Monkey Development - Revision history

Z8600021 at 19:44, 1 Ocak 2020

2020-01-01T19:44:09Z

← Older revision		Revision as of 06:44, 2 Ocak 2020
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			* '''In vitro culture of cynomolgus monkey embryos beyond early {{gastrulation}}'''{{#pmid:31672918\|PMID31672918}} "Gastrulation is a key event in embryonic development when the germ layers are specified and the basic animal body plan is established. The complexities of primate {{gastrulation}} remain a mystery because of the difficulties in accessing primate embryos at this stage. Here, we report the establishment of an in vitro culture (IVC) system that supports the continuous development of cynomolgus monkey blastocysts beyond early gastrulation up to 20 days after fertilization. The IVC embryos highly recapitulated the key events of in vivo early postimplantation development, including segregation of the epiblast and hypoblast, formation of the amniotic and yolk sac cavities, appearance of the primordial germ cells, and establishment of the anterior-posterior axis. Single-cell RNA-sequencing analyses of the IVC embryos provide information about lineage specification during primate early postimplantation development. This system provides a platform with which to explore the characteristics and mechanisms of early postimplantation embryogenesis in primates with possible conservation of cell movements and lineages in human embryogenesis."

	* '''Dynamic changes in ultrastructure of the primary cilium in migrating neuroblasts in the postnatal brain'''{{#pmid:31685650\|PMID31685650}} "New neurons, referred to as neuroblasts, are continuously generated in the ventricular-subventricular zone of the brain throughout an animal's life. These neuroblasts are characterized by their unique potential for proliferation, formation of chain-like cell aggregates, and long-distance and high-speed migration through the rostral migratory stream (RMS) toward the olfactory bulb (OB), where they decelerate and differentiate into mature interneurons. ... Together, our results highlight a close mutual relationship between spatiotemporal regulation of the primary cilium and efficient chain migration of neuroblasts in the postnatal brain. Immature neurons (neuroblasts) generated in the postnatal brain have a mitotic potential and migrate in chain-like cell aggregates toward the olfactory bulb. Here we report that migrating neuroblasts possess a tiny cellular protrusion called a primary cilium. Immunohistochemical studies with zebrafish, mouse, and monkey brains suggest that the presence of the primary cilium in migrating neuroblasts is evolutionarily conserved. Ciliogenesis in migrating neuroblasts in the RMS is suppressed during mitosis and promoted after cell cycle exit. Moreover, live imaging and three-dimensional electron microscopy revealed that ciliary localization and orientation change during saltatory movement of neuroblasts. Our results reveal highly organized dynamics in maturation and positioning of the primary cilium during neuroblast migration that underlie saltatory movement of postnatal-born neuroblasts." {{smell}} \| {{neural postnatal}}		* '''Dynamic changes in ultrastructure of the primary cilium in migrating neuroblasts in the postnatal brain'''{{#pmid:31685650\|PMID31685650}} "New neurons, referred to as neuroblasts, are continuously generated in the ventricular-subventricular zone of the brain throughout an animal's life. These neuroblasts are characterized by their unique potential for proliferation, formation of chain-like cell aggregates, and long-distance and high-speed migration through the rostral migratory stream (RMS) toward the olfactory bulb (OB), where they decelerate and differentiate into mature interneurons. ... Together, our results highlight a close mutual relationship between spatiotemporal regulation of the primary cilium and efficient chain migration of neuroblasts in the postnatal brain. Immature neurons (neuroblasts) generated in the postnatal brain have a mitotic potential and migrate in chain-like cell aggregates toward the olfactory bulb. Here we report that migrating neuroblasts possess a tiny cellular protrusion called a primary cilium. Immunohistochemical studies with zebrafish, mouse, and monkey brains suggest that the presence of the primary cilium in migrating neuroblasts is evolutionarily conserved. Ciliogenesis in migrating neuroblasts in the RMS is suppressed during mitosis and promoted after cell cycle exit. Moreover, live imaging and three-dimensional electron microscopy revealed that ciliary localization and orientation change during saltatory movement of neuroblasts. Our results reveal highly organized dynamics in maturation and positioning of the primary cilium during neuroblast migration that underlie saltatory movement of postnatal-born neuroblasts." {{smell}} \| {{neural postnatal}}

	* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."		* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."

