Respiratory System - Molecular - Revision history

Z8600021 at 04:45, 30 August 2016

2016-08-30T04:45:48Z

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	===Reviews===		===Reviews===
	<pubmed></pubmed>		<pubmed></pubmed>
	<pubmed></pubmed>		<pubmed>25329576</pubmed>
			<pubmed>25556243</pubmed>
			<pubmed>24449833</pubmed>
	<pubmed></pubmed>		<pubmed></pubmed>

Z8600021 at 04:44, 30 August 2016

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			* '''Review - Regulation of early lung morphogenesis: questions, facts and controversies.'''<ref name=PMID16613830><pubmed>16613830</pubmed></ref> "During early respiratory system development, the foregut endoderm gives rise to the tracheal and lung cell progenitors. Through branching morphogenesis, and in coordination with vascular development, a tree-like structure of epithelial tubules forms and differentiates to produce the airways and alveoli. Recent studies have implicated the fibroblast growth factor, sonic hedgehog, bone morphogenetic protein, retinoic acid and Wnt signaling pathways, and various transcription factors in regulating the initial stages of lung development. However, the precise roles of these molecules and how they interact in the developing lung is subject to debate. Here, we review early stages in lung development and highlight questions and controversies regarding their molecular regulation."

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Z8600021 at 04:41, 30 August 2016

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← Older revision		Revision as of 15:41, 30 August 2016
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	==Fibroblast Growth Factor==		==Fibroblast Growth Factor==
	[[File:Mouse- respiratory development 04.jpg\|thumb\|Mouse Respiratory Development Fibroblast Growth Factor Signaling<ref name=PMID20614584>[StemBook Cambridge (MA): Harvard Stem Cell Institute; 2008-. [http://www.ncbi.nlm.nih.gov/books/NBK27021/ Specification and patterning of the respiratory system]</ref>]]		[[File:Mouse- respiratory development 04.jpg\|thumb\|Mouse Respiratory Development Fibroblast Growth Factor Signaling<ref name=PMID20614584>StemBook Cambridge (MA): Harvard Stem Cell Institute; 2008-. [http://www.ncbi.nlm.nih.gov/books/NBK27021/ Specification and patterning of the respiratory system]</ref>]]
	===Lung Buds===		===Lung Buds===
	Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.		Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.

Z8600021 at 04:40, 30 August 2016

2016-08-30T04:40:38Z

← Older revision		Revision as of 15:40, 30 August 2016
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	==Fibroblast Growth Factor==		==Fibroblast Growth Factor==
	[[File:Mouse- respiratory development 04.jpg\|thumb\|Mouse Respiratory Development Fibroblast Growth Factor Signaling<ref name="PMID20614584">~~<pubmed>20614584<~~/~~pubmed>~~</ref>]]		[[File:Mouse- respiratory development 04.jpg\|thumb\|Mouse Respiratory Development Fibroblast Growth Factor Signaling<ref name=PMID20614584>[StemBook Cambridge (MA): Harvard Stem Cell Institute; 2008-. [http://www.ncbi.nlm.nih.gov/books/NBK27021/ Specification and patterning of the respiratory system]</ref>]]
	===Lung Buds===		===Lung Buds===
	Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.		Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.

Z8600021 at 04:36, 30 August 2016

2016-08-30T04:36:44Z

← Older revision		Revision as of 15:36, 30 August 2016
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	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=~~Respiratory~~ molecular ''~~Notch~~'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=lung+molecular+development ''lung molecular development'']

	<pubmed limit=5>~~Respiratory~~ molecular</pubmed>		<pubmed limit=5>lung molecular development</pubmed>
	\|}		\|}

Z8600021 at 04:35, 30 August 2016

2016-08-30T04:35:28Z

← Older revision		Revision as of 15:35, 30 August 2016
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	Loop process mediated through FGF-activated transcription factor genes Etv4 and Etv5.<ref name=PMID26555052><pubmed>26555052</pubmed></ref>		Loop process mediated through FGF-activated transcription factor genes Etv4 and Etv5.<ref name=PMID26555052><pubmed>26555052</pubmed></ref>

