Joint Development - Temporomandibular Joint - Revision history

Z8600021 at 02:40, 28 October 2018

2018-10-28T02:40:53Z

← Older revision		Revision as of 13:40, 28 October 2018
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			* '''Review - Diagnostic ultrasound assessment of temporomandibular joints'''{{#pmid:30285469\|PMID30285469}} "The purpose of this systematic review was to determine the diagnostic capability of Ultrasound (US) to assess TMJ alterations as disc displacement (DD), joint effusion (JE) and condylar changes (CC) using 3D imaging modalities as reference standard. ...This systematic review demonstrated the US has acceptable capability to screen for DD and JE in TMD patients. For screening of condylar changes, US needs further studies using CT or CBCT as reference standard to support its use. More advanced imaging such as MRI can thereafter be used to confirm the diagnosis if deemed necessary."

	* '''Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression‑associated congenital dysplasia of the temporomandibular joint in mice'''{{#pmid:26096903\|PMID26096903}} "The role of short stature homeobox 2 (shox2) in the development and homeostasis of the temporomandibular joint (TMJ) has been well documented. Shox2 is known to be expressed in the progenitor cells and perichondrium of the developing condyle. A previous study by our group reported that overexpression of shox2 leads to congenital dysplasia of the TMJ via downregulation of the Indian hedgehog (Ihh) signaling pathway, which is essential for embryonic disc primordium formation and mandibular condylar growth. To determine whether overexpression of Ihh may rescue the overexpression of shox2 leading to congenital dysplasia of the TMJ, a mouse model in which Ihh and shox2 were overexpressed (Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice) was utilized to assess the consequences of this overexpression on TMJ development during post-natal life. ... These combinatory cellular and molecular defects appeared to account for the observed congenital dysplasia of TMJ, suggesting that overexpression of Ihh partially rescued shox2 overexpression‑associated congenital dysplasia of the TMJ in mice." {{Mouse}} \|[http://omim.org/entry/600726 OMIM IHH] \| [http://omim.org/entry/602504 OMIM SHOX2]		* '''Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression‑associated congenital dysplasia of the temporomandibular joint in mice'''{{#pmid:26096903\|PMID26096903}} "The role of short stature homeobox 2 (shox2) in the development and homeostasis of the temporomandibular joint (TMJ) has been well documented. Shox2 is known to be expressed in the progenitor cells and perichondrium of the developing condyle. A previous study by our group reported that overexpression of shox2 leads to congenital dysplasia of the TMJ via downregulation of the Indian hedgehog (Ihh) signaling pathway, which is essential for embryonic disc primordium formation and mandibular condylar growth. To determine whether overexpression of Ihh may rescue the overexpression of shox2 leading to congenital dysplasia of the TMJ, a mouse model in which Ihh and shox2 were overexpressed (Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice) was utilized to assess the consequences of this overexpression on TMJ development during post-natal life. ... These combinatory cellular and molecular defects appeared to account for the observed congenital dysplasia of TMJ, suggesting that overexpression of Ihh partially rescued shox2 overexpression‑associated congenital dysplasia of the TMJ in mice." {{Mouse}} \|[http://omim.org/entry/600726 OMIM IHH] \| [http://omim.org/entry/602504 OMIM SHOX2]

