Lecture - Week 3 Development - Revision history

Z3485617 at 05:44, 24 September 2019

2019-09-24T05:44:11Z

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	In this lecture I will talk about [[week 3]] of embryonic development ({{GA}} week 5). I will cover concepts including early placentation, gastrulation and embryonic folding.		In this lecture I will talk about [[week 3]] of embryonic development ({{GA}} week 5). I will cover concepts including early placentation, gastrulation and embryonic folding.


	~~[[Media:ANAT2341Lecture 2018 - Week 3 Development.pdf\|2018 Lecture - Print PDF]]~~

	==Objectives==		==Objectives==

2018-07-30T23:40:29Z

Embryonic Disc

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	{\|		{\|
	\| width=~~310px~~\|[[File:Stage7 features.jpg\|300px]]		\| width=305px\|[[File:Stage7 features.jpg\|300px]]

	Embryonic Disc showing primitive streak ([[Carnegie stage 7]])		Embryonic Disc showing primitive streak ([[Carnegie stage 7]])
			\| width=305px\|[[File:Human Carnegie stage 1-23.jpg\|300px]]
	\| {{Week 3 mesoderm movie}}		\| {{Week 3 mesoderm movie}}
	~~\| [[File:Human Carnegie stage 1-23.jpg\|300px]]~~
	\|}		\|}

2018-07-30T23:39:50Z

Embryonic Disc

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	Embryonic Disc showing primitive streak ([[Carnegie stage 7]])		Embryonic Disc showing primitive streak ([[Carnegie stage 7]])
	\| {{Week 3 mesoderm movie}}		\| {{Week 3 mesoderm movie}}
			\| [[File:Human Carnegie stage 1-23.jpg\|300px]]
	\|}		\|}

2018-07-30T23:39:01Z

Embryonic Disc

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	\| width=310px\|[[File:Stage7 features.jpg\|300px]]		\| width=310px\|[[File:Stage7 features.jpg\|300px]]

	Embryonic Disc showing primitive streak		Embryonic Disc showing primitive streak ([[Carnegie stage 7]])
	\| {{Week 3 mesoderm movie}}		\| {{Week 3 mesoderm movie}}
	\|}		\|}

2018-07-30T23:24:38Z

Early Placentation

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	Early Utero-Placental exchange		Early Utero-Placental exchange
	* transfer of nutrition from maternal lacunae filled with secretions from uterine glands and maternal blood from blood vessels.		* transfer of nutrition from '''maternal lacunae''' filled with secretions from uterine glands and maternal blood from blood vessels.
	* development of trophoblast villi extending into the uterine decidua.		* development of trophoblast villi extending into the uterine decidua.
	* ongoing process with placental development (covered in future lecture)		* ongoing process with placental development (covered in future lecture)
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	# Primary Villi - cytotrophoblast		# Primary Villi - cytotrophoblast
	# Secondary Villi - cytotrophoblast + extraembryonic mesoderm		# Secondary Villi - cytotrophoblast + extraembryonic mesoderm
	# Tertiary Villi - cytotrophoblast + extraembryonic mesoderm+ blood vessels		# Tertiary Villi - cytotrophoblast + extraembryonic mesoderm + blood vessels



	There are two main types of early villi:		There are two main types of early villi:
	# Anchoring villi - attached to decidua		# '''Anchoring villi''' - attached to decidua
	# Floating villi - not attached to decidua, floating in maternal lacunae.		# '''Floating villi''' - not attached to decidua, floating in maternal lacunae.

2018-07-30T22:07:52Z

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			{{#pmid:29574800}}

			{{#pmid:28586710}}

	{{#pmid:27061115}}		{{#pmid:27061115}}

	{{#pmid:27383781}}		{{#pmid:27383781}}

	~~How do cellular physical interactions affect early development see this review.<br>~~
	~~{{#pmid:26820524}}~~
	\|}		\|}

2018-07-30T14:49:56Z

Epithelial to Mesenchymal Transition

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	\| [[File:Chicken-gastrulation3.jpg\|400px]]		\| [[File:Chicken-gastrulation3.jpg\|400px]]
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	* '''Epithelial cells''' (organised cellular layer) which loose their organisation and migrate/proliferate as a mesenchymal cells (disorganised cellular layers) are said to have undergone an Epithelial Mesenchymal Transition (EMT).		* '''Epithelial cells''' (organised cellular layer) which loose their organisation and migrate/proliferate as a mesenchymal cells (disorganised cellular layers) are said to have undergone an Epithelial Mesenchymal Transition (EMT).

	* '''Mesenchymal cells''' have an embryonic connective tissue-like cellular arrangement		* '''Mesenchymal cells''' have an embryonic connective tissue-like cellular arrangement
	** cells that have undergone this process may at a later time and under specific signaling conditions undergo the opposite process, mesenchyme to epithelia.		** cells that have undergone this process may at a later time and under specific signaling conditions undergo the opposite process, mesenchyme to epithelia.

	* In development, this process can be repeated several times during tissue differentiation.		* In development, this process can be repeated several times during tissue differentiation.

2018-07-30T14:48:49Z

Embryonic Disc

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	{\|		{\|
	\| [[File:Stage7 features.jpg\|300px]]		\| width=310px\|[[File:Stage7 features.jpg\|300px]]

	Embryonic Disc showing primitive streak		Embryonic Disc showing primitive streak

2018-07-30T14:48:12Z

Embryonic Disc

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	** Currently, the molecular and physical mechanisms that regulate patterning and migration during this key event are being investigated in several different animal models.		** Currently, the molecular and physical mechanisms that regulate patterning and migration during this key event are being investigated in several different animal models.
	** In humans, it is proposed that similar mechanisms regulate gastrulation to those found in other vertebrates.		** In humans, it is proposed that similar mechanisms regulate gastrulation to those found in other vertebrates.


	{\|		{\|
	\| [[File:Stage7 features.jpg\|300px]]		\| [[File:Stage7 features.jpg\|300px]]

2018-07-30T14:46:55Z

Lecture Resources

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	\| {{MPT2015cover_citation}}		\| {{MPT2015cover_citation}}
	\| The following chapter links only work with a UNSW connection.		\| The following chapter links only work with a UNSW connection.
	* [http://~~www~~.~~unsw.eblib~~.com.~~wwwproxy0~~.library.unsw.edu.au/~~patron~~/~~Read~~.~~aspx~~?p=2074364&pg=81 Third Week of Human Development]		* Chapter 4 [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074364&ppg=81 Third Week of Human Development]
	\|-		\|-
	\| {{SBBFP2015cover_citation}}		\| {{SBBFP2015cover_citation}}
	\| The following chapter links only work with a UNSW connection.		\| The following chapter links only work with a UNSW connection.
	* [http://~~www~~.~~unsw.eblib~~.com.~~wwwproxy0~~.library.unsw.edu.au/~~patron~~/~~Read~~.~~aspx~~?p=2074524&pg=75 Third Week: Becoming Trilaminar and Establishing Body Axes]		* Chapter 3 [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074524&ppg=75 Third Week: Becoming Trilaminar and Establishing Body Axes]
	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"