Neural - Diencephalon Development - Revision history

Z8600021 at 00:18, 2 March 2020

2020-03-02T00:18:20Z

← Older revision		Revision as of 10:18, 2 March 2020
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	{{Neural Links 2}}		{{Neural Links 2}}

	[[Historic Embryology Papers\|Historic ~~Neural~~ Embryology]]: [[Paper - Observations concerning the comparative anatomy of the diencephalon (1912)\|1912 Diencephalon]]		[[Historic Embryology Papers\|Historic Embryology]]: [[Paper - Observations concerning the comparative anatomy of the diencephalon (1912)\|1912 Diencephalon]]
	{{Historic Neural}}		{{Historic Neural}}
	==Some Recent Findings==		==Some Recent Findings==

Z8600021 at 00:17, 2 March 2020

2020-03-02T00:17:18Z

← Older revision		Revision as of 10:17, 2 March 2020
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	{{Neural Links 2}}		{{Neural Links 2}}

	[[Paper - Observations concerning the comparative anatomy of the diencephalon (1912)\|1912 Diencephalon]]		[[Historic Embryology Papers\|Historic Neural Embryology]]: [[Paper - Observations concerning the comparative anatomy of the diencephalon (1912)\|1912 Diencephalon]]
			{{Historic Neural}}
	==Some Recent Findings==		==Some Recent Findings==
	[[File:Mouse diencephalon territories 01.jpg\|thumb\|alt=Mouse diencephalon territories\|Mouse {{ME10.5}} diencephalon territories{{#pmid:22654731\|PMID22654731}}]]		[[File:Mouse diencephalon territories 01.jpg\|thumb\|alt=Mouse diencephalon territories\|Mouse {{ME10.5}} diencephalon territories{{#pmid:22654731\|PMID22654731}}]]

Z8600021 at 00:13, 2 March 2020

2020-03-02T00:13:21Z

← Older revision		Revision as of 10:13, 2 March 2020
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	{{Neural Links 2}}		{{Neural Links 2}}

			[[Paper - Observations concerning the comparative anatomy of the diencephalon (1912)\|1912 Diencephalon]]
	==Some Recent Findings==		==Some Recent Findings==
	[[File:Mouse diencephalon territories 01.jpg\|thumb\|alt=Mouse diencephalon territories\|Mouse {{ME10.5}} diencephalon territories{{#pmid:22654731\|PMID22654731}}]]		[[File:Mouse diencephalon territories 01.jpg\|thumb\|alt=Mouse diencephalon territories\|Mouse {{ME10.5}} diencephalon territories{{#pmid:22654731\|PMID22654731}}]]

Z8600021 at 04:12, 23 November 2019

2019-11-23T04:12:16Z

← Older revision		Revision as of 14:12, 23 November 2019
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	{{Neural Links 2}}		{{Neural Links 2}}
	==Some Recent Findings==		==Some Recent Findings==
			[[File:Mouse diencephalon territories 01.jpg\|thumb\|alt=Mouse diencephalon territories\|Mouse {{ME10.5}} diencephalon territories{{#pmid:22654731\|PMID22654731}}]]
	{\|		{\|
	\|-bgcolor="F5FAFF"		\|-bgcolor="F5FAFF"

Z8600021 at 04:07, 23 November 2019

2019-11-23T04:07:20Z

← Older revision		Revision as of 14:07, 23 November 2019
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	===Articles===		===Articles===
			{{#pmid:22654731}}

