Developmental Mechanism - Mesenchymal Epithelial Transition - Revision history

Z8600021 at 23:56, 12 September 2020

2020-09-12T23:56:29Z

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	{{#pmid:28811330}}		{{#pmid:28811330}}

			{{#pmid:17587803}}

	===Articles===		===Articles===

Z8600021 at 23:55, 12 September 2020

2020-09-12T23:55:57Z

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			* '''Mesenchymal-epithelial transition regulates initiation of pluripotency exit before {{gastrulation}}'''{{#pmid:32014865\|PMID32014865}} "The pluripotent epiblast gives rise to all tissues and organs in the adult body. Its differentiation starts at {{gastrulation}}, when the {{epiblast}} generates {{mesoderm}} and {{endoderm}} germ layers through epithelial-mesenchymal transition (EMT). Although gastrulation EMT coincides with loss of epiblast pluripotency, pluripotent cells in development and in vitro can adopt either mesenchymal or epithelial morphology. The relationship between epiblast cellular morphology and its pluripotency is not well understood. Here, using chicken epiblast and mammalian pluripotency stem cell (PSC) models, we show that PSCs undergo a mesenchymal-epithelial transition (MET) prior to EMT-associated pluripotency loss. Epiblast MET and its subsequent EMT are two distinct processes. The former, a partial MET, is associated with reversible initiation of pluripotency exit, whereas the latter, a full EMT, is associated with complete and irreversible pluripotency loss. We provide evidence that integrin-mediated cell-matrix interaction is a key player in pluripotency exit regulation. We propose that epiblast partial MET is an evolutionarily conserved process among all amniotic vertebrates and that epiblast pluripotency is restricted to an intermediate cellular state residing between the fully mesenchymal and fully epithelial states.}

	* '''Evidence from a Mouse Model That Epithelial Cell Migration and Mesenchymal-Epithelial Transition Contribute to Rapid Restoration of Uterine Tissue Integrity during Menstruation.'''{{#pmid:24466063\|PMID24466063}} "In women dynamic changes in uterine tissue architecture occur during each menstrual cycle. Menses, characterised by the shedding of the upper functional layer of the endometrium, is the culmination of a cascade of irreversible changes in tissue function including stromal decidualisation, inflammation and production of degradative enzymes. The molecular mechanisms that contribute to the rapid restoration of tissue homeostasis at time of menses are poorly understood. ...Analysis of mRNAs encoding genes expressed exclusively in the epithelial or stromal compartments, or implicated in MET, revealed dynamic changes in expression, consistent with a role for reprogramming of mesenchymal cells so that they could contribute to re-epithelialisation."		* '''Evidence from a Mouse Model That Epithelial Cell Migration and Mesenchymal-Epithelial Transition Contribute to Rapid Restoration of Uterine Tissue Integrity during Menstruation.'''{{#pmid:24466063\|PMID24466063}} "In women dynamic changes in uterine tissue architecture occur during each menstrual cycle. Menses, characterised by the shedding of the upper functional layer of the endometrium, is the culmination of a cascade of irreversible changes in tissue function including stromal decidualisation, inflammation and production of degradative enzymes. The molecular mechanisms that contribute to the rapid restoration of tissue homeostasis at time of menses are poorly understood. ...Analysis of mRNAs encoding genes expressed exclusively in the epithelial or stromal compartments, or implicated in MET, revealed dynamic changes in expression, consistent with a role for reprogramming of mesenchymal cells so that they could contribute to re-epithelialisation."
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	===Reviews===		===Reviews===

			{{#pmid:28811330}}

	===Articles===		===Articles===

Z8600021 at 23:52, 12 September 2020

2020-09-12T23:52:32Z

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	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Mesenchymal+Epithelial+Transition ''Mesenchymal Epithelial Transition'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Mesenchymal+Epithelial+Transition ''Mesenchymal Epithelial Transition'']

	\|}		\|}
			{\| class="wikitable mw-collapsible mw-collapsed"
			! Older papers
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			\| {{Older papers}}
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	The alternate process involves the conversion of the embryonic connective tissue organization (mesenchyme) to an epithelial organization (epithelium) that can occur during developmental processes.		The alternate process involves the conversion of the embryonic connective tissue organization (mesenchyme) to an epithelial organization (epithelium) that can occur during developmental processes.