			:'''Links:''' [[Developmental_Signals_-_Sonic_hedgehog\|sonic hedgehog\|SHH]]



			===Lipofibroblast Formation===
			Lipid-containing alveolar interstitial fibroblasts (lipofibroblasts) aid the type 2 alveolar epithelial cells in producing surfactant during neonatal life. A recent study in mouse shows FGF10 is required for this cell population to develop using Fgfr1b and Fgfr2b receptors.<ref name=PMID26511927><pubmed>26511927</pubmed></ref>

	~~:'''Links:''' [[Developmental_Signals_-_Sonic_hedgehog\|sonic hedgehog\|SHH]]~~
	==References==		==References==
	<references/>		<references/>

Z8600021 at 04:28, 30 August 2016

2016-08-30T04:28:08Z

← Older revision		Revision as of 15:28, 30 August 2016
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	==Fibroblast Growth Factor==		==Fibroblast Growth Factor==
			[[File:Mouse- respiratory development 04.jpg\|thumb\|Mouse Respiratory Development Fibroblast Growth Factor Signaling<ref name="PMID20614584"><pubmed>20614584</pubmed></ref>]]
	[[File:Mouse- respiratory development 04.jpg\|thumb\|Mouse Respiratory Development Fibroblast Growth Factor Signaling<ref name=PMID20614584><pubmed>20614584</pubmed></ref>]]
	===Lung Buds===		===Lung Buds===
	Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.		Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.

Z8600021 at 04:26, 30 August 2016

2016-08-30T04:26:57Z

← Older revision		Revision as of 15:26, 30 August 2016
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	Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.		Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.

			===Branching===
			Fibroblast growth factor 10 (FGF10) and [[Developmental_Signals_-_Sonic_hedgehog\|sonic hedgehog (SHH)]] form a feedback loop for branching
			* mesenchyme produced FGF10 signals to the distal epithelium to upregulate SHH expression.
			* SHH then feeds back to inhibit Fgf10 expression in the adjacent mesenchyme, dividing in two the Fgf10 expression domain.
			* new FGF10 signaling domains serve as two chemoattractant sources, leading to bifurcation of the epithelial tip.

			Loop process mediated through FGF-activated transcription factor genes Etv4 and Etv5.<ref name=PMID26555052><pubmed>26555052</pubmed></ref>


			:'''Links:''' [[Developmental_Signals_-_Sonic_hedgehog\|sonic hedgehog\|SHH]]
	==References==		==References==
	<references/>		<references/>
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	===Search Pubmed===		===Search Pubmed===
	'''Search Bookshelf''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=~~Notch Notch~~]		'''Search Bookshelf''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=Fibroblast%20growth%20factor%2010 Fibroblast growth factor 10]

	'''Search Pubmed Now:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=~~Notch~~%~~20Signaling Notch Signaling~~]		'''Search Pubmed Now:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Fibroblast%20growth%20factor%2010 Fibroblast growth factor 10]

	==External Links==		==External Links==

Z8600021 at 04:25, 30 August 2016

2016-08-30T04:25:12Z

← Older revision		Revision as of 15:25, 30 August 2016
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	\|}		\|}

	==~~Notch~~==		==Fibroblast Growth Factor==

			[[File:Mouse- respiratory development 04.jpg\|thumb\|Mouse Respiratory Development Fibroblast Growth Factor Signaling<ref name=PMID20614584><pubmed>20614584</pubmed></ref>]]
			===Lung Buds===
			Fibroblast growth factor 10 (FGF10) expression in mesoderm required for initial lung buds, through FGFR2IIIb transmembrane tyrosine kinase receptor protein.

Z8600021 at 04:23, 30 August 2016

2016-08-30T04:23:57Z

← Older revision		Revision as of 15:23, 30 August 2016
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	{{Respiratory ~~links~~}}		{{Respiratory Links}}

	{{Factor Links}}		{{Factor Links}}