			{{#pmid:20495559}}

	{{#pmid:16111550}}		{{#pmid:16111550}}

Z8600021 at 04:03, 23 November 2019

2019-11-23T04:03:48Z

← Older revision		Revision as of 14:03, 23 November 2019
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	\|-bgcolor="F5FAFF"		\|-bgcolor="F5FAFF"
	\|		\|
	* '''~~Autotaxin controls caudal diencephalon-mesencephalon development in~~ the ~~{{chick}}~~'''{{#pmid:~~20737506~~\|~~PMID20737506~~}} "The diencephalon is the ~~embryonic anlagen of~~ the ~~higher integration centers of the brain~~. ~~Recent studies have elucidated how the cells~~ in the ~~rostral~~ diencephalon ~~acquire their regional identities. However~~, the ~~understanding of the mechanisms under which the caudal diencephalon is formed is still limited. Here we focus on~~ the ~~role of Autotaxin~~ (~~ATX~~), a ~~lysophospholipid-generating exoenzyme, whose mRNA is detected~~ in the ~~caudal diencephalon~~. ~~RNA interference against ATX altered~~ the expression ~~pattern~~ of ~~Pax6-regualted genes~~, ~~Tcf4, Lim1, and En1, implying~~ that ~~ATX~~ is ~~required for~~ the ~~maintenance~~ of ~~the regional~~ identity of the ~~caudal~~ diencephalon and the ~~diencephalon-mesencephalon boundary (DMB)~~. ~~Furthermore~~, ~~ATX-RNAi inhibited neuroepithelial cell proliferation on both sides~~ of the ~~DMB. We propose a dual role~~ of ~~ATX in chick brain development~~, ~~in which ATX not only contributes to~~ the ~~formation~~ of ~~caudal diencephalon as~~ a ~~short-range signal~~, ~~but also regulates~~ the ~~growth~~ of ~~mesencephalon as a long-range signal~~."
			* '''Barhl2 Determines the Early Patterning of the Diencephalon by Regulating Shh'''{{#pmid:27349434\|PMID27349434}} "The diencephalon is the primary relay network transmitting sensory information to the anterior forebrain. During development, distinct progenitor domains in the diencephalon give rise to the pretectum (p1), the thalamus and epithalamus (p2), and the prethalamus (p3), respectively. Shh plays a significant role in establishing the progenitor domains. However, the upstream events influencing the expression of Shh are largely unknown. Here, we show that Barhl2 homeobox gene is expressed in the p1 and p2 progenitor domains and the in zona limitans intrathalamica (ZLI) and regulates the acquisition of identity of progenitor cells in the developing diencephalon. Targeted deletion of Barhl2 results in the ablation of Shh expression in the dorsal portion of ZLI and causes thalamic p2 progenitors to take the fate of p1 progenitors and form pretectal neurons. Moreover, loss of Barhl2 leads to the absence of thalamocortical axon projections, the loss of habenular afferents and efferents, and a gross diminution of the pineal gland. Thus, by acting upstream of Shh signaling pathway, Barhl2 plays a crucial role in patterning the progenitor domains and establishing the positional identities of progenitor cells in the diencephalon."


	\|}		\|}
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	\|-		\|-
	\| {{Older papers}}		\| {{Older papers}}
			* '''Autotaxin controls caudal diencephalon-mesencephalon development in the {{chick}}'''{{#pmid:20737506\|PMID20737506}} "The diencephalon is the embryonic anlagen of the higher integration centers of the brain. Recent studies have elucidated how the cells in the rostral diencephalon acquire their regional identities. However, the understanding of the mechanisms under which the caudal diencephalon is formed is still limited. Here we focus on the role of Autotaxin (ATX), a lysophospholipid-generating exoenzyme, whose mRNA is detected in the caudal diencephalon. RNA interference against ATX altered the expression pattern of Pax6-regualted genes, Tcf4, Lim1, and En1, implying that ATX is required for the maintenance of the regional identity of the caudal diencephalon and the diencephalon-mesencephalon boundary (DMB). Furthermore, ATX-RNAi inhibited neuroepithelial cell proliferation on both sides of the DMB. We propose a dual role of ATX in chick brain development, in which ATX not only contributes to the formation of caudal diencephalon as a short-range signal, but also regulates the growth of mesencephalon as a long-range signal."

	\|}		\|}
	== Development Overview ==		== Development Overview ==
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	===Articles===		===Articles===
			{{#pmid:16111550}}

	===Search PubMed===		===Search PubMed===

Z8600021 at 04:00, 23 November 2019

2019-11-23T04:00:36Z

← Older revision		Revision as of 14:00, 23 November 2019
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	\|}		\|}
	{\| class="wikitable collapsible collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
	! More recent papers		! More recent papers
	\|-		\|-
	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Diencephalon+Embryology ''Diencephalon Embryology'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Diencephalon+Development ''Diencephalon Development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Diencephalon+Embryology ''Diencephalon Embryology'']

			\|}
			{\| class="wikitable mw-collapsible mw-collapsed"
			! Older papers
			\|-
			\| {{Older papers}}
	\|}		\|}
	== Development Overview ==		== Development Overview ==