	This process can be seen occurring during early ~~[[Somitogenesis\|~~somitogenesis]].		This process can be seen occurring during early {{somitogenesis}}.


	It is also suggested that this mechanism occurs in the maternal uterus during endometrial regeneration following decidualization.~~<ref name=~~PMID24466063~~><pubmed>24466063</pubmed></ref><ref><pubmed>23216285</pubmed></ref>~~		It is also suggested that this mechanism occurs in the maternal uterus during endometrial regeneration following decidualization.{{#pmid:24466063\|PMID24466063}}


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	===Reviews===		===Reviews===
	~~<pubmed></pubmed>~~

	===Articles===		===Articles===

Z8600021 at 23:51, 12 September 2020

2020-09-12T23:51:07Z

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	Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Mesenchymal+Epithelial+Transition ''Mesenchymal Epithelial Transition'']		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Mesenchymal+Epithelial+Transition ''Mesenchymal Epithelial Transition'']

	~~<pubmed limit=5> Mesenchymal Epithelial Transition</pubmed>~~
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	:'''Links:''' [[Renal_System_-_Molecular\|Renal Molecular]] \| [[Renal System Development]]		:'''Links:''' [[Renal_System_-_Molecular\|Renal Molecular]] \| [[Renal System Development]]

	== References ==		== References ==
	<references/>		<references/>

Z8600021 at 22:35, 16 April 2018

2018-04-16T22:35:26Z

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	[[File:Chicken-gastrulation2.jpg\|thumb\|300px\|Gastrulation epithelial to mesenchymal transition]]		[[File:Chicken-gastrulation2.jpg\|thumb\|300px\|Gastrulation epithelial to mesenchymal transition]]

	In {{mesenchymal epithelial transition}}, mesenchymal cells form an embryonic connective tissue with a disorganised cellular organisation can undergo transition to an epithelial organisation (organised cellular layer) as a developmental process and are said to have undergone a Mesenchymal to Epithelial Transition (MET). This ~~morphologically~~ appears to be the opposite process to that seen in ~~[[Developmental Mechanism - Mesenchymal Epithelial Transition\|~~epithelial to mesenchymal transition]].		In {{mesenchymal epithelial transition}}, mesenchymal cells form an embryonic connective tissue with a disorganised cellular organisation can undergo transition to an epithelial organisation (organised cellular layer) as a developmental process and are said to have undergone a Mesenchymal to Epithelial Transition (MET). This morphological change appears to be the opposite process to that seen in {{epithelial mesenchymal transition}}.

Z8600021 at 22:26, 16 April 2018

2018-04-16T22:26:21Z

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	[[File:Chicken-gastrulation2.jpg\|thumb\|300px\|Gastrulation epithelial to mesenchymal transition]]		[[File:Chicken-gastrulation2.jpg\|thumb\|300px\|Gastrulation epithelial to mesenchymal transition]]

	~~Mesenchymal~~ cells, embryonic connective tissue with a disorganised cellular organisation can undergo transition to an epithelial organisation (organised cellular layer) as a developmental process and are said to have undergone a Mesenchymal to Epithelial Transition (MET). This morphologically appears to be the opposite process to that seen in [[Developmental Mechanism - Mesenchymal Epithelial Transition\|epithelial to mesenchymal transition]].		In {{mesenchymal epithelial transition}}, mesenchymal cells form an embryonic connective tissue with a disorganised cellular organisation can undergo transition to an epithelial organisation (organised cellular layer) as a developmental process and are said to have undergone a Mesenchymal to Epithelial Transition (MET). This morphologically appears to be the opposite process to that seen in [[Developmental Mechanism - Mesenchymal Epithelial Transition\|epithelial to mesenchymal transition]].