	* '''Assisted Reproductive Technologies (ART) With Baboons Generate Live Offspring: A Nonhuman Primate Model for ART and Reproductive Sciences.'''{{#pmid:20631291\|PMID20631291}} "Here, baboon ART protocols, including oocyte collection, in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), preimplantation development to blastocyst stage, and embryo transfer techniques are described. With baboon ART methodologies in place, motility during baboon fertilization was investigated by time-lapse video microscopy (TLVM). The first ART baboons produced by ICSI, a pair of male twins, were delivered naturally at 165 days postgestation. Genetic testing of these twins confirmed their ART parental origins and demonstrated that they are unrelated fraternal twins not identicals."

	* '''Monkey thalidomide model'''{{#pmid:19751816\|PMID19751816}} "Cynomolgus monkeys were orally administered thalidomide at 15 or 20mg/kg-d on days 26-28 of gestation, and fetuses were examined on day 100-102 of gestation. Limb defects such as micromelia/amelia, paw/foot hyperflexion, polydactyly, syndactyly, and brachydactyly were observed in seven of eight fetuses.' (More? {{Thalidomide}})
	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
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	\| {{Older papers}}		\| {{Older papers}}
			* '''Assisted Reproductive Technologies (ART) With Baboons Generate Live Offspring: A Nonhuman Primate Model for ART and Reproductive Sciences.'''{{#pmid:20631291\|PMID20631291}} "Here, baboon ART protocols, including oocyte collection, in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), preimplantation development to blastocyst stage, and embryo transfer techniques are described. With baboon ART methodologies in place, motility during baboon fertilization was investigated by time-lapse video microscopy (TLVM). The first ART baboons produced by ICSI, a pair of male twins, were delivered naturally at 165 days postgestation. Genetic testing of these twins confirmed their ART parental origins and demonstrated that they are unrelated fraternal twins not identicals."

			* '''Monkey thalidomide model'''{{#pmid:19751816\|PMID19751816}} "Cynomolgus monkeys were orally administered thalidomide at 15 or 20mg/kg-d on days 26-28 of gestation, and fetuses were examined on day 100-102 of gestation. Limb defects such as micromelia/amelia, paw/foot hyperflexion, polydactyly, syndactyly, and brachydactyly were observed in seven of eight fetuses.' (More? {{Thalidomide}})
	\|}		\|}

Z8600021: Undo revision 392885 by Z8600021 (talk)

2019-12-12T00:15:27Z

Undo revision 392885 by Z8600021 (talk)

← Older revision		Revision as of 11:15, 12 December 2019
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	== Introduction ==		== Introduction ==
	[[File:Monkey_-_cynomolgus.jpg\|thumb\|Monkey (cynomolgus)]]		[[File:Monkey_-_cynomolgus.jpg\|thumb\|Monkey (cynomolgus)]]
	The {{monkey}} is often used as a primate model for human development. Another historic model of primate development was the smaller [[Book_-_Normal_Plates_of_the_Development_of_Vertebrates_7\|tarsius]]<ref>{{Ref-Hubrecht1907}}</ref>		The monkey is often used as a primate model for human development. Another historic model of primate development was the smaller [[Book_-_Normal_Plates_of_the_Development_of_Vertebrates_7\|tarsius]]<ref>{{Ref-Hubrecht1907}}</ref>


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			* '''Dynamic changes in ultrastructure of the primary cilium in migrating neuroblasts in the postnatal brain'''{{#pmid:31685650\|PMID31685650}} "New neurons, referred to as neuroblasts, are continuously generated in the ventricular-subventricular zone of the brain throughout an animal's life. These neuroblasts are characterized by their unique potential for proliferation, formation of chain-like cell aggregates, and long-distance and high-speed migration through the rostral migratory stream (RMS) toward the olfactory bulb (OB), where they decelerate and differentiate into mature interneurons. ... Together, our results highlight a close mutual relationship between spatiotemporal regulation of the primary cilium and efficient chain migration of neuroblasts in the postnatal brain. Immature neurons (neuroblasts) generated in the postnatal brain have a mitotic potential and migrate in chain-like cell aggregates toward the olfactory bulb. Here we report that migrating neuroblasts possess a tiny cellular protrusion called a primary cilium. Immunohistochemical studies with zebrafish, mouse, and monkey brains suggest that the presence of the primary cilium in migrating neuroblasts is evolutionarily conserved. Ciliogenesis in migrating neuroblasts in the RMS is suppressed during mitosis and promoted after cell cycle exit. Moreover, live imaging and three-dimensional electron microscopy revealed that ciliary localization and orientation change during saltatory movement of neuroblasts. Our results reveal highly organized dynamics in maturation and positioning of the primary cilium during neuroblast migration that underlie saltatory movement of postnatal-born neuroblasts." {{smell}} \| {{neural postnatal}}

	* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."		* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."

