File:Intraepithelial lymphocyte differentiation 03.jpg - Revision history

Z8600021 at 04:56, 26 Ocak 2015

2015-01-26T04:56:37Z

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	The beneficial roles of natural and induced intraepithelial lymphocytes (IELs) in preserving the epithelium and restoring tissue integrity after injury.		The beneficial roles of natural and induced intraepithelial lymphocytes (IELs) in preserving the epithelium and restoring tissue integrity after injury.

	* '''Natural IELs''' - (previously ‘type b’ IELs) acquire ~~their~~ activated phenotype during development in the thymus in the presence of self antigens.		* '''Natural IELs''' - (previously ‘type b’ IELs) acquire activated phenotype during development in the thymus in the presence of self antigens.
	* '''Induced IELs''' - (previously ‘type a’ IELs) ~~are the~~ progeny of conventional T cells ~~that are~~ activated post-thymically in response to peripheral antigens.		* '''Induced IELs''' - (previously ‘type a’ IELs) progeny of conventional T cells activated post-thymically in response to peripheral antigens.

Z8600021 at 04:55, 26 Ocak 2015

2015-01-26T04:55:47Z

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	The beneficial roles of natural and induced intraepithelial lymphocytes (IELs) in preserving the epithelium and restoring tissue integrity after injury.		The beneficial roles of natural and induced intraepithelial lymphocytes (IELs) in preserving the epithelium and restoring tissue integrity after injury.

			* '''Natural IELs''' - (previously ‘type b’ IELs) acquire their activated phenotype during development in the thymus in the presence of self antigens.
			* '''Induced IELs''' - (previously ‘type a’ IELs) are the progeny of conventional T cells that are activated post-thymically in response to peripheral antigens.


	{{Immune Images 2}}		{{Immune Images 2}}

Z8600021 at 04:51, 26 Ocak 2015

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	==~~Thymic~~ and ~~peripheral differentiation of natural and induced intraepithelial lymphocytes~~==		==Natural and Induced Intraepithelial Lymphocyte Function==

	* IELs - intraepithelial lymphocytes
	* MLNs - mesenteric lymph nodes
	* APC - antigen-presenting cell

	In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection and differentiate into double-negative T cell receptor-αβ (TCRαβ)+ cells that are the precursors of natural TCRαβ+ intraepithelial lymphocytes (IELs). The TCRαβ+ natural IEL precursor cells partly acquire their antigen-experienced phenotype ‘naturally’ during selection with self antigens.

	Precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus. CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery.

	~~These naive T cells can differentiate into effector T cells in response to peripheral antigens and subsequently migrate to the gut and become incorporated into the induced IEL compartment.~~

			The beneficial roles of natural and induced intraepithelial lymphocytes (IELs) in preserving the epithelium and restoring tissue integrity after injury.

	{{Immune Images 2}}		{{Immune Images 2}}

Z8600021: ==Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes== * IELs - intraepithelial lymphocytes * MLNs - mesenteric lymph nodes * APC - antigen-presenting cell In the thymus, immature CD4+CD8αβ+CD8αα+ (triple pos...

2015-01-26T04:50:36Z

New page

==Thymic and peripheral differentiation of natural and induced intraepithelial lymphocytes==

* IELs - intraepithelial lymphocytes
* MLNs - mesenteric lymph nodes
* APC - antigen-presenting cell

In the thymus, immature CD4+CD8αβ+CD8αα+ (triple positive) thymocytes undergo agonist (‘alternative’) selection and differentiate into double-negative T cell receptor-αβ (TCRαβ)+ cells that are the precursors of natural TCRαβ+ intraepithelial lymphocytes (IELs). The TCRαβ+ natural IEL precursor cells partly acquire their antigen-experienced phenotype ‘naturally’ during selection with self antigens.

Precursor cells for TCRαβ+ and TCRγδ+ natural IELs upregulate intestinal homing receptors during their maturation in the thymus, which allows these cells to directly seed the intestinal epithelium after they leave the thymus. CD4+CD8αβ+ (double positive) thymocytes undergo ‘conventional’ thymic selection and differentiate into naive CD4+ and CD8αβ+ TCRαβ+ T cells that migrate to the periphery.

These naive T cells can differentiate into effector T cells in response to peripheral antigens and subsequently migrate to the gut and become incorporated into the induced IEL compartment.

{{Immune Images 2}}
===Reference===
<pubmed>21681197</pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140792 Nat Rev Immunol.]

====Copyright====
© 2011 Macmillan Publishers Limited. All rights reserved

Licensee: Mark A Hill
License Date: Jan 25, 2015
License Number: 3556220285761
Publication: Nature Reviews Immunology
Title: The light and dark sides of intestinal intraepithelial lymphocytes
Type Of Use: post on a website Figure 1. Nihms307956-23.jpg

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[[Category:Immune]] [[Category:Gastrointestinal Tract]][[Category:Cartoon]]