Neural - Tectum Development - Revision history

Z8600021 at 23:57, 13 October 2018

2018-10-13T23:57:54Z

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 ===Secondary Vesicles===
 [[Image:CNS secondary vesicles.jpg|600px]]
 == References ==

Z8600021 at 23:42, 13 October 2018

2018-10-13T23:42:49Z

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	* '''~~Genetic and physical interaction~~ of ~~Meis2, Pax3 and Pax7 during dorsal midbrain development~~'''{{#pmid:~~22390724~~\|~~PMID22390724~~}} "~~During early stages~~ of ~~brain~~ development~~, secreted molecules, components~~ of ~~intracellular signaling pathways~~ and ~~transcriptional regulators act~~ in ~~positive~~ and ~~negative feed-back~~ or ~~feed-forward loops at~~ the ~~mid-hindbrain boundary~~. ~~These genetic interactions are~~ of central ~~importance for the specification~~ and ~~subsequent development of~~ the ~~adjacent mid-~~ and ~~hindbrain~~. ~~Much less, however~~, is known about the ~~regulatory relationship and functional interaction~~ of ~~molecules~~ that ~~are expressed in~~ the ~~tectal anlage after tectal~~ fate ~~specification has taken place and tectal~~ development ~~has commenced~~. ~~The results described here suggest a model in which interdependent regulatory loops involving Pax3~~ and ~~Pax7 in~~ the ~~dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range~~ of ~~otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7~~."		* '''Dispersing movement of tangential neuronal migration in superficial layers of the developing chick optic tectum'''{{#pmid:29548944\|PMID29548944}} "Two distinct types of tangential migration in the middle and superficial layers have been reported in the development of the avian optic tectum. Here we show the dynamics of tangential cell movement in superficial layers of developing {{chicken}} optic tectum. Confocal time-lapse microscopy in organotypic slice cultures and flat-mount cultures revealed that vigorous cell migration continued during E6.5-E13.5, where horizontally elongated superficial cells spread out tangentially. Motile cells exhibited exploratory behavior in reforming the branched leading processes to determine their pathway, and intersected with each other for dispersion. At the tectal peripheral border, the cells retraced or turned around to avoid protruding over the border. The tangentially migrating cells were eventually distributed in the outer stratum griseum et fibrosum superficiale and differentiated into neurons of various morphologies."

			* '''Sonic Hedgehog Regulation of the Neural Precursor Cell Fate During {{chicken}} Optic Tectum Development'''{{#pmid:29285739\|PMID29285739}} "Sonic hedgehog ({{Shh}}) is a secreted protein and plays a key role in regulating vertebrate embryogenesis, especially in central nervous system (CNS) patterning, including neuronal migration and axonal projection in the brain and spinal cord. In the developing ventral midbrain, Shh is sufficient to specify a striped pattern of cell fates. Little is known about the molecular mechanisms underlying the Shh regulation of the neural precursor cell fate during the optic tectum development. ...In conclusion, we provide evidence that Shh regulates the neural precursor cell fate during chicken optic tectum development. Shh over-expression impairs neuronal migration and may affect the fate determination of transfected neurons."

	* '''Dynamic imaging of mammalian neural tube closure'''{{#pmid:20558153\|PMID20558153}}
	\|}		\|}
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	! More recent papers		! More recent papers
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	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}
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	<pubmed limit=5>Tectum Embryology</pubmed>		<pubmed limit=5>Tectum Embryology</pubmed>
			\|}
			{\| class="wikitable mw-collapsible mw-collapsed"
			! Older papers
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			* '''Genetic and physical interaction of Meis2, {{Pax}}3 and {{Pax}}7 during dorsal midbrain development'''{{#pmid:22390724\|PMID22390724}} "During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid- and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7."

