Mouse Timeline Detailed - Revision history

Z8600021 at 03:16, 12 Mayıs 2018

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	'''Stage11d '''Neural Plate, Presomite stage. Head folds continue to enlarge and the foregut pocket begins to form. Embryonic age = 7.5 dpc (range 7.25-8 dpc) ; LB-EHF-LHF (late allantoic bud to early head fold to late head fold) . Equivalent Downs & Davies stages: OB-EB (no allantoic bud to early allantoic bud)		'''Stage11d '''Neural Plate, Presomite stage. Head folds continue to enlarge and the foregut pocket begins to form. Embryonic age = 7.5 dpc (range 7.25-8 dpc) ; LB-EHF-LHF (late allantoic bud to early head fold to late head fold) . Equivalent Downs & Davies stages: OB-EB (no allantoic bud to early allantoic bud)

	* '''~~Heart~~''' - migration of anterior lateral plate mesoderm towards midline, forms a linear heart tube.~~<ref name=~~PMID16304598~~><pubmed>16304598</pubmed></ref>~~		* '''{{heart}}''' - migration of anterior lateral plate mesoderm towards midline, forms a linear heart tube.{{#pmid:16304598\|PMID16304598}}
	== Week 2 ==		== Week 2 ==

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	'''Heart''' - E12.5 (TS21) Progressive septation of the outflow tract and initiation of atrioventricular canal septation.~~<ref name=PMID19359541><pubmed>~~19359541~~</pubmed>~~\| ~~[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773446 PMC2773446] \| [http://tpx.sagepub.com/content/37/4/395.long Toxicol Pathol.]</ref>~~		'''Heart''' - E12.5 (TS21) Progressive septation of the outflow tract and initiation of atrioventricular canal septation.{{#pmid:19359541\|PMID19359541}}

	[[File:Mouse E12.5 gene expression.jpg\|600px]]		[[File:Mouse E12.5 gene expression.jpg\|600px]]

Z8600021 at 03:04, 12 Mayıs 2018

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	== Introduction ==		== Introduction ==
	[[File:Mouse.jpg\|left]]		[[File:Mouse.jpg\|left]]
	This page is organised to show a detailed day by day development of sytems and features with approximate timing of key events. The staging by "days" relate to in the female presence of a vaginal plug indicating that the mating occurred, see [[Mouse_Timeline_Detailed#Timed_Pregnancy\|timed pregnancy]].		This {{mouse}} page is organised to show a detailed day by day development of sytems and features with approximate timing of key events. The staging by "days" relate to in the female presence of a vaginal plug indicating that the mating occurred, see [[Mouse_Timeline_Detailed#Timed_Pregnancy\|timed pregnancy]].

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	{{Mouse}}		{{Mouse links}}

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	'''Theiler Stages''' divides mouse development into 26 prenatal and 2 postnatal stages. <ref name="The House Mouse">{{Ref-Theiler1972}}</ref>		'''Theiler Stages''' divides mouse development into 26 prenatal and 2 postnatal stages.<ref name="The House Mouse">{{Ref-Theiler1972}}</ref>

	'''Downs and Davies Stages''' is a more recent (1993) staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope.{{#pmid:8269852\|PMID8269852}}		'''Downs and Davies Stages''' is a more recent (1993) staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope.{{#pmid:8269852\|PMID8269852}}

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	=== Table Data ===		=== Table Data ===
	The main table data is modified from several different sources<ref name="The House Mouse">'''Edinburgh Mouse Atlas''' [http://genex.hgu.mrc.ac.uk/Documentation/Emage/Course/emage/Appendix4.html Appendix 4 Theiler Staging] \| [http://genex.hgu.mrc.ac.uk/Databases/Anatomy/MAstaging.shtml Staging Criteria] \| [http://genex.hgu.mrc.ac.uk/Databases/Anatomy/new/ Standard Anatomical Nomenclature]</ref> ~~<ref name="~~PMID8269852~~"><pubmed>8269852</pubmed></ref>~~ and includes additional sources as listed within the table.		The main table data is modified from several different sources<ref name="The House Mouse">{{Ref-Theiler1972}}</ref>
			{{#pmid:8269852\|PMID8269852}} and includes additional sources as listed within the table.