Z8600021 at 02:38, 28 October 2018

2018-10-28T02:38:05Z

← Older revision		Revision as of 13:38, 28 October 2018
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	* '''Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression‑associated congenital dysplasia of the temporomandibular joint in mice'''{{#pmid:26096903\|PMID26096903}} "The role of short stature homeobox 2 (shox2) in the development and homeostasis of the temporomandibular joint (TMJ) has been well documented. Shox2 is known to be expressed in the progenitor cells and perichondrium of the developing condyle. A previous study by our group reported that overexpression of shox2 leads to congenital dysplasia of the TMJ via downregulation of the Indian hedgehog (Ihh) signaling pathway, which is essential for embryonic disc primordium formation and mandibular condylar growth. To determine whether overexpression of Ihh may rescue the overexpression of shox2 leading to congenital dysplasia of the TMJ, a mouse model in which Ihh and shox2 were overexpressed (Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice) was utilized to assess the consequences of this overexpression on TMJ development during post-natal life. ... These combinatory cellular and molecular defects appeared to account for the observed congenital dysplasia of TMJ, suggesting that overexpression of Ihh partially rescued shox2 overexpression‑associated congenital dysplasia of the TMJ in mice." [[Mouse ~~Development]]~~ \|[http://omim.org/entry/600726 OMIM IHH] \| [http://omim.org/entry/602504 OMIM SHOX2]		* '''Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression‑associated congenital dysplasia of the temporomandibular joint in mice'''{{#pmid:26096903\|PMID26096903}} "The role of short stature homeobox 2 (shox2) in the development and homeostasis of the temporomandibular joint (TMJ) has been well documented. Shox2 is known to be expressed in the progenitor cells and perichondrium of the developing condyle. A previous study by our group reported that overexpression of shox2 leads to congenital dysplasia of the TMJ via downregulation of the Indian hedgehog (Ihh) signaling pathway, which is essential for embryonic disc primordium formation and mandibular condylar growth. To determine whether overexpression of Ihh may rescue the overexpression of shox2 leading to congenital dysplasia of the TMJ, a mouse model in which Ihh and shox2 were overexpressed (Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice) was utilized to assess the consequences of this overexpression on TMJ development during post-natal life. ... These combinatory cellular and molecular defects appeared to account for the observed congenital dysplasia of TMJ, suggesting that overexpression of Ihh partially rescued shox2 overexpression‑associated congenital dysplasia of the TMJ in mice." {{Mouse}} \|[http://omim.org/entry/600726 OMIM IHH] \| [http://omim.org/entry/602504 OMIM SHOX2]

	* '''Analysis by Light, Scanning, and Transmission Microscopy of the Intima Synovial of the Temporomandibular Joint of Human Fetuses during the Development'''{{#pmid:24527214\|PMID24527214}} "To characterize morphologically and ultrastructurally using light microscopy, the scanning electron microscopy and transmission electron microscopy the intima synovial of the temporomandibular joint (TMJ) of human fetuses between the 10th and the 38th week of development. Materials and Methods. The TMJ was dissected bilaterally in 37 human fetuses belonging to the Institute of Embryology of the University Complutense of Madrid and of the Federal University of São Paulo. Results. The outcome by light microscopy showed the morphology of the TMJ and that the formation of inferior joint cavity precedes the superior joint cavity and the presence of blood vessels in the synovial. Conclusion. By scanning and transmission electron microscopy we observed the presence of two well-defined cell types in the intima layer of synovial of the TMJ of human fetuses, macrophage-like type A cell and fibroblast-like type B cell, and the presence of the a third cell type, defined by the name of intermediate lining cell in the intima layer of the synovial."		* '''Analysis by Light, Scanning, and Transmission Microscopy of the Intima Synovial of the Temporomandibular Joint of Human Fetuses during the Development'''{{#pmid:24527214\|PMID24527214}} "To characterize morphologically and ultrastructurally using light microscopy, the scanning electron microscopy and transmission electron microscopy the intima synovial of the temporomandibular joint (TMJ) of human fetuses between the 10th and the 38th week of development. Materials and Methods. The TMJ was dissected bilaterally in 37 human fetuses belonging to the Institute of Embryology of the University Complutense of Madrid and of the Federal University of São Paulo. Results. The outcome by light microscopy showed the morphology of the TMJ and that the formation of inferior joint cavity precedes the superior joint cavity and the presence of blood vessels in the synovial. Conclusion. By scanning and transmission electron microscopy we observed the presence of two well-defined cell types in the intima layer of synovial of the TMJ of human fetuses, macrophage-like type A cell and fibroblast-like type B cell, and the presence of the a third cell type, defined by the name of intermediate lining cell in the intima layer of the synovial."
	\|}		\|}
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	! More recent papers		! More recent papers
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	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}
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	<pubmed limit=5>Temporomandibular Joint Development</pubmed>		<pubmed limit=5>Temporomandibular Joint Development</pubmed>
			\|}
			{\| class="wikitable mw-collapsible mw-collapsed"
			! Older papers
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	==Fetal Development==		==Fetal Development==

