File:Notch structure cartoon.jpg - Revision history

Z8600021 at 03:49, 31 August 2016

2016-08-31T03:49:08Z

← Older revision		Revision as of 14:49, 31 August 2016
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	{{JCB}}		{{JCB}}

			{{Footer}}
	[[Category:Notch]] [[Category:Molecular]] [[Category:Pattern]]		[[Category:Notch]] [[Category:Molecular]] [[Category:Pattern]]
	[[Category:Developmental Signal]]		[[Category:Developmental Signal]]

Z8600021: /* Notch Structure cartoon */

2015-02-10T20:42:49Z

Notch Structure cartoon

← Older revision		Revision as of 07:42, 11 February 2015
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	{\|		{\|
	\| The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).		\| The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).
	\| width=~~300px~~\|		\| width=400px\|
	* gray ovals - N-terminal 36 EGF-like repeats		* gray ovals - N-terminal 36 EGF-like repeats
	* orange ovals - (LNR) lin-12 Notch		* orange ovals - (LNR) lin-12 Notch

Z8600021: /* Notch Structure cartoon */

2015-02-10T20:42:28Z

Notch Structure cartoon

← Older revision		Revision as of 07:42, 11 February 2015
Line 2:		Line 2:
	{\|		{\|
	\| The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).		\| The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).
	\| width=300px}		\| width=300px\|
	* gray ovals - N-terminal 36 EGF-like repeats		* gray ovals - N-terminal 36 EGF-like repeats
	* orange ovals - (LNR) lin-12 Notch		* orange ovals - (LNR) lin-12 Notch

Z8600021: /* Notch Structure cartoon */

2015-02-10T20:42:08Z

Notch Structure cartoon

← Older revision		Revision as of 07:42, 11 February 2015
Line 2:		Line 2:
	{\|		{\|
	\| The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).		\| The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).
	\|		\| width=300px}
	* gray ovals - N-terminal 36 EGF-like repeats		* gray ovals - N-terminal 36 EGF-like repeats
	* orange ovals - (LNR) lin-12 Notch		* orange ovals - (LNR) lin-12 Notch

Z8600021: /* Notch Structure cartoon */

2015-02-10T20:41:35Z

Notch Structure cartoon

← Older revision		Revision as of 07:41, 11 February 2015
Line 1:		Line 1:
	==Notch Structure cartoon==		==Notch Structure cartoon==
			{\|
	The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).		\| The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).
			\|

	* gray ovals - N-terminal 36 EGF-like repeats		* gray ovals - N-terminal 36 EGF-like repeats
	* orange ovals - lin-12 Notch		* orange ovals - (LNR) lin-12 Notch
	* pink ovals - EGF repeats		* pink ovals - EGF repeats
	* gray rectangles - ankyrin (ANK) domain		* gray rectangles - ankyrin (ANK) domain
	* gray star - C-terminal PEST sequence		* gray star - C-terminal PEST sequence
	* red arrows - cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).		* red arrows - cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).
			\|}

	{{Notch links}}		{{Notch links}}

Z8600021 at 20:40, 10 February 2015

2015-02-10T20:40:32Z

← Older revision		Revision as of 07:40, 11 February 2015
Line 3:		Line 3:
	The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).		The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).


			* gray ovals - N-terminal 36 EGF-like repeats
			* orange ovals - lin-12 Notch
			* pink ovals - EGF repeats
			* gray rectangles - ankyrin (ANK) domain
			* gray star - C-terminal PEST sequence
			* red arrows - cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).

Z8600021: ==Notch Structure cartoon== The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an...

2015-02-04T10:49:31Z

New page

==Notch Structure cartoon==

The N-terminal part of the Notch ectodomain consists of 36 EGF-like repeats (gray ovals) and three LNRs (lin-12 Notch repeat; orange ovals). EGF repeats 11 and 12 interact with the ligands (pink ovals). NICD consists of an N-terminal RAM (recombination binding protein-J -associated molecule) domain, an ankyrin (ANK) domain (gray rectangles), and less-conserved regions, including a variable transactivation domain and a C-terminal PEST sequence (gray star). The red arrows indicate the cleavage sites: S1 (Furin), S2 (ADAM metalloprotease), and S3/S4 (γ-secretase).

{{Notch links}}

===Reference===

<pubmed>19255248</pubmed>

{{JCB}}

[[Category:Notch]] [[Category:Molecular]] [[Category:Pattern]]
[[Category:Developmental Signal]]