File:Role of FXN Gene.jpg - Revision history

S8600021 at 04:01, 29 October 2011

2011-10-29T04:01:47Z

← Older revision		Revision as of 15:01, 29 October 2011
Line 5:		Line 5:
	===References===		===References===

	<pubmed>2465796</pubmed>\| [~~http://~~http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2465796 PMC2465796]		<pubmed>2465796</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2465796 PMC2465796]


	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.		This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

			===Assessment===
			+ Relevant image to group project.
			+ This model is an important summary.
			+ Includes reference, copyright and student disclaimer.
			+/- Includes legend which appears to be original figure legend with no additional peer teaching component.

	{{Template:2011 Student Image}}		{{Template:2011 Student Image}}

Z3332250: /* References */

2011-10-06T01:01:25Z

References

← Older revision		Revision as of 12:01, 6 October 2011
Line 9:		Line 9:

	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.		This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.


			{{Template:2011 Student Image}}

Z3332250: A model of how cytosolic iron depletion decreases expression of frataxin in FA patients and may thereby exacerbate disease. Frataxin deficiency mainly caused by the triplet GAA repeat expansion in the first intron of frataxin gene leads to decreased frata

2011-10-04T09:34:59Z

New page

A model of how cytosolic iron depletion decreases expression of frataxin in FA patients and may thereby exacerbate disease. Frataxin deficiency mainly caused by the triplet GAA repeat expansion in the first intron of frataxin gene leads to decreased frataxin expression and impairment of mitochondrial iron–sulfur cluster [Fe–S] assembly. Mitochondrial iron overload develops as a consequence of deficient [Fe–S] assembly in mitochondria which leads to misregulation of mitochondrial iron homeostasis. Excess mitochondrial iron uptake and sequestration causes cytosolic iron depletion, which can further diminish frataxin expression by decreasing frataxin transcription. Thus, the decrease in frataxin levels caused by the trinucleotide repeat may be worsened as cells accumulate mitochondrial iron and deplete cytosolic iron stores. This negative feedback loop may contribute to progression of disease in long-lived cells, particularly neurons and cardiomyocytes.
----

===References===

<pubmed>2465796</pubmed>| [http://http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2465796 PMC2465796]

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.