Z8600021 at 07:00, 11 Mayıs 2018

2018-05-11T07:00:41Z

← Older revision		Revision as of 18:00, 11 Mayıs 2018
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	==Temporomandibular Abnormalities==		==Temporomandibular Abnormalities==



			==Historic==
			1910 - [[Book_-_Manual_of_Human_Embryology_11E#Tempomandibular_Joint\|Tempomandibular Joint]]<ref name=Bardeen1910>{{Ref-Bardeen1910}}</ref>

			This joint is developed between the membrane which covers the condyle of the mandible and the periosteum of the squamosum. In the loose tissue between the two a condensation marks the beginning of the differentiation of the discus articularis. On each side of this discus a joint cavity develops. Each joint cavity is throughout life lined by fibrous tissue. Beneath the joint periosteum of the mandible and of the temporal bone a thin layer of cartilage is produced (see Kjellberg, 1904).

			* according to Walliseh (1906), in the new-bom the tubereulum articulare is still undeveloped and the condyle is flatter than in the adult. The condyle reaches its definitive form and the tubereulum is developed after the teeth appear.
			* according to Fuebs (1905), tbe temparomandibular joint in rabbits, and hence by inference in other mammals, is homologous with the quadra to-articular joint of reptiles. As mentioned above, following Reiehert, most investigators have come to the conclusion that the reptilian quadra to-articular joint is represented in mammals by tbe joint between the malleus and incus, while the temporomandibular joint of mammals is phylogenetieally a new structure, a squamosodental joint. (See Gaupp, 1906.)


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	Fetal temporomandibular joint 02.jpg\|Fetal temporomandibular joint 12 weeks		Fetal temporomandibular joint 02.jpg\|Fetal temporomandibular joint 12 weeks
	</gallery>		</gallery>



	==External Links==		==External Links==

Z8600021 at 21:55, 8 Mayıs 2018

2018-05-08T21:55:53Z

← Older revision		Revision as of 08:55, 9 Mayıs 2018
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	{{Header}}		{{Header}}
	==Introduction==		==Introduction==
	The {{temporomandibular joint}} (TMJ) is a bilateral synovial articulation between the ends of the mandible (lower jaw) and temporal bone ( part of the {{skull}}). Both mastication and facial muscles are attached to the lower jaw.		The {{temporomandibular joint}} (TMJ) is a bilateral synovial articulation between the ends of the mandible (lower jaw) and temporal bone, part of the {{skull}}. Both mastication and facial muscles are attached to the lower jaw. The earliest review of human embryonic and fetal TMJ development is by Symons in 1952.{{#pmid:12980883\|PMID12980883}}

	The earliest review of human embryonic and fetal TMJ development is by Symons in 1952.{{#pmid:12980883\|PMID12980883}}

Z8600021 at 21:45, 8 Mayıs 2018

2018-05-08T21:45:57Z

← Older revision		Revision as of 08:45, 9 Mayıs 2018
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	{{Header}}		{{Header}}
	==Introduction==		==Introduction==
	The ~~Temporomandibular Joint~~ (TMJ) is a bilateral synovial articulation between the ends of the mandible (lower jaw) and temporal bone ( part of the skull).		The {{temporomandibular joint}} (TMJ) is a bilateral synovial articulation between the ends of the mandible (lower jaw) and temporal bone ( part of the {{skull}}). Both mastication and facial muscles are attached to the lower jaw.

