File:Trunk neural crest migration.jpg - Revision history

Z8600021: /* Reference */

2018-12-11T21:14:46Z

Reference

← Older revision		Revision as of 08:14, 12 December 2018
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	===Reference===		===Reference===
	~~<pubmed>~~19325129~~</pubmed>\| [http://www.pnas.org/content/106/15/6164.abstract PNAS]~~		{{#pmid:19325129}}


	{{PNAS}}		{{PNAS}}

Z8600021: /* Model SEMA3A and NRP1 control trunk Neural Crest Cell migration to organise Mouse PNS neurons */

2016-05-26T03:33:27Z

Model SEMA3A and NRP1 control trunk Neural Crest Cell migration to organise Mouse PNS neurons

← Older revision		Revision as of 14:33, 26 Mayıs 2016
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	(A and B) NCC migration pathways at 9.5 dpc.		(A and B) NCC migration pathways at 9.5 dpc.

	* A - In wild-types, only a few intermediate wave NCCs are NRP1-negative (green) and travel alongside intersomitic and perisomitic vessels (red). Rather, most NCCs are NRP1-positive (yellow) and are channeled into the anterior sclerotome by repulsive SEMA3A signals. Accordingly, Sema3A (blue) is expressed in 2 domains, a narrow stripe in the dermomyotome adjacent to the preceding intersomitic furrow, and a broader domain in the posterior dermomyotome that extends into the posterior sclerotome.		* '''A''' - In wild-types, only a few intermediate wave NCCs are NRP1-negative (green) and travel alongside intersomitic and perisomitic vessels (red). Rather, most NCCs are NRP1-positive (yellow) and are channeled into the anterior sclerotome by repulsive SEMA3A signals. Accordingly, Sema3A (blue) is expressed in 2 domains, a narrow stripe in the dermomyotome adjacent to the preceding intersomitic furrow, and a broader domain in the posterior dermomyotome that extends into the posterior sclerotome.
	* B - In the absence of NRP1 signaling, intermediate wave NCCs are blind to SEMA3A (now shown in gray) and preferentially migrate alongside intersomitic blood vessels (red), similar to early wave NCCs. (C and D) Peripheral neuron position in wild-types and Nrp1-null mutants at 11.5 dpc reflects the migratory patterns of their NCC precursors.		* '''B''' - In the absence of NRP1 signaling, intermediate wave NCCs are blind to SEMA3A (now shown in gray) and preferentially migrate alongside intersomitic blood vessels (red), similar to early wave NCCs. (C and D) Peripheral neuron position in wild-types and Nrp1-null mutants at 11.5 dpc reflects the migratory patterns of their NCC precursors.
	* C - In wild-types, sensory neurons condense into segmentally arranged dorsal root ganglia in the anterior sclerotome of the somites, while sympathetic neurons form paired, but nonsegmented primary sympathetic cords next to the dorsal aorta.		* '''C''' - In wild-types, sensory neurons condense into segmentally arranged dorsal root ganglia in the anterior sclerotome of the somites, while sympathetic neurons form paired, but nonsegmented primary sympathetic cords next to the dorsal aorta.
	* D - In the absence of SEMA3A/NRP1 signaling, sensory and sympathetic neurons differentiate in ectopic positions corresponding to the earlier position of their NCC precursors. Consequently, both the segmentation of the sensory system and the assembly of the sympathetic cords are disrupted.		* '''D''' - In the absence of SEMA3A/NRP1 signaling, sensory and sympathetic neurons differentiate in ectopic positions corresponding to the earlier position of their NCC precursors. Consequently, both the segmentation of the sensory system and the assembly of the sympathetic cords are disrupted.

	Abbreviations: da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.		Abbreviations: da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.

Z8600021 at 01:23, 29 March 2016

2016-03-29T01:23:15Z

← Older revision		Revision as of 12:23, 29 March 2016
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	==Model SEMA3A and NRP1 control trunk Neural Crest Cell migration to ~~organize~~ PNS neurons==		==Model SEMA3A and NRP1 control trunk Neural Crest Cell migration to organise Mouse PNS neurons==

	(A and B) NCC migration pathways at 9.5 dpc.		(A and B) NCC migration pathways at 9.5 dpc.

Z8600021 at 01:22, 29 March 2016

2016-03-29T01:22:34Z

← Older revision		Revision as of 12:22, 29 March 2016
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	Abbreviations: da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.		Abbreviations: da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.


			{{Neural Crest Links}}

	===Reference===		===Reference===

Z8600021 at 01:21, 29 March 2016

2016-03-29T01:21:46Z

← Older revision		Revision as of 12:21, 29 March 2016
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	Abbreviations: da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.		Abbreviations: da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.

	~~Original File: Fig. 7. http://www.pnas.org/content/106/15/6164/F7.large.jpg~~

	===Reference===		===Reference===
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			Original File: Fig. 7. http://www.pnas.org/content/106/15/6164/F7.large.jpg

			{{Footer}}

	[[Category:Neural Crest]] [[Category:Mouse]] [[Category:Mouse E9.5]] [[Category:Mouse E11.5]]		[[Category:Neural Crest]] [[Category:Mouse]] [[Category:Mouse E9.5]] [[Category:Mouse E11.5]]

Z8600021 at 05:36, 8 September 2014

2014-09-08T05:36:07Z

← Older revision		Revision as of 16:36, 8 September 2014
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	==Model: SEMA3A and NRP1 control trunk Neural Crest Cell migration to organize PNS neurons==		==Model SEMA3A and NRP1 control trunk Neural Crest Cell migration to organize PNS neurons==

	(A and B) NCC migration pathways at 9.5 dpc.		(A and B) NCC migration pathways at 9.5 dpc.