			* '''Dynamic imaging of mammalian neural tube closure'''{{#pmid:20558153\|PMID20558153}}
	\|}		\|}
	==Developmental Signaling Model==		==Developmental Signaling Model==
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	== References ==		== References ==
	<references/>		<references/>

	===Reviews===		===Reviews===
			{{#pmid:30193861}}

			{{#pmid:29977193}}

			{{#pmid:29935867}}

			{{#pmid:27780043}}

			{{#pmid:27420378}}

	{{#pmid:19206138}}		{{#pmid:19206138}}

	===Articles===		===Articles===

			{{#pmid:30265665}}

			{{#pmid:29680273}}

	{{#pmid:18230116}}		{{#pmid:18230116}}

Z8600021 at 23:29, 13 October 2018

2018-10-13T23:29:11Z

← Older revision		Revision as of 09:29, 14 October 2018
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	{{Footer}}		{{Footer}}
	[[Category:Neural]][[Category:Mesencephalon]]		[[Category:Neural]][[Category:Mesencephalon]][[Category:Hearing]][[Category:Vision]]

Z8600021 at 23:28, 13 October 2018

2018-10-13T23:28:12Z

← Older revision		Revision as of 09:28, 14 October 2018
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	* '''Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development'''~~<ref name "PMID22390724"><pubmed>~~22390724~~</pubmed>~~\| ~~[http://www.biomedcentral.com/1471-213X/12/10 BMC Dev Biol.]</ref>~~ "During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid- and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7."		* '''Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development'''{{#pmid:22390724\|PMID22390724}} "During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid- and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7."
	* '''Dynamic imaging of mammalian neural tube closure'''~~<ref><pubmed>~~20558153~~</pubmed></ref>~~
			* '''Dynamic imaging of mammalian neural tube closure'''{{#pmid:20558153\|PMID20558153}}
	\|}		\|}
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	[[File:Tectum signaling model 01.jpg]]		[[File:Tectum signaling model 01.jpg]]

	Model of interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. ~~<ref name "PMID22390724"><pubmed>~~22390724~~</pubmed>~~\| ~~[http://www.biomedcentral.com/1471-213X/12/10 BMC Dev Biol.]</ref>~~		Model of interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. {{#pmid:22390724\|PMID22390724}}

	== Development Overview ==		== Development Overview ==
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	{{~~Template:~~Neural Table}}		{{Neural Table}}

	==Early Brain Vesicles==		==Early Brain Vesicles==
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	<references/>		<references/>
	===Reviews===		===Reviews===
	~~<pubmed>~~19206138~~</pubmed>~~		{{#pmid:19206138}}

	===Articles===		===Articles===
	~~<pubmed>~~18230116~~</pubmed>~~		{{#pmid:18230116}}

	===Search PubMed===		===Search PubMed===
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	{{~~Template:~~Glossary}}		{{Glossary}}


	{{~~Template:~~Footer}}		{{Footer}}
			[[Category:Neural]][[Category:Mesencephalon]]

Z8600021 at 00:53, 29 Haziran 2014

2014-06-29T00:53:33Z

← Older revision		Revision as of 10:53, 29 Haziran 2014
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	* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref>		* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref>
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Z8600021 at 11:19, 11 March 2014

2014-03-11T11:19:25Z

← Older revision		Revision as of 21:19, 11 March 2014
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	<div style="background:#F5FFFA; border: 1px solid #CEF2E0; padding: 1em; margin: auto; width: 98%; float:left;"><div style="margin:0;background-color:#cef2e0;font-family:sans-serif;font-size:120%;font-weight:bold;border:1px solid #a3bfb1;text-align:left;color:#000;padding-left:0.4em;padding-top:0.2em;padding-bottom:0.2em;">Notice - Mark Hill</div>Currently this is only a template page and is being updated (this notice removed when completed).</div>		{{Header}}

	[[File:Stage10_sem6.jpg\|right\|150px]]		[[File:Stage10_sem6.jpg\|right\|150px]]
	==Introduction==		==Introduction==
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	~~:{{Template:Neural Links}}~~

			{{Neural Links}}

			{{Neural Links 2}}
	==Some Recent Findings==		==Some Recent Findings==
	{\|		{\|
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	* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref>		* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref>
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			{\| class="wikitable collapsible collapsed"
			! More recent papers
			\|-
			\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	[~~[Talk~~:~~Neural -~~ Tectum ~~Development\|Recent References]] \| [[#References\|References]~~]		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Tectum+Embryology ''Tectum Embryology'']

			<pubmed limit=5>Tectum Embryology</pubmed>
			\|}
	==Developmental Signaling Model==		==Developmental Signaling Model==

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	{{Template:Glossary}}		{{Template:Glossary}}


	{{Template:Footer}}		{{Template:Footer}}

Z8600021: /* Introduction */

2012-06-10T22:02:43Z

Introduction

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	Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system.		Neural development is one of the earliest systems to begin and the last to be completed after birth. This development generates the most complex structure within the embryo and the long time period of development means in utero insult during pregnancy may have consequences to development of the nervous system.