	The earliest review of human embryonic and fetal TMJ development is by Symons in 1952.{{#pmid:12980883\|PMID12980883}}		The earliest review of human embryonic and fetal TMJ development is by Symons in 1952.{{#pmid:12980883\|PMID12980883}}

Z8600021 at 12:57, 21 March 2018

2018-03-21T12:57:42Z

← Older revision		Revision as of 23:57, 21 March 2018
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	The Temporomandibular Joint (TMJ) is a bilateral synovial articulation between the ends of the mandible (lower jaw) and temporal bone ( part of the skull).		The Temporomandibular Joint (TMJ) is a bilateral synovial articulation between the ends of the mandible (lower jaw) and temporal bone ( part of the skull).

	The earliest review of human embryonic and fetal TMJ development is by Symons in 1952.~~<ref name="PMID12980883"><pubmed>~~12980883~~</pubmed>~~\| ~~[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1273756/pdf/janat00473-0110.pdf PDF]</ref>~~		The earliest review of human embryonic and fetal TMJ development is by Symons in 1952.{{#pmid:12980883\|PMID12980883}}


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	* '''Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression‑associated congenital dysplasia of the temporomandibular joint in mice'''~~<ref name="PMID26096903"><pubmed>~~26096903~~</pubmed>~~\| ~~[http://www.spandidos-publications.com/10.3892/mmr.2015.3959 Mol Med Rep.]</ref>~~ "The role of short stature homeobox 2 (shox2) in the development and homeostasis of the temporomandibular joint (TMJ) has been well documented. Shox2 is known to be expressed in the progenitor cells and perichondrium of the developing condyle. A previous study by our group reported that overexpression of shox2 leads to congenital dysplasia of the TMJ via downregulation of the Indian hedgehog (Ihh) signaling pathway, which is essential for embryonic disc primordium formation and mandibular condylar growth. To determine whether overexpression of Ihh may rescue the overexpression of shox2 leading to congenital dysplasia of the TMJ, a mouse model in which Ihh and shox2 were overexpressed (Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice) was utilized to assess the consequences of this overexpression on TMJ development during post-natal life. ... These combinatory cellular and molecular defects appeared to account for the observed congenital dysplasia of TMJ, suggesting that overexpression of Ihh partially rescued shox2 overexpression‑associated congenital dysplasia of the TMJ in mice." [[Mouse Development]] \|[http://omim.org/entry/600726 OMIM IHH] \| [http://omim.org/entry/602504 OMIM SHOX2]		* '''Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression‑associated congenital dysplasia of the temporomandibular joint in mice'''{{#pmid:26096903\|PMID26096903}} "The role of short stature homeobox 2 (shox2) in the development and homeostasis of the temporomandibular joint (TMJ) has been well documented. Shox2 is known to be expressed in the progenitor cells and perichondrium of the developing condyle. A previous study by our group reported that overexpression of shox2 leads to congenital dysplasia of the TMJ via downregulation of the Indian hedgehog (Ihh) signaling pathway, which is essential for embryonic disc primordium formation and mandibular condylar growth. To determine whether overexpression of Ihh may rescue the overexpression of shox2 leading to congenital dysplasia of the TMJ, a mouse model in which Ihh and shox2 were overexpressed (Wnt1-Cre; pMes-stop shox2; pMes-stop Ihh mice) was utilized to assess the consequences of this overexpression on TMJ development during post-natal life. ... These combinatory cellular and molecular defects appeared to account for the observed congenital dysplasia of TMJ, suggesting that overexpression of Ihh partially rescued shox2 overexpression‑associated congenital dysplasia of the TMJ in mice." [[Mouse Development]] \|[http://omim.org/entry/600726 OMIM IHH] \| [http://omim.org/entry/602504 OMIM SHOX2]