Z8600021 at 00:15, 12 December 2019

2019-12-12T00:15:03Z

← Older revision		Revision as of 11:15, 12 December 2019
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	== Introduction ==		== Introduction ==
	[[File:Monkey_-_cynomolgus.jpg\|thumb\|Monkey (cynomolgus)]]		[[File:Monkey_-_cynomolgus.jpg\|thumb\|Monkey (cynomolgus)]]
	The monkey is often used as a primate model for human development. Another historic model of primate development was the smaller [[Book_-_Normal_Plates_of_the_Development_of_Vertebrates_7\|tarsius]]<ref>{{Ref-Hubrecht1907}}</ref>		The {{monkey}} is often used as a primate model for human development. Another historic model of primate development was the smaller [[Book_-_Normal_Plates_of_the_Development_of_Vertebrates_7\|tarsius]]<ref>{{Ref-Hubrecht1907}}</ref>


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	* '''Dynamic changes in ultrastructure of the primary cilium in migrating neuroblasts in the postnatal brain'''{{#pmid:31685650\|PMID31685650}} "New neurons, referred to as neuroblasts, are continuously generated in the ventricular-subventricular zone of the brain throughout an animal's life. These neuroblasts are characterized by their unique potential for proliferation, formation of chain-like cell aggregates, and long-distance and high-speed migration through the rostral migratory stream (RMS) toward the olfactory bulb (OB), where they decelerate and differentiate into mature interneurons. ... Together, our results highlight a close mutual relationship between spatiotemporal regulation of the primary cilium and efficient chain migration of neuroblasts in the postnatal brain. Immature neurons (neuroblasts) generated in the postnatal brain have a mitotic potential and migrate in chain-like cell aggregates toward the olfactory bulb. Here we report that migrating neuroblasts possess a tiny cellular protrusion called a primary cilium. Immunohistochemical studies with zebrafish, mouse, and monkey brains suggest that the presence of the primary cilium in migrating neuroblasts is evolutionarily conserved. Ciliogenesis in migrating neuroblasts in the RMS is suppressed during mitosis and promoted after cell cycle exit. Moreover, live imaging and three-dimensional electron microscopy revealed that ciliary localization and orientation change during saltatory movement of neuroblasts. Our results reveal highly organized dynamics in maturation and positioning of the primary cilium during neuroblast migration that underlie saltatory movement of postnatal-born neuroblasts." {{smell}} \| {{neural postnatal}}

	* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."		* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."

