Neural Crest - Peripheral Nervous System - Revision history

Z8600021 at 21:24, 11 December 2018

2018-12-11T21:24:40Z

← Older revision		Revision as of 07:24, 12 December 2018
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	* '''D''' - In the absence of SEMA3A/NRP1 signaling, sensory and sympathetic neurons differentiate in ectopic positions corresponding to the earlier position of their NCC precursors. Consequently, both the segmentation of the sensory system and the assembly of the sympathetic cords are disrupted.		* '''D''' - In the absence of SEMA3A/NRP1 signaling, sensory and sympathetic neurons differentiate in ectopic positions corresponding to the earlier position of their NCC precursors. Consequently, both the segmentation of the sensory system and the assembly of the sympathetic cords are disrupted.

	~~Abbreviations~~: ~~da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.~~		Figure and text modified from{{#pmid:19325129\|PMID19325129}}

	\| [[File:Trunk neural crest migration.jpg\|600px]]		\| [[File:Trunk neural crest migration.jpg\|600px]]

			Abbreviations: da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.
	\|}		\|}

Z8600021 at 21:23, 11 December 2018

2018-12-11T21:23:28Z

← Older revision		Revision as of 07:23, 12 December 2018
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	* '''stage 14''' - about 33 present		* '''stage 14''' - about 33 present
	* '''stage 15-23''' - 30–35 ganglia		* '''stage 15-23''' - 30–35 ganglia
			==Animal Models==
	==Mouse ~~Peripheral Nervous System~~==		===Mouse===

	{\|		{\|

Z8600021 at 21:22, 11 December 2018

2018-12-11T21:22:52Z

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 * '''stage 14''' - about 33 present
 * '''stage 15-23'''  - 30–35 ganglia
 == References ==

Z8600021 at 11:00, 25 March 2018

2018-03-25T11:00:27Z

← Older revision		Revision as of 21:00, 25 March 2018
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	== Development Overview ==		== Development Overview ==
	The following cranial and trunk data is based upon 185 serially sectioned staged (Carnegie) human embryos.~~<ref><pubmed>~~17848161~~</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2375817 PMC2375817]~~ \| ~~[http://onlinelibrary.wiley.com/doi/10.1111/j.1469-7580.2007.00773.x/full J Anat.]</ref>~~		The following cranial and trunk data is based upon 185 serially sectioned staged (Carnegie) human embryos.{{#pmid:17848161\|PMID17848161}}

