File:Mouse mammary development 01.jpg - Revision history

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2018-03-19T23:04:30Z

Reference

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	===Reference===		===Reference===
	{{#pmid:16168142}}		{{#pmid:16168142}}

			====Copyright====

	{{BMC copyright}}		{{BMC copyright}}

	13058_2005_1285_Fig1_HTML.jpg		Fig. 1 - 13058_2005_1285_Fig1_HTML.jpg Text modified from original figure legend.


	~~Text modified from original figure legend~~.		Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland.

	Breast Cancer Res. 2005;7(5):220-4. Epub 2005 Aug 10.		Breast Cancer Res. 2005;7(5):220-4. Epub 2005 Aug 10.
	~~Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland.~~
	Hens JR1, Wysolmerski JJ.		Hens JR1, Wysolmerski JJ.
	~~Author information~~
	Abstract		Abstract

	The development of the embryonic mammary gland involves communication between the epidermis and mesenchyme and is coordinated temporally and spatially by various signaling pathways. Although many more genes are likely to control mammary gland development, functional roles have been identified for Wnt, fibroblast growth factor, and parathyroid hormone-related protein signaling. This review describes what is known about the molecular mechanisms that regulate embryonic mammary gland development.		The development of the embryonic mammary gland involves communication between the epidermis and mesenchyme and is coordinated temporally and spatially by various signaling pathways. Although many more genes are likely to control mammary gland development, functional roles have been identified for Wnt, fibroblast growth factor, and parathyroid hormone-related protein signaling. This review describes what is known about the molecular mechanisms that regulate embryonic mammary gland development.

	PMID 16168142 PMCID: PMC1242158 DOI: 10.1186/bcr1306		PMID: 16168142 PMCID: PMC1242158 DOI: 10.1186/bcr1306

	{{Footer}}		{{Footer}}

Z8600021 at 22:48, 19 March 2018

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-Embryonic mammary development. (a) Embryonic day (E)12.5. The epithelial cells have invaginated to form the initial bud, but the dense mammary mesenchyme has not yet formed. (b) Female bud at E14.5. The bud is fully formed. The epithelial cells are arrayed in a ball-on-stalk, or inverted bulb shape. The mesenchymal cells are arranged in four to five layers in a radial fashion around the epithelial cells. (c) Male bud at E14.5. Under the influence of testosterone, the mesenchymal cells condense around the stalk of the bud (arrowheads), constricting it until the connection with the surface epidermis is severed. After this occurs mammary mesenchyme cells and many epithelial cells undergo apoptosis. (d) Mammary sprout at E18.5. The epithelial bud has grown out from the mammary mesenchyme into the lower dermis, where it will enter the mammary fat pad and begin a period of active ductal branching morphogenesis. (e) A whole mount of the initial primary duct system from a 2-day-old mouse, the end- result of embryonic mammary morphogenesis. The arrowhead denotes the connection of the primary duct to the skin.
+==Embryonic Mouse Mammary Development==
 Breast Cancer Res. 2005;7(5):220-4. Epub 2005 Aug 10.
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 Abstract
 The development of the embryonic mammary gland involves communication between the epidermis and mesenchyme and is coordinated temporally and spatially by various signaling pathways. Although many more genes are likely to control mammary gland development, functional roles have been identified for Wnt, fibroblast growth factor, and parathyroid hormone-related protein signaling. This review describes what is known about the molecular mechanisms that regulate embryonic mammary gland development.
-{{BMC copyright}}
+PMID 16168142 PMCID: PMC1242158 DOI: 10.1186/bcr1306
-_2005_1285_Fig1_HTML.jpg
+{{Footer}}

Z8600021: Embryonic mammary development. (a) Embryonic day (E)12.5. The epithelial cells have invaginated to form the initial bud, but the dense mammary mesenchyme has not yet formed. (b) Female bud at E14.5. The bud is fully formed. The epithelial cells are arr...

2018-03-19T22:39:32Z

New page

Embryonic mammary development. (a) Embryonic day (E)12.5. The epithelial cells have invaginated to form the initial bud, but the dense mammary mesenchyme has not yet formed. (b) Female bud at E14.5. The bud is fully formed. The epithelial cells are arrayed in a ball-on-stalk, or inverted bulb shape. The mesenchymal cells are arranged in four to five layers in a radial fashion around the epithelial cells. (c) Male bud at E14.5. Under the influence of testosterone, the mesenchymal cells condense around the stalk of the bud (arrowheads), constricting it until the connection with the surface epidermis is severed. After this occurs mammary mesenchyme cells and many epithelial cells undergo apoptosis. (d) Mammary sprout at E18.5. The epithelial bud has grown out from the mammary mesenchyme into the lower dermis, where it will enter the mammary fat pad and begin a period of active ductal branching morphogenesis. (e) A whole mount of the initial primary duct system from a 2-day-old mouse, the end- result of embryonic mammary morphogenesis. The arrowhead denotes the connection of the primary duct to the skin.

Breast Cancer Res. 2005;7(5):220-4. Epub 2005 Aug 10.
Key stages of mammary gland development: molecular mechanisms involved in the formation of the embryonic mammary gland.
Hens JR1, Wysolmerski JJ.
Author information
Abstract
The development of the embryonic mammary gland involves communication between the epidermis and mesenchyme and is coordinated temporally and spatially by various signaling pathways. Although many more genes are likely to control mammary gland development, functional roles have been identified for Wnt, fibroblast growth factor, and parathyroid hormone-related protein signaling. This review describes what is known about the molecular mechanisms that regulate embryonic mammary gland development.
PMID: 16168142 PMCID: PMC1242158 DOI: 10.1186/bcr1306
===Reference===
{{#pmid:16168142}}

{{BMC copyright}}

13058_2005_1285_Fig1_HTML.jpg