Z8600021 at 00:13, 12 December 2019

2019-12-12T00:13:22Z

← Older revision		Revision as of 11:13, 12 December 2019
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	* '''Dynamic changes in ultrastructure of the primary cilium in migrating neuroblasts in the postnatal brain'''{{#pmid:31685650\|PMID31685650}} "New neurons, referred to as neuroblasts, are continuously generated in the ventricular-subventricular zone of the brain throughout an animal's life. These neuroblasts are characterized by their unique potential for proliferation, formation of chain-like cell aggregates, and long-distance and high-speed migration through the rostral migratory stream (RMS) toward the olfactory bulb (OB), where they decelerate and differentiate into mature interneurons. ... Together, our results highlight a close mutual relationship between spatiotemporal regulation of the primary cilium and efficient chain migration of neuroblasts in the postnatal brain. Immature neurons (neuroblasts) generated in the postnatal brain have a mitotic potential and migrate in chain-like cell aggregates toward the olfactory bulb. Here we report that migrating neuroblasts possess a tiny cellular protrusion called a primary cilium. Immunohistochemical studies with zebrafish, mouse, and monkey brains suggest that the presence of the primary cilium in migrating neuroblasts is evolutionarily conserved. Ciliogenesis in migrating neuroblasts in the RMS is suppressed during mitosis and promoted after cell cycle exit. Moreover, live imaging and three-dimensional electron microscopy revealed that ciliary localization and orientation change during saltatory movement of neuroblasts. Our results reveal highly organized dynamics in maturation and positioning of the primary cilium during neuroblast migration that underlie saltatory movement of postnatal-born neuroblasts." {{smell} \| {{neural postnatal}}		* '''Dynamic changes in ultrastructure of the primary cilium in migrating neuroblasts in the postnatal brain'''{{#pmid:31685650\|PMID31685650}} "New neurons, referred to as neuroblasts, are continuously generated in the ventricular-subventricular zone of the brain throughout an animal's life. These neuroblasts are characterized by their unique potential for proliferation, formation of chain-like cell aggregates, and long-distance and high-speed migration through the rostral migratory stream (RMS) toward the olfactory bulb (OB), where they decelerate and differentiate into mature interneurons. ... Together, our results highlight a close mutual relationship between spatiotemporal regulation of the primary cilium and efficient chain migration of neuroblasts in the postnatal brain. Immature neurons (neuroblasts) generated in the postnatal brain have a mitotic potential and migrate in chain-like cell aggregates toward the olfactory bulb. Here we report that migrating neuroblasts possess a tiny cellular protrusion called a primary cilium. Immunohistochemical studies with zebrafish, mouse, and monkey brains suggest that the presence of the primary cilium in migrating neuroblasts is evolutionarily conserved. Ciliogenesis in migrating neuroblasts in the RMS is suppressed during mitosis and promoted after cell cycle exit. Moreover, live imaging and three-dimensional electron microscopy revealed that ciliary localization and orientation change during saltatory movement of neuroblasts. Our results reveal highly organized dynamics in maturation and positioning of the primary cilium during neuroblast migration that underlie saltatory movement of postnatal-born neuroblasts." {{smell}} \| {{neural postnatal}}

	* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."		* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."

Z8600021 at 00:12, 12 December 2019

2019-12-12T00:12:09Z

← Older revision		Revision as of 11:12, 12 December 2019
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			* '''Dynamic changes in ultrastructure of the primary cilium in migrating neuroblasts in the postnatal brain'''{{#pmid:31685650\|PMID31685650}} "New neurons, referred to as neuroblasts, are continuously generated in the ventricular-subventricular zone of the brain throughout an animal's life. These neuroblasts are characterized by their unique potential for proliferation, formation of chain-like cell aggregates, and long-distance and high-speed migration through the rostral migratory stream (RMS) toward the olfactory bulb (OB), where they decelerate and differentiate into mature interneurons. ... Together, our results highlight a close mutual relationship between spatiotemporal regulation of the primary cilium and efficient chain migration of neuroblasts in the postnatal brain. Immature neurons (neuroblasts) generated in the postnatal brain have a mitotic potential and migrate in chain-like cell aggregates toward the olfactory bulb. Here we report that migrating neuroblasts possess a tiny cellular protrusion called a primary cilium. Immunohistochemical studies with zebrafish, mouse, and monkey brains suggest that the presence of the primary cilium in migrating neuroblasts is evolutionarily conserved. Ciliogenesis in migrating neuroblasts in the RMS is suppressed during mitosis and promoted after cell cycle exit. Moreover, live imaging and three-dimensional electron microscopy revealed that ciliary localization and orientation change during saltatory movement of neuroblasts. Our results reveal highly organized dynamics in maturation and positioning of the primary cilium during neuroblast migration that underlie saltatory movement of postnatal-born neuroblasts." {{smell} \| {{neural postnatal}}

	* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."		* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."

Z8600021 at 02:05, 31 Mayıs 2019

2019-05-31T02:05:05Z

← Older revision		Revision as of 13:05, 31 Mayıs 2019
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	===Macaque Timeline===		===Macaque Timeline===
			{{Macaque Placental Timeline table}}
	{\|
	~~\|+ '''~~Macaque Placental Timeline~~'''~~
	\|-
	~~! Day~~
	~~! Event~~
	\|-
	~~\| 9~~
	~~\| OvuIn beginning contact. Endometrial proliferation to form epithelial plaque.~~
	\|-
	~~\| 10~~
	~~\| Invasion. Erosion of strorna, gland and vessels. Lacunae beginning. Transition of cytotrophoblast to syncytium.~~
	\|-
	~~\| 12~~
	~~\| Trabeculae and cascades of trophoblast cells. Mesoblast, yolk sac. Ovum walls collapsed, no sinusoids.~~
	\|-
	~~\| 13~~
	~~\| Sinusoids communicate with lacunae. Villi begin. Ovum walls dilated, abembryonic wall hypertrophies preparatory to formation of second implantation site.~~
	\|-
	~~\| 15~~
	~~\| Maternal epithelium reaches end of proliferative period.~~
	\|-
	~~\| 17~~
	~~\| Necrotic border zone. Blood in glands. Primitive body mesoderm.~~
	\|-
	~~\| 19th~~
	~~\| Villi with three zones established, and branching. Pinocytosis (imbibing of liquid substances}.~~
	\|-
	~~\| 22.5~~
	~~\| Villi vascular. Oedema at junction zone.~~
	\|-
	~~\| colspan=2\|Data from <ref name=Gatenby1945>{{Ref-Gatenby1945}~~}~~</ref>~~
	\|}