	===Cranial Neural Crest===		===Cranial Neural Crest===

Z8600021 at 10:58, 25 March 2018

2018-03-25T10:58:17Z

← Older revision		Revision as of 20:58, 25 March 2018
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	* '''Neuronal differentiation in the developing human spinal ganglia'''~~<ref name=~~PMID27225905~~><pubmed>27225905</pubmed></ref>~~ "The spatiotemporal developmental pattern of the neural crest cells differentiation towards the first appearance of the neuronal subtypes was investigated in developing human spinal ganglia between the 5th -10th developmental week using immunohistochemistry and immunofluorescence methods. First NF200 (neurofilament-200, likely-myelinated mechanoreceptors) and isolectin-B4 positive neurons (likely-unmyelinated nociceptors) appeared already in the 5/6th developmental week and their number subsequently increased during progression of development. Proportion of NF200 positive cells was higher in the ventral parts of the spinal ganglia than in the dorsal parts, particularly during the 5/6th and 9/10th developmental weeks (Mann-Whitney, p=0.040 and p=0.003). NF200 and IB4 co-localized during the whole investigated period. Calcitonin gene-related peptide (CGRP, nociceptive responses), vanilloid-receptor-1 (VR1, polymodal nociceptors) and calretinin (calcium signalling) cell immunoreactivity first appeared in the 6th and 8th week, respectively, especially in the dorsal parts of the spinal ganglia. VR1 and CGRP co-localized with NF00 during the whole investigated period. Our results indicate the high potential of early differentiated neuronal cells, which slightly decreased with progression of spinal ganglia differentiation. On the contrary, the number of neuronal subtypes displayed increasing differentiation at later developmental stage."		* '''Neuronal differentiation in the developing human spinal ganglia'''{{#pmid:27225905\|PMID27225905}} "The spatiotemporal developmental pattern of the neural crest cells differentiation towards the first appearance of the neuronal subtypes was investigated in developing human spinal ganglia between the 5th -10th developmental week using immunohistochemistry and immunofluorescence methods. First NF200 (neurofilament-200, likely-myelinated mechanoreceptors) and isolectin-B4 positive neurons (likely-unmyelinated nociceptors) appeared already in the 5/6th developmental week and their number subsequently increased during progression of development. Proportion of NF200 positive cells was higher in the ventral parts of the spinal ganglia than in the dorsal parts, particularly during the 5/6th and 9/10th developmental weeks (Mann-Whitney, p=0.040 and p=0.003). NF200 and IB4 co-localized during the whole investigated period. Calcitonin gene-related peptide (CGRP, nociceptive responses), vanilloid-receptor-1 (VR1, polymodal nociceptors) and calretinin (calcium signalling) cell immunoreactivity first appeared in the 6th and 8th week, respectively, especially in the dorsal parts of the spinal ganglia. VR1 and CGRP co-localized with NF00 during the whole investigated period. Our results indicate the high potential of early differentiated neuronal cells, which slightly decreased with progression of spinal ganglia differentiation. On the contrary, the number of neuronal subtypes displayed increasing differentiation at later developmental stage."
	* '''The role of the transcription factor Rbpj in the development of dorsal root ganglia'''~~<ref><pubmed>~~21510873~~</pubmed></ref>~~ "The dorsal root ganglion (DRG) is composed of well-characterized populations of sensory neurons and glia derived from a common pool of neural crest stem cells (NCCs), and is a good system to study the mechanisms of neurogenesis and gliogenesis. Notch signaling is known to play important roles in DRG development, but the full scope of Notch functions in mammalian DRG development remains poorly understood."
	* '''Cranial neural crest migration: new rules for an old road.'''~~<ref><pubmed>~~20399765~~</pubmed></ref>~~ "In this review, we discuss recent cellular and molecular discoveries of the CNCC migratory pattern. We focus on events from the time when CNCCs encounter the tissue adjacent to the neural tube and their travel through different microenvironments and into the branchial arches. We describe the patterning of discrete cell migratory streams that emerge from the hindbrain, rhombomere (r) segments r1-r7, and the signals that coordinate directed migration."		* '''The role of the transcription factor Rbpj in the development of dorsal root ganglia'''{{#pmid:21510873\|PMID21510873}} "The dorsal root ganglion (DRG) is composed of well-characterized populations of sensory neurons and glia derived from a common pool of neural crest stem cells (NCCs), and is a good system to study the mechanisms of neurogenesis and gliogenesis. Notch signaling is known to play important roles in DRG development, but the full scope of Notch functions in mammalian DRG development remains poorly understood."

			* '''Cranial neural crest migration: new rules for an old road.'''{{#pmid:20399765\|PMID20399765}} "In this review, we discuss recent cellular and molecular discoveries of the CNCC migratory pattern. We focus on events from the time when CNCCs encounter the tissue adjacent to the neural tube and their travel through different microenvironments and into the branchial arches. We describe the patterning of discrete cell migratory streams that emerge from the hindbrain, rhombomere (r) segments r1-r7, and the signals that coordinate directed migration."
	\|}		\|}
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	Movie Source: Original Neural Crest movies kindly provided by Paul Kulesa.~~<ref><pubmed>~~10683170~~</pubmed></ref>~~		Movie Source: Original Neural Crest movies kindly provided by Paul Kulesa.{{#pmid:10683170\|PMID10683170}}