	==Postnatal==		==Postnatal==

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	'''Theiler Stages''' divides mouse development into 26 prenatal and 2 postnatal stages. <ref name="The House Mouse">~~The House Mouse: Atlas of Mouse Development''' by Theiler Springer~~-~~Verlag, NY (1972, 1989). \| [http://genex.hgu.mrc.ac.uk/Atlas/Theiler_book_download.html online book]~~</ref>		'''Theiler Stages''' divides mouse development into 26 prenatal and 2 postnatal stages. <ref name="The House Mouse">{{Ref-Theiler1972}}</ref>

	'''Downs and Davies Stages''' is a more recent (1993) staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope.{{#pmid:8269852\|PMID8269852}}		'''Downs and Davies Stages''' is a more recent (1993) staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope.{{#pmid:8269852\|PMID8269852}}

Z8600021 at 00:49, 17 April 2018

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Z8600021 at 00:32, 18 February 2017

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	'''Downs and Davies Stages''' is a more recent (1993) staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope.<ref name="PMID8269852"><pubmed>8269852</pubmed> \| [http://www.biologists.com/Development/118/04/dev4072.html Development]</ref>		'''Downs and Davies Stages''' is a more recent (1993) staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope.<ref name="PMID8269852"><pubmed>8269852</pubmed> \| [http://www.biologists.com/Development/118/04/dev4072.html Development]</ref>


			There have been early online atlas<ref name=PMID9007211><pubmed>9007211</pubmed></ref> and several new staging papers and online atlases released.<ref name=PMID26487781><pubmed>26487781</pubmed></ref><ref name=PMID28185240><pubmed>28185240</pubmed></ref>

← Older revision		Revision as of 11:49, 17 April 2018
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	'''Theiler Stages''' divides mouse development into 26 prenatal and 2 postnatal stages. <ref name="The House Mouse">The House Mouse: Atlas of Mouse Development''' by Theiler Springer-Verlag, NY (1972, 1989). \| [http://genex.hgu.mrc.ac.uk/Atlas/Theiler_book_download.html online book]</ref>		'''Theiler Stages''' divides mouse development into 26 prenatal and 2 postnatal stages. <ref name="The House Mouse">The House Mouse: Atlas of Mouse Development''' by Theiler Springer-Verlag, NY (1972, 1989). \| [http://genex.hgu.mrc.ac.uk/Atlas/Theiler_book_download.html online book]</ref>

	'''Downs and Davies Stages''' is a more recent (1993) staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope.~~<ref name="PMID8269852"><pubmed>~~8269852~~</pubmed>~~ \| ~~[http://www.biologists.com/Development/118/04/dev4072.html Development]</ref>~~		'''Downs and Davies Stages''' is a more recent (1993) staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope.{{#pmid:8269852\|PMID8269852}}


	There have been early online atlas~~<ref name=~~PMID9007211~~><pubmed>9007211</pubmed></ref>~~ and several new staging papers and online atlases released.~~<ref name=~~PMID26487781~~><pubmed>26487781</pubmed></ref><ref name=~~PMID28185240~~><pubmed>28185240</pubmed></ref>~~		There have been early online atlas{{#pmid:9007211\|PMID9007211}} and several new staging papers and online atlases released.{{#pmid:26487781\|PMID26487781}}{{#pmid:28185240\|PMID28185240}}


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	* '''Limb''' - An increasingly prominent ridge on the lateral body wall, approximately at the level of the 8th-12th somite, indicates the site of the future forelimb bud. Absent: forelimb bud. Embryonic age = 9 dpc (range 8.5-9.75 dpc) 13-20 somite pairs		* '''Limb''' - An increasingly prominent ridge on the lateral body wall, approximately at the level of the 8th-12th somite, indicates the site of the future forelimb bud. Absent: forelimb bud. Embryonic age = 9 dpc (range 8.5-9.75 dpc) 13-20 somite pairs

	* '''Heart''' - Heart tube undergoes looping at E8.5. The second heart field (pharyngeal mesoderm cells) contributes to parts of the right ventricle, the interventricular septum, the venous pole, and the base of the outflow tract.~~<ref name=~~PMID16304598~~><pubmed>16304598</pubmed></ref>~~		* '''Heart''' - Heart tube undergoes looping at E8.5. The second heart field (pharyngeal mesoderm cells) contributes to parts of the right ventricle, the interventricular septum, the venous pole, and the base of the outflow tract.{{#pmid:16304598\|PMID16304598}}

	===Day 9 (E9.0)===		===Day 9 (E9.0)===
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	Theiler Stage 15 - Closure of posterior neuropore. Hind limb bud and tail bud. The hind limb bud becomes visible at the level of the 23rd-28th somites. The tail bud appears as a short stump and the 3rd and 4th branchial arches are distinctly concave. Rathke's pouch and the nasal processes start to form. At the end of this stage the posterior neuropore begins to close. Absent: thin and long tail. Embryonic age = 10 dpc (range 9.5-10.75 dpc) 30-34 somite pairs.		Theiler Stage 15 - Closure of posterior neuropore. Hind limb bud and tail bud. The hind limb bud becomes visible at the level of the 23rd-28th somites. The tail bud appears as a short stump and the 3rd and 4th branchial arches are distinctly concave. Rathke's pouch and the nasal processes start to form. At the end of this stage the posterior neuropore begins to close. Absent: thin and long tail. Embryonic age = 10 dpc (range 9.5-10.75 dpc) 30-34 somite pairs.

