Developmental Mechanism - Left-Right Axis - Revision history

Z8600021 at 02:44, 18 Ocak 2019

2019-01-18T02:44:18Z

← Older revision		Revision as of 13:44, 18 Ocak 2019
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	* vertebrates - left side {{Nodal}} expression		* vertebrates - left side {{Nodal}} expression
	* sea urchins - right side {{Nodal}} expression, inhibit the right mesodermal coelomic pouch (CP) from forming the adult rudiment		* sea urchins - right side {{Nodal}} expression, inhibit the right mesodermal coelomic pouch (CP) from forming the adult rudiment
			<br>
	Signaling Factors		Signaling Factors
	* {{Nodal}} - induces its own expression and that of Lefty.		* {{Nodal}} - induces its own expression and that of Lefty.
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	\| Embryo left-right asymmetry pathway{{#pmid:23256866\|PMID23256866}}		\| Embryo left-right asymmetry pathway{{#pmid:23256866\|PMID23256866}}
	\|}		\|}
			<br>
	{{Axes Links}}		{{Axes Links}}

Z8600021 at 01:50, 18 Ocak 2019

2019-01-18T01:50:24Z

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	\|}		\|}
	{\| class="wikitable mw-collapsible mw-collapsed"		{\| class="wikitable mw-collapsible mw-collapsed"
	! More recent papers		! More recent papers
	\|-		\|-
	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

Z8600021 at 01:48, 18 Ocak 2019

2019-01-18T01:48:04Z

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	\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}		\| [[File:Mark_Hill.jpg\|90px\|left]] {{Most_Recent_Refs}}

	Search term: ''Left-Right Axis''		Search term: [http://www.ncbi.nlm.nih.gov/pubmed/?term=Left-Right+Axis ''Left-Right Axis''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Axis+Formation ''Axis Formation''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Molecular+Axis+Development ''Molecular Axis Development''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Dorso-ventral+Axis ''Dorso-ventral Axis''] \| [http://www.ncbi.nlm.nih.gov/pubmed/?term=Rostro-caudal+Axis ''Rostro-caudal Axis'']

	\|}		\|}

Z8600021 at 01:33, 18 Ocak 2019

2019-01-18T01:33:53Z

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	\|}		\|}

			{{Axes Links}}

	[[Developmental_Mechanism_-_Axes_Formation\|Axes Formation]]: [[Developmental Mechanism - Dorsal-Ventral Axis\|Dorsal-Ventral Axis]] \| [[Developmental Mechanism - Cranio-Caudal Axis\|Cranio-Caudal Axis]] \| {{left-right axis}}		<br>

	{{Mechanism Links}}		{{Mechanism Links}}

Z8600021 at 01:30, 18 Ocak 2019

2019-01-18T01:30:03Z

← Older revision		Revision as of 12:30, 18 Ocak 2019
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	[[Developmental_Mechanism_-_Axes_Formation\|Axes Formation]]: [[Developmental Mechanism - Dorsal-Ventral Axis\|Dorsal-Ventral Axis]] \| [[Developmental Mechanism - Cranio-Caudal Axis\|Cranio-Caudal Axis]] \| {{~~Left~~-~~Right Axis~~}}		[[Developmental_Mechanism_-_Axes_Formation\|Axes Formation]]: [[Developmental Mechanism - Dorsal-Ventral Axis\|Dorsal-Ventral Axis]] \| [[Developmental Mechanism - Cranio-Caudal Axis\|Cranio-Caudal Axis]] \| {{left-right axis}}

	{{Mechanism Links}}		{{Mechanism Links}}

Z8600021 at 01:29, 18 Ocak 2019

2019-01-18T01:29:37Z

← Older revision		Revision as of 12:29, 18 Ocak 2019
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	{{Header}}		{{Header}}

	==Introduction==		==Introduction==

	''Draft Page - notice removed when complete.''		''Draft Page - notice removed when complete.''


	[[File:Anatomical_axes_comparison.jpg\|300px\|thumb\|alt=Anatomical axes comparison\|Anatomical axes comparison]]		[[File:Anatomical_axes_comparison.jpg\|300px\|thumb\|alt=Anatomical axes comparison\|Anatomical axes comparison]]
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	Left-right axis (L-R) transverse plane		Left-right axis (L-R) transverse plane

	* vertebrates - left side Nodal expression		* vertebrates - left side {{Nodal}} expression
	* sea urchins - right side Nodal expression, inhibit the right mesodermal coelomic pouch (CP) from forming the adult rudiment		* sea urchins - right side {{Nodal}} expression, inhibit the right mesodermal coelomic pouch (CP) from forming the adult rudiment

