumb\|300px\|Adult Gastrointestinal Tract]]
			[[File:Gray1024.jpg\|thumb\|alt=Submandibular Gland\|Salivary Glands (Gray's Anatomy)]]
	The {{salivary gland}}s arise as epithelial buds in the oral cavity between week 6 to 7 ({{GA}} week 8 to 9) and extend into the underlying mesenchyme. The three paired groups of salivary glands are named by their anatomical location: parotid, submandibular and sublingual.		The {{salivary gland}}s arise as epithelial buds in the oral cavity between week 6 to 7 ({{GA}} week 8 to 9) and extend into the underlying mesenchyme. The three paired groups of salivary glands are named by their anatomical location: parotid, submandibular and sublingual.

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	===Anatomy===		===Anatomy===
	~~[[File:Gray1024.jpg\|thumb\|alt=Submandibular Gland\|Submandibular Gland (Gray's Anatomy)]]~~
	* locate inferior space of the mylohyoid.		* locate inferior space of the mylohyoid.
	* submandibular duct (Wharton’s duct)		* submandibular duct (Wharton’s duct)