Z8600021 at 02:04, 31 Mayıs 2019

2019-05-31T02:04:20Z

← Older revision		Revision as of 13:04, 31 Mayıs 2019
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	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+development ''Monkey development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+embryology ''Monkey embryology''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+embryo ''Monkey embryo'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Primate+development ''Primate development''] \| \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+development ''Monkey development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+embryology ''Monkey embryology''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+embryo ''Monkey embryo'']

	\|}		\|}

Z8600021 at 01:59, 31 Mayıs 2019

2019-05-31T01:59:02Z

← Older revision		Revision as of 12:59, 31 Mayıs 2019
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	{{Header}}		{{Header}}

	== Introduction ==		== Introduction ==
	[[File:Monkey_-_cynomolgus.jpg\|thumb\|Monkey (cynomolgus)]]		[[File:Monkey_-_cynomolgus.jpg\|thumb\|Monkey (cynomolgus)]]
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	[[File:Swapping mitochondrial DNA mammalian oocytes.jpg\|alt=Swapping mitochondrial DNA mammalian oocytes\|400px]]		[[File:Swapping mitochondrial DNA mammalian oocytes.jpg\|alt=Swapping mitochondrial DNA mammalian oocytes\|400px]]

	Swapping mitochondrial DNA mammalian oocytes~~<ref name="~~PMID19759608~~"><pubmed>19759608</pubmed></ref>~~		Swapping mitochondrial DNA mammalian oocytes{{#pmid:19759608\|PMID19759608}}
	:'''Links:''' [[:Category:Monkey\|Category:Monkey]]		:'''Links:''' [[:Category:Monkey\|Category:Monkey]]
	==Some Recent Findings==		==Some Recent Findings==
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	\|		\|
	* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''~~<ref name="~~PMID27165688~~"><pubmed>27165688</pubmed></ref>~~ "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."		* '''Nuclear-mitochondrial incompatibility in interorder rhesus monkey-cow embryos derived from somatic cell nuclear transfer'''{{#pmid:27165688\|PMID27165688}} "Monkey interorder somatic cell nuclear transfer (iSCNT) using enucleated cow oocytes yielded poor blastocysts development and contradictory results among research groups. Determining the reason for this low blastocyst development is a prerequisite for optimizing iSCNT in rhesus monkeys. The aim of this study was to elucidate nuclear-mitochondrial incompatibility of rhesus monkey-cow iSCNT embryos and its relationship to low blastocyst development. ...Collectively, rhesus monkey iSCNT embryos reconstructed with cow oocytes have nuclear-mitochondrial incompatibility due to fundamental species differences between rhesus monkeys and cattle. Nuclear-mitochondrial incompatibility seems to correlate with low ETC activity and extremely low blastocyst development of rhesus monkey-cow iSCNT embryos."
	* '''Assisted Reproductive Technologies (ART) With Baboons Generate Live Offspring: A Nonhuman Primate Model for ART and Reproductive Sciences.'''~~<ref><pubmed>~~20631291~~</pubmed></ref>~~ "Here, baboon ART protocols, including oocyte collection, in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), preimplantation development to blastocyst stage, and embryo transfer techniques are described. With baboon ART methodologies in place, motility during baboon fertilization was investigated by time-lapse video microscopy (TLVM). The first ART baboons produced by ICSI, a pair of male twins, were delivered naturally at 165 days postgestation. Genetic testing of these twins confirmed their ART parental origins and demonstrated that they are unrelated fraternal twins not identicals."
	* '''Monkey thalidomide model'''~~<ref name="~~PMID19751816~~"><pubmed>19751816</pubmed></ref>~~ "Cynomolgus monkeys were orally administered thalidomide at 15 or 20mg/kg-d on days 26-28 of gestation, and fetuses were examined on day 100-102 of gestation. Limb defects such as micromelia/amelia, paw/foot hyperflexion, polydactyly, syndactyly, and brachydactyly were observed in seven of eight fetuses.' (More? ~~[[Abnormal Development -~~ Thalidomide]])		* '''Assisted Reproductive Technologies (ART) With Baboons Generate Live Offspring: A Nonhuman Primate Model for ART and Reproductive Sciences.'''{{#pmid:20631291\|PMID20631291}} "Here, baboon ART protocols, including oocyte collection, in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), preimplantation development to blastocyst stage, and embryo transfer techniques are described. With baboon ART methodologies in place, motility during baboon fertilization was investigated by time-lapse video microscopy (TLVM). The first ART baboons produced by ICSI, a pair of male twins, were delivered naturally at 165 days postgestation. Genetic testing of these twins confirmed their ART parental origins and demonstrated that they are unrelated fraternal twins not identicals."

