Developmental Signals - Six - Revision history

Z8600021 at 01:45, 24 Ocak 2019

2019-01-24T01:45:30Z

← Older revision		Revision as of 11:45, 24 Ocak 2019
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	{{Header}}		{{Header}}

	==Introduction==		==Introduction==
	Sine oculis-related homeobox (~~Six~~) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.		Sine oculis-related homeobox ({{SIX}}) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.


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	Search term: ''Development Six''		Search term: ''Development Six''

	~~<pubmed limit=5>Development Six</pubmed>~~
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	==Transcription Factor==		==Transcription Factor==

Z8600021 at 06:11, 1 November 2018

2018-11-01T06:11:00Z

← Older revision		Revision as of 16:11, 1 November 2018
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	==Introduction==		==Introduction==
	Sine oculis-related homeobox (Six) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.		Sine oculis-related homeobox (Six) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.



	~~:''Draft Page.''~~



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			* '''Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human {{omphalocele}}'''{{#pmid:30237319\|PMID30237319}} "Omphalocele is a human congenital anomaly in ventral body wall closure and may be caused by impaired formation of the primary abdominal wall (PAW) and/or defects in abdominal muscle development. Here, we report that mice doubly deficient in homeobox genes Six4 and Six5 showed the same ventral body wall closure defects as those seen in human omphalocele. SIX4 and SIX5 were localized in surface ectodermal cells and somatic mesoderm-derived mesenchymal and coelomic epithelial cells (CECs) in the PAW." {{omphalocele}}

	* '''Activation of Six1 Expression in Vertebrate Sensory Neurons'''{{#pmid:26313368\|PMID26313368}} "SIX1 homeodomain protein is one of the essential key regulators of sensory organ development. Six1-deficient mice lack the olfactory epithelium, vomeronasal organs, cochlea, vestibule and vestibuloacoustic ganglion, and also show poor neural differentiation in the distal part of the cranial ganglia. Simultaneous loss of both Six1 and Six4 leads to additional abnormalities such as small trigeminal ganglion and abnormal dorsal root ganglia (DRG)."		* '''Activation of Six1 Expression in Vertebrate Sensory Neurons'''{{#pmid:26313368\|PMID26313368}} "SIX1 homeodomain protein is one of the essential key regulators of sensory organ development. Six1-deficient mice lack the olfactory epithelium, vomeronasal organs, cochlea, vestibule and vestibuloacoustic ganglion, and also show poor neural differentiation in the distal part of the cranial ganglia. Simultaneous loss of both Six1 and Six4 leads to additional abnormalities such as small trigeminal ganglion and abnormal dorsal root ganglia (DRG)."
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	! More recent papers		! More recent papers
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	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}
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	==Abnormalities==		==Abnormalities==

			{{omphalocele}} - Mice doubly deficient in Six4 and Six5 show ventral body wall defects reproducing human {{omphalocele}} {{#pmid:30237319\|PMID30237319}}

Z8600021 at 11:04, 19 March 2018

2018-03-19T11:04:48Z

← Older revision		Revision as of 21:04, 19 March 2018
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	* '''Activation of Six1 Expression in Vertebrate Sensory Neurons'''~~<ref name=~~PMID26313368~~><pubmed>26313368</pubmed></ref>~~ "SIX1 homeodomain protein is one of the essential key regulators of sensory organ development. Six1-deficient mice lack the olfactory epithelium, vomeronasal organs, cochlea, vestibule and vestibuloacoustic ganglion, and also show poor neural differentiation in the distal part of the cranial ganglia. Simultaneous loss of both Six1 and Six4 leads to additional abnormalities such as small trigeminal ganglion and abnormal dorsal root ganglia (DRG)."		* '''Activation of Six1 Expression in Vertebrate Sensory Neurons'''{{#pmid:26313368\|PMID26313368}} "SIX1 homeodomain protein is one of the essential key regulators of sensory organ development. Six1-deficient mice lack the olfactory epithelium, vomeronasal organs, cochlea, vestibule and vestibuloacoustic ganglion, and also show poor neural differentiation in the distal part of the cranial ganglia. Simultaneous loss of both Six1 and Six4 leads to additional abnormalities such as small trigeminal ganglion and abnormal dorsal root ganglia (DRG)."
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	===Reviews===		===Reviews===
	~~<pubmed></pubmed>~~
	~~<pubmed></pubmed>~~
	~~<pubmed></pubmed>~~
	===Articles===		===Articles===
	~~<pubmed></pubmed>~~		{{#pmid:26313368}}
	~~<pubmed>26313368</pubmed>~~
	~~<pubmed>~~24885223~~</pubmed>~~		{{#pmid:24885223}}
	===Search Pubmed===		===Search Pubmed===

