Neural - Epithalamus Development - Revision history

Z8600021 at 23:00, 23 February 2020

2020-02-23T23:00:18Z

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			* '''Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration'''{{#pmid:31498774\|PMID31498774}} "Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple mechanical and chemical cues. Recently, we described that focal activation of the FGF pathway promotes the migration of the parapineal in the zebrafish epithalamus. How FGF activity is restricted to leading cells in this system is, however, unclear. Here, we address the role of Notch signaling in modulating FGF activity within the parapineal. While Notch loss-of-function results in an increased number of parapineal cells activating the FGF pathway, global activation of Notch signaling decreases it; both contexts result in defects in parapineal migration and specification. Decreasing or increasing FGF signaling in a Notch loss-of-function context respectively rescues or aggravates parapineal migration defects without affecting parapineal cells specification. We propose that Notch signaling controls the migration of the parapineal through its capacity to restrict FGF pathway activation to a few leading cells."

	* '''Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration'''{{#pmid:31498774\|PMID31498774}} "Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple mechanical and chemical cues. Recently, we described that focal activation of the FGF pathway promotes the migration of the parapineal in the zebrafish epithalamus. How FGF activity is restricted to leading cells in this system is, however, unclear. Here, we address the role of Notch signaling in modulating FGF activity within the parapineal. While Notch loss-of-function results in an increased number of parapineal cells activating the FGF pathway, global activation of Notch signaling decreases it; both contexts result in defects in parapineal migration and specification. Decreasing or increasing FGF signaling in a Notch loss-of-function context respectively rescues or aggravates parapineal migration defects without affecting parapineal cells specification. We propose that Notch signaling controls the migration of the parapineal through its capacity to restrict FGF pathway activation to a few leading cells."		* '''Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration'''{{#pmid:31498774\|PMID31498774}} "Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple mechanical and chemical cues. Recently, we described that focal activation of the FGF pathway promotes the migration of the parapineal in the zebrafish epithalamus. How FGF activity is restricted to leading cells in this system is, however, unclear. Here, we address the role of Notch signaling in modulating FGF activity within the parapineal. While Notch loss-of-function results in an increased number of parapineal cells activating the FGF pathway, global activation of Notch signaling decreases it; both contexts result in defects in parapineal migration and specification. Decreasing or increasing FGF signaling in a Notch loss-of-function context respectively rescues or aggravates parapineal migration defects without affecting parapineal cells specification. We propose that Notch signaling controls the migration of the parapineal through its capacity to restrict FGF pathway activation to a few leading cells."

Z8600021 at 22:48, 23 February 2020

2020-02-23T22:48:44Z

← Older revision		Revision as of 09:48, 24 February 2020
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			* '''Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration'''{{#pmid:31498774\|PMID31498774}} "Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple mechanical and chemical cues. Recently, we described that focal activation of the FGF pathway promotes the migration of the parapineal in the zebrafish epithalamus. How FGF activity is restricted to leading cells in this system is, however, unclear. Here, we address the role of Notch signaling in modulating FGF activity within the parapineal. While Notch loss-of-function results in an increased number of parapineal cells activating the FGF pathway, global activation of Notch signaling decreases it; both contexts result in defects in parapineal migration and specification. Decreasing or increasing FGF signaling in a Notch loss-of-function context respectively rescues or aggravates parapineal migration defects without affecting parapineal cells specification. We propose that Notch signaling controls the migration of the parapineal through its capacity to restrict FGF pathway activation to a few leading cells."

	* '''Foxg1 deletion impairs the development of the epithalamus'''{{#pmid:29394901\|PMID29394901}} "The epithalamus, which is dorsal to the thalamus, consists of the habenula, pineal gland and third ventricle choroid plexus and plays important roles in the stress response and sleep-wake cycle in vertebrates. During development, the epithalamus arises from the most dorsal part of prosomere 2. However, the mechanism underlying epithalamic development remains largely unknown. Foxg1 is critical for the development of the telencephalon, but its role in diencephalic development has been under-investigated. Patients suffering from FOXG1-related disorders exhibit severe anxiety, sleep disturbance and choroid plexus cysts, indicating that Foxg1 likely plays a role in epithalamic development. In this study, we identified the specific expression of Foxg1 in the developing epithalamus. Using a "self-deletion" approach, we found that the habenula significantly expanded and included an increased number of habenular subtype neurons. The innervations, particularly the habenular commissure, were severely impaired. Meanwhile, the Foxg1 mutants exhibited a reduced pineal gland and more branched choroid plexus. After ablation of Foxg1 no obvious changes in Shh and Fgf signalling were observed, suggesting that Foxg1 regulates the development of the epithalamus without the involvement of {{Shh}} and {{Fgf}}s."		* '''Foxg1 deletion impairs the development of the epithalamus'''{{#pmid:29394901\|PMID29394901}} "The epithalamus, which is dorsal to the thalamus, consists of the habenula, pineal gland and third ventricle choroid plexus and plays important roles in the stress response and sleep-wake cycle in vertebrates. During development, the epithalamus arises from the most dorsal part of prosomere 2. However, the mechanism underlying epithalamic development remains largely unknown. Foxg1 is critical for the development of the telencephalon, but its role in diencephalic development has been under-investigated. Patients suffering from FOXG1-related disorders exhibit severe anxiety, sleep disturbance and choroid plexus cysts, indicating that Foxg1 likely plays a role in epithalamic development. In this study, we identified the specific expression of Foxg1 in the developing epithalamus. Using a "self-deletion" approach, we found that the habenula significantly expanded and included an increased number of habenular subtype neurons. The innervations, particularly the habenular commissure, were severely impaired. Meanwhile, the Foxg1 mutants exhibited a reduced pineal gland and more branched choroid plexus. After ablation of Foxg1 no obvious changes in Shh and Fgf signalling were observed, suggesting that Foxg1 regulates the development of the epithalamus without the involvement of {{Shh}} and {{Fgf}}s."