Z8600021 at 03:59, 23 November 2019

2019-11-23T03:59:12Z

← Older revision		Revision as of 13:59, 23 November 2019
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	\|-bgcolor="F5FAFF"		\|-bgcolor="F5FAFF"
	\|		\|
	* '''Autotaxin controls caudal diencephalon-mesencephalon development in the chick'''~~<ref><pubmed>~~20737506~~</pubmed></ref>~~ "The diencephalon is the embryonic anlagen of the higher integration centers of the brain. Recent studies have elucidated how the cells in the rostral diencephalon acquire their regional identities. However, the understanding of the mechanisms under which the caudal diencephalon is formed is still limited. Here we focus on the role of Autotaxin (ATX), a lysophospholipid-generating exoenzyme, whose mRNA is detected in the caudal diencephalon. RNA interference against ATX altered the expression pattern of Pax6-regualted genes, Tcf4, Lim1, and En1, implying that ATX is required for the maintenance of the regional identity of the caudal diencephalon and the diencephalon-mesencephalon boundary (DMB). Furthermore, ATX-RNAi inhibited neuroepithelial cell proliferation on both sides of the DMB. We propose a dual role of ATX in chick brain development, in which ATX not only contributes to the formation of caudal diencephalon as a short-range signal, but also regulates the growth of mesencephalon as a long-range signal."		* '''Autotaxin controls caudal diencephalon-mesencephalon development in the {{chick}}'''{{#pmid:20737506\|PMID20737506}} "The diencephalon is the embryonic anlagen of the higher integration centers of the brain. Recent studies have elucidated how the cells in the rostral diencephalon acquire their regional identities. However, the understanding of the mechanisms under which the caudal diencephalon is formed is still limited. Here we focus on the role of Autotaxin (ATX), a lysophospholipid-generating exoenzyme, whose mRNA is detected in the caudal diencephalon. RNA interference against ATX altered the expression pattern of Pax6-regualted genes, Tcf4, Lim1, and En1, implying that ATX is required for the maintenance of the regional identity of the caudal diencephalon and the diencephalon-mesencephalon boundary (DMB). Furthermore, ATX-RNAi inhibited neuroepithelial cell proliferation on both sides of the DMB. We propose a dual role of ATX in chick brain development, in which ATX not only contributes to the formation of caudal diencephalon as a short-range signal, but also regulates the growth of mesencephalon as a long-range signal."

	\|}		\|}
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	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Diencephalon+Embryology ''Diencephalon Embryology'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Diencephalon+Embryology ''Diencephalon Embryology'']

	~~<pubmed limit=5>Diencephalon Embryology</pubmed>~~
	\|}		\|}
	== Development Overview ==		== Development Overview ==
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	==Early Brain Vesicles==		==Early Brain Vesicles==

	===Primary Vesicles===		===Primary Vesicles===
	[[Image:CNS primary vesicles.jpg\|600px]]		[[Image:CNS primary vesicles.jpg\|600px]]
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	<references/>		<references/>
	===Reviews===		===Reviews===
	~~<pubmed>~~19206138~~</pubmed>~~		{{#pmid:19206138}}

Z8600021 at 03:58, 23 November 2019

2019-11-23T03:58:57Z

← Older revision		Revision as of 13:58, 23 November 2019
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	\|-bgcolor="F5FAFF"		\|-bgcolor="F5FAFF"
	\|		\|
	* '''Autotaxin controls caudal diencephalon-mesencephalon development in the {{chick}}'''~~{{#pmid:~~20737506~~\|PMID20737506}}~~ "The diencephalon is the embryonic anlagen of the higher integration centers of the brain. Recent studies have elucidated how the cells in the rostral diencephalon acquire their regional identities. However, the understanding of the mechanisms under which the caudal diencephalon is formed is still limited. Here we focus on the role of Autotaxin (ATX), a lysophospholipid-generating exoenzyme, whose mRNA is detected in the caudal diencephalon. RNA interference against ATX altered the expression pattern of Pax6-regualted genes, Tcf4, Lim1, and En1, implying that ATX is required for the maintenance of the regional identity of the caudal diencephalon and the diencephalon-mesencephalon boundary (DMB). Furthermore, ATX-RNAi inhibited neuroepithelial cell proliferation on both sides of the DMB. We propose a dual role of ATX in chick brain development, in which ATX not only contributes to the formation of caudal diencephalon as a short-range signal, but also regulates the growth of mesencephalon as a long-range signal."		* '''Autotaxin controls caudal diencephalon-mesencephalon development in the chick'''<ref><pubmed>20737506</pubmed></ref> "The diencephalon is the embryonic anlagen of the higher integration centers of the brain. Recent studies have elucidated how the cells in the rostral diencephalon acquire their regional identities. However, the understanding of the mechanisms under which the caudal diencephalon is formed is still limited. Here we focus on the role of Autotaxin (ATX), a lysophospholipid-generating exoenzyme, whose mRNA is detected in the caudal diencephalon. RNA interference against ATX altered the expression pattern of Pax6-regualted genes, Tcf4, Lim1, and En1, implying that ATX is required for the maintenance of the regional identity of the caudal diencephalon and the diencephalon-mesencephalon boundary (DMB). Furthermore, ATX-RNAi inhibited neuroepithelial cell proliferation on both sides of the DMB. We propose a dual role of ATX in chick brain development, in which ATX not only contributes to the formation of caudal diencephalon as a short-range signal, but also regulates the growth of mesencephalon as a long-range signal."

