Developmental Mechanism - Time - Revision history

Z8600021 at 03:25, 4 October 2018

2018-10-04T03:25:24Z

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	{{Factor Links}}		{{Factor Links}}
	==Some Recent Findings==		==Some Recent Findings==
	~~[[File:Xenopus red fluorescence.jpg\|thumb\|Xenopus red fluorescence{{#pmid:19549299\|PMID19549299}}]]~~

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Z8600021 at 03:25, 4 October 2018

2018-10-04T03:25:01Z

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	* '''Scaling of pattern formations and morphogen gradients'''{{#pmid:28097650\|PMID28097650}} "The concentration gradient of morphogens provides positional information for an embryo and plays a pivotal role in pattern formation of tissues during the developmental processes. Morphogen-dependent pattern formations show robustness despite various perturbations. Although tissues usually grow and dynamically change their size during histogenesis, proper patterns are formed without the influence of size variations. Furthermore, even when the blastula embryo of Xenopus laevis is bisected into dorsal and ventral halves, the dorsal half of the embryo leads to proportionally patterned half-sized embryos. This robustness of pattern formation despite size variations is termed as scaling. In this review, I focused on the morphogen-dependent dorsal-ventral axis formation in Xenopus and described how morphogens form a proper gradient shape according to the embryo size."		* '''Scaling of pattern formations and morphogen gradients'''{{#pmid:28097650\|PMID28097650}} "The concentration gradient of morphogens provides positional information for an embryo and plays a pivotal role in pattern formation of tissues during the developmental processes. Morphogen-dependent pattern formations show robustness despite various perturbations. Although tissues usually grow and dynamically change their size during histogenesis, proper patterns are formed without the influence of size variations. Furthermore, even when the blastula embryo of Xenopus laevis is bisected into dorsal and ventral halves, the dorsal half of the embryo leads to proportionally patterned half-sized embryos. This robustness of pattern formation despite size variations is termed as scaling. In this review, I focused on the morphogen-dependent dorsal-ventral axis formation in Xenopus and described how morphogens form a proper gradient shape according to the embryo size."

			* '''Heterochrony and Morphological Variation of Epithalamic Asymmetry'''{{#pmid:27659033\|PMID27659033}} "Heterochrony is one proposed mechanism to explain how morphological variation and novelty arise during evolution. To experimentally approach heterochrony in a comprehensive manner, we must consider all three aspects of developmental time (sequence, timing, duration). This task is only possible in developmental models that allow the acquisition of high-quality temporal data in the context of normalized developmental time. Here we propose that epithalamic asymmetry of teleosts is one such model. Comparative studies among related teleost species have revealed heterochronic shifts in the timing of ontogenic events leading to the development of epithalamic asymmetry. Such temporal changes involve neural structures critical for tissue-tissue interactions underlying the generation of asymmetry and are concurrent with the appearance of morphological differences in the pattern of asymmetry between species. Based on these findings, we hypothesize that interspecies variation of epithalamic asymmetry results from changes in the timing of tissue-tissue interactions critical for the establishment of asymmetry during ontogeny. Importantly, this hypothesis can be tested by systematic comparative approaches among teleosts species based on normalized developmental time, combined with experimental manipulation of epithalamic asymmetry development."

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Z8600021 at 03:06, 4 October 2018

2018-10-04T03:06:38Z

← Older revision		Revision as of 13:06, 4 October 2018
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	{{Header}}		{{Header}}
	==Introduction==		==Introduction==
	These notes are intended to introduce the concept of time as a developmental mechanism.		These notes are intended to introduce the concept of time as a developmental mechanism. See also [[Timeline human development]].

	The concept can historically be seen in the staging of development and gestation by hours, days, and months ~~in different species~~.		The concept can historically be seen in the staging of different species development and gestation by hours, days, and months.

			More recently with molecular development and cellular dynamics we are looking at changes in the range from minutes down.

	{{Mechanism Links}}		{{Mechanism Links}}

Z8600021: Created page with "{{Header}} ==Introduction== These notes are intended to introduce the concept of time as a developmental mechanism. The concept can historically be seen in the staging of de..."

2018-10-04T03:04:11Z

Created page with "{{Header}} ==Introduction== These notes are intended to introduce the concept of time as a developmental mechanism. The concept can historically be seen in the staging of de..."

New page

{{Header}}
==Introduction==
These notes are intended to introduce the concept of time as a developmental mechanism.

The concept can historically be seen in the staging of development and gestation by hours, days, and months in different species.

{{Mechanism Links}}

{{Molecular Links}}

{{Factor Links}}
==Some Recent Findings==
[[File:Xenopus red fluorescence.jpg|thumb|Xenopus red fluorescence{{#pmid:19549299|PMID19549299}}]]

{|
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* '''Scaling of pattern formations and morphogen gradients'''{{#pmid:28097650|PMID28097650}} "The concentration gradient of morphogens provides positional information for an embryo and plays a pivotal role in pattern formation of tissues during the developmental processes. Morphogen-dependent pattern formations show robustness despite various perturbations. Although tissues usually grow and dynamically change their size during histogenesis, proper patterns are formed without the influence of size variations. Furthermore, even when the blastula embryo of Xenopus laevis is bisected into dorsal and ventral halves, the dorsal half of the embryo leads to proportionally patterned half-sized embryos. This robustness of pattern formation despite size variations is termed as scaling. In this review, I focused on the morphogen-dependent dorsal-ventral axis formation in Xenopus and described how morphogens form a proper gradient shape according to the embryo size."
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! More recent papers  
|-
| [[File:Mark_Hill.jpg|90px|left]] {{Most_Recent_Refs}}

Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Developmental+Mechanisms ''Developmental Mechanisms'']

<pubmed limit=5>Developmental Mechanisms</pubmed>
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==Species Timelines==
{{CarnegieComparisonHRM}}

{{timeline}}

== References ==
<references/>

===Journals===

===Reviews===

===Search PubMed===

'''Search PubMed:''' [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=search&term=Developmental+Mechanisms Developmental Mechanisms]

==External Links==
{{External Links}}

{{Mechanism Links}}

{{Glossary}}

{{Footer}}

[[Category:Developmental Mechanism]]