File:Cloacal septation model.jpg - Revision history

Z8600021: /* Model for cloacal septation */

2012-04-18T13:28:09Z

Model for cloacal septation

← Older revision		Revision as of 00:28, 19 April 2012
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	('''B''') Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activity promotes cell survival, proliferation and apical-basal polarity of cell divisions in the endoderm (red arrows) which facilitates topological separation of the rectum and urethra. Apical-basal polarity of cell divisions is required for epithelial differentiation and expression of K14.		('''B''') Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activity promotes cell survival, proliferation and apical-basal polarity of cell divisions in the endoderm (red arrows) which facilitates topological separation of the rectum and urethra. Apical-basal polarity of cell divisions is required for epithelial differentiation and expression of K14.



	===Reference===		===Reference===

Z8600021: /* Model for cloacal septation */

2012-04-18T13:27:57Z

Model for cloacal septation

← Older revision		Revision as of 00:27, 19 April 2012
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	(A) E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line. (B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activity promotes cell survival, proliferation and apical-basal polarity of cell divisions in the endoderm (red arrows) which facilitates topological separation of the rectum and urethra. Apical-basal polarity of cell divisions is required for epithelial differentiation and expression of K14.		('''A''') E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line.

			('''B''') Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activity promotes cell survival, proliferation and apical-basal polarity of cell divisions in the endoderm (red arrows) which facilitates topological separation of the rectum and urethra. Apical-basal polarity of cell divisions is required for epithelial differentiation and expression of K14.

	===Reference===		===Reference===

Z8600021: ==Model for cloacal septation== (A) E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line. (B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK acti

2012-04-18T13:27:24Z

New page

==Model for cloacal septation==

(A) E11.5 Bmp7lacZ/+ embryo stained with X-gal. Position of the cloacal section depicted in (B) is indicated with dashed line. (B) Signaling by Bmp7 from the URM (blue) activates JNK in the cloacal endoderm. Bmp7/JNK activity promotes cell survival, proliferation and apical-basal polarity of cell divisions in the endoderm (red arrows) which facilitates topological separation of the rectum and urethra. Apical-basal polarity of cell divisions is required for epithelial differentiation and expression of K14.

===Reference===

<pubmed>22253716</pubmed>| [http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0029372 PLoS One.]

Citation: Xu K, Wu X, Shapiro E, Huang H, Zhang L, et al. (2012) Bmp7 Functions via a Polarity Mechanism to Promote Cloacal Septation. PLoS ONE 7(1): e29372. doi:10.1371/journal.pone.0029372

Copyright: © 2012 Xu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.