File:Fetal adrenal gland steroidogenesis.jpg - Revision history

Z8600021: /* Fetal Adrenal Gland Steroidogenesis */

2019-03-06T02:02:15Z

Fetal Adrenal Gland Steroidogenesis

← Older revision		Revision as of 13:02, 6 March 2019
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	\| width=500px\|Ontogenesis of steroidogenic enzymes in the human fetal adrenal gland. This schematic representation is divided into portions showing the fetal adrenal gland (right) at the first, second and third trimesters of pregnancy, and the adult adrenal gland (left). During the first trimester, the fetal gland is composed of a definitive zone (DZ, light grey) and a fetal zone (FZ, dark grey).		\| width=500px\|Ontogenesis of steroidogenic enzymes in the human fetal adrenal gland. This schematic representation is divided into portions showing the fetal adrenal gland (right) at the first, second and third trimesters of pregnancy, and the adult adrenal gland (left). During the first trimester, the fetal gland is composed of a definitive zone (DZ, light grey) and a fetal zone (FZ, dark grey).

	'''Fetal zone''' (FZ) - expressing the P450C17 cytochrome, is responsible for massive secretion of DHEA and DHEA/S, used by the placenta as estrogen precursors.		'''Fetal zone''' (FZ) - expressing the P450C17 cytochrome, is responsible for massive secretion of DHEA and DHEA/S, used by the {{placenta}} as {{estrogen}} precursors.

	'''Second trimester''' - chromaffin cells (CC, black) originating from the neural crests migrate through the fetal cortex to progressively colonize the center of the gland to form the future medulla (Med).		'''Second trimester''' - chromaffin cells (CC, black) originating from the neural crests migrate through the fetal cortex to progressively colonize the center of the gland to form the future medulla (Med).

Z8600021 at 23:21, 21 October 2018

2018-10-21T23:21:54Z

← Older revision		Revision as of 10:21, 22 October 2018
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	'''Adult''' - adult adrenal gland is composed of the zona glomerulosa (ZGlo, light grey), zona fasciculata (ZFasc , medium grey) and zona reticularis (ZRet, dark grey) responsible for the production of mineralocorticoids (aldosterone), glucocorticoids (cortisol) and androgens (DHEA-DHEA/S), respectively.		'''Adult''' - adult adrenal gland is composed of the zona glomerulosa (ZGlo, light grey), zona fasciculata (ZFasc , medium grey) and zona reticularis (ZRet, dark grey) responsible for the production of mineralocorticoids (aldosterone), glucocorticoids (cortisol) and androgens (DHEA-DHEA/S), respectively.

	~~{based on data from PMID 9183569)~~
	\| width=250px\|		\| width=250px\|
	* '''P450scc''' - cytochrome P450 side chain cleavage		* '''P450scc''' - cytochrome P450 side chain cleavage
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	{{#pmid:16172742}}		{{#pmid:16172742}}

			Some Data - {{#pmid:9183569}}
	====Copyright====		====Copyright====
	All the contents of www.scielo.br, except where otherwise noted, is licensed under a Creative Commons Attribution License.		All the contents of www.scielo.br, except where otherwise noted, is licensed under a Creative Commons Attribution License.

Z8600021 at 06:44, 25 February 2018

2018-02-25T06:44:17Z

← Older revision		Revision as of 17:44, 25 February 2018
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	:'''Links:''' [[Endocrine - Adrenal Development\|Adrenal Development]]		:'''Links:''' [[Endocrine - Adrenal Development\|Adrenal Development]]
	===Reference===		===Reference===
	~~<pubmed>~~16172742~~</pubmed>\| [http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000006&lng=en&nrm=iso Braz J Med Biol Res.]~~		{{#pmid:16172742}}

	====Copyright====		====Copyright====

Z8600021 at 22:45, 10 November 2015

2015-11-10T22:45:29Z

← Older revision		Revision as of 09:45, 11 November 2015
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	'''Second trimester''' - chromaffin cells (CC, black) originating from the neural crests migrate through the fetal cortex to progressively colonize the center of the gland to form the future medulla (Med).		'''Second trimester''' - chromaffin cells (CC, black) originating from the neural crests migrate through the fetal cortex to progressively colonize the center of the gland to form the future medulla (Med).

	~~At the end of the 2nd~~ trimester, the newly constituted transitional zone (TZ, medium grey) acquires the enzyme 3ß-HSD while the expression of P450C17 remains, thus allowing the production of fetal cortisol. Near birth, cells of the definitive zone which express only 3ß-HSD, acquire the P450aldo and begin to secrete mineralocorticoids such as aldosterone.		'''Third trimester''' - the newly constituted transitional zone (TZ, medium grey) acquires the enzyme 3ß-HSD while the expression of P450C17 remains, thus allowing the production of fetal cortisol. Near birth, cells of the definitive zone which express only 3ß-HSD, acquire the P450aldo and begin to secrete mineralocorticoids such as aldosterone.

