File:Mouse cranial nerve model SHH.jpg - Revision history

Z8600021: /* Mouse cranial nerve model Sonic Hedgehog */

2018-05-06T04:03:20Z

Mouse cranial nerve model Sonic Hedgehog

← Older revision		Revision as of 15:03, 6 Mayıs 2018
Line 1:		Line 1:
	==Mouse ~~cranial nerve model~~ Sonic Hedgehog==		==Mouse Cranial Nerve Model - Sonic Hedgehog==

	During mouse normal development, neural crest cells migrating from rhombomere 2 (r2) or 4 (r4) interact with placodal cells to develop the cranial nerves.		During {{mouse}} normal development, {{neural crest}} cells migrating from rhombomere 2 (r2) or 4 (r4) interact with placodal cells to develop the cranial nerves.


	:'''Links:''' {{sonic hedgehog}} \| ~~[[Neural - Cranial Nerve Development\|~~cranial nerve]] \| {{~~cranial nerve~~}}
			:'''Links:''' {{sonic hedgehog}} \| {{cranial nerve}} \| {{mouse}}

	===Reference===		===Reference===

Z8600021 at 04:02, 6 Mayıs 2018

2018-05-06T04:02:26Z

← Older revision		Revision as of 15:02, 6 Mayıs 2018
Line 4:		Line 4:


	:'''Links:''' {{sonic hedgehog}} \|		:'''Links:''' {{sonic hedgehog}} \| [[Neural - Cranial Nerve Development\|cranial nerve]] \| {{cranial nerve}}

	===Reference===		===Reference===

Z8600021 at 04:01, 6 Mayıs 2018

2018-05-06T04:01:50Z

← Older revision		Revision as of 15:01, 6 Mayıs 2018
Line 4:		Line 4:


	:'''Links:''' {{sonic hedgehog}}		:'''Links:''' {{sonic hedgehog}} \|

	===Reference===		===Reference===

Z8600021 at 04:01, 6 Mayıs 2018

2018-05-06T04:01:31Z

← Older revision		Revision as of 15:01, 6 Mayıs 2018
Line 4:		Line 4:


	:'''Links:''' ~~[[Developmental Signals - Sonic~~ hedgehog~~\|Sonic hedgehog]]~~		:'''Links:''' {{sonic hedgehog}}

	===Reference===		===Reference===
			{{#pmid:25799573}}

	~~<pubmed>25799573 </pubmed>\| [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120821 PLoS One.]~~

	====Copyright====		====Copyright====

Z8600021 at 08:38, 14 April 2016

2016-04-14T08:38:08Z

← Older revision		Revision as of 19:38, 14 April 2016
Line 2:		Line 2:

	During mouse normal development, neural crest cells migrating from rhombomere 2 (r2) or 4 (r4) interact with placodal cells to develop the cranial nerves.		During mouse normal development, neural crest cells migrating from rhombomere 2 (r2) or 4 (r4) interact with placodal cells to develop the cranial nerves.


			:'''Links:''' [[Developmental Signals - Sonic hedgehog\|Sonic hedgehog]]

	===Reference===		===Reference===
Line 14:		Line 17:
	{{Footer}}		{{Footer}}

	[[Category:Cartoon]][[Category:Cranial Nerve]][[Category:~~Shh~~]]		[[Category:Cartoon]][[Category:Cranial Nerve]][[Category:Sonic Hedgehog]]

Z8600021: /* Mouse cranial nerve model SHH */

2016-04-14T08:36:30Z

Mouse cranial nerve model SHH

← Older revision		Revision as of 19:36, 14 April 2016
Line 1:		Line 1:
	==Mouse cranial nerve model ~~SHH~~==		==Mouse cranial nerve model Sonic Hedgehog==

	During mouse normal development, neural crest cells migrating from rhombomere 2 (r2) or 4 (r4) interact with placodal cells to develop the cranial nerves.		During mouse normal development, neural crest cells migrating from rhombomere 2 (r2) or 4 (r4) interact with placodal cells to develop the cranial nerves.

