Lecture - Musculoskeletal Development - Revision history

Z8600021: /* Hypertrophic Chondrocytes */

2018-09-10T01:32:29Z

Hypertrophic Chondrocytes

← Older revision		Revision as of 11:32, 10 September 2018
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	(review your Histology materials)		(review your Histology materials)
	===Hypertrophic Chondrocytes===		===Hypertrophic Chondrocytes===
	* secrete VEGF, promoting vascular invasion		* secrete {{VEGF}}, promoting vascular invasion
	* hypertrophic calcified cartilage becomes resorbed, by recruited chondroclasts/osteoclasts via MMP9		* hypertrophic calcified cartilage becomes resorbed, by recruited chondroclasts/osteoclasts via MMP9

Z8600021 at 01:31, 10 September 2018

2018-09-10T01:31:22Z

← Older revision		Revision as of 11:31, 10 September 2018
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	Note that genes that control skeleton patterning and cell differentiation are different.		Note that genes that control skeleton patterning and cell differentiation are different.

			[[Media:ANAT2341Lecture 2018 - Musculoskeletal Development.pdf\|2018 Lecture - Print PDF]]

	\| valign=top\|[[File:Axial skeleton.jpg\|200px]]		\| valign=top\|[[File:Axial skeleton.jpg\|200px]]

Z8600021 at 01:56, 6 September 2018

2018-09-06T01:56:41Z

← Older revision		Revision as of 11:56, 6 September 2018
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	Appendicular skeleton		Appendicular skeleton
	\|}

	~~{\| class="wikitable mw-collapsible mw-collapsed"~~
	~~! 2016 Lecture Video Recording  ~~
	\|-
	~~\| This 2016 lecture video recording is similar in content to the current 2017 online lecture.~~

	~~<html5media height="600" width="800">File:2016Lecture-Musculoskeletal.mp4</html5media>~~

	~~Click to play new window - [[Media:2016Lecture-Musculoskeletal.mp4\|'''2016 Lecture Video''']] (48 MB)~~
	\|}		\|}

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	{{Musculoskeletal Links}}		{{Musculoskeletal Links}}

	Archive: [[Media:Lecture 2016 - Musculoskeletal Development.pdf\|2016 PDF]] \| [https://embryology.med.unsw.edu.au/embryology/index.php?title=Lecture_-_Musculoskeletal_Development&oldid=246812 2015] \| [[Media:ANAT2341_Lecture_17_-_2014_Musculoskeletal_Development.pdf\|2014 PDF]] \| [https://embryology.med.unsw.edu.au/embryology/index.php?title=Lecture_-_Musculoskeletal_Development&oldid=1465882014 2014]		Archive: [https://embryology.med.unsw.edu.au/embryology/index.php?title=Lecture_-_Musculoskeletal_Development&oldid=304642 2017] \| [[Media:Lecture 2016 - Musculoskeletal Development.pdf\|2016 PDF]] \| [https://embryology.med.unsw.edu.au/embryology/index.php?title=Lecture_-_Musculoskeletal_Development&oldid=246812 2015] \| [[Media:ANAT2341_Lecture_17_-_2014_Musculoskeletal_Development.pdf\|2014 PDF]] \| [https://embryology.med.unsw.edu.au/embryology/index.php?title=Lecture_-_Musculoskeletal_Development&oldid=1465882014 2014]

	Virtual Slide: [[:File:Stage_22_image_025.jpg\|Musculoskeletal Embryo Stage 22]]		Virtual Slide: [[:File:Stage_22_image_025.jpg\|Musculoskeletal Embryo Stage 22]]
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	\|}		\|}

	== Patterning and differentiation of the somitic mesoderm ==		{\| class="wikitable mw-collapsible mw-collapsed"
			! 2016 Lecture Video Recording
			\|-
			\| This 2016 lecture video recording is similar in content to the current 2017 online lecture.

