File:Mouse placenta 01.jpg - Revision history

Z8600021: /* Mouse placental blood vessels */

2012-06-02T05:38:21Z

Mouse placental blood vessels

← Older revision		Revision as of 16:38, 2 Haziran 2012
Line 9:		Line 9:


	:'''Links:''' [[:File:Mouse placenta 02.jpg\|Mouse placental blood vessels Lateral View]] \| [[Mouse Development]] \| [[Placenta Development]~~] \| [http://embryology.med.unsw.edu.au/Notes/placenta.htm original Placenta Notes~~]		:'''Links:''' [[:File:Mouse placenta 02.jpg\|Mouse placental blood vessels Lateral View]] \| [[Mouse Development]] \| [[Placenta Development]]

S8600021: /* Mouse placental blood vessels */

2011-08-17T22:10:34Z

Mouse placental blood vessels

← Older revision		Revision as of 09:10, 18 August 2011
Line 8:		Line 8:
	Resin casts are generated by filling the existing vascular beds (day 16.5 p.c.) with a resin that sets and the surrounding materials are then removed, leaving just the vascular beds.		Resin casts are generated by filling the existing vascular beds (day 16.5 p.c.) with a resin that sets and the surrounding materials are then removed, leaving just the vascular beds.

	'''Links:''' [[:File:Mouse placenta 02.jpg\|Mouse placental blood vessels Lateral View]] \| [[Mouse Development]] \| [[Placenta Development]] \| [http://embryology.med.unsw.edu.au/Notes/placenta.htm original Placenta Notes]

	'''~~Original File~~:''' ~~Plmouseresin1~~.jpg http://embryology.med.unsw.edu.au/Notes/~~placenta6~~.htm		:'''Links:''' [[:File:Mouse placenta 02.jpg\|Mouse placental blood vessels Lateral View]] \| [[Mouse Development]] \| [[Placenta Development]] \| [http://embryology.med.unsw.edu.au/Notes/placenta.htm original Placenta Notes]



	Thanks to '''Dr Sally Dunwoodie''', Developmental Biology Program, Victor Chang Cardiac Research Institute who provided both images and information on (mouse) placental development. (Email: [mailto:s.dunwoodie@victorchang.unsw.edu.au Sally Dunwoodie])		Thanks to '''Dr Sally Dunwoodie''', Developmental Biology Program, Victor Chang Cardiac Research Institute who provided both images and information on (mouse) placental development. (Email: [mailto:s.dunwoodie@victorchang.unsw.edu.au Sally Dunwoodie])

S8600021: /* Mouse placental blood vessels */

2011-08-17T22:10:15Z

Mouse placental blood vessels

← Older revision		Revision as of 09:10, 18 August 2011
Line 13:		Line 13:

	Thanks to '''Dr Sally Dunwoodie''', Developmental Biology Program, Victor Chang Cardiac Research Institute who provided both images and information on (mouse) placental development. (Email: [mailto:s.dunwoodie@victorchang.unsw.edu.au Sally Dunwoodie])		Thanks to '''Dr Sally Dunwoodie''', Developmental Biology Program, Victor Chang Cardiac Research Institute who provided both images and information on (mouse) placental development. (Email: [mailto:s.dunwoodie@victorchang.unsw.edu.au Sally Dunwoodie])

			===Reference===

	'''Citation:''' Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL. Mol Cell Biol. 2004 Jan;24(1):228-44. [http://www.ncbi.nlm.nih.gov/pubmed/14673158 PMID: 14673158]		'''Citation:''' Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL. Mol Cell Biol. 2004 Jan;24(1):228-44. [http://www.ncbi.nlm.nih.gov/pubmed/14673158 PMID: 14673158]

S8600021 at 22:09, 17 August 2011

2011-08-17T22:09:57Z

← Older revision		Revision as of 09:09, 18 August 2011
Line 1:		Line 1:
	~~'''~~Mouse placental blood vessels~~'''~~ (E16.5) superior view (maternal side)		==Mouse placental blood vessels==