	~~Shortly after birth,~~ the fetal adrenal regresses strongly (mainly due to the regression of the fetal zone) and recovers progressively during the first years of extra-uterine life. ~~Finally, the~~ adult adrenal gland is composed of the zona glomerulosa (ZGlo, light grey), zona fasciculata (ZFasc , medium grey) and zona reticularis (ZRet, dark grey) responsible for the production of mineralocorticoids (aldosterone), glucocorticoids (cortisol) and androgens (DHEA-DHEA/S), respectively.		'''Neonatal''' - the fetal adrenal regresses strongly (mainly due to the regression of the fetal zone) and recovers progressively during the first years of extra-uterine life.

			'''Adult''' - adult adrenal gland is composed of the zona glomerulosa (ZGlo, light grey), zona fasciculata (ZFasc , medium grey) and zona reticularis (ZRet, dark grey) responsible for the production of mineralocorticoids (aldosterone), glucocorticoids (cortisol) and androgens (DHEA-DHEA/S), respectively.

	{based on data from PMID 9183569)		{based on data from PMID 9183569)

Z8600021: /* Fetal Adrenal Gland Steroidogenesis */

2015-11-10T22:36:18Z

Fetal Adrenal Gland Steroidogenesis

← Older revision		Revision as of 09:36, 11 November 2015
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	\| width=500px\|Ontogenesis of steroidogenic enzymes in the human fetal adrenal gland. This schematic representation is divided into portions showing the fetal adrenal gland (right) at the first, second and third trimesters of pregnancy, and the adult adrenal gland (left). During the first trimester, the fetal gland is composed of a definitive zone (DZ, light grey) and a fetal zone (FZ, dark grey).		\| width=500px\|Ontogenesis of steroidogenic enzymes in the human fetal adrenal gland. This schematic representation is divided into portions showing the fetal adrenal gland (right) at the first, second and third trimesters of pregnancy, and the adult adrenal gland (left). During the first trimester, the fetal gland is composed of a definitive zone (DZ, light grey) and a fetal zone (FZ, dark grey).

	~~The fetal~~ zone, expressing the P450C17 cytochrome, is responsible for massive secretion of DHEA and DHEA/S, used by the placenta as estrogen precursors.		'''Fetal zone''' (FZ) - expressing the P450C17 cytochrome, is responsible for massive secretion of DHEA and DHEA/S, used by the placenta as estrogen precursors.

	~~During the 2nd~~ trimester, chromaffin cells (CC, black) originating from the neural crests migrate through the fetal cortex to progressively colonize the center of the gland to form the future medulla (Med).		'''Second trimester''' - chromaffin cells (CC, black) originating from the neural crests migrate through the fetal cortex to progressively colonize the center of the gland to form the future medulla (Med).

	At the end of the 2nd trimester, the newly constituted transitional zone (TZ, medium grey) acquires the enzyme 3ß-HSD while the expression of P450C17 remains, thus allowing the production of fetal cortisol. Near birth, cells of the definitive zone which express only 3ß-HSD, acquire the P450aldo and begin to secrete mineralocorticoids such as aldosterone.		At the end of the 2nd trimester, the newly constituted transitional zone (TZ, medium grey) acquires the enzyme 3ß-HSD while the expression of P450C17 remains, thus allowing the production of fetal cortisol. Near birth, cells of the definitive zone which express only 3ß-HSD, acquire the P450aldo and begin to secrete mineralocorticoids such as aldosterone.

Z8600021: /* Fetal Adrenal Gland Steroidogenesis */

2015-11-10T22:35:14Z

Fetal Adrenal Gland Steroidogenesis

← Older revision		Revision as of 09:35, 11 November 2015
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	{based on data from PMID 9183569)		{based on data from PMID 9183569)
	\| width=~~200px~~\|		\| width=250px\|
	* '''P450scc''' - cytochrome P450 side chain cleavage		* '''P450scc''' - cytochrome P450 side chain cleavage
	* '''Pregn.''' - pregnenolone		* '''Pregn.''' - pregnenolone

Z8600021 at 22:34, 10 November 2015

2015-11-10T22:34:57Z

← Older revision		Revision as of 09:34, 11 November 2015
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	Shortly after birth, the fetal adrenal regresses strongly (mainly due to the regression of the fetal zone) and recovers progressively during the first years of extra-uterine life. Finally, the adult adrenal gland is composed of the zona glomerulosa (ZGlo, light grey), zona fasciculata (ZFasc , medium grey) and zona reticularis (ZRet, dark grey) responsible for the production of mineralocorticoids (aldosterone), glucocorticoids (cortisol) and androgens (DHEA-DHEA/S), respectively.		Shortly after birth, the fetal adrenal regresses strongly (mainly due to the regression of the fetal zone) and recovers progressively during the first years of extra-uterine life. Finally, the adult adrenal gland is composed of the zona glomerulosa (ZGlo, light grey), zona fasciculata (ZFasc , medium grey) and zona reticularis (ZRet, dark grey) responsible for the production of mineralocorticoids (aldosterone), glucocorticoids (cortisol) and androgens (DHEA-DHEA/S), respectively.