Z8600021 at 22:46, 23 February 2020

2020-02-23T22:46:04Z

← Older revision		Revision as of 09:46, 24 February 2020
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	==Introduction==		==Introduction==

	The uppermost portion of the {{diencephalon}} that includes the trigonum habenulae (habenula), the {{pineal}} (gland or body), the posterior commissure, and the medullary layers of {{thalamus}}.		The uppermost portion of the {{diencephalon}} that includes the trigonum habenulae (habenula), the {{pineal}} (gland or body), the posterior commissure, and the medullary layers of {{thalamus}}. The epithalamus develops from the diencephalon most dorsal part of prosomere 2.

	The adult habenular nuclei acts as a neural relay system, connecting the forebrain with the brain stem. The function appears to be to regulate cognitive behaviors by modulating a range of transmitter system (cholinergic, dopaminergic and serotonergic) activities.		The adult habenular nuclei acts as a neural relay system, connecting the forebrain with the brain stem. The function appears to be to regulate cognitive behaviors by modulating a range of transmitter system (cholinergic, dopaminergic and serotonergic) activities.
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			* '''Foxg1 deletion impairs the development of the epithalamus'''{{#pmid:29394901\|PMID29394901}} "The epithalamus, which is dorsal to the thalamus, consists of the habenula, pineal gland and third ventricle choroid plexus and plays important roles in the stress response and sleep-wake cycle in vertebrates. During development, the epithalamus arises from the most dorsal part of prosomere 2. However, the mechanism underlying epithalamic development remains largely unknown. Foxg1 is critical for the development of the telencephalon, but its role in diencephalic development has been under-investigated. Patients suffering from FOXG1-related disorders exhibit severe anxiety, sleep disturbance and choroid plexus cysts, indicating that Foxg1 likely plays a role in epithalamic development. In this study, we identified the specific expression of Foxg1 in the developing epithalamus. Using a "self-deletion" approach, we found that the habenula significantly expanded and included an increased number of habenular subtype neurons. The innervations, particularly the habenular commissure, were severely impaired. Meanwhile, the Foxg1 mutants exhibited a reduced pineal gland and more branched choroid plexus. After ablation of Foxg1 no obvious changes in Shh and Fgf signalling were observed, suggesting that Foxg1 regulates the development of the epithalamus without the involvement of {{Shh}} and {{Fgf}}s."

	* '''Pitx2c ensures habenular asymmetry by restricting parapineal cell number'''{{#pmid:24598158\|PMID24598158}} "Left-right (L/R) asymmetries in the brain are thought to underlie lateralised cognitive functions. Understanding how neuroanatomical asymmetries are established has been achieved through the study of the zebrafish epithalamus. ...We provide evidence suggesting that antagonism between Nodal and Pitx2c activities sets an upper limit on parapineal cell numbers. We conclude that restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry."		* '''Pitx2c ensures habenular asymmetry by restricting parapineal cell number'''{{#pmid:24598158\|PMID24598158}} "Left-right (L/R) asymmetries in the brain are thought to underlie lateralised cognitive functions. Understanding how neuroanatomical asymmetries are established has been achieved through the study of the zebrafish epithalamus. ...We provide evidence suggesting that antagonism between Nodal and Pitx2c activities sets an upper limit on parapineal cell numbers. We conclude that restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry."