			Mouse (E16.5) superior view (maternal side)

	* Venous side - red resin		* Venous side - red resin
Line 16:		Line 18:
	:"Cited1 is a transcriptional cofactor that interacts with Smad4, estrogen receptors alpha and beta, TFAP2, and CBP/p300. It is expressed in a restricted manner in the embryo as well as in extraembryonic tissues during embryonic development. In this study we report the engineering of a loss-of-function Cited1 mutation in the mouse. Cited1 null mutants show growth restriction at 18.5 days postcoitum, and most of them die shortly after birth. Half the heterozygous females, i.e., those that carry a paternally inherited wild-type Cited1 allele, are similarly affected. Cited1 is normally expressed in trophectoderm-derived c ells of the placenta; however, in these heterozygous females, Cited1 is not expressed in these cells. This occurs because Cited1 is located on the X chromosome, and thus the wild-type Cited1 allele is not expressed because the paternal X chromosome is preferentially inactivated. Loss of Cited1 resulted in abnormal placental development. In mutants, the spongiotrophoblast layer is irregular in shape and enlarged while the labyrinthine layer is reduced in size. In addition, the blood spaces within the labyrinthine layer are disrupted; the maternal sinusoids are considerably larger in mutants, leading to a reduction in the surface area available for nutrient exchange. We conclude that Cited1 is required in trophoblasts for normal placental development and subsequently for embryo viability."		:"Cited1 is a transcriptional cofactor that interacts with Smad4, estrogen receptors alpha and beta, TFAP2, and CBP/p300. It is expressed in a restricted manner in the embryo as well as in extraembryonic tissues during embryonic development. In this study we report the engineering of a loss-of-function Cited1 mutation in the mouse. Cited1 null mutants show growth restriction at 18.5 days postcoitum, and most of them die shortly after birth. Half the heterozygous females, i.e., those that carry a paternally inherited wild-type Cited1 allele, are similarly affected. Cited1 is normally expressed in trophectoderm-derived c ells of the placenta; however, in these heterozygous females, Cited1 is not expressed in these cells. This occurs because Cited1 is located on the X chromosome, and thus the wild-type Cited1 allele is not expressed because the paternal X chromosome is preferentially inactivated. Loss of Cited1 resulted in abnormal placental development. In mutants, the spongiotrophoblast layer is irregular in shape and enlarged while the labyrinthine layer is reduced in size. In addition, the blood spaces within the labyrinthine layer are disrupted; the maternal sinusoids are considerably larger in mutants, leading to a reduction in the surface area available for nutrient exchange. We conclude that Cited1 is required in trophoblasts for normal placental development and subsequently for embryo viability."

	[[Category:Mouse]] [[Category:Placenta]]		[[Category:Mouse]] [[Category:Placenta]] [[Category:Mouse E16.5]]

S8600021 at 01:16, 16 April 2010

2010-04-16T01:16:27Z

← Older revision		Revision as of 12:16, 16 April 2010
Line 6:		Line 6:
	Resin casts are generated by filling the existing vascular beds (day 16.5 p.c.) with a resin that sets and the surrounding materials are then removed, leaving just the vascular beds.		Resin casts are generated by filling the existing vascular beds (day 16.5 p.c.) with a resin that sets and the surrounding materials are then removed, leaving just the vascular beds.

	'''Links:''' [[:File:Mouse placenta 02.jpg\|Mouse placental blood vessels Lateral View]] \| [[Mouse Development]] \| [[Placenta Development]]		'''Links:''' [[:File:Mouse placenta 02.jpg\|Mouse placental blood vessels Lateral View]] \| [[Mouse Development]] \| [[Placenta Development]] \| [http://embryology.med.unsw.edu.au/Notes/placenta.htm original Placenta Notes]

	'''Original File:''' Plmouseresin1.jpg http://embryology.med.unsw.edu.au/Notes/placenta6.htm		'''Original File:''' Plmouseresin1.jpg http://embryology.med.unsw.edu.au/Notes/placenta6.htm