Z8600021 at 08:34, 14 April 2016

2016-04-14T08:34:34Z

← Older revision		Revision as of 19:34, 14 April 2016
Line 14:		Line 14:
	{{Footer}}		{{Footer}}

	[[Category:Cartoon]][[Category:Cranial Nerve]][[Category:~~SHH~~]]		[[Category:Cartoon]][[Category:Cranial Nerve]][[Category:Shh]]

Z8600021 at 08:34, 14 April 2016

2016-04-14T08:34:14Z

← Older revision		Revision as of 19:34, 14 April 2016
Line 13:		Line 13:

	{{Footer}}		{{Footer}}

			[[Category:Cartoon]][[Category:Cranial Nerve]][[Category:SHH]]

Z8600021 at 08:31, 14 April 2016

2016-04-14T08:31:55Z

← Older revision		Revision as of 19:31, 14 April 2016
Line 1:		Line 1:
	==Mouse cranial nerve model SHH==		==Mouse cranial nerve model SHH==

	During mouse normal development, neural crest cells migrating from rhombomere 2 (r2) or 4 (r4) interact with placodal cells to develop the cranial nerves		During mouse normal development, neural crest cells migrating from rhombomere 2 (r2) or 4 (r4) interact with placodal cells to develop the cranial nerves.

			===Reference===

			<pubmed>25799573 </pubmed>\| [http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120821 PLoS One.]

	Journal.pone.0120821.g007.jpg		====Copyright====
			© 2015 Kurosaka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

			Fig. 7 . Journal.pone.0120821.g007.jpg Panel A cropped from full figure and relabelled.

			{{Footer}}

Z8600021 at 08:28, 14 April 2016

2016-04-14T08:28:22Z

← Older revision		Revision as of 19:28, 14 April 2016
Line 1:		Line 1:
			==Mouse cranial nerve model SHH==

	During mouse normal development, neural crest cells migrating from rhombomere 2 (r2) or 4 (r4) interact with placodal cells to develop the cranial nerves		During mouse normal development, neural crest cells migrating from rhombomere 2 (r2) or 4 (r4) interact with placodal cells to develop the cranial nerves

	~~PLoS One. 2015 Mar 23;10(3):e0120821. doi: 10.1371/journal.pone.0120821. eCollection 2015.~~
	~~Cranial nerve development requires co-ordinated Shh and canonical Wnt signaling.~~
	~~Kurosaka H1, Trainor PA2, Leroux-Berger M3, Iulianella A4.~~
	~~Author information~~
	~~Abstract~~
	Cranial nerves govern sensory and motor information exchange between the brain and tissues of the head and neck. The cranial nerves are derived from two specialized populations of cells, cranial neural crest cells and ectodermal placode cells. Defects in either cell type can result in cranial nerve developmental defects. Although several signaling pathways are known to regulate cranial nerve formation our understanding of how intercellular signaling between neural crest cells and placode cells is coordinated during cranial ganglia morphogenesis is poorly understood. Sonic Hedgehog (Shh) signaling is one key pathway that regulates multiple aspects of craniofacial development, but whether it co-ordinates cranial neural crest cell and placodal cell interactions during cranial ganglia formation remains unclear. In this study we examined a new Patched1 (Ptch1) loss-of-function mouse mutant and characterized the role of Ptch1 in regulating Shh signaling during cranial ganglia development. Ptch1(Wig/ Wig) mutants exhibit elevated Shh signaling in concert with disorganization of the trigeminal and facial nerves. Importantly, we discovered that enhanced Shh signaling suppressed canonical Wnt signaling in the cranial nerve region. This critically affected the survival and migration of cranial neural crest cells and the development of placodal cells as well as the integration between neural crest and placodes. Collectively, our findings highlight a novel and critical role for Shh signaling in cranial nerve development via the cross regulation of canonical Wnt signaling.

	~~PMID 25799573~~

	Journal.pone.0120821.g007.jpg		Journal.pone.0120821.g007.jpg