	'''Related Movies:''' [[Chicken Neural Crest Migration Movie 1\|Migration 01]] \| [[Chicken Neural Crest Migration Movie 2\|Migration 02]] \| [[Chicken Neural Crest Migration Movie 3\|Migration 03]] \| [[Chicken Neural Crest Migration Movie 4\|Migration 04]] \| [[Chicken Neural Crest Migration Movie 5\|Migration 05]] \| [[Chicken Neural Crest Migration Movie 6\|Migration 06]] \| [[Chicken Neural Crest Migration Movie 7\|Migration 07]]		'''Related Movies:''' [[Chicken Neural Crest Migration Movie 1\|Migration 01]] \| [[Chicken Neural Crest Migration Movie 2\|Migration 02]] \| [[Chicken Neural Crest Migration Movie 3\|Migration 03]] \| [[Chicken Neural Crest Migration Movie 4\|Migration 04]] \| [[Chicken Neural Crest Migration Movie 5\|Migration 05]] \| [[Chicken Neural Crest Migration Movie 6\|Migration 06]] \| [[Chicken Neural Crest Migration Movie 7\|Migration 07]]
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	===Reviews===		===Reviews===
	~~<pubmed>~~20683859~~</pubmed>~~		{{#pmid:20683859}}
	~~<pubmed>~~19387688~~</pubmed>~~
	~~<pubmed>~~16225807~~</pubmed>~~		{{#pmid:19387688}}
	~~<pubmed>~~12593987~~</pubmed>~~
	~~<pubmed>~~11336393~~</pubmed>~~		{{#pmid:16225807}}

			{{#pmid:12593987}}

			{{#pmid:11336393}}

	===Articles===		===Articles===

Z8600021 at 14:36, 2 Haziran 2017

2017-06-02T14:36:30Z

← Older revision		Revision as of 00:36, 3 Haziran 2017
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	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Peripheral+Nervous+System+Development ''Peripheral Nervous System Development'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Peripheral+Nervous+System+Development ''Peripheral Nervous System Development'']

			<pubmed limit=5>Peripheral Nervous System Development</pubmed>

	<pubmed ~~limit~~=~~5>Peripheral Nervous System~~ Development~~</pubmed>~~		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Dorsal+Root+Ganglia+Development ''Dorsal Root Ganglia Development'']

	<pubmed limit=5>Dorsal Root Ganglia Development</pubmed>		<pubmed limit=5>Dorsal Root Ganglia Development</pubmed>

			Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Sympathetic+Development ''Sympathetic Development'']

	<pubmed limit=5>Sympathetic Development</pubmed>		<pubmed limit=5>Sympathetic Development</pubmed>

Z8600021 at 14:34, 2 Haziran 2017

2017-06-02T14:34:34Z

← Older revision		Revision as of 00:34, 3 Haziran 2017
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	<pubmed limit=5>Peripheral Nervous System Development</pubmed>		<pubmed limit=5>Peripheral Nervous System Development</pubmed>

			<pubmed limit=5>Dorsal Root Ganglia Development</pubmed>

			<pubmed limit=5>Sympathetic Development</pubmed>
	\|}		\|}
	==Neural Crest Migration==		==Neural Crest Migration==

Z8600021 at 14:28, 2 Haziran 2017

2017-06-02T14:28:24Z

← Older revision		Revision as of 00:28, 3 Haziran 2017
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	\|}		\|}
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	! More recent papers		! More recent papers
	\|-		\|-
	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

Z8600021 at 13:19, 9 Haziran 2016

2016-06-09T13:19:56Z

← Older revision		Revision as of 23:19, 9 Haziran 2016
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	Movie Source: Original Neural Crest movies kindly provided by Paul Kulesa.<ref><pubmed>10683170</pubmed></ref>		Movie Source: Original Neural Crest movies kindly provided by Paul Kulesa.<ref><pubmed>10683170</pubmed></ref>

	'''Related Movies:''' [[~~Movie -~~ Chicken Neural Crest Migration 01\|Migration 01]] \| [[~~Movie -~~ Chicken Neural Crest Migration 02\|Migration 02]] \| [[~~Movie -~~ Chicken Neural Crest Migration 03\|Migration 03]] \| [[~~Movie -~~ Chicken Neural Crest Migration 04\|Migration 04]] \| [[~~Movie -~~ Chicken Neural Crest Migration 05\|Migration 05]] \| [[~~Movie -~~ Chicken Neural Crest Migration 06\|Migration 06]] \| [[~~Movie -~~ Chicken Neural Crest Migration 07\|Migration 07]]		'''Related Movies:''' [[Chicken Neural Crest Migration Movie 1\|Migration 01]] \| [[Chicken Neural Crest Migration Movie 2\|Migration 02]] \| [[Chicken Neural Crest Migration Movie 3\|Migration 03]] \| [[Chicken Neural Crest Migration Movie 4\|Migration 04]] \| [[Chicken Neural Crest Migration Movie 5\|Migration 05]] \| [[Chicken Neural Crest Migration Movie 6\|Migration 06]] \| [[Chicken Neural Crest Migration Movie 7\|Migration 07]]