	~~The early central nervous system begins as a simple neural plate that folds~~ to ~~form a groove then tube, open initially~~ at ~~each end~~. ~~Failure of these opening~~ to ~~close contributes a major class of neural abnormalities (neural tube defects)~~.		Differences between birds and mammals:
			* both - have retinal axons projecting topographically to targets in the brain.
			* birds - the visual fibers from the entire retina decussate at the optic chiasm.
			* mammals - some axons from the temporal retina diverge at the midline to project ipsilaterally.

	Within the neural tube stem cells generate the 2 major classes of cells that make the majority of the nervous system : neurons and glia. Both these classes of cells differentiate into many different types generated with highly specialized functions and shapes. This section covers the establishment of neural populations, the inductive influences of surrounding tissues and the sequential generation of neurons establishing the layered structure seen in the brain and spinal cord.		Neural development beginnings quite early, therefore also look at notes covering Week 3- neural tube and Week 4-early nervous system. Development of the neural crest and sensory systems (hearing/vision/smell) are only introduced in these notes and are covered in other notes sections.

	* Neural development beginnings quite early, therefore also look at notes covering Week 3- neural tube and Week 4-early nervous system.
	* Development of the neural crest and sensory systems (hearing/vision/smell) are only introduced in these notes and are covered in other notes sections.

Z8600021: /* Some Recent Findings */

2012-06-10T21:52:09Z

Some Recent Findings

← Older revision		Revision as of 07:52, 11 Haziran 2012
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			* '''Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development'''<ref name "PMID22390724"><pubmed>22390724</pubmed>\| [http://www.biomedcentral.com/1471-213X/12/10 BMC Dev Biol.]</ref> "During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid- and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7."
	Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development<ref name "PMID22390724"><pubmed>22390724</pubmed>\| [http://www.biomedcentral.com/1471-213X/12/10 BMC Dev Biol.]</ref> "During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid- and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7."
	* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref>		* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref>
	\|}		\|}

	[[Talk:Neural - Tectum Development\|Recent References]] \| [[#References\|References]]		[[Talk:Neural - Tectum Development\|Recent References]] \| [[#References\|References]]

			==Developmental Signaling Model==

			[[File:Tectum signaling model 01.jpg]]

			Model of interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development. <ref name "PMID22390724"><pubmed>22390724</pubmed>\| [http://www.biomedcentral.com/1471-213X/12/10 BMC Dev Biol.]</ref>

	== Development Overview ==		== Development Overview ==

Z8600021: /* Some Recent Findings */

2012-06-10T21:50:06Z

Some Recent Findings

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	Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development<ref><pubmed>22390724</pubmed>\| [http://www.biomedcentral.com/1471-213X/12/10 BMC Dev Biol.]</ref> "During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid- and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7."		Genetic and physical interaction of Meis2, Pax3 and Pax7 during dorsal midbrain development<ref name "PMID22390724"><pubmed>22390724</pubmed>\| [http://www.biomedcentral.com/1471-213X/12/10 BMC Dev Biol.]</ref> "During early stages of brain development, secreted molecules, components of intracellular signaling pathways and transcriptional regulators act in positive and negative feed-back or feed-forward loops at the mid-hindbrain boundary. These genetic interactions are of central importance for the specification and subsequent development of the adjacent mid- and hindbrain. Much less, however, is known about the regulatory relationship and functional interaction of molecules that are expressed in the tectal anlage after tectal fate specification has taken place and tectal development has commenced. The results described here suggest a model in which interdependent regulatory loops involving Pax3 and Pax7 in the dorsal mesencephalic vesicle modulate Meis2 expression. Physical interaction with Meis2 may then confer tectal specificity to a wide range of otherwise broadly expressed transcriptional regulators, including Otx2, Pax3 and Pax7."
	* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref>		* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref>
	\|}		\|}

Z8600021: /* Some Recent Findings */

2012-06-10T21:42:18Z

Some Recent Findings

← Older revision		Revision as of 07:42, 11 Haziran 2012
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	* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref>		* '''Dynamic imaging of mammalian neural tube closure'''<ref><pubmed>20558153</pubmed></ref>
	\|}		\|}

			[[Talk:Neural - Tectum Development\|Recent References]] \| [[#References\|References]]

	== Development Overview ==		== Development Overview ==