	* '''Analysis by Light, Scanning, and Transmission Microscopy of the Intima Synovial of the Temporomandibular Joint of Human Fetuses during the Development'''~~<ref name="PMID24527214"><pubmed>~~24527214~~</pubmed>~~\| ~~[http://www.hindawi.com/journals/ari/2014/732720 Anat Res Int.]</ref>~~ "To characterize morphologically and ultrastructurally using light microscopy, the scanning electron microscopy and transmission electron microscopy the intima synovial of the temporomandibular joint (TMJ) of human fetuses between the 10th and the 38th week of development. Materials and Methods. The TMJ was dissected bilaterally in 37 human fetuses belonging to the Institute of Embryology of the University Complutense of Madrid and of the Federal University of São Paulo. Results. The outcome by light microscopy showed the morphology of the TMJ and that the formation of inferior joint cavity precedes the superior joint cavity and the presence of blood vessels in the synovial. Conclusion. By scanning and transmission electron microscopy we observed the presence of two well-defined cell types in the intima layer of synovial of the TMJ of human fetuses, macrophage-like type A cell and fibroblast-like type B cell, and the presence of the a third cell type, defined by the name of intermediate lining cell in the intima layer of the synovial."
			* '''Analysis by Light, Scanning, and Transmission Microscopy of the Intima Synovial of the Temporomandibular Joint of Human Fetuses during the Development'''{{#pmid:24527214\|PMID24527214}} "To characterize morphologically and ultrastructurally using light microscopy, the scanning electron microscopy and transmission electron microscopy the intima synovial of the temporomandibular joint (TMJ) of human fetuses between the 10th and the 38th week of development. Materials and Methods. The TMJ was dissected bilaterally in 37 human fetuses belonging to the Institute of Embryology of the University Complutense of Madrid and of the Federal University of São Paulo. Results. The outcome by light microscopy showed the morphology of the TMJ and that the formation of inferior joint cavity precedes the superior joint cavity and the presence of blood vessels in the synovial. Conclusion. By scanning and transmission electron microscopy we observed the presence of two well-defined cell types in the intima layer of synovial of the TMJ of human fetuses, macrophage-like type A cell and fibroblast-like type B cell, and the presence of the a third cell type, defined by the name of intermediate lining cell in the intima layer of the synovial."
	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
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	===Reviews===		===Reviews===
	~~<pubmed></pubmed>~~		{{#pmid:18778456}}
	~~<pubmed>18778456</pubmed>~~
	~~<pubmed>~~17234536~~</pubmed>~~		{{#pmid:17234536}}
	~~<pubmed>~~12980883~~</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1273756/pdf/janat00473-0110.pdf PDF]~~
			{{#pmid:12980883}}
	===Articles===		===Articles===
	~~<pubmed></pubmed>~~		{{#pmid:10321990}}
	~~<pubmed></pubmed>~~
	~~<pubmed></pubmed>~~		{{#pmid:3855934}}
	~~<pubmed>10321990</pubmed>~~
	~~<pubmed>~~3855934~~</pubmed>~~