	== Development Overview ==		== Development Overview ==

Z8600021 at 13:16, 9 Haziran 2016

2016-06-09T13:16:59Z

← Older revision		Revision as of 23:16, 9 Haziran 2016
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			* '''Neuronal differentiation in the developing human spinal ganglia'''<ref name=PMID27225905><pubmed>27225905</pubmed></ref> "The spatiotemporal developmental pattern of the neural crest cells differentiation towards the first appearance of the neuronal subtypes was investigated in developing human spinal ganglia between the 5th -10th developmental week using immunohistochemistry and immunofluorescence methods. First NF200 (neurofilament-200, likely-myelinated mechanoreceptors) and isolectin-B4 positive neurons (likely-unmyelinated nociceptors) appeared already in the 5/6th developmental week and their number subsequently increased during progression of development. Proportion of NF200 positive cells was higher in the ventral parts of the spinal ganglia than in the dorsal parts, particularly during the 5/6th and 9/10th developmental weeks (Mann-Whitney, p=0.040 and p=0.003). NF200 and IB4 co-localized during the whole investigated period. Calcitonin gene-related peptide (CGRP, nociceptive responses), vanilloid-receptor-1 (VR1, polymodal nociceptors) and calretinin (calcium signalling) cell immunoreactivity first appeared in the 6th and 8th week, respectively, especially in the dorsal parts of the spinal ganglia. VR1 and CGRP co-localized with NF00 during the whole investigated period. Our results indicate the high potential of early differentiated neuronal cells, which slightly decreased with progression of spinal ganglia differentiation. On the contrary, the number of neuronal subtypes displayed increasing differentiation at later developmental stage."
	* '''The role of the transcription factor Rbpj in the development of dorsal root ganglia'''<ref><pubmed>21510873</pubmed></ref> "The dorsal root ganglion (DRG) is composed of well-characterized populations of sensory neurons and glia derived from a common pool of neural crest stem cells (NCCs), and is a good system to study the mechanisms of neurogenesis and gliogenesis. Notch signaling is known to play important roles in DRG development, but the full scope of Notch functions in mammalian DRG development remains poorly understood."		* '''The role of the transcription factor Rbpj in the development of dorsal root ganglia'''<ref><pubmed>21510873</pubmed></ref> "The dorsal root ganglion (DRG) is composed of well-characterized populations of sensory neurons and glia derived from a common pool of neural crest stem cells (NCCs), and is a good system to study the mechanisms of neurogenesis and gliogenesis. Notch signaling is known to play important roles in DRG development, but the full scope of Notch functions in mammalian DRG development remains poorly understood."
	* '''Cranial neural crest migration: new rules for an old road.'''<ref><pubmed>20399765</pubmed></ref> "In this review, we discuss recent cellular and molecular discoveries of the CNCC migratory pattern. We focus on events from the time when CNCCs encounter the tissue adjacent to the neural tube and their travel through different microenvironments and into the branchial arches. We describe the patterning of discrete cell migratory streams that emerge from the hindbrain, rhombomere (r) segments r1-r7, and the signals that coordinate directed migration."		* '''Cranial neural crest migration: new rules for an old road.'''<ref><pubmed>20399765</pubmed></ref> "In this review, we discuss recent cellular and molecular discoveries of the CNCC migratory pattern. We focus on events from the time when CNCCs encounter the tissue adjacent to the neural tube and their travel through different microenvironments and into the branchial arches. We describe the patterning of discrete cell migratory streams that emerge from the hindbrain, rhombomere (r) segments r1-r7, and the signals that coordinate directed migration."