	[[Integumentary System Development]] [[Neural Crest Development]] - Melanoblasts precursors derived from the neural crest at around E9.5.~~<ref name="PMID20067551"><pubmed>~~20067551~~</pubmed>~~\| ~~[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2859249 PMC2859249]</ref>~~		[[Integumentary System Development]] [[Neural Crest Development]] - Melanoblasts precursors derived from the neural crest at around E9.5.{{#pmid:20067551\|PMID20067551}}


	{\|		{\|
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	[[File:Mouse E9.5 gene expression.jpg\|600px]]		[[File:Mouse E9.5 gene expression.jpg\|600px]]

	Mouse Stage E9.5 Specific Gene Expression~~<ref name=PMID22174793><pubmed>~~22174793~~</pubmed>~~\| ~~[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235105 PMC3235105] \| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028358 PLoS One.]</ref>~~		Mouse Stage E9.5 Specific Gene Expression{{#pmid:22174793\|PMID22174793}}

	===Day 10 (E10.0)===		===Day 10 (E10.0)===
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	'''Theiler Stage 17''' - Deep Lens Indentation The most obvious distinguishing features are the deepening of the lens pit, with a narrowing of its outer pore-like opening, and the first appearance of the physiological umbilical hernia. The 1st branchial arch is conspicuously divided into maxillary and mandibular components. There is advanced development of the brain tube and the tail elongates and thins. Absent: nasal pits. Embryonic age = 10.5 dpc (range 10-11.25 dpc) 35-39 somite pairs		'''Theiler Stage 17''' - Deep Lens Indentation The most obvious distinguishing features are the deepening of the lens pit, with a narrowing of its outer pore-like opening, and the first appearance of the physiological umbilical hernia. The 1st branchial arch is conspicuously divided into maxillary and mandibular components. There is advanced development of the brain tube and the tail elongates and thins. Absent: nasal pits. Embryonic age = 10.5 dpc (range 10-11.25 dpc) 35-39 somite pairs

	[[Integumentary System Development]] ~~[[Neural Crest Development]]~~ - Neural crest melanoblasts upregulate early specific markers (Mitf, Tyrosinase, Dct, Kit) E10.5.~~<ref name="~~PMID20067551~~" /~~>		[[Integumentary System Development]] {{neural crest}} - Neural crest melanoblasts upregulate early specific markers (Mitf, Tyrosinase, Dct, Kit) E10.5.{{#pmid:20067551\|PMID20067551}}>

	~~[[Sensory_-_Hearing_and_Balance_Development\|Hearing and Balance]]~~ - Formation of vestibular (otic) ganglion cells (E10-12) Afferent processes of vestibular ganglion cells invade the macula utricle and saccule and cristae of the semicircular canals (10.5)~~<ref name="~~PMID18298265~~"><pubmed>18298265</pubmed></ref>~~		{{hearing}} - Formation of vestibular (otic) ganglion cells (E10-12) Afferent processes of vestibular ganglion cells invade the macula utricle and saccule and cristae of the semicircular canals (10.5){{#pmid:18298265\|PMID18298265}}

	{\|		{\|
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	\|-		\|-
	\| [[File:Mouse-Gastrointestinal-tract-E10.5-01.jpg\|300px]]		\| [[File:Mouse-Gastrointestinal-tract-E10.5-01.jpg\|300px]]
	\| [[Gastrointestinal Tract Development]] - differential gene expression of some selected markers during development (E10.5 and E13.5) of the mouse gastrointestinal tract.~~<ref><pubmed>~~19300477~~</pubmed>~~\| ~~[http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000427 PLoS Genet.]</ref>~~		\| [[Gastrointestinal Tract Development]] - differential gene expression of some selected markers during development (E10.5 and E13.5) of the mouse gastrointestinal tract.{{#pmid:19300477\|PMID19300477}}
	\|-		\|-
	\| [[File:Primordial germ cell 003 icon.jpg\|150px\|link=Movie_-_Primordial germ cell migration 03]]		\| [[File:Primordial germ cell 003 icon.jpg\|150px\|link=Movie_-_Primordial germ cell migration 03]]
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	[[File:Mouse-_embryo_E10.5.jpg]] [[File:Mouse_CT_E10.5.jpg\|200px]]		[[File:Mouse-_embryo_E10.5.jpg]] [[File:Mouse_CT_E10.5.jpg\|200px]]