			* '''Monkey thalidomide model'''{{#pmid:19751816\|PMID19751816}} "Cynomolgus monkeys were orally administered thalidomide at 15 or 20mg/kg-d on days 26-28 of gestation, and fetuses were examined on day 100-102 of gestation. Limb defects such as micromelia/amelia, paw/foot hyperflexion, polydactyly, syndactyly, and brachydactyly were observed in seven of eight fetuses.' (More? {{Thalidomide}})
	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
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	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+development ''Monkey development'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+development ''Monkey development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+embryology ''Monkey embryology''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+embryo ''Monkey embryo'']

	~~<pubmed limit=5>Monkey development</pubmed>~~
	~~<br>~~
	~~Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+embryo ''Monkey embryo'']~~

	~~<pubmed limit=5>Monkey embryo</pubmed>~~
	\|}		\|}
			{\| class="wikitable mw-collapsible mw-collapsed"
			! Older papers
			\|-
			\| {{Older papers}}
			\|}

	===Macaque Timeline===		===Macaque Timeline===
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	[[File:Baboon-_fetal_brain.jpg\|600px]]		[[File:Baboon-_fetal_brain.jpg\|600px]]

	Mapping primary gyrogenesis during fetal development in primate brains: high-resolution in utero structural MRI of fetal brain development in pregnant baboons~~<ref><pubmed>~~20631812~~</pubmed>~~\| ~~[http://www.frontiersin.org/neurogenesis/10.3389/fnins.2010.00020/full Front Neurosci.]~~		Mapping primary gyrogenesis during fetal development in primate brains: high-resolution in utero structural MRI of fetal brain development in pregnant baboons{{#pmid:20631812\|PMID20631812}}
	~~</ref>~~