	(A) In wild-types, only a few intermediate wave NCCs are NRP1-negative (green) and travel alongside intersomitic and perisomitic vessels (red). Rather, most NCCs are NRP1-positive (yellow) and are channeled into the anterior sclerotome by repulsive SEMA3A signals. Accordingly, Sema3A (blue) is expressed in 2 domains, a narrow stripe in the dermomyotome adjacent to the preceding intersomitic furrow, and a broader domain in the posterior dermomyotome that extends into the posterior sclerotome.		* A - In wild-types, only a few intermediate wave NCCs are NRP1-negative (green) and travel alongside intersomitic and perisomitic vessels (red). Rather, most NCCs are NRP1-positive (yellow) and are channeled into the anterior sclerotome by repulsive SEMA3A signals. Accordingly, Sema3A (blue) is expressed in 2 domains, a narrow stripe in the dermomyotome adjacent to the preceding intersomitic furrow, and a broader domain in the posterior dermomyotome that extends into the posterior sclerotome.
			* B - In the absence of NRP1 signaling, intermediate wave NCCs are blind to SEMA3A (now shown in gray) and preferentially migrate alongside intersomitic blood vessels (red), similar to early wave NCCs. (C and D) Peripheral neuron position in wild-types and Nrp1-null mutants at 11.5 dpc reflects the migratory patterns of their NCC precursors.
	(B) In the absence of NRP1 signaling, intermediate wave NCCs are blind to SEMA3A (now shown in gray) and preferentially migrate alongside intersomitic blood vessels (red), similar to early wave NCCs. (C and D) Peripheral neuron position in wild-types and Nrp1-null mutants at 11.5 dpc reflects the migratory patterns of their NCC precursors.		* C - In wild-types, sensory neurons condense into segmentally arranged dorsal root ganglia in the anterior sclerotome of the somites, while sympathetic neurons form paired, but nonsegmented primary sympathetic cords next to the dorsal aorta.
			* D - In the absence of SEMA3A/NRP1 signaling, sensory and sympathetic neurons differentiate in ectopic positions corresponding to the earlier position of their NCC precursors. Consequently, both the segmentation of the sensory system and the assembly of the sympathetic cords are disrupted.
	(C) In wild-types, sensory neurons condense into segmentally arranged dorsal root ganglia in the anterior sclerotome of the somites, while sympathetic neurons form paired, but nonsegmented primary sympathetic cords next to the dorsal aorta.

	(D) In the absence of SEMA3A/NRP1 signaling, sensory and sympathetic neurons differentiate in ectopic positions corresponding to the earlier position of their NCC precursors. Consequently, both the segmentation of the sensory system and the assembly of the sympathetic cords are disrupted.

	Abbreviations: da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.		Abbreviations: da, dorsal aorta; dm, dermomyotome; isv, intersomitic vessel; psv, perisomitic vessel; pcv, posterior cardinal vein; scl, sclerotome.
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	Original File: Fig. 7. http://www.pnas.org/content/106/15/6164/F7.large.jpg		Original File: Fig. 7. http://www.pnas.org/content/106/15/6164/F7.large.jpg

	==Reference==		===Reference===
	<pubmed>19325129</pubmed>\| [http://www.pnas.org/content/106/15/6164.abstract PNAS]		<pubmed>19325129</pubmed>\| [http://www.pnas.org/content/106/15/6164.abstract PNAS]


	{{~~Template:~~PNAS}}		{{PNAS}}

S8600021 at 07:26, 31 August 2010

2010-08-31T07:26:56Z

← Older revision		Revision as of 18:26, 31 August 2010
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	[[Category:Neural Crest]]		[[Category:Neural Crest]] [[Category:Mouse]] [[Category:Mouse E9.5]] [[Category:Mouse E11.5]]

S8600021: /* Reference */

2010-08-31T07:24:35Z

Reference

← Older revision		Revision as of 18:24, 31 August 2010
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	{{Template:PNAS}}		{{Template:PNAS}}

	~~Open Access Article~~


	[[Category:Neural Crest]]		[[Category:Neural Crest]]

S8600021: /* Reference */

2010-08-31T07:24:08Z

Reference

← Older revision		Revision as of 18:24, 31 August 2010
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	==Reference==		==Reference==
	<pubmed>19325129</pubmed>\| [http://www.pnas.org/content/106/15/6164.abstract PNAS]		<pubmed>19325129</pubmed>\| [http://www.pnas.org/content/106/15/6164.abstract PNAS]


			{{Template:PNAS}}

	Open Access Article		Open Access Article

	[[Category:Neural Crest]]		[[Category:Neural Crest]]

S8600021 at 07:23, 31 August 2010

2010-08-31T07:23:37Z

← Older revision		Revision as of 18:23, 31 August 2010
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	Open Access Article		Open Access Article

			[[Category:Neural Crest]]