Z8600021 at 22:40, 23 February 2020

2020-02-23T22:40:04Z

← Older revision		Revision as of 09:40, 24 February 2020
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	==Introduction==		==Introduction==

	The uppermost portion of the diencephalon that includes the trigonum habenulae (habenula), the ~~[[Endocrine - Pineal Development\|~~pineal]] (gland or body), the posterior commissure, and the medullary layers of thalamus.		The uppermost portion of the {{diencephalon}} that includes the trigonum habenulae (habenula), the {{pineal}} (gland or body), the posterior commissure, and the medullary layers of {{thalamus}}.

	The adult habenular nuclei acts as a neural relay system, connecting the forebrain with the brain stem. The function appears to be to regulate cognitive behaviors by modulating a range of transmitter system (cholinergic, dopaminergic and serotonergic) activities.		The adult habenular nuclei acts as a neural relay system, connecting the forebrain with the brain stem. The function appears to be to regulate cognitive behaviors by modulating a range of transmitter system (cholinergic, dopaminergic and serotonergic) activities.
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	* Pitx2c ensures habenular asymmetry by restricting parapineal cell number~~<ref><pubmed>~~24598158~~</pubmed></ref>~~ "Left-right (L/R) asymmetries in the brain are thought to underlie lateralised cognitive functions. Understanding how neuroanatomical asymmetries are established has been achieved through the study of the zebrafish epithalamus. ...We provide evidence suggesting that antagonism between Nodal and Pitx2c activities sets an upper limit on parapineal cell numbers. We conclude that restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry."		* '''Pitx2c ensures habenular asymmetry by restricting parapineal cell number'''{{#pmid:24598158\|PMID24598158}} "Left-right (L/R) asymmetries in the brain are thought to underlie lateralised cognitive functions. Understanding how neuroanatomical asymmetries are established has been achieved through the study of the zebrafish epithalamus. ...We provide evidence suggesting that antagonism between Nodal and Pitx2c activities sets an upper limit on parapineal cell numbers. We conclude that restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry."
	* '''A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei'''~~<ref><pubmed>~~20495559~~</pubmed></ref>~~ "Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior."
			* '''A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei'''{{#pmid:20495559\|PMID20495559}} "Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior."
	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
	! More recent papers		! More recent papers
	\|-		\|-
	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Epithalamus+Embryology ''Epithalamus Embryology'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Epithalamus+Development ''Epithalamus Development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Epithalamus+Embryology ''Epithalamus Embryology'']

	~~<pubmed limit=5>Epithalamus Embryology</pubmed>~~

	~~Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Epithalamus+Development ''Epithalamus Development'']~~

	~~<pubmed limit=5>Epithalamus Development</pubmed>~~
	\|}		\|}
			{\| class="wikitable mw-collapsible mw-collapsed"
			! Older papers
			\|-
			\| {{Older papers}}
			\|}

	{{Neural Table}}		{{Neural Table}}
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	<references/>		<references/>

			===Revoews===

			===Articles===

	===Textbooks===		===Textbooks===

Z8600021 at 21:21, 25 Mayıs 2015

2015-05-25T21:21:00Z

← Older revision		Revision as of 08:21, 26 Mayıs 2015
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	The uppermost portion of the diencephalon that includes the trigonum habenulae (habenula), the [[Endocrine - Pineal Development\|pineal]] (gland or body), the posterior commissure, and the medullary layers of thalamus.		The uppermost portion of the diencephalon that includes the trigonum habenulae (habenula), the [[Endocrine - Pineal Development\|pineal]] (gland or body), the posterior commissure, and the medullary layers of thalamus.

			The adult habenular nuclei acts as a neural relay system, connecting the forebrain with the brain stem. The function appears to be to regulate cognitive behaviors by modulating a range of transmitter system (cholinergic, dopaminergic and serotonergic) activities.

	{\|		{\|
	\| [[File:pineal-body.jpg\|400px\|link=Endocrine_-_Pineal_Development]]		\| [[File:pineal-body.jpg\|400px\|link=Endocrine_-_Pineal_Development]]

Z8600021 at 21:16, 25 Mayıs 2015

2015-05-25T21:16:44Z

← Older revision		Revision as of 08:16, 26 Mayıs 2015
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	<pubmed limit=5>Epithalamus Embryology</pubmed>		<pubmed limit=5>Epithalamus Embryology</pubmed>

			Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Epithalamus+Development ''Epithalamus Development'']

			<pubmed limit=5>Epithalamus Development</pubmed>
	\|}		\|}

Z8600021 at 21:15, 25 Mayıs 2015

2015-05-25T21:15:56Z

← Older revision		Revision as of 08:15, 26 Mayıs 2015
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	* '''A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei'''<ref><pubmed>20495559</pubmed></ref> "Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior."		* '''A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei'''<ref><pubmed>20495559</pubmed></ref> "Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior."
	\|}		\|}
	{\| class="wikitable collapsible collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
	! More recent papers		! More recent papers
	\|-		\|-