	:"The global and regional changes in the fetal cerebral cortex in primates were mapped during primary gyrification (PG; weeks 17-25 of 26 weeks total gestation). Studying pregnant baboons using high-resolution MRI in utero, measurements included cerebral volume, cortical surface area, gyrification index and length and depth of 10 primary cortical sulci. Seven normally developing fetuses were imaged in two animals longitudinally and sequentially. We compared these results to those on PG that from the ferret studies and analyzed them in the context of our recent studies of phylogenetics of cerebral gyrification. We observed that in both primates and non-primates, the cerebrum undergoes a very rapid transformation into the gyrencephalic state, subsequently accompanied by an accelerated growth in brain volume and cortical surface area. However, PG trends in baboons exhibited some critical differences from those observed in ferrets. For example, in baboons, the growth along the long (length) axis of cortical sulci was unrelated to the growth along the short (depth) axis and far outpaced it. Additionally, the correlation between the rate of growth along the short sulcal axis and heritability of sulcal depth was negative and approached significance (r = -0.60; p < 0.10), while the same trend for long axis was positive and not significant (p = 0.3; p = 0.40). These findings, in an animal that shares a highly orchestrated pattern of PG with humans, suggest that ontogenic processes that influence changes in sulcal length and depth are diverse and possibly driven by different factors in primates than in non-primates."		:"The global and regional changes in the fetal cerebral cortex in primates were mapped during primary gyrification (PG; weeks 17-25 of 26 weeks total gestation). Studying pregnant baboons using high-resolution MRI in utero, measurements included cerebral volume, cortical surface area, gyrification index and length and depth of 10 primary cortical sulci. Seven normally developing fetuses were imaged in two animals longitudinally and sequentially. We compared these results to those on PG that from the ferret studies and analyzed them in the context of our recent studies of phylogenetics of cerebral gyrification. We observed that in both primates and non-primates, the cerebrum undergoes a very rapid transformation into the gyrencephalic state, subsequently accompanied by an accelerated growth in brain volume and cortical surface area. However, PG trends in baboons exhibited some critical differences from those observed in ferrets. For example, in baboons, the growth along the long (length) axis of cortical sulci was unrelated to the growth along the short (depth) axis and far outpaced it. Additionally, the correlation between the rate of growth along the short sulcal axis and heritability of sulcal depth was negative and approached significance (r = -0.60; p < 0.10), while the same trend for long axis was positive and not significant (p = 0.3; p = 0.40). These findings, in an animal that shares a highly orchestrated pattern of PG with humans, suggest that ontogenic processes that influence changes in sulcal length and depth are diverse and possibly driven by different factors in primates than in non-primates."
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	==Thalidomide Model==		==Thalidomide Model==
	[[File:Monkey - cynomolgus.jpg\|thumb\|Cynomolgus monkey]]		[[File:Monkey - cynomolgus.jpg\|thumb\|Cynomolgus monkey]]
	Crab-eating Macaque (Macaca fascicularis, Cynomolgus Monkey, Philippine Monkey, Long-tailed Macaque)~~<ref name="~~PMID19751816~~"><pubmed>19751816</pubmed></ref>~~ "Cynomolgus monkeys were orally administered thalidomide at 15 or 20mg/kg-d on days 26-28 of gestation, and fetuses were examined on day 100-102 of gestation. Limb defects such as micromelia/amelia, paw/foot hyperflexion, polydactyly, syndactyly, and brachydactyly were observed in seven of eight fetuses."		Crab-eating Macaque (Macaca fascicularis, Cynomolgus Monkey, Philippine Monkey, Long-tailed Macaque){{#pmid:19751816\|PMID19751816}} "Cynomolgus monkeys were orally administered thalidomide at 15 or 20mg/kg-d on days 26-28 of gestation, and fetuses were examined on day 100-102 of gestation. Limb defects such as micromelia/amelia, paw/foot hyperflexion, polydactyly, syndactyly, and brachydactyly were observed in seven of eight fetuses."


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	=== West Nile Virus ===		=== West Nile Virus ===

	===Plasmodium vivax===		===Plasmodium vivax===

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	===Articles===		===Articles===
	~~<pubmed>~~3788819~~</pubmed>~~		{{#pmid:3788819}}

	===Search Pubmed===		===Search Pubmed===
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	'''Search Pubmed:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Monkey%20development Monkey development] \| [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=rhesus%20monkey%20development rhesus monkey development]		'''Search Pubmed:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Monkey%20development Monkey development] \| [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=rhesus%20monkey%20development rhesus monkey development]

			===Historic===
			{{Ref-Bartelmez1957}}

			{{Ref-Enders1983}}

			{{Ref-Hart1893}}

			{{Ref-Heuser1932a}}

			{{Ref-Heuser1938}}

			{{Ref-Heuser1940}}

			{{Ref-HeuserStreeter1941}}

			{{Ref-Luckett1971}}

			{{Ref-Luckett1973}}

			{{Ref-Luckett1978}}

			{{Ref-Ramsey1960}}

			{{Ref-WislockiBennett1943}}
	==External Links==		==External Links==
	{{External Links}}		{{External Links}}

Z8600021 at 02:02, 4 October 2018

2018-10-04T02:02:13Z

← Older revision		Revision as of 13:02, 4 October 2018
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	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+development ''Monkey development'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+development ''Monkey development'']

	<pubmed limit=5>Monkey development</pubmed>		<pubmed limit=5>Monkey development</pubmed>
			<br>
			Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+embryo ''Monkey embryo'']

	~~Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Monkey+embryo ''Monkey embryo'']~~
	<pubmed limit=5>Monkey embryo</pubmed>		<pubmed limit=5>Monkey embryo</pubmed>
	\|}		\|}

Z8600021 at 02:00, 4 October 2018

2018-10-04T02:00:21Z

← Older revision		Revision as of 13:00, 4 October 2018
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	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
	! More recent papers		! More recent papers
	\|-		\|-
	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}