File:Mouse ventral body wall development 02.jpg - Revision history

Z8600021 at 02:21, 11 April 2019

2019-04-11T02:21:47Z

← Older revision		Revision as of 13:21, 11 April 2019
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	The omphalocele, pubic diastasis, loss of pubic bones and polydactyly in Gli3Xt; Alx4Lst; Shh combinatorial mutants.		The omphalocele, pubic diastasis, loss of pubic bones and polydactyly in Gli3Xt; Alx4Lst; Shh combinatorial mutants.

	The lateral view of the embryonic ventral body wall (A–D, E, H) and frontal view of the pelvic girdle (A'–D', F, I). Gli3Xt/Xt embryos (B), Gli3Xt/Xt; Alx4Lst/+ embryos (C) and Gli3Xt/Xt; Alx4Lst/Lst embryos (D) showed a graded extent of omphaloceles by the introduction of additional Alx4Lst alleles into the Gli3Xt/Xt background (B–D; white arrows). The dorsal parts of the genital tubercle were hypoplastic in Gli3Xt/Xt; Alx4Lst/+ and Gli3Xt/Xt; Alx4Lst/Lst embryos (C, D; red arrowheads). The pubic symphysis of wild-type embryo was already formed at ~~E18~~.5 (A'; asterisk). Pubic diastasis also became evident by the introduction of Alx4Lst mutation (B'–D'). Gli3Xt/Xt; Alx4Lst/+ and Gli3Xt/Xt; Alx4Lst/Lst embryos showed partial loss of pubic bone components (C', D'; yellow arrowheads). Black arrows indicate the unclosed pelvis. Gli3Xt/+; Alx4Lst/Lst embryos showed omphalocele (E; red arrow), severe polydactyly (G), pubic diastasis and loss of pubic bones (F). Black arrows show the unclosed pelvis. Gli3Xt/+; Alx4Lst/Lst; Shh+/− embryos did not show omphalocele phenotypes (H). The pubic symphysis was formed but pubic bones were lost (I; asterisk). Polydactyly was still observed in Gli3Xt/+; Alx4Lst/Lst; Shh+/− embryos (J). Black arrowheads indicate extra digits.		The lateral view of the embryonic ventral body wall (A–D, E, H) and frontal view of the pelvic girdle (A'–D', F, I). Gli3Xt/Xt embryos (B), Gli3Xt/Xt; Alx4Lst/+ embryos (C) and Gli3Xt/Xt; Alx4Lst/Lst embryos (D) showed a graded extent of omphaloceles by the introduction of additional Alx4Lst alleles into the Gli3Xt/Xt background (B–D; white arrows). The dorsal parts of the genital tubercle were hypoplastic in Gli3Xt/Xt; Alx4Lst/+ and Gli3Xt/Xt; Alx4Lst/Lst embryos (C, D; red arrowheads).

			The pubic symphysis of wild-type embryo was already formed at {{ME18.5}} (A'; asterisk). Pubic diastasis also became evident by the introduction of Alx4Lst mutation (B'–D'). Gli3Xt/Xt; Alx4Lst/+ and Gli3Xt/Xt; Alx4Lst/Lst embryos showed partial loss of pubic bone components (C', D'; yellow arrowheads). Black arrows indicate the unclosed pelvis. Gli3Xt/+; Alx4Lst/Lst embryos showed omphalocele (E; red arrow), severe polydactyly (G), pubic diastasis and loss of pubic bones (F). Black arrows show the unclosed pelvis. Gli3Xt/+; Alx4Lst/Lst; Shh+/− embryos did not show omphalocele phenotypes (H). The pubic symphysis was formed but pubic bones were lost (I; asterisk). Polydactyly was still observed in Gli3Xt/+; Alx4Lst/Lst; Shh+/− embryos (J). Black arrowheads indicate extra digits.