	Signaling Factors		Signaling Factors
	* Nodal - induces its own expression and that of Lefty.		* {{Nodal}} - induces its own expression and that of Lefty.
	* Lefty - a Nodal feedback inhibitor with a longer diffusion range.		* Lefty - a Nodal feedback inhibitor with a longer diffusion range.
	{\|		{\|
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	[[Developmental_Mechanism_-_Axes_Formation\|Axes Formation]]: [[Developmental Mechanism - Dorsal-Ventral Axis\|Dorsal-Ventral Axis]] \| [[Developmental Mechanism - Cranio-Caudal Axis\|Cranio-Caudal Axis]] \| ~~[[Developmental Mechanism - Left-Right Axis\|~~Left-Right Axis]]		[[Developmental_Mechanism_-_Axes_Formation\|Axes Formation]]: [[Developmental Mechanism - Dorsal-Ventral Axis\|Dorsal-Ventral Axis]] \| [[Developmental Mechanism - Cranio-Caudal Axis\|Cranio-Caudal Axis]] \| {{Left-Right Axis}}

	{{Mechanism Links}}		{{Mechanism Links}}

Z8600021 at 01:28, 18 Ocak 2019

2019-01-18T01:28:34Z

← Older revision		Revision as of 12:28, 18 Ocak 2019
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	\|-		\|-
	\| Primitive node cilia (human [[Carnegie stage 8\|stage 8]])		\| Primitive node cilia (human [[Carnegie stage 8\|stage 8]])
	\| Embryo left-right asymmetry pathway~~<ref name="PMID23256866"><pubmed>~~23256866~~</pubmed>~~\| ~~[http://www.biomedcentral.com/1741-7007/10/102 BMC Biology]</ref>~~		\| Embryo left-right asymmetry pathway{{#pmid:23256866\|PMID23256866}}
	\|}		\|}

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	\|-bgcolor="F5FAFF"		\|-bgcolor="F5FAFF"
	\|		\|
	* '''~~Paraxial Nodal Expression Reveals a Novel Conserved Structure~~ of ~~the Left-Right Organizer in Four Mammalian Species~~'''~~<ref name=PMID26741372><pubmed>26741372</pubmed></ref>~~ "~~Nodal activity~~ in the ~~left lateral plate~~ mesoderm is a ~~conserved sign~~ of ~~irreversible left-right asymmetry at early somite stages of the vertebrate embryo~~. ~~An earlier~~, ~~paraxial nodal domain accompanies~~ the ~~emergence~~ and ~~initial extension~~ of the ~~notochord~~ and ~~is either left~~-~~sided, as~~ in the ~~chick~~ and ~~pig~~, ~~or symmetrical~~, as in the ~~mouse~~ and ~~rabbit; intriguingly~~, ~~this interspecific dichotomy is mirrored by divergent morphological features of the posterior notochord (also known as the left-right organizer)~~, ~~which is ventrally exposed to the yolk sac cavity~~ and ~~carries motile cilia~~ in ~~the latter 2 species only~~. ~~By introducing the cattle embryo as a new model organism for early left-right patterning~~, ~~we present data to establish 2 groups~~ of ~~mammals characterized by both the morphology~~ of ~~the left-right organizer~~ and the ~~dynamics~~ of ~~paraxial nodal expression: presence and absence of a ventrally open surface of the early (plate-like) posterior notochord correlates with a symmetrical (in mice~~ and ~~rabbits) versus an asymmetrical (in pigs and cattle) paraxial nodal~~ expression ~~domain next to the notochordal plate~~. ~~High-resolution histological analysis reveals that the latter domain defines in all 4 mammals a novel 'parachordal' axial mesoderm compartment~~, the ~~topography~~ of ~~which changes according to the specific regression of the similarly novel subchordal mesoderm during the initial phases of notochord development~~. ~~In conclusion~~, the mammalian axial mesoderm compartment (1) shares critical conserved features despite the marked differences in early notochord morphology and early left-right patterning and (2) provides a dynamic topographical framework for nodal activity as part of ~~the mammalian left-right organiser~~."		* '''{{Zebrafish}} znfl1s regulate left-right asymmetry patterning through controlling the expression of fgfr1a'''{{#pmid:30317609\|PMID30317609}} "Proper left-right (LR) axis establishment is critical for organogenesis in vertebrates. Previously, we reported that zinc finger transcription factors zinc finger transcription factor 1 (znfl1s) are expressed in the tailbud and axial mesoderm in zebrafish. However, a role of znfl1s in LR axis development has not been demonstrated. Here, we discovered that the knockdown of znfl1s using morpholino (MO) in whole embryos or dorsal forerunner cells (DFCs) interrupted LR asymmetry and normal development of the heart, liver, and pancreas. Whole-embryo knockdown of znfl1s by MO or clustered regularly interspaced short palindromic repeat (CRISPR) interference (CRISPRi) resulted in the absent expression of nodal gene spaw and Nodal signaling-related genes lft1, lft2, and pitx2c in the left lateral plate mesoderm (LPM), and Spaw, Lft1, Lft2, and Pitx2c play important roles in LR axis development in zebrafish. However, specific knockdown of znfl1s in DFCs resulted in random expression of spaw, lft1, lft2, and pitx2c. Knockdown of znfl1s led to abnormal cilia formation by the downregulation of fgfr1a and foxj1a expression. The expression of spaw, lft1, lft2, and pitx2c was partially rescued by the overexpression of fgfr1a mRNA in znfl1s morphants. Taken together, our results suggest that znfl1s regulate laterality development in zebrafish embryos through controlling the expression of fgfr1a."