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	* '''Evidence from a Mouse Model That Epithelial Cell Migration and Mesenchymal-Epithelial Transition Contribute to Rapid Restoration of Uterine Tissue Integrity during Menstruation.'''~~<ref name=~~PMID24466063~~><pubmed>24466063</pubmed></ref>~~ "In women dynamic changes in uterine tissue architecture occur during each menstrual cycle. Menses, characterised by the shedding of the upper functional layer of the endometrium, is the culmination of a cascade of irreversible changes in tissue function including stromal decidualisation, inflammation and production of degradative enzymes. The molecular mechanisms that contribute to the rapid restoration of tissue homeostasis at time of menses are poorly understood. ...Analysis of mRNAs encoding genes expressed exclusively in the epithelial or stromal compartments, or implicated in MET, revealed dynamic changes in expression, consistent with a role for reprogramming of mesenchymal cells so that they could contribute to re-epithelialisation."		* '''Evidence from a Mouse Model That Epithelial Cell Migration and Mesenchymal-Epithelial Transition Contribute to Rapid Restoration of Uterine Tissue Integrity during Menstruation.'''{{#pmid:24466063\|PMID24466063}} "In women dynamic changes in uterine tissue architecture occur during each menstrual cycle. Menses, characterised by the shedding of the upper functional layer of the endometrium, is the culmination of a cascade of irreversible changes in tissue function including stromal decidualisation, inflammation and production of degradative enzymes. The molecular mechanisms that contribute to the rapid restoration of tissue homeostasis at time of menses are poorly understood. ...Analysis of mRNAs encoding genes expressed exclusively in the epithelial or stromal compartments, or implicated in MET, revealed dynamic changes in expression, consistent with a role for reprogramming of mesenchymal cells so that they could contribute to re-epithelialisation."
	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"

Z8600021 at 02:24, 27 August 2016

2016-08-27T02:24:29Z

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	* '''Evidence from a Mouse Model That Epithelial Cell Migration and Mesenchymal-Epithelial Transition Contribute to Rapid Restoration of Uterine Tissue Integrity during Menstruation.'''<ref name=PMID24466063><pubmed>24466063</pubmed></ref> "In women dynamic changes in uterine tissue architecture occur during each menstrual cycle. Menses, characterised by the shedding of the upper functional layer of the endometrium, is the culmination of a cascade of irreversible changes in tissue function including stromal decidualisation, inflammation and production of degradative enzymes. The molecular mechanisms that contribute to the rapid restoration of tissue homeostasis at time of menses are poorly understood. ...Analysis of mRNAs encoding genes expressed exclusively in the epithelial or stromal compartments, or implicated in MET, revealed dynamic changes in expression, consistent with a role for reprogramming of mesenchymal cells so that they could contribute to re-epithelialisation."		* '''Evidence from a Mouse Model That Epithelial Cell Migration and Mesenchymal-Epithelial Transition Contribute to Rapid Restoration of Uterine Tissue Integrity during Menstruation.'''<ref name=PMID24466063><pubmed>24466063</pubmed></ref> "In women dynamic changes in uterine tissue architecture occur during each menstrual cycle. Menses, characterised by the shedding of the upper functional layer of the endometrium, is the culmination of a cascade of irreversible changes in tissue function including stromal decidualisation, inflammation and production of degradative enzymes. The molecular mechanisms that contribute to the rapid restoration of tissue homeostasis at time of menses are poorly understood. ...Analysis of mRNAs encoding genes expressed exclusively in the epithelial or stromal compartments, or implicated in MET, revealed dynamic changes in expression, consistent with a role for reprogramming of mesenchymal cells so that they could contribute to re-epithelialisation."
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	{\| class="wikitable collapsible collapsed"		! More recent papers
	! More recent papers
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	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