	* f - femur		* f - femur

	* fl - fore limb		* fl - fore limb

	* gt - genital tubercle		* gt - genital tubercle

	* il - iliac bone		* il - iliac bone

	* is - ischial bone		* is - ischial bone

	* om - omphalocele		* om - omphalocele

	* ps - pubic symphysis		* ps - pubic symphysis

	* pu - pubic bone		* pu - pubic bone

	* t - tail		* t - tail

	* uc - umbilical cord		* uc - umbilical cord

	Original file name: Figure 3. Journal.pone.0016260.g003.jpg doi:10.1371/journal.pone.0016260.g003		Original file name: Figure 3. Journal.pone.0016260.g003.jpg doi:10.1371/journal.pone.0016260.g003


	===Reference===		===Reference===

Z8600021 at 10:36, 8 April 2018

2018-04-08T10:36:53Z

← Older revision		Revision as of 21:36, 8 April 2018
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	===Reference===		===Reference===
			{{#pmid:21283718}}

	~~<pubmed>21283718</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024424 PMC3024424] \| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0016260 PLoS One.]~~		====Copyright====


	© 2011 Matsumaru et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.		© 2011 Matsumaru et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

			{{Footer}}
	[[Category:Mouse]] [[Category:Mouse E18.5]]		[[Category:Mouse]] [[Category:Mouse E18.5]]

S8600021 at 06:06, 2 September 2011

2011-09-02T06:06:50Z

← Older revision		Revision as of 17:06, 2 September 2011
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	© 2011 Matsumaru et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.		© 2011 Matsumaru et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

	[[Category:Mouse]]		[[Category:Mouse]] [[Category:Mouse E18.5]]

	~~[[Category:Mouse E11.5]] [[Category:Mouse E12.5]] [[Category:Mouse E14.5]] [[Category:Mouse E16.5]]~~ [[Category:Mouse E18.5]]

S8600021: ==Mouse Ventral Body Wall Development== The omphalocele, pubic diastasis, loss of pubic bones and polydactyly in Gli3Xt; Alx4Lst; Shh combinatorial mutants. The lateral view of the embryonic ventral body wall (A–D, E, H) and frontal view of the pelvic

2011-09-02T06:04:23Z

New page

==Mouse Ventral Body Wall Development==

The omphalocele, pubic diastasis, loss of pubic bones and polydactyly in Gli3Xt; Alx4Lst; Shh combinatorial mutants.

The lateral view of the embryonic ventral body wall (A–D, E, H) and frontal view of the pelvic girdle (A'–D', F, I). Gli3Xt/Xt embryos (B), Gli3Xt/Xt; Alx4Lst/+ embryos (C) and Gli3Xt/Xt; Alx4Lst/Lst embryos (D) showed a graded extent of omphaloceles by the introduction of additional Alx4Lst alleles into the Gli3Xt/Xt background (B–D; white arrows). The dorsal parts of the genital tubercle were hypoplastic in Gli3Xt/Xt; Alx4Lst/+ and Gli3Xt/Xt; Alx4Lst/Lst embryos (C, D; red arrowheads). The pubic symphysis of wild-type embryo was already formed at E18.5 (A'; asterisk). Pubic diastasis also became evident by the introduction of Alx4Lst mutation (B'–D'). Gli3Xt/Xt; Alx4Lst/+ and Gli3Xt/Xt; Alx4Lst/Lst embryos showed partial loss of pubic bone components (C', D'; yellow arrowheads). Black arrows indicate the unclosed pelvis. Gli3Xt/+; Alx4Lst/Lst embryos showed omphalocele (E; red arrow), severe polydactyly (G), pubic diastasis and loss of pubic bones (F). Black arrows show the unclosed pelvis. Gli3Xt/+; Alx4Lst/Lst; Shh+/− embryos did not show omphalocele phenotypes (H). The pubic symphysis was formed but pubic bones were lost (I; asterisk). Polydactyly was still observed in Gli3Xt/+; Alx4Lst/Lst; Shh+/− embryos (J). Black arrowheads indicate extra digits.

* f - femur
* fl - fore limb
* gt - genital tubercle
* il - iliac bone
* is - ischial bone
* om - omphalocele
* ps - pubic symphysis
* pu - pubic bone
* t - tail
* uc - umbilical cord

Original file name: Figure 3. Journal.pone.0016260.g003.jpg doi:10.1371/journal.pone.0016260.g003

===Reference===

<pubmed>21283718</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024424 PMC3024424] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0016260 PLoS One.]

© 2011 Matsumaru et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

[[Category:Mouse]]

[[Category:Mouse E11.5]] [[Category:Mouse E12.5]] [[Category:Mouse E14.5]] [[Category:Mouse E16.5]] [[Category:Mouse E18.5]]