			Thanks to '''Dr Sally Dunwoodie''', Developmental Biology Program, Victor Chang Cardiac Research Institute who provided both images and information on (mouse) placental development. (Email: [mailto:s.dunwoodie@victorchang.unsw.edu.au Sally Dunwoodie])

	'''Citation:''' Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL. Mol Cell Biol. 2004 Jan;24(1):228-44. [http://www.ncbi.nlm.nih.gov/pubmed/14673158 PMID: 14673158]		'''Citation:''' Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL. Mol Cell Biol. 2004 Jan;24(1):228-44. [http://www.ncbi.nlm.nih.gov/pubmed/14673158 PMID: 14673158]

S8600021 at 01:11, 16 April 2010

2010-04-16T01:11:05Z

← Older revision		Revision as of 12:11, 16 April 2010
Line 4:		Line 4:
	* Arterial side - blue resin		* Arterial side - blue resin

	Resin casts are generated by filling the existing vascular beds (day 16.5 p.c.) with a resin that sets and the surrounding materials are then removed, leaving just the vascular beds.		Resin casts are generated by filling the existing vascular beds (day 16.5 p.c.) with a resin that sets and the surrounding materials are then removed, leaving just the vascular beds.

			'''Links:''' [[:File:Mouse placenta 02.jpg\|Mouse placental blood vessels Lateral View]] \| [[Mouse Development]] \| [[Placenta Development]]

	'''Original File:''' Plmouseresin1.jpg http://embryology.med.unsw.edu.au/Notes/placenta6.htm		'''Original File:''' Plmouseresin1.jpg http://embryology.med.unsw.edu.au/Notes/placenta6.htm

S8600021 at 01:06, 16 April 2010

2010-04-16T01:06:58Z

← Older revision		Revision as of 12:06, 16 April 2010
Line 1:		Line 1:
	Mouse placental blood vessels (E16.5) superior view (maternal side)		'''Mouse placental blood vessels''' (E16.5) superior view (maternal side)

	* Venous side - red resin		* Venous side - red resin
Line 6:		Line 6:
	Resin casts are generated by filling the existing vascular beds (day 16.5 p.c.) with a resin that sets and the surrounding materials are then removed, leaving just the vascular beds.		Resin casts are generated by filling the existing vascular beds (day 16.5 p.c.) with a resin that sets and the surrounding materials are then removed, leaving just the vascular beds.

	Original File: Plmouseresin1.jpg http://embryology.med.unsw.edu.au/Notes/placenta6.htm		'''Original File:''' Plmouseresin1.jpg http://embryology.med.unsw.edu.au/Notes/placenta6.htm

	Citation: Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL. Mol Cell Biol. 2004 Jan;24(1):228-44. [http://www.ncbi.nlm.nih.gov/pubmed/14673158 PMID: 14673158]		'''Citation:''' Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL. Mol Cell Biol. 2004 Jan;24(1):228-44. [http://www.ncbi.nlm.nih.gov/pubmed/14673158 PMID: 14673158]