			{based on data from PMID 9183569)
	\| width=200px\|		\| width=200px\|
	* '''P450scc''' - cytochrome P450 side chain cleavage		* '''P450scc''' - cytochrome P450 side chain cleavage

Z8600021: Z8600021 uploaded a new version of File:Fetal adrenal gland steroidogenesis.jpg

2015-11-10T22:33:56Z

Z8600021 uploaded a new version of File:Fetal adrenal gland steroidogenesis.jpg

← Older revision

Revision as of 09:33, 11 November 2015

Z8600021: /* Fetal Adrenal Gland Steroidogenesis */

2015-11-10T22:33:09Z

Fetal Adrenal Gland Steroidogenesis

← Older revision		Revision as of 09:33, 11 November 2015
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	Shortly after birth, the fetal adrenal regresses strongly (mainly due to the regression of the fetal zone) and recovers progressively during the first years of extra-uterine life. Finally, the adult adrenal gland is composed of the zona glomerulosa (ZGlo, light grey), zona fasciculata (ZFasc , medium grey) and zona reticularis (ZRet, dark grey) responsible for the production of mineralocorticoids (aldosterone), glucocorticoids (cortisol) and androgens (DHEA-DHEA/S), respectively.		Shortly after birth, the fetal adrenal regresses strongly (mainly due to the regression of the fetal zone) and recovers progressively during the first years of extra-uterine life. Finally, the adult adrenal gland is composed of the zona glomerulosa (ZGlo, light grey), zona fasciculata (ZFasc , medium grey) and zona reticularis (ZRet, dark grey) responsible for the production of mineralocorticoids (aldosterone), glucocorticoids (cortisol) and androgens (DHEA-DHEA/S), respectively.
	\| width=200px\|		\| width=200px\|
	* P450scc - cytochrome P450 side chain cleavage		* '''P450scc''' - cytochrome P450 side chain cleavage
	* Pregn. - pregnenolone		* '''Pregn.''' - pregnenolone
	* P450C17 - cytochrome P450 17a-hydroxylase, 17-20 lyase		* '''P450C17''' - cytochrome P450 17a-hydroxylase, 17-20 lyase
	* 17OHP5 - 17-hydroxy-pregnenolone		* '''17OHP5''' - 17-hydroxy-pregnenolone
	* DHEA/S - dehydroepiandrosterone-sulfate		* '''DHEA/S''' - dehydroepiandrosterone-sulfate
	* S-Tfase - DHEA sulfotransferase		* '''S-Tfase''' - DHEA sulfotransferase
	* 3ß-HSD - 3ß-hydroxysteroid dehydrogenase		* '''3ß-HSD''' - 3ß-hydroxysteroid dehydrogenase
	* Prog. - progesterone		* '''Prog.''' - progesterone
	* 17OHP4 - 17-hydroxyprogesterone		* '''17OHP4''' - 17-hydroxyprogesterone
	* P450C21 - cytochrome P450 21-hydroxylase		* '''P450C21''' - cytochrome P450 21-hydroxylase
	* P450C11 - cytochrome P450 11ß-hydroxylase		* '''P450C11''' - cytochrome P450 11ß-hydroxylase
	* P450aldo - cytochrome P450 aldosterone synthase.		* '''P450aldo''' - cytochrome P450 aldosterone synthase.
	\|}		\|}
	:'''Links:''' [[Endocrine - Adrenal Development\|Adrenal Development]]		:'''Links:''' [[Endocrine - Adrenal Development\|Adrenal Development]]

Z8600021: /* Fetal Adrenal Gland Steroidogenesis */

2015-11-10T22:32:15Z

Fetal Adrenal Gland Steroidogenesis

← Older revision		Revision as of 09:32, 11 November 2015
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	==Fetal Adrenal Gland Steroidogenesis==		==Fetal Adrenal Gland Steroidogenesis==
	{\|		{\|
	\| width=~~400px~~\|Ontogenesis of steroidogenic enzymes in the human fetal adrenal gland. This schematic representation is divided into portions showing the fetal adrenal gland (right) at the first, second and third trimesters of pregnancy, and the adult adrenal gland (left). During the first trimester, the fetal gland is composed of a definitive zone (DZ, light grey) and a fetal zone (FZ, dark grey).		\| width=500px\|Ontogenesis of steroidogenic enzymes in the human fetal adrenal gland. This schematic representation is divided into portions showing the fetal adrenal gland (right) at the first, second and third trimesters of pregnancy, and the adult adrenal gland (left). During the first trimester, the fetal gland is composed of a definitive zone (DZ, light grey) and a fetal zone (FZ, dark grey).

	The fetal zone, expressing the P450C17 cytochrome, is responsible for massive secretion of DHEA and DHEA/S, used by the placenta as estrogen precursors.		The fetal zone, expressing the P450C17 cytochrome, is responsible for massive secretion of DHEA and DHEA/S, used by the placenta as estrogen precursors.