Z8600021 at 21:14, 25 Mayıs 2015

2015-05-25T21:14:37Z

← Older revision		Revision as of 08:14, 26 Mayıs 2015
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	==Introduction==		==Introduction==

	The uppermost portion of the diencephalon that includes the trigonum habenulae, the pineal body, the posterior commissure, and the medullary layers of thalamus.		The uppermost portion of the diencephalon that includes the trigonum habenulae (habenula), the [[Endocrine - Pineal Development\|pineal]] (gland or body), the posterior commissure, and the medullary layers of thalamus.
	{\|		{\|
	\| [[File:pineal-body.jpg\|400px\|link=Endocrine_-_Pineal_Development]]		\| [[File:pineal-body.jpg\|400px\|link=Endocrine_-_Pineal_Development]]

Z8600021 at 23:32, 15 Mayıs 2014

2014-05-15T23:32:59Z

← Older revision		Revision as of 10:32, 16 Mayıs 2014
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	The uppermost portion of the diencephalon that includes the trigonum habenulae, the pineal body, the posterior commissure, and the medullary layers of thalamus.		The uppermost portion of the diencephalon that includes the trigonum habenulae, the pineal body, the posterior commissure, and the medullary layers of thalamus.
	{\|		{\|
	\| [[File:pineal-body.jpg\|400px]]		\| [[File:pineal-body.jpg\|400px\|link=Endocrine_-_Pineal_Development]]
	\| [[File:Pineal gland position.jpg\|400px]]		\| [[File:Pineal gland position.jpg\|400px\|link=Endocrine_-_Pineal_Development]]
	\|-		\|-
	\| '''Adult pineal body''' (mid-sagittal section view)		\| '''Adult pineal body''' (mid-sagittal section view)
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	* Pitx2c ensures habenular asymmetry by restricting parapineal cell number<ref><pubmed>24598158</pubmed></ref> "Left-right (L/R) asymmetries in the brain are thought to underlie lateralised cognitive functions. Understanding how neuroanatomical asymmetries are established has been achieved through the study of the zebrafish epithalamus. "		* Pitx2c ensures habenular asymmetry by restricting parapineal cell number<ref><pubmed>24598158</pubmed></ref> "Left-right (L/R) asymmetries in the brain are thought to underlie lateralised cognitive functions. Understanding how neuroanatomical asymmetries are established has been achieved through the study of the zebrafish epithalamus. ...We provide evidence suggesting that antagonism between Nodal and Pitx2c activities sets an upper limit on parapineal cell numbers. We conclude that restricting parapineal cell number is crucial for the correct elaboration of epithalamic asymmetry."
	* '''A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei'''<ref><pubmed>20495559</pubmed></ref> "Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior."		* '''A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei'''<ref><pubmed>20495559</pubmed></ref> "Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior."
	\|}		\|}

Z8600021 at 23:31, 15 Mayıs 2014

2014-05-15T23:31:38Z

← Older revision		Revision as of 10:31, 16 Mayıs 2014
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	* Pitx2c ensures habenular asymmetry by restricting parapineal cell number<ref><pubmed>24598158</pubmed></ref>		* Pitx2c ensures habenular asymmetry by restricting parapineal cell number<ref><pubmed>24598158</pubmed></ref> "Left-right (L/R) asymmetries in the brain are thought to underlie lateralised cognitive functions. Understanding how neuroanatomical asymmetries are established has been achieved through the study of the zebrafish epithalamus. "
	* '''A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei'''<ref><pubmed>20495559</pubmed></ref> "Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior."		* '''A neuronal migratory pathway crossing from diencephalon to telencephalon populates amygdala nuclei'''<ref><pubmed>20495559</pubmed></ref> "Neurons usually migrate and differentiate in one particular encephalic vesicle. We identified a murine population of diencephalic neurons that colonized the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior."
	\|}		\|}

← Older revision		Revision as of 08:21, 26 Mayıs 2015
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	The uppermost portion of the diencephalon that includes the trigonum habenulae (habenula), the [[Endocrine - Pineal Development\|pineal]] (gland or body), the posterior commissure, and the medullary layers of thalamus.		The uppermost portion of the diencephalon that includes the trigonum habenulae (habenula), the [[Endocrine - Pineal Development\|pineal]] (gland or body), the posterior commissure, and the medullary layers of thalamus.

			The adult habenular nuclei acts as a neural relay system, connecting the forebrain with the brain stem. The function appears to be to regulate cognitive behaviors by modulating a range of transmitter system (cholinergic, dopaminergic and serotonergic) activities.

	{\|		{\|
	\| [[File:pineal-body.jpg\|400px\|link=Endocrine_-_Pineal_Development]]		\| [[File:pineal-body.jpg\|400px\|link=Endocrine_-_Pineal_Development]]