Z3389343: The pedigree of a family affected by Friedreich's Ataxia. Due to the anticipating nature of the inheritance, the severity of symptoms increases while the age of onset decreases with each generation. Heterozygous individuals who possess one allele with the

2011-10-10T06:42:47Z

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The pedigree of a family affected by Friedreich's Ataxia. Due to the anticipating nature of the inheritance, the severity of symptoms increases while the age of onset decreases with each generation. Heterozygous individuals who possess one allele with the repeat expansion do not develop symptoms, and are thus unaffected carriers. The expression of Friedreich's Ataxia occurs only when an individual carries two mutated frataxin alleles.
Please note that this pedigree is entirely fictional and solely serves as a model to illustrate the mode of inheritance.

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Z3389343: The pedigree of a family affected by Friedreich's Ataxia. Due to the anticipating nature of the inheritance, the severity of symptoms increases while the age of onset decreases with each generation. Heterozygous individuals who possess one allele with the