File:Neural tube SHH patterning cartoon.jpg - Revision history

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	===Reference===		===Reference===
	~~<pubmed>~~19197245~~</pubmed>~~		{{#pmid:19197245}}

	~~PMCID: PMC2647768~~

	====Copyright====		====Copyright====

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	Original file name: Emboj200912f1.jpg		Original file name: Emboj200912f1.jpg

			{{Footer}}
	[[Category:Neural]] [[Category:Molecular]] [[Category:Spinal Cord]] [[Category:Sonic Hedgehog]]		[[Category:Neural]] [[Category:Molecular]] [[Category:Spinal Cord]] [[Category:Sonic Hedgehog]]

Z8600021 at 22:14, 20 February 2015

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	<pubmed>19197245</pubmed>		<pubmed>19197245</pubmed>

	~~EMBO J. 2009 March 4; 28(5): 457–465. Published online 2009 February 5. doi: 10.1038/emboj.2009.12.~~
	PMCID: PMC2647768		PMCID: PMC2647768

Z8600021: /* Reference */

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Reference

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	===Reference===		===Reference===
	~~Making a grade: Sonic Hedgehog signalling and the control of neural cell fate~~		<pubmed>19197245</pubmed>
	~~James Briscoe~~

	EMBO J. 2009 March 4; 28(5): 457–465. Published online 2009 February 5. doi: 10.1038/emboj.2009.12.		EMBO J. 2009 March 4; 28(5): 457–465. Published online 2009 February 5. doi: 10.1038/emboj.2009.12.

Z8600021 at 22:11, 20 February 2015

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	==Sonic Hedgehog acts in a graded manner to pattern the ventral neural tube==		==Sonic Hedgehog acts in a graded manner to pattern the ventral neural tube==

	(A) A morphogen can pattern a developing tissue. A secreted signal (blue) is produced from a localized source (S) and spreads through the tissue to establish a gradient. Cells respond to different concentrations of the signal by regulating different sets of genes (red, orange and yellow). This induces distinct cell fates (A, B and C) at different distances from S (adapted from the French Flag Model in Wolpert, 1969).		'''A''' A morphogen can pattern a developing tissue. A secreted signal (blue) is produced from a localized source (S) and spreads through the tissue to establish a gradient. Cells respond to different concentrations of the signal by regulating different sets of genes (red, orange and yellow). This induces distinct cell fates (A, B and C) at different distances from S (adapted from the French Flag Model in Wolpert, 1969).

	(B) Shh protein (brown) is produced from the notochord (n) and floor plate at the ventral midline of the neural tube. Shh spreads dorsally establishing a gradient that controls the generation of distinct neuronal subtypes (interneurons (V0–V3) and motor neurons (MN)). In vitro, different concentrations of Shh are sufficient to induce the distinct neuronal subtypes. The concentration of Shh necessary to induce a specific subtype corresponds to its position of generation in vivo.		'''B''' Shh protein (brown) is produced from the notochord (n) and floor plate at the ventral midline of the neural tube. Shh spreads dorsally establishing a gradient that controls the generation of distinct neuronal subtypes (interneurons (V0–V3) and motor neurons (MN)). In vitro, different concentrations of Shh are sufficient to induce the distinct neuronal subtypes. The concentration of Shh necessary to induce a specific subtype corresponds to its position of generation in vivo.


			{{Sonic hedgehog links}}

	===Reference===		===Reference===

Z8600021 at 22:10, 20 February 2015

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	(B) Shh protein (brown) is produced from the notochord (n) and floor plate at the ventral midline of the neural tube. Shh spreads dorsally establishing a gradient that controls the generation of distinct neuronal subtypes (interneurons (V0–V3) and motor neurons (MN)). In vitro, different concentrations of Shh are sufficient to induce the distinct neuronal subtypes. The concentration of Shh necessary to induce a specific subtype corresponds to its position of generation in vivo.		(B) Shh protein (brown) is produced from the notochord (n) and floor plate at the ventral midline of the neural tube. Shh spreads dorsally establishing a gradient that controls the generation of distinct neuronal subtypes (interneurons (V0–V3) and motor neurons (MN)). In vitro, different concentrations of Shh are sufficient to induce the distinct neuronal subtypes. The concentration of Shh necessary to induce a specific subtype corresponds to its position of generation in vivo.

	~~Original file name: Emboj200912f1.jpg~~


			===Reference===
	Making a grade: Sonic Hedgehog signalling and the control of neural cell fate		Making a grade: Sonic Hedgehog signalling and the control of neural cell fate
	James Briscoe		James Briscoe
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	PMCID: PMC2647768		PMCID: PMC2647768

			====Copyright====
	This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation without specific permission.		This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation without specific permission.

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	Published online 2009 February 5. doi: 10.1038/emboj.2009.12.		Published online 2009 February 5. doi: 10.1038/emboj.2009.12.
	Copyright © 2009, European Molecular Biology Organization		Copyright © 2009, European Molecular Biology Organization

			Original file name: Emboj200912f1.jpg

	[[Category:Neural]] [[Category:Molecular]] [[Category:Spinal Cord]] [[Category:Sonic Hedgehog]]		[[Category:Neural]] [[Category:Molecular]] [[Category:Spinal Cord]] [[Category:Sonic Hedgehog]]

Z8600021: ==Sonic Hedgehog acts in a graded manner to pattern the ventral neural tube== (A) A morphogen can pattern a developing tissue. A secreted signal (blue) is produced from a localized source (S) and spreads through the tissue to establish a gradient. Cel...

2015-02-20T22:09:23Z

New page

==Sonic Hedgehog acts in a graded manner to pattern the ventral neural tube==

(A) A morphogen can pattern a developing tissue. A secreted signal (blue) is produced from a localized source (S) and spreads through the tissue to establish a gradient. Cells respond to different concentrations of the signal by regulating different sets of genes (red, orange and yellow). This induces distinct cell fates (A, B and C) at different distances from S (adapted from the French Flag Model in Wolpert, 1969).

(B) Shh protein (brown) is produced from the notochord (n) and floor plate at the ventral midline of the neural tube. Shh spreads dorsally establishing a gradient that controls the generation of distinct neuronal subtypes (interneurons (V0–V3) and motor neurons (MN)). In vitro, different concentrations of Shh are sufficient to induce the distinct neuronal subtypes. The concentration of Shh necessary to induce a specific subtype corresponds to its position of generation in vivo.

Original file name: Emboj200912f1.jpg

Making a grade: Sonic Hedgehog signalling and the control of neural cell fate
James Briscoe

EMBO J. 2009 March 4; 28(5): 457–465. Published online 2009 February 5. doi: 10.1038/emboj.2009.12.
PMCID: PMC2647768

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation without specific permission.

EMBO J. 2009 March 4; 28(5): 457–465.
Published online 2009 February 5. doi: 10.1038/emboj.2009.12.
Copyright © 2009, European Molecular Biology Organization

[[Category:Neural]] [[Category:Molecular]] [[Category:Spinal Cord]] [[Category:Sonic Hedgehog]]