File:Integumentary touch dome model 01.jpg - Revision history

Z8600021 at 04:41, 12 August 2017

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	[[Category:Integumentary]][[Category:Cartoon]][[Category:Senses]][[Category:Touch]]		[[Category:Integumentary]][[Category:Cartoon]][[Category:Senses]][[Category:Touch]]
	[[Category:Mouse]][[Category:Mouse E14]][[Category:Mouse E15.5]]		[[Category:Mouse]][[Category:Mouse E14]][[Category:Mouse E15.5]][[Category:Sonic Hedgehog]]

Z8600021 at 04:39, 12 August 2017

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	(left) Model of the signaling cascade that regulates the development of TD MCs and their adjacent guard hair follicle, along with experimental interventions that disrupted or rescued the developmental processes. (right) Graphical representation of the sequential signaling mechanisms that drive TD MC specification in embryonic mouse skin. TD MC specification requires mesenchymal Wnt signaling which allows Eda signaling to Edar in the developing primary hair placodes and subsequent Shh signaling from the primary hair placodes/germs to adjacent ectoderm containing the TD anlages. Square cells, surface ectoderm. Trapezoidal cells, hair placode/germ cells. Oval cells, periderm.		(left) Model of the signaling cascade that regulates the development of TD MCs and their adjacent guard hair follicle, along with experimental interventions that disrupted or rescued the developmental processes. (right) Graphical representation of the sequential signaling mechanisms that drive TD MC specification in embryonic mouse skin. TD MC specification requires mesenchymal Wnt signaling which allows Eda signaling to Edar in the developing primary hair placodes and subsequent Shh signaling from the primary hair placodes/germs to adjacent ectoderm containing the TD anlages. Square cells, surface ectoderm. Trapezoidal cells, hair placode/germ cells. Oval cells, periderm.

			{{Integumentary Links}}
	===Reference===		===Reference===
	<pubmed>27414798</pubmed>		<pubmed>27414798</pubmed>

Z8600021 at 04:37, 12 August 2017

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	[[Category:Integumentary]][[Category:Cartoon]][[Category:Senses]][[Category:Touch]][[Category:Mouse]]		[[Category:Integumentary]][[Category:Cartoon]][[Category:Senses]][[Category:Touch]]
			[[Category:Mouse]][[Category:Mouse E14]][[Category:Mouse E15.5]]

Z8600021 at 04:36, 12 August 2017

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	[[Category:Integumentary]][[Category:Cartoon]][[Category:Senses]][[Category:Touch]]		[[Category:Integumentary]][[Category:Cartoon]][[Category:Senses]][[Category:Touch]][[Category:Mouse]]

Z8600021 at 04:36, 12 August 2017

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	==~~Proposed model of the~~ developmental signaling requirements for ~~TD MC~~ production==		==Model for developmental signaling requirements for touch dome Merkel cell production==

	touch dome (TD) is a specialized epidermal sensory structure composed of K8+ Merkel cells (MCs)		The touch dome (TD) is a specialized epidermal sensory structure composed of K8+ Merkel cells (MCs).

	(left) Model of the signaling cascade that regulates the development of TD MCs and their adjacent guard hair follicle, along with experimental interventions that disrupted or rescued the developmental processes. (right) Graphical representation of the sequential signaling mechanisms that drive TD MC specification in embryonic mouse skin. TD MC specification requires mesenchymal Wnt signaling which allows Eda signaling to Edar in the developing primary hair placodes and subsequent Shh signaling from the primary hair placodes/germs to adjacent ectoderm containing the TD anlages. Square cells, surface ectoderm. Trapezoidal cells, hair placode/germ cells. Oval cells, periderm.		(left) Model of the signaling cascade that regulates the development of TD MCs and their adjacent guard hair follicle, along with experimental interventions that disrupted or rescued the developmental processes. (right) Graphical representation of the sequential signaling mechanisms that drive TD MC specification in embryonic mouse skin. TD MC specification requires mesenchymal Wnt signaling which allows Eda signaling to Edar in the developing primary hair placodes and subsequent Shh signaling from the primary hair placodes/germs to adjacent ectoderm containing the TD anlages. Square cells, surface ectoderm. Trapezoidal cells, hair placode/germ cells. Oval cells, periderm.

			===Reference===
			<pubmed>27414798</pubmed>

	~~PMID 27414798~~		Xiao Y, Thoresen DT, Miao L, Williams JS, Wang C, Atit RP, et al. (2016) A Cascade of Wnt, Eda, and Shh Signaling Is Essential for Touch Dome Merkel Cell Development. PLoS Genet 12(7): e1006150. doi:10.1371/journal.pgen.1006150
	Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.		====Copyright====
			This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

	Fig 7. doi:10.1371/journal.pgen.1006150.g007		Fig 7. doi:10.1371/journal.pgen.1006150.g007

			{{Footer}}
			[[Category:Integumentary]][[Category:Cartoon]][[Category:Senses]][[Category:Touch]]

Z8600021: ==Proposed model of the developmental signaling requirements for TD MC production== touch dome (TD) is a specialized epidermal sensory structure composed of K8+ Merkel cells (MCs) (left) Model of the signaling cascade that regulates the development o...

2017-08-12T04:34:02Z

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==Proposed model of the developmental signaling requirements for TD MC production==

touch dome (TD) is a specialized epidermal sensory structure composed of K8+ Merkel cells (MCs)

(left) Model of the signaling cascade that regulates the development of TD MCs and their adjacent guard hair follicle, along with experimental interventions that disrupted or rescued the developmental processes. (right) Graphical representation of the sequential signaling mechanisms that drive TD MC specification in embryonic mouse skin. TD MC specification requires mesenchymal Wnt signaling which allows Eda signaling to Edar in the developing primary hair placodes and subsequent Shh signaling from the primary hair placodes/germs to adjacent ectoderm containing the TD anlages. Square cells, surface ectoderm. Trapezoidal cells, hair placode/germ cells. Oval cells, periderm.

PMID 27414798
Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.

Fig 7. doi:10.1371/journal.pgen.1006150.g007