			* '''Paraxial Nodal Expression Reveals a Novel Conserved Structure of the Left-Right Organizer in Four Mammalian Species'''{{#pmid:30317609\|PMID26741372}} "Nodal activity in the left lateral plate mesoderm is a conserved sign of irreversible left-right asymmetry at early somite stages of the vertebrate embryo. An earlier, paraxial nodal domain accompanies the emergence and initial extension of the notochord and is either left-sided, as in the chick and pig, or symmetrical, as in the mouse and rabbit; intriguingly, this interspecific dichotomy is mirrored by divergent morphological features of the posterior notochord (also known as the left-right organizer), which is ventrally exposed to the yolk sac cavity and carries motile cilia in the latter 2 species only. By introducing the cattle embryo as a new model organism for early left-right patterning, we present data to establish 2 groups of mammals characterized by both the morphology of the left-right organizer and the dynamics of paraxial nodal expression: presence and absence of a ventrally open surface of the early (plate-like) posterior notochord correlates with a symmetrical (in mice and rabbits) versus an asymmetrical (in pigs and cattle) paraxial nodal expression domain next to the notochordal plate. High-resolution histological analysis reveals that the latter domain defines in all 4 mammals a novel 'parachordal' axial mesoderm compartment, the topography of which changes according to the specific regression of the similarly novel subchordal mesoderm during the initial phases of notochord development. In conclusion, the mammalian axial mesoderm compartment (1) shares critical conserved features despite the marked differences in early notochord morphology and early left-right patterning and (2) provides a dynamic topographical framework for nodal activity as part of the mammalian left-right organiser."

	\|}		\|}
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	Search term: ''Left-Right Axis''		Search term: ''Left-Right Axis''

	~~<pubmed limit=5>Left-Right Axis</pubmed>~~
	\|}		\|}

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	===Reviews===		===Reviews===
	~~<pubmed></pubmed>~~
	~~<pubmed></pubmed>~~

	===Articles===		===Articles===
	~~<pubmed></pubmed>~~

Z8600021 at 04:07, 18 Ocak 2016

2016-01-18T04:07:22Z

← Older revision		Revision as of 15:07, 18 Ocak 2016
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	==Lefty1==		==Lefty1==
	Lefty1 and Lefty2 are expressed in developing mouse embryos on the left side. These are members of the TGF-beta gene family.		Lefty1 and Lefty2 are expressed in developing mouse embryos on the left side. These are members of the TGF-beta gene family.

			LEFTY A and LEFTY B are the human homologues of murine genes implicated in left-right axis development.


	:'''Links:''' [http://omim.org/entry/603037 OMIM603037]		:'''Links:''' [http://omim.org/entry/603037 OMIM603037]

Z8600021 at 04:06, 18 Ocak 2016

2016-01-18T04:06:05Z

← Older revision		Revision as of 15:06, 18 Ocak 2016
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	==Lefty1==		==Lefty1==
	Lefty1 and Lefty2 are expressed in developing mouse embryos on the left side.		Lefty1 and Lefty2 are expressed in developing mouse embryos on the left side. These are members of the TGF-beta gene family.

	:'''Links:''' [http://omim.org/entry/603037 OMIM603037]		:'''Links:''' [http://omim.org/entry/603037 OMIM603037]

Z8600021 at 04:05, 18 Ocak 2016

2016-01-18T04:05:22Z

← Older revision		Revision as of 15:05, 18 Ocak 2016
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	==Lefty1==		==Lefty1==
			Lefty1 and Lefty2 are expressed in developing mouse embryos on the left side.

	:'''Links:''' [http://omim.org/entry/603037 OMIM603037]		:'''Links:''' [http://omim.org/entry/603037 OMIM603037]