			<html5media height="600" width="800">File:2016Lecture-Musculoskeletal.mp4</html5media>

			Click to play new window - [[Media:2016Lecture-Musculoskeletal.mp4\|'''2016 Lecture Video''']] (48 MB)
			\|}

			== Patterning and differentiation of the somitic mesoderm ==
	{\|		{\|
	\| [[File:Mesoderm-cartoon4.jpg]]		\| [[File:Mesoderm-cartoon4.jpg]]
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	* Week 3 to 4 - '''paraxial mesoderm''' forms '''somites''' (somitogenesis) along the rostro-caudal axis establishes the axial body plan		* Week 3 to 4 - '''paraxial mesoderm''' forms '''somites''' (somitogenesis) along the rostro-caudal axis establishes the axial body plan
	** paraxial mesoderm remains unsegmented in the head		** paraxial mesoderm remains unsegmented in the head
	* '''Hox''' gene clusters control rostro-caudal patterning of the axial musculoskeletal system		* '''{{Hox}}''' gene clusters control rostro-caudal patterning of the axial musculoskeletal system
	** provide positional clues for the development of specific structures e.g. cervical, thoracic, lumbar and sacral vertebrae.		** provide positional clues for the development of specific structures e.g. cervical, thoracic, lumbar and sacral vertebrae.

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	{{~~2017ANAT2341 footer~~}}		{{2018ANAT2341}}

Z8600021: /* Introduction */

2017-09-10T04:06:07Z

Introduction

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	* appendicular skeleton - 126 bones (shoulders, pelvis, and limbs)		* appendicular skeleton - 126 bones (shoulders, pelvis, and limbs)

	~~{{2017ANAT2341draftnotice}}~~

	Note that genes that control skeleton patterning and cell differentiation are different.		Note that genes that control skeleton patterning and cell differentiation are different.

Z8600021: /* Lecture Resources */

2017-09-10T02:01:40Z

Lecture Resources

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	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
	! References		! colspan=2\|References
	\|-		\|-
	\| {{Embryo logocitation}}		\| {{Embryo logocitation}}
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	* [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074524&ppg=190 Development of the Musculoskeletal System]		* [http://ebookcentral.proquest.com.wwwproxy1.library.unsw.edu.au/lib/unsw/reader.action?docID=2074524&ppg=190 Development of the Musculoskeletal System]
	\|}		\|}


	== Patterning and differentiation of the somitic mesoderm ==		== Patterning and differentiation of the somitic mesoderm ==

Z8600021: /* Introduction */

2017-09-10T02:00:47Z

Introduction

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	Appendicular skeleton		Appendicular skeleton
			\|}

			{\| class="wikitable mw-collapsible mw-collapsed"
			! 2016 Lecture Video Recording
			\|-
			\| This 2016 lecture video recording is similar in content to the current 2017 online lecture.

			<html5media height="600" width="800">File:2016Lecture-Musculoskeletal.mp4</html5media>

			Click to play new window - [[Media:2016Lecture-Musculoskeletal.mp4\|'''2016 Lecture Video''']] (48 MB)
	\|}		\|}

Z8600021: /* Skeletal Muscle Stages */

2017-09-10T01:42:21Z

Skeletal Muscle Stages

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	! Mouse muscle development		! Mouse muscle development
	\|-		\|-
	\| [[File:Mouse limb tissue development.jpg]]		\| [[File:Mouse limb tissue development.jpg\|800px]]
	\|}		\|}

Z8600021: /* Skeletal Muscle Stages */

2017-09-10T01:42:02Z

Skeletal Muscle Stages

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	## primary myofibres - first-formed myofibres, act as a structural framework upon which myoblasts proliferate, fuse in linear sequence		## primary myofibres - first-formed myofibres, act as a structural framework upon which myoblasts proliferate, fuse in linear sequence
	## secondary myofibers - second later population of myofibres that form surrounding the primary fibres.		## secondary myofibers - second later population of myofibres that form surrounding the primary fibres.

			{\| class="wikitable mw-collapsible mw-collapsed"
			! Mouse muscle development
			\|-
			\| [[File:Mouse limb tissue development.jpg]]
			\|}

	'''Muscle Fibre Types'''		'''Muscle Fibre Types'''

Z8600021 at 01:33, 10 September 2017

2017-09-10T01:33:12Z

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 == Terms ==
-* '''annulus fibrosus''' -  the circularly arranged fibers (derived from sclerotome)that together with the nucleus pulposus (derived from notochord) form the [[#intervertebral disc|intervertebral disc]] (IVD) of the vertebral column.
+{{Bone terms}}
-* '''axial mesoderm''' -  (=notochord)
-* '''cartilage''' -  connective tissue from mesoderm in the embryo forms the initial skeleton which is replaced by bone. In adult, found on the surface of bone joints.
 ==Images==
 <gallery>

Z8600021: /* Myotome */

2017-09-10T01:28:35Z

Myotome

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 * S3, 4 and 5 supply the bladder, bowel, sex organs, anal and other pelvic muscles.
 |}
 ==Puberty==
 * Musculoskeletal mass doubles by the end of puberty