	===Search PubMed===		===Search PubMed===

Z8600021 at 01:48, 1 March 2018

2018-03-01T01:48:12Z

← Older revision		Revision as of 12:48, 1 March 2018
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	{{Joint Links}}		{{Joint Links}}

	Historic Embryology:		'''Historic Embryology:'''

			* {{Ref-Symons1952}}

	* {{Ref-Whillis1940}}		* {{Ref-Whillis1940}}

	* {{Ref-Symons1952}}		<br>

	{{Musculoskeletal Links}}		{{Musculoskeletal Links}}
	==Some Recent Findings==		==Some Recent Findings==

Z8600021 at 01:45, 1 March 2018

2018-03-01T01:45:07Z

← Older revision		Revision as of 12:45, 1 March 2018
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	{{Joint Links}}~~\| [[Musculoskeletal System - Skull Development\|Skull Development]]~~		{{Joint Links}}

			Historic Embryology:

			* {{Ref-Whillis1940}}

			* {{Ref-Symons1952}}

	{{Musculoskeletal Links}}		{{Musculoskeletal Links}}

Z8600021 at 14:49, 15 July 2015

2015-07-15T14:49:23Z

← Older revision		Revision as of 01:49, 16 July 2015
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	In the adult, the region where two skeletal bones meet and articulate is called a "joint", that are classified based upon their: anatomical structure, mobility and shape. In the embryo, the majority of the vertebrate skeleton is initially formed as a cartilage template, that is later replaced by bone except at the interface between two adjacent bones, leaving in the adult a layer of cartilage in this region. The musculoskeletal system consists of skeletal muscle, bone, and cartilage and is mainly mesoderm in origin with some neural crest contribution.		In the adult, the region where two skeletal bones meet and articulate is called a "joint", that are classified based upon their: anatomical structure, mobility and shape. In the embryo, the majority of the vertebrate skeleton is initially formed as a cartilage template, that is later replaced by bone except at the interface between two adjacent bones, leaving in the adult a layer of cartilage in this region. The musculoskeletal system consists of skeletal muscle, bone, and cartilage and is mainly mesoderm in origin with some neural crest contribution.


	{{Joint Links}}\| [[Musculoskeletal System - Skull Development\|Skull Development]]		{{Joint Links}}\| [[Musculoskeletal System - Skull Development\|Skull Development]]


	{{Musculoskeletal Links}}		{{Musculoskeletal Links}}

Z8600021 at 02:19, 3 July 2015

2015-07-03T02:19:15Z

← Older revision		Revision as of 13:19, 3 July 2015
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	The Temporomandibular Joint (TMJ) is a bilateral synovial articulation between the ends of the mandible (lower jaw) and temporal bone ( part of the skull).		The Temporomandibular Joint (TMJ) is a bilateral synovial articulation between the ends of the mandible (lower jaw) and temporal bone ( part of the skull).

	~~In the adult, the region where two skeletal bones meet~~ and ~~articulate~~ is ~~called a~~ "~~joint~~"~~, that are classified based upon their~~: ~~anatomical structure, mobility and shape~~.		The earliest review of human embryonic and fetal TMJ development is by Symons in 1952.<ref name="PMID12980883"><pubmed>12980883</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1273756/pdf/janat00473-0110.pdf PDF]</ref>

	In the embryo, the majority of the vertebrate skeleton is initially formed as a cartilage template, that is later replaced by bone except at the interface between two adjacent bones, leaving in the adult a layer of cartilage in this region. The musculoskeletal system consists of skeletal muscle, bone, and cartilage and is mainly mesoderm in origin with some neural crest contribution.

			In the adult, the region where two skeletal bones meet and articulate is called a "joint", that are classified based upon their: anatomical structure, mobility and shape. In the embryo, the majority of the vertebrate skeleton is initially formed as a cartilage template, that is later replaced by bone except at the interface between two adjacent bones, leaving in the adult a layer of cartilage in this region. The musculoskeletal system consists of skeletal muscle, bone, and cartilage and is mainly mesoderm in origin with some neural crest contribution.

	{{Joint Links}}\| [[Musculoskeletal System - Skull Development\|Skull Development]]		{{Joint Links}}\| [[Musculoskeletal System - Skull Development\|Skull Development]]
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	===Reviews===		===Reviews===
	<pubmed></pubmed>		<pubmed></pubmed>
	<pubmed></pubmed>		<pubmed>18778456</pubmed>
	<pubmed></pubmed>		<pubmed>17234536</pubmed>
			<pubmed>12980883</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1273756/pdf/janat00473-0110.pdf PDF]
	===Articles===		===Articles===
	<pubmed></pubmed>		<pubmed></pubmed>
Line 112:		Line 113:
	<pubmed>10321990</pubmed>		<pubmed>10321990</pubmed>
	<pubmed>3855934</pubmed>		<pubmed>3855934</pubmed>
	~~<pubmed>12980883</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1273756/pdf/janat00473-0110.pdf PDF]~~

	===Search PubMed===		===Search PubMed===