File:Developmental gene expression context model.jpg - Revision history

Z8600021 at 06:52, 15 Haziran 2015

2015-06-15T06:52:36Z

← Older revision		Revision as of 17:52, 15 Haziran 2015
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			{{Footer}}
	~~Licensee: Mark A Hill~~
	~~License Date: Mar 24, 2014~~
	~~License Number: 3355220263169~~
	~~Publication: Nature~~
	~~Title: Topology of mammalian developmental enhancers and their regulatory landscapes~~
	~~Type Of Use: post on a website~~

Z8600021 at 07:27, 24 March 2014

2014-03-24T07:27:06Z

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	====Copyright====		====Copyright====
			Reprinted by permission from Macmillan Publishers Ltd: NATURE (Nature. 2013 Oct 24;502(7472):499-506. doi: 10.1038/nature12753), copyright (2013)

	http://www.nature.com/nature/journal/v502/n7472/fig_tab/nature12753_F2.html Nature12753-f2.jpg		http://www.nature.com/nature/journal/v502/n7472/fig_tab/nature12753_F2.html Nature12753-f2.jpg



			Licensee: Mark A Hill
			License Date: Mar 24, 2014
			License Number: 3355220263169
			Publication: Nature
			Title: Topology of mammalian developmental enhancers and their regulatory landscapes
			Type Of Use: post on a website

Z8600021 at 07:25, 24 March 2014

2014-03-24T07:25:11Z

← Older revision		Revision as of 18:25, 24 March 2014
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	==Developmental Gene Expression Model==		==Developmental Gene Expression Model==

	A model of three hypothetical genes (yellow, red and green) and their hypothetical expression pattern at a given stage of embryonic development are shown. Embryos coloured blue show the activity of a given reporter gene integrated at different chromosomal locations (adapted from ref. 16). They illustrate that genomic context critically determines expression patterns. Thus, a, various insertion sites may display comparable expression patterns despite being spread over a large chromosomal interval. Note that these reporter genes incorporate most of the regulatory activities acting on the downstream gene shown in yellow. b, Often, the reporter gene incorporates the enhancer activities that control the expression of one the nearest genes (red gene). c, Tissue-specific reporter gene expression can sometimes be seen at sites close to housekeeping genes (green gene). In addition, two closely linked integration sites may show very distinct expression patterns that reveal highly localized regulatory circuits. d, At some chromosomal sites, the reporter gene is inactive and apparently not capable of capturing enhancer activity.		A model of three hypothetical genes (yellow, red and green) and their hypothetical expression pattern at a given stage of embryonic development are shown. Embryos coloured blue show the activity of a given reporter gene integrated at different chromosomal locations (adapted from ref. 16). They illustrate that genomic context critically determines expression patterns.

			a, various insertion sites may display comparable expression patterns despite being spread over a large chromosomal interval. Note that these reporter genes incorporate most of the regulatory activities acting on the downstream gene shown in yellow.

			b, Often, the reporter gene incorporates the enhancer activities that control the expression of one the nearest genes (red gene).

	Nature12753-f2.jpg		c, Tissue-specific reporter gene expression can sometimes be seen at sites close to housekeeping genes (green gene). In addition, two closely linked integration sites may show very distinct expression patterns that reveal highly localized regulatory circuits.

			d, At some chromosomal sites, the reporter gene is inactive and apparently not capable of capturing enhancer activity.

			===Reference===

			<pubmed>24153303</pubmed>\| [http://www.nature.com/nature/journal/v502/n7472/full/nature12753.html Nature]

			====Copyright====

			http://www.nature.com/nature/journal/v502/n7472/fig_tab/nature12753_F2.html Nature12753-f2.jpg

Z8600021: ==Developmental Gene Expression Model== A model of three hypothetical genes (yellow, red and green) and their hypothetical expression pattern at a given stage of embryonic development are shown. Embryos coloured blue show the activity of a given repor...

2014-03-24T07:23:18Z

New page

==Developmental Gene Expression Model==

A model of three hypothetical genes (yellow, red and green) and their hypothetical expression pattern at a given stage of embryonic development are shown. Embryos coloured blue show the activity of a given reporter gene integrated at different chromosomal locations (adapted from ref. 16). They illustrate that genomic context critically determines expression patterns. Thus, a, various insertion sites may display comparable expression patterns despite being spread over a large chromosomal interval. Note that these reporter genes incorporate most of the regulatory activities acting on the downstream gene shown in yellow. b, Often, the reporter gene incorporates the enhancer activities that control the expression of one the nearest genes (red gene). c, Tissue-specific reporter gene expression can sometimes be seen at sites close to housekeeping genes (green gene). In addition, two closely linked integration sites may show very distinct expression patterns that reveal highly localized regulatory circuits. d, At some chromosomal sites, the reporter gene is inactive and apparently not capable of capturing enhancer activity.

Nature12753-f2.jpg