Neural System - Molecular - Revision history

Z8600021 at 00:11, 13 Mayıs 2020

2020-05-13T00:11:38Z

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	[[File:Brain stem subdivisions 01.jpg\|alt=Brain stem ~~subdivisions600px~~]]		[[File:Brain stem subdivisions 01.jpg\|alt=Brain stem subdivisions\|600px]]

	New Brain Stem Subdivisions{{#pmid:30809133\|PMID30809133}}		New Brain Stem Subdivisions{{#pmid:30809133\|PMID30809133}}

Z8600021 at 00:11, 13 Mayıs 2020

2020-05-13T00:11:20Z

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			[[File:Brain stem subdivisions 01.jpg\|alt=Brain stem subdivisions600px]]

			New Brain Stem Subdivisions{{#pmid:30809133\|PMID30809133}}
	<br><br>		<br><br>
	{{Factor Links}}		{{Factor Links}}

Z8600021 at 00:09, 13 Mayıs 2020

2020-05-13T00:09:41Z

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	{\|		{\|
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			* '''Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates'''{{#pmid:32375049\|PMID32375049}} "Better understanding of the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here, we use RNA sequencing, cell imaging, and lineage tracing of mouse and human in vitro NSCs and monkey brain sections to model the generation of cortical neuronal fates. We show that conserved signaling mechanisms regulate the acute transition from proliferative NSCs to committed glutamatergic excitatory neurons. As human telencephalic NSCs develop from pluripotency in vitro, they transition through organizer states that spatially pattern the cortex before generating glutamatergic precursor fates. NSCs derived from multiple human pluripotent lines vary in these early patterning states, leading differentially to dorsal or ventral telencephalic fates. This work furthers systematic analyses of the earliest patterning events that generate the major neuronal trajectories of the human {{telencephalon}}."

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	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Notch ''Notch'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Notch ''Notch'']

	~~<pubmed limit=5>Notch</pubmed>~~
	\|}		\|}

Z8600021 at 02:19, 21 March 2018

2018-03-21T02:19:49Z

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			<br><br>
	{{Factor Links}}		{{Factor Links}}
			<br>
	{{Mechanism Links}}		{{Mechanism Links}}
			<br>
	{{Molecular System Links}}		{{Molecular System Links}}
			<br>
			{{Neural Links}}
	==Some Recent Findings==		==Some Recent Findings==
	{\|		{\|

Z8600021 at 02:18, 21 March 2018

2018-03-21T02:18:53Z

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	===Spinal Cord===		===Spinal Cord===
	{\|		{\|
	\| Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.~~<ref><pubmed>~~18000541~~</pubmed>~~\| ~~[http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001169 PLoS ONE]</ref>~~		\| Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.{{#pmid:18000541\|PMID18000541}}
	* Caudal to rostral decreasing FGF gradient, leads to Delta-1 expression decrease in cells that leave the stem zone (light blue) and move into the PNTZ where they intermingle with cells that do not express Delta-1.		* Caudal to rostral decreasing FGF gradient, leads to Delta-1 expression decrease in cells that leave the stem zone (light blue) and move into the PNTZ where they intermingle with cells that do not express Delta-1.
	* Generates differences in DELTA/NOTCH signalling between adjacent cells that may initiate lateral inhibition.		* Generates differences in DELTA/NOTCH signalling between adjacent cells that may initiate lateral inhibition.
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	[[File:Hypothalamus gene interaction model.jpg\|600px]]		[[File:Hypothalamus gene interaction model.jpg\|600px]]

	Hypothalamus Development Gene Interaction Model~~<ref name=PMID>~~24360028~~<pubmed>24360028</pubmed>~~\| ~~[http://www.neuraldevelopment.com/content/8//25 Neural Dev.]</ref>~~		Hypothalamus Development Gene Interaction Model{{#pmid:24360028\|PMID24360028}}

	:'''Links:''' [[Endocrine_-_Hypothalamus_Development\|Hypothalamus Development]]		:'''Links:''' [[Endocrine_-_Hypothalamus_Development\|Hypothalamus Development]]
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	===Reviews===		===Reviews===
	~~<pubmed></pubmed>~~
	~~<pubmed></pubmed>~~
	~~<pubmed></pubmed>~~

	===Search Pubmed===		===Search Pubmed===

Z8600021 at 01:46, 27 August 2016

2016-08-27T01:46:27Z

← Older revision		Revision as of 12:46, 27 August 2016
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	{{Mechanism Links}}		{{Mechanism Links}}

			{{Molecular System Links}}
	==Some Recent Findings==		==Some Recent Findings==
	{\|		{\|

Z8600021 at 01:42, 27 August 2016

2016-08-27T01:42:30Z

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	{{Factor Links}}		{{Factor Links}}