Z8600021 at 00:33, 3 September 2015

2015-09-03T00:33:49Z

← Older revision		Revision as of 10:33, 3 September 2015
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	==Introduction==		==Introduction==
	Sine oculis-related homeobox (Six) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.		Sine oculis-related homeobox (Six) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.



			:''Draft Page.''

Z8600021 at 00:32, 3 September 2015

2015-09-03T00:32:34Z

← Older revision		Revision as of 10:32, 3 September 2015
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	<pubmed></pubmed>		<pubmed></pubmed>
	<pubmed>26313368</pubmed>		<pubmed>26313368</pubmed>
	<pubmed></pubmed>		<pubmed>24885223</pubmed>
	===Search Pubmed===		===Search Pubmed===

Z8600021 at 00:31, 3 September 2015

2015-09-03T00:31:04Z

← Older revision		Revision as of 10:31, 3 September 2015
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	==Introduction==		==Introduction==
			Sine oculis-related homeobox (Six) is a homeobox gene family. In humans, mutations of SIX1 cause branchio-oto-renal (BOR) syndrome, an autosomal dominant disorder characterized by hearing loss, pharyngeal arch defects and various renal abnormalities.

Z8600021: Created page with "{{Header}} ==Introduction== {{Factor Links}} ==Some Recent Findings== {| |-bgcolor="F5FAFF" | * '''Activation of Six1 Expression in Vertebrate Sensory Neurons'''
2015-09-03T00:28:11Z

Created page with "{{Header}} ==Introduction== {{Factor Links}} ==Some Recent Findings== {| |-bgcolor="F5FAFF" | * '''Activation of Six1 Expression in Vertebrate Sensory Neurons'''<ref name=..."

New page
{{Header}}

==Introduction==

{{Factor Links}}
==Some Recent Findings==
{|
|-bgcolor="F5FAFF"
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* '''Activation of Six1 Expression in Vertebrate Sensory Neurons'''<ref name=PMID26313368><pubmed>26313368</pubmed></ref> "SIX1 homeodomain protein is one of the essential key regulators of sensory organ development. Six1-deficient mice lack the olfactory epithelium, vomeronasal organs, cochlea, vestibule and vestibuloacoustic ganglion, and also show poor neural differentiation in the distal part of the cranial ganglia. Simultaneous loss of both Six1 and Six4 leads to additional abnormalities such as small trigeminal ganglion and abnormal dorsal root ganglia (DRG)."
|}
{| class="wikitable mw-collapsible mw-collapsed"
! More recent papers
|-
| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}}

Search term: ''Development Six''

<pubmed limit=5>Development Six</pubmed>
|}
==Transcription Factor==

==Neural Development==

==Vision Development==

==Abnormalities==

==References==
<references/>

'''Search Bookshelf''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=Books&cmd=search&term=Six Six]

===Reviews===
<pubmed></pubmed>
<pubmed></pubmed>
<pubmed></pubmed>
===Articles===
<pubmed></pubmed>
<pubmed>26313368</pubmed>
<pubmed></pubmed>
===Search Pubmed===

'''Search Pubmed Now:''' [http://www.ncbi.nlm.nih.gov/sites/entrez?db=pubmed&cmd=search&term=Six Six]

http://www.ncbi.nlm.nih.gov/omim

==External Links==
{{External Links}}
* OMIM - [http://www.omim.org/entry/601205 Six1]

{{Glossary}}

{{Footer}}

[[Category:Pax]] [[Category:Molecular]] [[Category:Pattern]]
[[Category:Neural]][[Category:Transcription Factor]]