	:"Cited1 is a transcriptional cofactor that interacts with Smad4, estrogen receptors alpha and beta, TFAP2, and CBP/p300. It is expressed in a restricted manner in the embryo as well as in extraembryonic tissues during embryonic development. In this study we report the engineering of a loss-of-function Cited1 mutation in the mouse. Cited1 null mutants show growth restriction at 18.5 days postcoitum, and most of them die shortly after birth. Half the heterozygous females, i.e., those that carry a paternally inherited wild-type Cited1 allele, are similarly affected. Cited1 is normally expressed in trophectoderm-derived c ells of the placenta; however, in these heterozygous females, Cited1 is not expressed in these cells. This occurs because Cited1 is located on the X chromosome, and thus the wild-type Cited1 allele is not expressed because the paternal X chromosome is preferentially inactivated. Loss of Cited1 resulted in abnormal placental development. In mutants, the spongiotrophoblast layer is irregular in shape and enlarged while the labyrinthine layer is reduced in size. In addition, the blood spaces within the labyrinthine layer are disrupted; the maternal sinusoids are considerably larger in mutants, leading to a reduction in the surface area available for nutrient exchange. We conclude that Cited1 is required in trophoblasts for normal placental development and subsequently for embryo viability."		:"Cited1 is a transcriptional cofactor that interacts with Smad4, estrogen receptors alpha and beta, TFAP2, and CBP/p300. It is expressed in a restricted manner in the embryo as well as in extraembryonic tissues during embryonic development. In this study we report the engineering of a loss-of-function Cited1 mutation in the mouse. Cited1 null mutants show growth restriction at 18.5 days postcoitum, and most of them die shortly after birth. Half the heterozygous females, i.e., those that carry a paternally inherited wild-type Cited1 allele, are similarly affected. Cited1 is normally expressed in trophectoderm-derived c ells of the placenta; however, in these heterozygous females, Cited1 is not expressed in these cells. This occurs because Cited1 is located on the X chromosome, and thus the wild-type Cited1 allele is not expressed because the paternal X chromosome is preferentially inactivated. Loss of Cited1 resulted in abnormal placental development. In mutants, the spongiotrophoblast layer is irregular in shape and enlarged while the labyrinthine layer is reduced in size. In addition, the blood spaces within the labyrinthine layer are disrupted; the maternal sinusoids are considerably larger in mutants, leading to a reduction in the surface area available for nutrient exchange. We conclude that Cited1 is required in trophoblasts for normal placental development and subsequently for embryo viability."

	[[Category:Mouse]] [[Category:Placenta]]		[[Category:Mouse]] [[Category:Placenta]]

S8600021: Mouse placental blood vessels (E16.5) superior view (maternal side) * Venous side - red resin * Arterial side - blue resin Resin casts are generated by filling the existing vascular beds (day 16.5 p.c.) with a resin that sets and the surrounding materia

2010-04-16T01:06:32Z

New page

Mouse placental blood vessels (E16.5) superior view (maternal side)

* Venous side - red resin
* Arterial side - blue resin

Resin casts are generated by filling the existing vascular beds (day 16.5 p.c.) with a resin that sets and the surrounding materials are then removed, leaving just the vascular beds.

Original File: Plmouseresin1.jpg http://embryology.med.unsw.edu.au/Notes/placenta6.htm

Citation: Cited1 is required in trophoblasts for placental development and for embryo growth and survival. Rodriguez TA, Sparrow DB, Scott AN, Withington SL, Preis JI, Michalicek J, Clements M, Tsang TE, Shioda T, Beddington RS, Dunwoodie SL. Mol Cell Biol. 2004 Jan;24(1):228-44. [http://www.ncbi.nlm.nih.gov/pubmed/14673158 PMID: 14673158]

:"Cited1 is a transcriptional cofactor that interacts with Smad4, estrogen receptors alpha and beta, TFAP2, and CBP/p300. It is expressed in a restricted manner in the embryo as well as in extraembryonic tissues during embryonic development. In this study we report the engineering of a loss-of-function Cited1 mutation in the mouse. Cited1 null mutants show growth restriction at 18.5 days postcoitum, and most of them die shortly after birth. Half the heterozygous females, i.e., those that carry a paternally inherited wild-type Cited1 allele, are similarly affected. Cited1 is normally expressed in trophectoderm-derived c ells of the placenta; however, in these heterozygous females, Cited1 is not expressed in these cells. This occurs because Cited1 is located on the X chromosome, and thus the wild-type Cited1 allele is not expressed because the paternal X chromosome is preferentially inactivated. Loss of Cited1 resulted in abnormal placental development. In mutants, the spongiotrophoblast layer is irregular in shape and enlarged while the labyrinthine layer is reduced in size. In addition, the blood spaces within the labyrinthine layer are disrupted; the maternal sinusoids are considerably larger in mutants, leading to a reduction in the surface area available for nutrient exchange. We conclude that Cited1 is required in trophoblasts for normal placental development and subsequently for embryo viability."

[[Category:Mouse]] [[Category:Placenta]]