			{{Mechanism Links}}

	==Some Recent Findings==		==Some Recent Findings==

Z8600021 at 01:28, 27 August 2016

2016-08-27T01:28:17Z

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	{{Header}}		{{Header}}
	==Introduction==		==Introduction==
	''Draft Page - notice removed when complete.		''Draft Page - notice removed when complete.''
	''

	{{Factor Links}}		{{Factor Links}}

Z8600021 at 03:45, 18 Ocak 2016

2016-01-18T03:45:03Z

← Older revision		Revision as of 14:45, 18 Ocak 2016
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	==Notch==		==Notch==
			[[Developmental Signals - Notch]]
	===Spinal Cord===		===Spinal Cord===
	{\|		{\|
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	<pubmed></pubmed>		<pubmed></pubmed>
	<pubmed></pubmed>		<pubmed></pubmed>
	~~<pubmed>23165243</pubmed>~~
	~~<pubmed> 22399351</pubmed>~~
	~~<pubmed>22397947</pubmed>~~
	~~<pubmed>21828089</pubmed>~~

	===Search Pubmed===		===Search Pubmed===

Z8600021: Created page with "{{Header}} ==Introduction== ''Draft Page - notice removed when complete. '' {{Factor Links}} ==Some Recent Findings== {| |-bgcolor="F5FAFF" | |} {| class="wikitable mw-col..."

2016-01-18T03:43:45Z

Created page with "{{Header}} ==Introduction== ''Draft Page - notice removed when complete. '' {{Factor Links}} ==Some Recent Findings== {| |-bgcolor="F5FAFF" | |} {| class="wikitable mw-col..."

New page

{{Header}}
==Introduction==
''Draft Page - notice removed when complete.
''

{{Factor Links}}

==Some Recent Findings==
{|
|-bgcolor="F5FAFF"
|

|}
{| class="wikitable mw-collapsible mw-collapsed"
! More recent papers
|-
| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}}

Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Notch ''Notch'']

<pubmed limit=5>Notch</pubmed>
|}

==Notch==
===Spinal Cord===
{|
| Model of the embryonic rostro-caudal gradient of neurogenesis along the chicken spinal cord from the stem zone to the neurogenic neural tube summarising how DELTA-NOTCH signalling may be involved in these processes.<ref><pubmed>18000541</pubmed>| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001169 PLoS ONE]</ref>
* Caudal to rostral decreasing FGF gradient, leads to Delta-1 expression decrease in cells that leave the stem zone (light blue) and move into the PNTZ where they intermingle with cells that do not express Delta-1.
* Generates differences in DELTA/NOTCH signalling between adjacent cells that may initiate lateral inhibition.
* Upregulation of Delta-1 in single NP cells which signal (blue arrows) and activate NOTCH signalling in adjacent cells, which as a consequence express Hes5 and are maintained in a proliferating state.
* Delta-1 expressing NP cell divides into two cells that express Tis21.
* Double Delta-1/Tis21 labelled NP down regulate the expression of Delta-1 as they reach the NZ and begin to divide in a neurogenic manner.
* One of the daughter cells upregulates Delta-1 expression and differentiates as a neuron while the other one, which receives NOTCH signalling (blue arrows), remains as neurogenic NP. Hensen node (HN), neural tube (NT), neurogenic zone (NZ), proliferation to neurogenesis transition zone (PNTZ), presomitic territory (PS), somite (S).

| [[File:Spinal cord delta notch model.png|500px]]
|}

===Hypothalamus===

[[File:Hypothalamus gene interaction model.jpg|600px]]

Hypothalamus Development Gene Interaction Model<ref name=PMID>24360028<pubmed>24360028</pubmed>| [http://www.neuraldevelopment.com/content/8//25 Neural Dev.]</ref>

:'''Links:''' [[Endocrine_-_Hypothalamus_Development|Hypothalamus Development]]

==References==
<references/>

===Reviews===
<pubmed></pubmed>
<pubmed></pubmed>
<pubmed></pubmed>
<pubmed>23165243</pubmed>
<pubmed> 22399351</pubmed>
<pubmed>22397947</pubmed>
<pubmed>21828089</pubmed>

===Search Pubmed===
'''Search Bookshelf''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=Notch Notch]

'''Search Pubmed Now:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Notch%20Signaling Notch Signaling]

==External Links==
{{External Links}}

* OMIM - [http://www.ncbi.nlm.nih.gov/omim/190198 NOTCH 1]

{{Glossary}}

{{Footer}}

[[Category:Notch]] [[Category:Molecular]] [[Category:Pattern]]
[[Category:Neural]]
[[Category:Developmental Signal]]