Z8600021 at 02:23, 27 August 2016

2016-08-27T02:23:37Z

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	\| During early somite formation (somitogenesis) the mesenchymal paraxial mesoderm undergoes a MET to form the initial segment of the somite "ball". This ball of mesoderm has an epithelial outer layer and a core of mesenchyme. The early somite also contains a space, the somitoceol, that is lost as the mesoderm proliferates to form a solid ball.		\| During early somite formation (somitogenesis) the mesenchymal paraxial mesoderm undergoes a MET to form the initial segment of the somite "ball". This ball of mesoderm has an epithelial outer layer and a core of mesenchyme. The early somite also contains a space, the somitoceol, that is lost as the mesoderm proliferates to form a solid ball.

	The epithelial layer then breaks down as the somite disperses to form sclerotome and dermomyotome. The dermomyotome initially remains as an epithelial layer, that also is lost as the dermatome and myotome proliferate and migrate.		The somite epithelial layer then breaks down as the somite disperses to form the sclerotome and dermomyotome. The dermomyotome initially remains as an epithelial layer, that also is lost as the dermatome and myotome proliferate and migrate.




	:'''Links:''' [[Somitogenesis]]		:'''Links:''' [[Somitogenesis]]

Z8600021 at 02:22, 27 August 2016

2016-08-27T02:22:43Z

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	==Somitogenesis==		==Somitogenesis==
	~~[[File:Stage11 sem100.jpg~~\|~~thumb~~\|~~300px\|Human embryo ([[week 4]], [[Carnegie stage 11]]) Somites]]~~		{\|
	During early somite formation (somitogenesis) the mesenchymal paraxial mesoderm undergoes a MET to form the initial segment of the somite "ball". This ball of mesoderm has an epithelial outer layer and a core of mesenchyme. The early somite also contains a space, the somitoceol, that is lost as the mesoderm proliferates to form a solid ball.		\| During early somite formation (somitogenesis) the mesenchymal paraxial mesoderm undergoes a MET to form the initial segment of the somite "ball". This ball of mesoderm has an epithelial outer layer and a core of mesenchyme. The early somite also contains a space, the somitoceol, that is lost as the mesoderm proliferates to form a solid ball.

	The epithelial layer then breaks down as the somite disperses to form sclerotome and dermomyotome. The dermomyotome initially remains as an epithelial layer, that also is lost as the dermatome and myotome proliferate and migrate.		The epithelial layer then breaks down as the somite disperses to form sclerotome and dermomyotome. The dermomyotome initially remains as an epithelial layer, that also is lost as the dermatome and myotome proliferate and migrate.

	:'''Links:''' [[Somitogenesis]]		:'''Links:''' [[Somitogenesis]]
			\| [[File:Stage11 sem100.jpg\|300px]]

			Human embryo ([[week 4]], [[Carnegie stage 11]]) somites
			\|}
	==Renal==		==Renal==
	{\|		{\|

Z8600021 at 02:21, 27 August 2016

2016-08-27T02:21:53Z

← Older revision		Revision as of 13:21, 27 August 2016
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	==Somitogenesis==		==Somitogenesis==
			[[File:Stage11 sem100.jpg\|thumb\|300px\|Human embryo ([[week 4]], [[Carnegie stage 11]]) Somites]]
	During early somite formation (somitogenesis) the mesenchymal paraxial mesoderm undergoes a MET to form the initial segment of the somite "ball". This ball of mesoderm has an epithelial outer layer and a core of mesenchyme. The early somite also contains a space, the somitoceol, that is lost as the mesoderm proliferates to form a solid ball.		During early somite formation (somitogenesis) the mesenchymal paraxial mesoderm undergoes a MET to form the initial segment of the somite "ball". This ball of mesoderm has an epithelial outer layer and a core of mesenchyme. The early somite also contains a space, the somitoceol, that is lost as the mesoderm proliferates to form a solid ball.