File:Frog germ layer signaling 01.jpg - Revision history

Z8600021: /* Transcriptional regulation of X-TSK and model of X-TSK function in germ layer formation and patterning */

2012-10-11T03:41:50Z

Transcriptional regulation of X-TSK and model of X-TSK function in germ layer formation and patterning

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	==Transcriptional regulation of X-TSK and model of X-TSK function in germ layer formation and patterning==		==Transcriptional regulation of X-TSK and model of X-TSK function in germ layer formation and patterning==

	(A) Semi-quantitative RT-PCR of X-TSK expression in animal caps injected with 1 ng XFD, 50 pg V-ras or 50 pg caFGFR. WE = Whole embryo, WOC = Water only control. Inhibition of FGF signals with XFD enhances TSK expression, whereas activation of FGF signals with V-ras or caFGFR reduces TSK expression levels. (B) Model of TSK function in Xenopus germ layer formation and patterning: dorsal-ventral mesoderm patterning. X-TSK in dorsal mesoderm (red) inhibits BMP signaling to promote dorsal mesoderm formation, as marked by Gsc expression. This is possibly also enhanced through activation of Xnr2 signals by TSK. MAPK activation inhibits X-TSK expression in ventrolateral mesoderm, where X-TSK inhibits expression of ventrolateral mesoderm markers such as Xbra, through inhibition of FGF signaling. This network of signaling may contribute to clear patterning of the mesoderm. (C) Model of TSK function in endoderm formation. X-TSK coordinates inhibition of FGF and BMP signals with activation of Xnr2 signaling to induce endoderm formation (green), as marked by Sox17α. Again, X-TSK inhibits expression of ventrolateral mesoderm (blue) markers such as Xbra, through inhibition of FGF signaling and may contribute to the distinction between endoderm and mesoderm specific gene expression.		(B) Model of TSK function in Xenopus germ layer formation and patterning: dorsal-ventral mesoderm patterning. X-TSK in dorsal mesoderm (red) inhibits BMP signaling to promote dorsal mesoderm formation, as marked by Gsc expression. This is possibly also enhanced through activation of Xnr2 signals by TSK. MAPK activation inhibits X-TSK expression in ventrolateral mesoderm, where X-TSK inhibits expression of ventrolateral mesoderm markers such as Xbra, through inhibition of FGF signaling. This network of signaling may contribute to clear patterning of the mesoderm.


			(C) Model of TSK function in endoderm formation. X-TSK coordinates inhibition of FGF and BMP signals with activation of Xnr2 signaling to induce endoderm formation (green), as marked by Sox17α. Again, X-TSK inhibits expression of ventrolateral mesoderm (blue) markers such as Xbra, through inhibition of FGF signaling and may contribute to the distinction between endoderm and mesoderm specific gene expression.

			{{Frog links}}

	===Reference===		===Reference===

Z8600021: /* Reference */

2012-10-11T03:40:23Z

Reference

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	===Reference===		===Reference===
	<pubmed>17925852</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994590 PMC1994590/] \| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001004 PLoS ONE]		<pubmed>17925852</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994590 PMC1994590] \| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001004 PLoS ONE]

Z8600021 at 03:36, 11 October 2012

2012-10-11T03:36:53Z

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	===Reference===		===Reference===
	<pubmed>17925852</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994590/ PMC1994590/] \| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001004		<pubmed>17925852</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994590 PMC1994590/] \| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001004 PLoS ONE]

Z8600021: /* Reference */

2012-10-11T03:35:06Z

Reference

← Older revision		Revision as of 14:35, 11 October 2012
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	===Reference===		===Reference===
	<pubmed>17925852<pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994590/ PMC1994590/] \| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001004		<pubmed>17925852</pubmed>\| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994590/ PMC1994590/] \| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001004

Z8600021: ==Transcriptional regulation of X-TSK and model of X-TSK function in germ layer formation and patterning== (A) Semi-quantitative RT-PCR of X-TSK expression in animal caps injected with 1 ng XFD, 50 pg V-ras or 50 pg caFGFR. WE = Whole embryo, WOC = Water

2012-10-11T03:34:19Z

New page

==Transcriptional regulation of X-TSK and model of X-TSK function in germ layer formation and patterning==

(A) Semi-quantitative RT-PCR of X-TSK expression in animal caps injected with 1 ng XFD, 50 pg V-ras or 50 pg caFGFR. WE = Whole embryo, WOC = Water only control. Inhibition of FGF signals with XFD enhances TSK expression, whereas activation of FGF signals with V-ras or caFGFR reduces TSK expression levels. (B) Model of TSK function in Xenopus germ layer formation and patterning: dorsal-ventral mesoderm patterning. X-TSK in dorsal mesoderm (red) inhibits BMP signaling to promote dorsal mesoderm formation, as marked by Gsc expression. This is possibly also enhanced through activation of Xnr2 signals by TSK. MAPK activation inhibits X-TSK expression in ventrolateral mesoderm, where X-TSK inhibits expression of ventrolateral mesoderm markers such as Xbra, through inhibition of FGF signaling. This network of signaling may contribute to clear patterning of the mesoderm. (C) Model of TSK function in endoderm formation. X-TSK coordinates inhibition of FGF and BMP signals with activation of Xnr2 signaling to induce endoderm formation (green), as marked by Sox17α. Again, X-TSK inhibits expression of ventrolateral mesoderm (blue) markers such as Xbra, through inhibition of FGF signaling and may contribute to the distinction between endoderm and mesoderm specific gene expression.

===Reference===
<pubmed>17925852<pubmed>| [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994590/ PMC1994590/] | [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0001004

Citation: Morris SA, Almeida AD, Tanaka H, Ohta K, Ohnuma S-i (2007) Tsukushi Modulates Xnr2, FGF and BMP Signaling: Regulation of Xenopus Germ Layer Formation. PLoS ONE 2(10): e1004. doi:10.1371/journal.pone.0001004

Copyright: © 2007 Morris et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Figure 10. Journal.pone.0001004.g010.jpg

[[Category:Frog]]