	\|}		\|}
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	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Diencephalon+Embryology ''Diencephalon Embryology'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Diencephalon+Embryology ''Diencephalon Embryology'']

			<pubmed limit=5>Diencephalon Embryology</pubmed>
	\|}		\|}
	== Development Overview ==		== Development Overview ==
Line 43:		Line 44:

	==Early Brain Vesicles==		==Early Brain Vesicles==

	===Primary Vesicles===		===Primary Vesicles===
	[[Image:CNS primary vesicles.jpg\|600px]]		[[Image:CNS primary vesicles.jpg\|600px]]
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	<references/>		<references/>
	===Reviews===		===Reviews===
	~~{{#pmid:~~19206138}}		<pubmed>19206138</pubmed>

Z8600021 at 03:58, 23 November 2019

2019-11-23T03:58:53Z

← Older revision		Revision as of 13:58, 23 November 2019
Line 23:		Line 23:
	\|-bgcolor="F5FAFF"		\|-bgcolor="F5FAFF"
	\|		\|
	* '''Autotaxin controls caudal diencephalon-mesencephalon development in the chick'''~~<ref><pubmed>~~20737506~~</pubmed></ref>~~ "The diencephalon is the embryonic anlagen of the higher integration centers of the brain. Recent studies have elucidated how the cells in the rostral diencephalon acquire their regional identities. However, the understanding of the mechanisms under which the caudal diencephalon is formed is still limited. Here we focus on the role of Autotaxin (ATX), a lysophospholipid-generating exoenzyme, whose mRNA is detected in the caudal diencephalon. RNA interference against ATX altered the expression pattern of Pax6-regualted genes, Tcf4, Lim1, and En1, implying that ATX is required for the maintenance of the regional identity of the caudal diencephalon and the diencephalon-mesencephalon boundary (DMB). Furthermore, ATX-RNAi inhibited neuroepithelial cell proliferation on both sides of the DMB. We propose a dual role of ATX in chick brain development, in which ATX not only contributes to the formation of caudal diencephalon as a short-range signal, but also regulates the growth of mesencephalon as a long-range signal."		* '''Autotaxin controls caudal diencephalon-mesencephalon development in the {{chick}}'''{{#pmid:20737506\|PMID20737506}} "The diencephalon is the embryonic anlagen of the higher integration centers of the brain. Recent studies have elucidated how the cells in the rostral diencephalon acquire their regional identities. However, the understanding of the mechanisms under which the caudal diencephalon is formed is still limited. Here we focus on the role of Autotaxin (ATX), a lysophospholipid-generating exoenzyme, whose mRNA is detected in the caudal diencephalon. RNA interference against ATX altered the expression pattern of Pax6-regualted genes, Tcf4, Lim1, and En1, implying that ATX is required for the maintenance of the regional identity of the caudal diencephalon and the diencephalon-mesencephalon boundary (DMB). Furthermore, ATX-RNAi inhibited neuroepithelial cell proliferation on both sides of the DMB. We propose a dual role of ATX in chick brain development, in which ATX not only contributes to the formation of caudal diencephalon as a short-range signal, but also regulates the growth of mesencephalon as a long-range signal."

	\|}		\|}
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	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Diencephalon+Embryology ''Diencephalon Embryology'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Diencephalon+Embryology ''Diencephalon Embryology'']

	~~<pubmed limit=5>Diencephalon Embryology</pubmed>~~
	\|}		\|}
	== Development Overview ==		== Development Overview ==
Line 44:		Line 43:

	==Early Brain Vesicles==		==Early Brain Vesicles==

	===Primary Vesicles===		===Primary Vesicles===
	[[Image:CNS primary vesicles.jpg\|600px]]		[[Image:CNS primary vesicles.jpg\|600px]]
Line 52:		Line 52:
	<references/>		<references/>
	===Reviews===		===Reviews===
	~~<pubmed>~~19206138~~</pubmed>~~		{{#pmid:19206138}}