	[[Renal System Development]] - metanephric mesenchyme present, an area of intermediate mesoderm caudal to the mesonephros and adjacent to a widening of the ‘nephric duct, metanephric portion’ that gives rise to the metanephros.~~<ref name="PMID17452023"><pubmed>~~17452023~~</pubmed>~~\| ~~[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2117077 PMC2117077]</ref>~~		[[Renal System Development]] - metanephric mesenchyme present, an area of intermediate mesoderm caudal to the mesonephros and adjacent to a widening of the ‘nephric duct, metanephric portion’ that gives rise to the metanephros.{{#pmid:17452023\|PMID17452023}}

	[[File:Mouse embryo E10.5.jpg]]		[[File:Mouse embryo E10.5.jpg]]
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	</gallery>		</gallery>

	Pecam 1 and Smooth muscle actin (SMA) staining~~<ref name=PMID22615991><pubmed>~~22615991~~</pubmed>~~\| ~~[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355134 PMC3355134] \| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0037365 PLoS ONE]</ref>~~		Pecam 1 and Smooth muscle actin (SMA) staining{{#pmid:22615991\|PMID22615991}}


	[[File:Mouse E10.5 gene expression.jpg\|600px]]		[[File:Mouse E10.5 gene expression.jpg\|600px]]

	Mouse Stage E10.5 Specific Gene Expression~~<ref name=PMID22174793><pubmed>~~22174793~~</pubmed>~~\| ~~[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235105 PMC3235105] \| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028358 PLoS One.]</ref>~~		Mouse Stage E10.5 Specific Gene Expression{{#pmid:22174793\|PMID22174793}}

	===Day 11 (E11.0)===		===Day 11 (E11.0)===
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	'''Theiler Stage 19'''		'''Theiler Stage 19'''

	Closure of Lens Vesicle. The primary externally recognisable feature is the progressive closure of the lens vesicle. The somites in the cervical region are no longer visible and the rapid growth of the brain is striking. The nasal pits start to form. Absent~~: auditory hillocks,~~ anterior footplate. Embryonic age = 11 dpc (range 10.5-11.25 dpc) 40-44 somite pairs		{{vision}} - Closure of Lens Vesicle. The primary externally recognisable feature is the progressive closure of the lens vesicle. The somites in the cervical region are no longer visible and the rapid growth of the brain is striking.

			{{smell}} - The nasal pits start to form. Absent anterior footplate. Embryonic age = 11 dpc (range 10.5-11.25 dpc) 40-44 somite pairs

	~~[[Palate Development]]~~ - palatal shelves protrude from bilateral maxillary processes.		{{palate}} - palatal shelves protrude from bilateral maxillary processes.

	~~[[Sensory_-_Hearing_and_Balance_Development\|Hearing and Balance]]~~ - Efferent nerve endings first approach hair cells (E11-12)<ref name="PMID18298265"/>		{{hearing}} - Auditory hillocks absent. Efferent nerve endings first approach hair cells (E11-12)<ref name="PMID18298265"/>

	[[Genital_System_Development\|Genital System]] - gonad between E11 to E12 differentiates from a bipotential to sexually-differentiated state, based upon transcriptome analysis.~~<ref name=PMID23874228><pubmed>~~23874228~~</pubmed>~~\| ~~[http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003630 PLoS Genet.]</ref>~~		[[Genital_System_Development\|Genital System]] - gonad between E11 to E12 differentiates from a bipotential to sexually-differentiated state, based upon transcriptome analysis.{{#pmid:23874228\|PMID23874228}}

	~~[[Cardiovascular_System_Development\|Cardiovascular System]]~~ - Heart outflow tract supported by the right ventricle, characteristic bend dividing the outflow tract into proximal and distal portions and the distal portion extends to the margins of the pericardial cavity~~<ref name=~~PMID12923046~~><pubmed>12923046</pubmed></ref>~~ [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1767864/figure/f3/ Fig. 3 SEM Heart 42 somites]		{{cardiovascular}} - Heart outflow tract supported by the right ventricle, characteristic bend dividing the outflow tract into proximal and distal portions and the distal portion extends to the margins of the pericardial cavity{{#pmid:12923046\|PMID12923046}} [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1767864/figure/f3/ Fig. 3 SEM Heart 42 somites]